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Journal Articles

Impact of Clonal Heterogeneity in Newly Diagnosed, Transplant-Eligible Multiple Myeloma - Subgroup Analysis of the GMMG HD6 Phase III Trial

Maximilian Merz, Ema Pozek, Kaya Miah, Uta Bertsch, Britta Besemer, Mathias Hänel, Julia Krzykalla, Roland Fenk, Jana Schlenzka, Markus Munder, Christine Hanoun, Christoph Mann, Niels Weinhold, Christof Scheid, Roland Schroers, Igor Wolfgang Blau, Stefanie Huhn, Dirk Hose, Anna Jauch, Christina Kunz, Ivana von Metzler, Aneta Schieferdecker, Jörg Thomalla, Peter Reimer, Rolf Mahlberg, Ullrich Graeven, Stephan Kremers, Uwe Martens, Manfred Hensel, Axel Benner, Andrea Seidel-Glätzer, Katja C. Weisel, Marc S. Raab, Hans Salwender, Hartmut Goldschmidt, Elias K. Mai
Journal: Blood
Blood (2024) 144 (Supplement 1): 84.
https://doi.org/10.1182/blood-2024-201972
Published: 2024
Journal Articles

Immunological Subgroups Predicting Efficacy of Elotuzumab in Multiple Myeloma Patients: Insights from the GMMG-HD6 Clinical Trial

Gigi Nu Hoang Quy Ton, Katharina Kriegsmann, Mohamed H.S. Awwad, Axel Benner, Uta Bertsch, Britta Besemer, Mathias Hänel, Roland Fenk, Jana Schlenzka, Markus Munder, Jan Dürig, Igor Wolfgang Blau, Stefanie Huhn, Dirk Hose, Anna Jauch, Andreas Neubauer, Niels Weinhold, Christof Scheid, Roland Schroers, Ivana von Metzler, Aneta Schieferdecker, Jörg Thomalla, Peter Reimer, Rolf Mahlberg, Ullrich Graeven, Stephan Kremers, Uwe Martens, Christian Kunz, Manfred Hensel, Andrea Seidel-Glätzer, Katja Weisel, Hans Salwender, Carsten Müller-Tidow, Marc S. Raab, Hartmut Goldschmidt, Elias K. Mai, Michael Hundemer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1991.
https://doi.org/10.1182/blood-2023-189169
Published: 2023
Journal Articles

Implications and Prognostic Impact of Mass Spectrometry in Patients with Newly-Diagnosed Multiple Myeloma

Elias K Mai, Stefanie Huhn, Kaya Miah, Alexandra M Poos, Christof Scheid, Katja Weisel, Uta Bertsch, Markus Munder, Oscar Berlanga, Dirk Hose, Anja Seckinger, Anna Jauch, Igor Wolfgang Blau, Mathias Haenel, Hans Salwender, Axel Benner, Marc S Raab, Hartmut Goldschmidt, Niels Weinhold
Journal: Blood
Blood (2022) 140 (Supplement 1): 2341–2343.
https://doi.org/10.1182/blood-2022-156169
Published: 2022
Journal Articles

Elotuzumab in Combination with Lenalidomide, Bortezomib, Dexamethasone and Autologous Transplantation for Newly-Diagnosed Multiple Myeloma: Results from the Randomized Phase III GMMG-HD6 Trial

Hartmut Goldschmidt, Elias K Mai, Uta Bertsch, Britta Besemer, Mathias Haenel, Kaya Miah, Roland Fenk, Jana Schlenzka, Markus Munder, Jan Dürig, Igor Wolfgang Blau, Stefanie Huhn, Dirk Hose, Anna Jauch, Christina Kunz, Andreas Neubauer, Christof Scheid, Roland Schroers, Ivana v. Metzler, Aneta Schieferdecker, Joerg Thomalla, Peter Reimer, Rolf Mahlberg, Ullrich Graeven, Stephan Kremers, Uwe M. Martens, Christian Kunz, Manfred Hensel, Andrea Seidel-Glaetzer, Katja Weisel, Marc-Steffen Raab, Hans Salwender
Journal: Blood
Blood (2021) 138 (Supplement 1): 486.
https://doi.org/10.1182/blood-2021-147323
Published: 2021
Journal Articles

Gain 1q21 Is an Adverse Prognostic Factor in Patients with Relapsed/Refractory AL Amyloidosis Treated with Lenalidomide and Dexamethasone

Marco Basset, MD, Christoph Kimmich, Tobias Dittrich, MD, Kaya Veelken, MD, Hartmut Goldschmidt, MD, Dirk Hose, MD, Anja Seckinger, MD, Anna Jauch, Carsten Mueller-Tidow, MD, Ute Hegenbart, MD, Stefan Schönland, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142701
Published: 2020
Journal Articles

Daratumumab for systemic AL amyloidosis: prognostic factors and adverse outcome with nephrotic-range albuminuria

Clinical Trials & Observations
Christoph R. Kimmich, Tobias Terzer, Axel Benner, Tobias Dittrich, Kaya Veelken, Alexander Carpinteiro, Timon Hansen, Hartmut Goldschmidt, Anja Seckinger, Dirk Hose, Anna Jauch, Stefan Wörner, Jörg Beimler, Carsten Müller-Tidow, Ute Hegenbart, Stefan O. Schönland
Journal: Blood
Blood (2020) 135 (18): 1517–1530.
https://doi.org/10.1182/blood.2019003633
Published: 2020
Includes: Supplemental data
Journal Articles

RNA-Sequencing Based Assessment of Targets, Risk and Long Term Survival for Personalized Treatment of Multiple Myeloma

Martina Emde, Susanne Beck, Vladimir Benes, Jerome Moreaux, PhD, Anja Seckinger, Dirk Hose, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1801.
https://doi.org/10.1182/blood-2019-131159
Published: 2019
Journal Articles

Biallelic Inactivation of Multiple Tumor Suppressors Is Associated with Early Relapse after Stem Cell Transplant in Newly Diagnosed Myeloma

Niels Weinhold, PhD, Jing Xu, PhD, Martina Fröhlich, PhD, Alexandra M Poos, PhD, Lukas John, MD, Carsten Müller-Tidow, MD, Sandra Sauer, MD, Stefanie Huhn, PhD, Dirk Hose, MD, Anja Seckinger, Kari Hemminki, MD PhD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Nicola Giesen, MD, Marc S Raab, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1783.
https://doi.org/10.1182/blood-2019-131195
Published: 2019
Journal Articles

Prediction of Malingant Plasma Cell Biology Related Survival in AL-Amyloidosis

Susanne Beck, Martina Emde, Jerome Moreaux, PhD, Anja Seckinger, Dirk Hose, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3078.
https://doi.org/10.1182/blood-2019-131161
Published: 2019
Journal Articles

Multiple Myeloma Pathogenesis: The Role of Junb in Bone Marrow Angiogenesis

Fengjuan Fan, PhD, Stefano Malvestiti, MD, Yujia Shen, PhD, Eugenio Morelli, MD, Yuji Mishima, MD, Anja Seckinger, Dirk Hose, MD, Latifa Bakiri, PhD, Sonia Vallet, MD, Martin Sattler, PhD, Aldo M. Roccaro, MD PhD, Hartmut Goldschmidt, MD, Martin Percherstorfer, MD, Chunyan Sun, MD PhD, Yu Hu, MD PhD, Erwin F Wagner, PhD, Piefrancesco Tassone, MD, Irene M. Ghobrial, MD, Dirk Jaeger, MD, Klaus Podar, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4341.
https://doi.org/10.1182/blood-2019-128854
Published: 2019
Journal Articles

Crowdsourced High-Risk Classifiers for Multiple Myeloma Patients Commonly Identify PHF19 As a Robust Progression Biomarker

Michael J Mason, PhD, Carolina D. Schinke, MD, Christine Eng, PhD, Fadi Towfic, PhD, Fred Gruber, PhD, Brian S. White, Yi Cui, PhD, Bailiang Li, PhD, Thomas Yu, BS, William S. Dalton, PhDMD, Hartmut Goldschmidt, MD, Herve Avet-Loiseau, MD PhD, Mehmet Samur, PhD, Maria Ortiz, Matthew Trotter, PhD, Boris Hayete, PhD, Andrew Dervan, Erin Flynt, Hongyue Dai, PhD, Douglas Bassett, PhD, Pieter Sonneveld, Kenneth H. Shain, MD PhD, Nikhil C. Munshi, MD, Daniel Auclair, Dirk Hose, MD, Gareth Morgan, MDPhDFRCP, Jonathan Göke, PhD, Brian A Walker, PhD, Anjan Thakurta, Justin Guinney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4370.
https://doi.org/10.1182/blood-2019-127362
Published: 2019
Journal Articles

MCT1 As Molecularly Validated Predictive Marker for Lenalidomide-Maintenance Therapy in Multiple Myeloma

Jacob Stroh, Anja Seckinger, Michael Heider, Ruth Eichner, Martina Emde, Hans Salwender, Uta Bertsch, Hartmut Goldschmidt, MD, Katja Weisel, Christof Scheid, MD, Dirk Hose, MD, Florian Bassermann, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3187.
https://doi.org/10.1182/blood-2019-130734
Published: 2019
Journal Articles

Bortezomib-Based Induction and Maintenance Overcomes the Negative Prognostic Impact of Renal Impairment and del17p in Transplant-Eligible Myeloma Patients: Long Term Results from the Phase III HOVON-65/GMMG-HD4 Study after Median 137 Months Follow up

Christof Scheid, MD, Henk Lokhorst, MD PhD, Igor W Blau, MD PhD, Bronno Van Der Holt, PhD, Uta Bertsch, Sonja Zweegman, MD PhD, Katja Weisel, Edo Vellenga, Marie José Kersten, MD PhD, Sandra Croockewit, Elias K Mai, MD, Reinier Raymakers, MD PhD, Dirk Hose, MD, Anna Jauch, Jens Hillengass, MD, Marian Stevens-Kroef, PhD, Marc S Raab, MD PhD, Kai Neben, Stephan Stilgenbauer, Annemiek Broyl, MD PhD, Hans-Walter Lindemann, MD, Gerard Bos, MD PhD, Peter Brossart, MD, Marinus van Marwijk Kooij, MD PhD, Paula F Ypma, MD PhD, Ulrich Dührsen, Prof, MD PhD, Ron Schaafsma, MD PhD, Thomas Hielscher, Hans Salwender, Hartmut Goldschmidt, MD, Pieter Sonneveld
Journal: Blood
Blood (2019) 134 (Supplement_1): 3308.
https://doi.org/10.1182/blood-2019-129684
Published: 2019
Journal Articles

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Weng Hua Khoo, Guy Ledergor, Assaf Weiner, Daniel L. Roden, Rachael L. Terry, Michelle M. McDonald, Ryan C. Chai, Kim De Veirman, Katie L. Owen, Khatora S. Opperman, Kate Vandyke, Justine R. Clark, Anja Seckinger, Natasa Kovacic, Akira Nguyen, Sindhu T. Mohanty, Jessica A. Pettitt, Ya Xiao, Alexander P. Corr, Christine Seeliger, Mark Novotny, Roger S. Lasken, Tuan V. Nguyen, Babatunde O. Oyajobi, Dana Aftab, Alexander Swarbrick, Belinda Parker, Duncan R. Hewett, Dirk Hose, Karin Vanderkerken, Andrew C. W. Zannettino, Ido Amit, Tri Giang Phan, Peter I. Croucher
Journal: Blood
Blood (2019) 134 (1): 30–43.
https://doi.org/10.1182/blood.2018880930
Published: 2019
Includes: Supplemental data
Journal Articles

Quantitative Integrative Prediction of Survival Probability in Multiple Myeloma Using Molecular and Clinical Prognostic Factors in 657 Patients Treated with Bortezomib-Based Induction, High-Dose Therapy and Autologous Stem Cell Transplantation

Manuela Hummel, Thomas Hielscher, Hans Jürgen Salwender, MD, Christof Scheid, Hans Martin, MD, Uta Bertsch, MD, Hartmut Goldschmidt, MD, Anja Seckinger, Dirk Hose, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 403.
https://doi.org/10.1182/blood-2018-99-113307
Published: 2018
Journal Articles

Treatment Response and Long-Term Survival in Multiple Myeloma in the GMMG-HD4 Trial - Neither Profit All Molecular Entities Alike, Nor Are Remissions to Different Regimen Equal

Anja Seckinger, Hans Jürgen Salwender, MD, Hans Martin, MD, Christof Scheid, Thomas Hielscher, Uta Bertsch, MD, Manuela Hummel, Anna Jauch, PhD, Wolfgang Knauf, Martina Emde, Susanne Beck, Kai Neben, Henk M. Lokhorst, MD PhD, Bronno van der Holt, PhD, Ulrich Duehrsen, MD, Jan Dürig, Hans-Walter Lindemann, MD, Ingo Schmidt-Wolf, Mathias Haenel, MD, Bernd Lathan, Marc S Raab, MD PhD, Carsten Müller-Tidow, MD, Pieter Sonneveld, MD PhD, Igor Wolfgang Blau, Jens Hillengass, MD, Katja Weisel, MD, Hartmut Goldschmidt, MD, Dirk Hose, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4485.
https://doi.org/10.1182/blood-2018-99-113284
Published: 2018
Journal Articles

AL Amyloidosis — Pathogenesis and Prognosis Are Determined By the Amyloidogenic Potential of the Light Chain and the Molecular Characteristics of Malignant Plasma Cells

Anja Seckinger, Ute Hegenbart, Susanne Beck, Martina Emde, Tilmann Bochtler, Christoph Kimmich, Carsten Müller-Tidow, MD, Anna Jauch, PhD, Stefan Schönland, Dirk Hose, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 187.
https://doi.org/10.1182/blood-2018-187
Published: 2018
Journal Articles

Crowdsourcing a High-Risk Classifier for Multiple Myeloma Patients

Andrew P Dervan, Michael Mason, PhD, Fadi Towfic, PhD, Michael Amatangelo, PhD, Daniel Auclair, PhD, Douglas Bassett, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Samuel Danziger, PhD, Erin Flynt, PhD, Hartmut Goldschmidt, MD, Justin Guinney, PhD, Dirk Hose, MD, Konstantimos Mavrommatis, PhD, Gareth J. Morgan, MD PhD, Nikhil Munshi, MD, Alexander Ratushny, PhD, Dan Rozelle, PhD, Mehmet Kemal Samur, PhD, Frank Schmitz, MD PhD, Kenneth H Shain, MD PhD, Matthew Trotter, PhD, Brian A Walker, PhD, Brian S. White, PhD, Thomas Yu, BS, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 265.
https://doi.org/10.1182/blood.V130.Suppl_1.265.265
Published: 2017
Journal Articles

Combined Inhibition of Chk1 and Wee1 As a New Therapeutic Strategy for High-Risk Multiple Myeloma Patients

Angelique Bruyer, Hugues de Boussac, PhD, Thibaut Martin, Alboukadel Kassambara, PhD, Nicolas Robert, Guillaume Cartron, Dirk Hose, MD, Anja Seckinger, Philippe Pasero, PhD, Jerome Moreaux, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1777.
https://doi.org/10.1182/blood.V130.Suppl_1.1777.1777
Published: 2017
Journal Articles

A Predictive Score for Early Mortality during Induction Therapy in Newly Diagnosed Transplant-Eligible Multiple Myeloma - an Analysis from Five GMMG and HOVON Multicenter Phase III Trials

Elias K Mai, MD, Thomas Hielscher, PhD, Uta Bertsch, MD, Jana Schlenzka, MD, Hans Jürgen Salwender, Henk M Lokhorst, Markus Munder, MD, Bronno van der Holt, Christian Gerecke, MD, Michael Pfreundschuh, MD, Ulrich Duhrsen, Peter Brossart, MD, Sonja Zweegman, MD PhD, Kai Neben, Jens Hillengass, MD, Marc-Steffen S Raab, Dirk Hose, MD, Edo Vellenga, MD, Maximilian Merz, MD, Iris Breitkreutz, MD, Anna Jauch, Marie José Kersten, MD, Hans Martin, Hans-Walter Lindemann, Norma Peter, MD, Sandra Croockewit, MD, Igor Wolfgang Blau, MD, Christof Scheid, MD, Katja C. Weisel, Pieter Sonneveld, MDPhD, Hartmut Goldschmidt, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2016.
https://doi.org/10.1182/blood.V130.Suppl_1.2016.2016
Published: 2017