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Journal Articles

Characteristics and outcomes in Acute Myeloid Leukemia with Mecom rearrangement treated with hypomethylating agent plus venetoclax

Free
Leora Boussi, Elizabeth Corley, Andriy Derkach, Alex Ambinder, Somedeb Ball, Stephen Chung, Kateryna Fedorov, Ashwini Yenamandra, Emily F. Mason, Bao Duy An Hoang, Christopher Famulare, Meira Yisraeli Salman, Justin Wheat, Meghan Thompson, Sheng Cai, Eytan Stein, Yanming Zhang, Aaron Goldberg
Journal: Blood
Blood (2025) 146 (Supplement 1): 1616.
https://doi.org/10.1182/blood-2025-1616
Published: 2025
Journal Articles

Integrating single-cell whole genome and transcriptome sequencing to track the clonal evolution of TP53-mutated myeloid neoplasms

Free
Sarun Sereewattanawoot, Maria Sirenko, Georgios Asimomitis, Sheng Cai, Shoron Mowla, Kaitlyn Ko, Francesco Maura, Ross Levine, Sohrab Shah, Andrew McPherson, Gunes Gundem, Elli Papaemmanuil
Journal: Blood
Blood (2025) 146 (Supplement 1): 5014.
https://doi.org/10.1182/blood-2025-5014
Published: 2025
Journal Articles

Detection of MEN1 resistance mutations in cell-free DNA from acute leukemia patients treated with menin inhibitors

Free
Neerav Shukla, Karmelina Charalambous, Shanita Li, Maria Lapshina, Kaitlyn Ko, Hilary Casanova, Cassidy Cobbs, Ruchi Patel, Mark Ewalt, Neeman Mohibullah, Michael Berger, Eytan Stein, Ronak Shah, Sheng Cai
Journal: Blood
Blood (2025) 146 (Supplement 1): 938.
https://doi.org/10.1182/blood-2025-938
Published: 2025
Journal Articles

A Phase 1/2 study of the menin inhibitor revumenib with the celmod mezigdomide in relapsed/refractory KMT2A-rearanged, NPM1-mutant, and NUP98-rearranged acute leukemias

Free
Kuo-Kai Chin, Sheng Cai, Andriy Derkach, Gabrielle Melamed, Natalie Smith, Neerav Shukla, Joshua Zeidner, Ibrahim Aldoss, Ghayas Issa, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 1657.
https://doi.org/10.1182/blood-2025-1657
Published: 2025
Journal Articles

The outcomes of patients who are relapsed or refractory to menin inhibitors is poor with a limited overall survival

Free
Kuo-Kai Chin, Brian Ball, Yasmin Abaza, Jessica Altman, Rahul Thakur, Moiez Ali, Andriy Derkach, Mark Geyer, Aaron Goldberg, Tamanna Haque, Meghan Thompson, Jae Park, Martin Tallman, Sheng Cai, Eunice Wang, Ibrahim Aldoss, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 39.
https://doi.org/10.1182/blood-2025-39
Published: 2025
Journal Articles

Outpatient Vs Inpatient Hidac Consolidation for AML: The MSKCC Experience

Free
Leora Boussi, Hannah Burton, Andriy Derkach, David Nemirovsky, Jenna Ciervo, Martin S. Tallman, Eytan M. Stein, Sheng Cai
Journal: Blood
Blood (2024) 144 (Supplement 1): 445.
https://doi.org/10.1182/blood-2024-204449
Published: 2024
Journal Articles

A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated with Upregulation of HOX Genes: Trial in Progress

Free
Ghayas C. Issa, Kuo-Kai Chin, James S. Blachly, Aziz Farhat, Lianchun Xiao, Jing Ning, Branko Cuglievan, Neerav Shukla, Koji Sasaki, Sanam Loghavi, Sheng Cai, Hagop M. Kantarjian, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 5995.
https://doi.org/10.1182/blood-2024-203466
Published: 2024
Journal Articles

Molecular Predictors and Current Management of Minimal Residual Disease (MRD) Following Induction Chemotherapy for Acute Myeloid Leukemia (AML)

Free
Aaron D Goldberg, MDPhD, Christopher Famulare, MS, Sean M Devlin, PhD, Noushin Farnoud, PhD, Kamal Menghrajani, MD, Minal Patel, BA, Sheng Cai, MD PhD, Andrew Dunbar, MD, Zachary D. Epstein-Peterson, MD, Erin McGovern, BA, Jessica Schulman, Jacob L Glass, MDPhD, Justin Taylor, MD, Aaron D Viny, MDMS, Bartlomiej Getta, FRCPA, FRACP, MBBS, Maria E Arcila, MD, Ross L. Levine, MD, Brian C. Shaffer, MD, Boglarka Gyurkocza, MD, Esperanza B. Papadopoulos, MD, Miguel-Angel Perales, MD, Elli Papaemmanuil, PhD, Sergio Giralt, MD, Yanming Zhang, MD, Mikhail Roshal, MD PhD, Martin S. Tallman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 292.
https://doi.org/10.1182/blood-2018-99-112938
Published: 2018
Journal Articles

Loss of Plasmacytoid Dendritic Cell Differentiation Is Highly Predictive for Persistent Measurable Residual Disease and Poor Outcomes in Acute Myeloid Leukemia

Free
Wenbin Xiao, MD, Aaron D Goldberg, MD PhD, Christopher Famulare, MS, Sean Delvin, Minal Patel, BA, Erin McGovern, BA, Akshar Patel, BA, Jessica Schulman, Andrew Dunbar, MD, Zachary D. Epstein-Peterson, MD, Kamal Menghrajani, MD, Bartlomiej Getta, Sheng Cai, MD PhD, Mark Blaine Geyer, MD, Jacob L Glass, MD PhD, Justin Taylor, MD, Aaron D Viny, MD MS, Ross L. Levine, MD, Yanming Zhang, MD, Martin S. Tallman, MD, Mikhail Roshal, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1523.
https://doi.org/10.1182/blood-2018-99-112591
Published: 2018
Journal Articles

LSD1 Inhibition Exerts Its Anti-Leukemic Effect By Recommissioning PU.1- and C/Ebpα-Dependent Enhancers in AML

Free
Monica Cusan, MD, Sheng Cai, MD PhD, Helai P Mohammad, PhD, Andrei V. Krivtsov, PhD, Alan Chramiec, Evangelia Loizou, Daniel G. Tenen, MD, Min Ye, PhD, Britta Will, PhD, Ulrich G. Steidl, MDPhD, Ryan G. Kruger, PhD, Richard Koche, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 242.
https://doi.org/10.1182/blood.V130.Suppl_1.242.242
Published: 2017
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Free
Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016