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Margaret Tonda
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Journal Articles

Long-Term Safety and Efficacy of Voxelotor for Patients with Sickle Cell Disease: Results from an Open-Label Extension of the Phase 3 HOPE Trial

Free
Maureen Achebe, Hoda Hassab, Salam Alkindi, R. Clark Clark Brown, Paul Telfer, Bart J. Biemond, Victor R. Gordeuk, Thokozeni Lipato, Margaret Tonda, Sarah Gray, Joanna Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3114.
https://doi.org/10.1182/blood-2021-153582
Published: 2021
Journal Articles

Higher Hemoglobin Levels Achieved with Voxelotor Are Associated with Lower Vaso-occlusive Crisis Incidence: 72-Week Analysis from the HOPE Study

Free
Elliott Vichinsky, MD, Victor R. Gordeuk, MD, Paul Telfer, DM, FRCP, Adlette Inati, MD FAAP, Margaret Tonda, PharmD, Sarah Gray, PhD, Irene Agodoa, MD, Kenneth I. Ataga, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-140863
Published: 2020
Journal Articles

Efficacy and Safety of Voxelotor in Adolescents and Adults with Sickle Cell Disease: HOPE Trial 72-Week Analysis

Free
Jo Howard, MBBChir, MRCP, FRCPath, Kenneth I. Ataga, MD, R. Clark Brown, MD PhD, Maureen Achebe, MD MPH, Videlis Nduba, MD, Amal El-Beshlawy, MD, Hoda Hassab, MD, Irene Agodoa, MD, Margaret Tonda, PharmD, Sarah Gray, PhD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Elliott Vichinsky, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19.
https://doi.org/10.1182/blood-2020-140553
Published: 2020
Journal Articles

Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study

Free
Russell E. Ware, MD PhD, Clark Brown, MD PhD, Mariane de Montalembert, MD PhD, Margaret Tonda, PharmD, Barbara Tong, PhD, Carolyn Hoppe, MD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Miguel R. Abboud, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1003.
https://doi.org/10.1182/blood-2019-130767
Published: 2019
Journal Articles

Correlation of Voxelotor Exposure with Hemoglobin Response and Measures of Hemolysis in Patients from the HOPE Study

Free
Jo Howard, MB, BChir, Elliott Vichinsky, MD UCSF, Jennifer Knight-Madden, MBBS, PhD, Margaret Tonda, PharmD, Carla Washington, Barbara Tong, PhD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Victor R Gordeuk, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1020.
https://doi.org/10.1182/blood-2019-130802
Published: 2019
Journal Articles

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Free
Satheesh Chonat, MD, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, PhD, Sandy Dixon, Margaret Tonda, PharmD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Clark Brown, MD PhD, David R. Archer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2281.
https://doi.org/10.1182/blood-2019-129351
Published: 2019
Journal Articles

Incidence of Vaso-Occlusive Crisis Does Not Increase with Achieving Higher Hemoglobin Levels on Voxelotor Treatment or after Discontinuation: Analyses of the HOPE Study

Free
Elliott P. Vichinsky, MD, Paul Telfer, DM, FRCP, Adlette Inati, MD, Margaret Tonda, PharmD, Barbara Tong, PhD, Irene Agodoa, MD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Kenneth I. Ataga, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2313.
https://doi.org/10.1182/blood-2019-129026
Published: 2019
Journal Articles

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Free
Clinical Trials & Observations
Jo Howard, Claire Jane Hemmaway, Paul Telfer, D. Mark Layton, John Porter, Moji Awogbade, Timothy Mant, Daniel D. Gretler, Kobina Dufu, Athiwat Hutchaleelaha, Mira Patel, Vincent Siu, Sandra Dixon, Noel Landsman, Margaret Tonda, Joshua Lehrer-Graiwer
Journal: Blood
Blood (2019) 133 (17): 1865–1875.
https://doi.org/10.1182/blood-2018-08-868893
Published: 2019
Journal Articles

Efficacy and Safety of 1500 mg Voxelotor in a Phase 2a Study (GBT440-007) in Adolescents with Sickle Cell Disease

Free
Clark Brown, Carolyn Hoppe, Adlette Inati, Miguel R. Abboud, Winfred Wang, MD, Robert Liem, MD, Gerald Woods, Lewis L. Hsu, Victor R. Gordeuk, MD, Connie Piccone, Richard A. Drachtman, Erica Fong, Sandra Dixon, Margaret Tonda, PharmD, Carla Washington, Joshua Lehrer-Graiwer
Journal: Blood
Blood (2018) 132 (Supplement 1): 509.
https://doi.org/10.1182/blood-2018-99-117510
Published: 2018
Journal Articles

Results from Part A of the Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization (HOPE) Trial (GBT440-031), a Placebo-Controlled Randomized Study Evaluating Voxelotor (GBT440) in Adults and Adolescents with Sickle Cell Disease

Free
Elliott Vichinsky, MD, Carolyn Hoppe, Jo Howard, Kenneth I. Ataga, Videlis Nduba, Amal El-Beshlawy, David L. Diuguid, Salam Al-Kindi, Clark Brown, Hoda Hassab, MD, Paul Telfer, Dimitris A. Tsitsikas, Selma Unal, Julie Kanter, MD, Miguel R. Abboud, Victor R. Gordeuk, MD, Joshua Lehrer-Graiwer, Claire Sherman, Margaret Tonda, PharmD, Allison Intondi, Yifah Yaron, Russell E. Ware, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 505.
https://doi.org/10.1182/blood-2018-99-118508
Published: 2018
Journal Articles

Efficacy and Safety of Carfilzomib, Lenalidomide, and Dexamethasone Vs Lenalidomide and Dexamethasone in Patients with Relapsed Multiple Myeloma Based on Cytogenetic Risk Status: Subgroup Analysis from the Phase 3 Study Aspire (NCT01080391)

Free
Hervé Avet-Loiseau, MD, Rafael Fonseca, MD, David Siegel, MD PhD, Meletios A. Dimopoulos, Ivan Spicka, Tamás Masszi, Roman Hájek, Laura Rosiñol, Vesselina Goranova-Marinova, Georgi Mihaylov, Vladimír Maisnar, Maria-Victoria Mateos, Michael Wang, MD, Ruben Niesvizky, MD, Albert Oriol, Andrzej Jakubowiak, MD PhD, Jiri Minarik, Antonio Palumbo, William Bensinger, MD, Vishal Kukreti, Dina Ben-Yehuda, Margaret Tonda, Mihaela Obreja, Philippe Moreau
Journal: Blood
Blood (2015) 126 (23): 731.
https://doi.org/10.1182/blood.V126.23.731.731
Published: 2015