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Journal Articles

Rituximab Reduces Immunogenicity and Increases Complete Remissions without Minimal Residual Disease in Relapsed/Refractory Hairy Cell Leukemia Patients Receiving Moxetumomab Pasudotox

Robert J. Kreitman, Constance M. Yuan, Hao-Wei Wang, Hong Zhou, Mark Raffeld, Liqiang Xi, Evgeny Arons, Julie Feurtado, Lacey James, Raul C. Braylan, Katherine R. Calvo, Irina Maric, Ira Pastan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6791.
https://doi.org/10.1182/blood-2024-199569
Published: 2024
Journal Articles

A Randomized Phase 2 Trial of 2nd-Line Cladribine with Concurrent or Delayed Rituximab in Patients with Classic Hairy Cell Leukemia

Robert J. Kreitman, Hao-Wei Wang, Dana I. Delgado Colon, Hong Zhou, Evgeny Arons, Mark Raffeld, Liqiang Xi, Julie Feurtado, Lacey James, Raul C. Braylan, Katherine R. Calvo, Irina Maric, Constance M. Yuan
Journal: Blood
Blood (2024) 144 (Supplement 1): 863.
https://doi.org/10.1182/blood-2024-202793
Published: 2024
Journal Articles

Non-V600E BRAF Gene Alterations in Hairy Cell Leukemia

Evgeny Arons, Chin-Hsien Tai, Suraj Joshi, Yuelin Liu, Chi-ping Day, Mark Raffeld, Liqiang Xi, Hong Zhou, Mory Gould, Isaac Shpilman, Christopher C. Oakes, Seema A Bhat, Michael R. Grever, Kerry A. Rogers, Hao-Wei Wang, Constance M. Yuan, Cenk Sahinalp, Robert J. Kreitman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1586.
https://doi.org/10.1182/blood-2024-204016
Published: 2024
Journal Articles

DNA Methylation-Based Classification of Hairy Cell Leukemia and Splenic B Cell Lymphoma

Kyoko Yamaguchi, Salma Abdelbaky, Evgeny Arons, Matthew Cross, Yue-Zhong Wu, Christoph Weigel, Mirela Iulia Anghelina, Helen Parker, Artur Kibler, Marta Salido, Constance Regina Baer, Manja Meggendorfer, Benjamin Durham, Omar Abdel-Wahab, Seema A Bhat, Gerard Lozanski, Kerry A Rogers, Yonghong Wang, Paul S. Meltzer, Sunil Iyengar, Sascha Dietrich, Thorsten Zenz, James S. Blachly, Aurelie Verney, Lucile Baseggio, Alexandra Traverse-Glehen, Marc Seifert, Ralf Kuppers, Richard Burack, Clive S Zent, Versha Banerji, James B. Johnston, David Graham Oscier, Renata Walewska, Kostas Stamatopoulos, Torsten Haferlach, Ana Ferrer, Catherine Thieblemont, Francesco Forconi, Robert Kreitman, Michael R. Grever, Jonathan C. Strefford, Piers Blombery, Christopher C. Oakes
Journal: Blood
Blood (2023) 142 (Supplement 1): 174.
https://doi.org/10.1182/blood-2023-189835
Published: 2023
Journal Articles

Dabrafenib plus trametinib in patients with relapsed/refractory BRAF V600E mutation–positive hairy cell leukemia

Clinical Trials & Observations
Robert J. Kreitman, Philippe Moreau, Farhad Ravandi, Martin Hutchings, Anas Gazzah, Anne-Sophie Michallet, Zev A. Wainberg, Alexander Stein, Sascha Dietrich, Maja J. A. de Jonge, Wolfgang Willenbacher, Jacques De Grève, Evgeny Arons, Palanichamy Ilankumaran, Paul Burgess, Eduard Gasal, Vivek Subbiah
Journal: Blood
Blood (2023) 141 (9): 996–1006.
https://doi.org/10.1182/blood.2021013658
Published: 2023
Includes: Supplemental data
Journal Articles

An Immunogenetic Imprint of Ongoing Antigen Interactions in Hairy Cell Leukemia Expressing IGHV4-34 Receptors

Electra Sofou, Maria Karypidou, Laura Zaragoza-Infante, Nikolaos Pechlivanis, Fotis Psomopoulos, Elisavet Georgiou, Evgeny Arons, Robert J. Kreitman, Anastasia Chatzidimitriou, Kostas Stamatopoulos
Journal: Blood
Blood (2022) 140 (Supplement 1): 6399–6400.
https://doi.org/10.1182/blood-2022-168554
Published: 2022
Journal Articles

Extended Follow up of a Phase 2 Study of Ibrutinib in Hairy Cell Leukemia

Kerry A. Rogers, Eric McLaughlin, Lai Wei, Mirela Iulia Anghelina, Mir Khader Ali, Leslie A. Andritsos, Evgeny Arons, James S. Blachly, Timothy G. Call, S. Percy Ivy, Lacey James-Echenique, Jeffrey A. Jones, Robert J. Kreitman, Gerard Lozanski, Farhad Ravandi, Charles A. Schiffer, William E. Carson, III, Michael R. Grever
Journal: Blood
Blood (2022) 140 (Supplement 1): 6494–6495.
https://doi.org/10.1182/blood-2022-165795
Published: 2022
Journal Articles

Long Term Follow-up of a Phase II Study of Cladribine with Concurrent Rituximab in Patients with Hairy Cell Leukemia Variant

Dai Chihara, MD PhD, Evgeny Arons, PhD, Maryalice Stetler-Stevenson, MD PhD, Constance M. Yuan, MD PhD, Hao-Wei Wang, MD PhD, Hong Zhou, Mark Raffeld, MD, Liqiang Xi, MD, Seth M. Steinberg, PhD, Julie Feurtado, RN, Lacey James-Echenique, CRNP, Wyndham Wilson, MD, Raul C. Braylan, MD, Katherine R. Calvo, MD PhD, Irina Maric, MD MSci, Alina Dulau-Florea, MD, Robert J. Kreitman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1536.
https://doi.org/10.1182/blood-2019-124515
Published: 2019
Journal Articles

Molecular Remissions with Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox Are Associated with Improved Complete Remission Durations during Phase I and III Testing

Evgeny Arons, PhD, Daniel Gorelik, Maryalice Stetler-Stevenson, MD PhD, Constance M. Yuan, MD PhD, Mark Sokolsky, Hong Zhou, Nai Shun (nancy) Yao, MD, Shannon Marshall, PhD, Katherine Potocka, Erin Fykes, Ira Pastan, MD, Robert J. Kreitman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1861.
https://doi.org/10.1182/blood-2018-99-113419
Published: 2018
Journal Articles

Treatment with Combination of Dabrafenib and Trametinib in Patients with Recurrent/Refractory BRAF V600E-Mutated Hairy Cell Leukemia (HCL)

Robert J. Kreitman, MD, Philippe Moreau, Martin Hutchings, MD, Anas Gazzah, MD, Jean-Yves Blay, MD PhD, Zev A. Wainberg, MD, Alexander Stein, MD, Sascha Dietrich, MD, Maja J.A. de Jonge, MD, Wolfgang Willenbacher, MD, Jacques De Greve, MD, Evgeny Arons, PhD, Farhad Ravandi, MD, Fatima Rangwala, Paul Burgess, Bijoyesh Mookerjee, Vivek Subbiah, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 391.
https://doi.org/10.1182/blood-2018-99-113135
Published: 2018
Journal Articles

Increased Expression of Myc in Hairy Cell Leukemia, and Cell-Sensitivity to JQ1

Evgeny Arons, PhD, Hong Zhou, Yonghong Wang, PhD, Daniel Edelman, PhD, Robert J. Kreitman, MD, Holly S Stevenson, Josh J Waterfall, PhD, Paul S. Meltzer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5112.
https://doi.org/10.1182/blood.V128.22.5112.5112
Published: 2016
Journal Articles

Molecular Evidence of Ongoing Antigen Driven Somatic Hypermutation in the Natural History of Classic and Variant Hairy Cell Leukemia

Evgeny Arons, PhD, Sarah Davies, Katherine Still, Nathan Chai, Katherine Potocka, Hong Zhou, Robert J. Kreitman, MD
Journal: Blood
Blood (2015) 126 (23): 2648.
https://doi.org/10.1182/blood.V126.23.2648.2648
Published: 2015
Journal Articles

High Response Rate of Moxetumomab Pasudotox in Relapsed/Refractory Hairy Cell Leukemia Includes Eradication of Minimal Residual Disease: Potential Importance for Outcome

Robert J. Kreitman, MD, Evgeny Arons, PhD, Martin S Tallman, MD, Robak Tadeusz, MD PhD, Steven Coutre, MD, Wyndham H Wilson, MD PhD, Maryalice Stetler-Stevenson, MD PhD, Constance M. Yuan, MD PhD, Mark Lanasa, MD PhD, David JP FitzGerald, PhD, Ira Pastan, MD
Journal: Blood
Blood (2015) 126 (23): 4161.
https://doi.org/10.1182/blood.V126.23.4161.4161
Published: 2015
Journal Articles

Series of Hairy Cell Leukemia Patients with Co-Existent Plasma Cell Disorders

Neha Korde, MD, Sham Mailankody, MD, Evgeny Arons, PhD, Raul C. Braylan, MD, Mark Raffeld, MD, Elizabeth Maestri, RN, Constance Yuan, MD PhD, Maryalice Stetler-Stevenson, MD PhD, Ola Landgren, MD PhD, Irina Maric, MD, Robert J. Kreitman, MD
Journal: Blood
Blood (2014) 124 (21): 5647.
https://doi.org/10.1182/blood.V124.21.5647.5647
Published: 2014
Journal Articles

Minimal Residual Disease By Patient-Specific Taqman Real Time PCR in Newly Diagnosed Hairy Cell Leukemia Patients Randomized to Initial Vs Delayed Rituximab in Combination with Cladribine

Evgeny Arons, PhD, Katherine Still, BS, Sarah Davies, BS, Hong Zhou, BS, Robert J. Kreitman, MD
Journal: Blood
Blood (2014) 124 (21): 1747.
https://doi.org/10.1182/blood.V124.21.1747.1747
Published: 2014
Journal Articles

Pharmacokinetic Analysis Of Response In Hairy Cell Leukemia Treated By Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

Robert J. Kreitman, MD, Evgeny Arons, PhD, Maryalice Stetler-Stevenson, MD, PhD, Wyndham H Wilson, MD, PhD, David J. P. FitzGerald, PhD, Ira Pastan, MD
Journal: Blood
Blood (2013) 122 (21): 2871.
https://doi.org/10.1182/blood.V122.21.2871.2871
Published: 2013
Journal Articles

Bruton's Tyrosine Kinase (BTK) Inhibitor Ibrutinib (PCI-32765) Blocks Hairy Cell Leukemia (HCL) Survival, Proliferation, and BCR Signaling: A New Therapeutic Approach for HCL

Mariela Sivina, PhD, Robert J. Kreitman, MD, Evgeny Arons, PhD, Joseph J. Buggy, PhD, Farhad Ravandi, MD, Jan A. Burger, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1802.
https://doi.org/10.1182/blood.V120.21.1802.1802
Published: 2012
Journal Articles

The HLA-DRB1*11 Antigen Is Preferentially Expressed in Hairy Cell Leukemia, Particularly in Patients Who Had Hemolytic Uremic Syndrome with Recombinant Immunotoxin BL22.

Evgeny Arons, PhD, Laura Roth, Sharon Adams, CHS, Jeffery Sapolsky, Ira Pastan, MD, Robert J. Kreitman, MD
Journal: Blood
Blood (2012) 120 (21): 2488.
https://doi.org/10.1182/blood.V120.21.2488.2488
Published: 2012
Journal Articles

Resolution of Hairy Cell Leukemia Minimal Residual Disease by Both BRAF and Clone-Specific Real-Time Quantitative PCR (RQ-PCR) After Treatment with Moxetumomab Pasudotox.

Robert J. Kreitman, MD, Evgeny Arons, PhD, Sapolsky Jeffrey, Laura Roth, Hong Zhou, BS, Maryalice Stetler-Stevenson, MD, PhD, Wyndham H. Wilson, MD, PhD, Mark Raffeld, MD, David J. P. FitzGerald, PhD, Ji Fei, PhD, Ramy Ibrahim, MD, Ira Pastan, MD
Journal: Blood
Blood (2012) 120 (21): 2896.
https://doi.org/10.1182/blood.V120.21.2896.2896
Published: 2012
Journal Articles

Both variant and IGHV4-34–expressing hairy cell leukemia lack the BRAF V600E mutation

Brief Report
Liqiang Xi, Evgeny Arons, Winnifred Navarro, Katherine R. Calvo, Maryalice Stetler-Stevenson, Mark Raffeld, Robert J. Kreitman
Journal: Blood
Blood (2012) 119 (14): 3330–3332.
https://doi.org/10.1182/blood-2011-09-379339
Published: 2012
Includes: Supplemental data