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Aintzane Zabaleta
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Journal Articles

An IFNγ-Mediated Immune Inflamed Microenvironment State in Multiple Myeloma with TP53 Loss That Can be Therapeutically Exploited

Marta Larrayoz, Elena Arriazu, Aintzane Zabaleta, Carmen Roncal, Ibon Tamayo, Diana Llopiz, Maddalen Jimenez, Carla Castro, Jon Celay, Carmen Vicente, Camila Guerrero, Sonia Sanz, Maria J Garcia-Barchino, Naroa Barrena, Noemi Puig, Maria Teresa Cedena Romero, Maria Jose Calasanz, Paula Rodríguez-Otero, Jesús F. San-Miguel, Mikel Hernaez, Xabier Agirre, Pablo Sarobe, Felipe Prosper, Bruno Paiva, Jose A. Martinez-Climent
Journal: Blood
Blood (2024) 144 (Supplement 1): 670.
https://doi.org/10.1182/blood-2024-194041
Published: 2024
Journal Articles

Molecular Mechanisms Promoting Long-Term Cytopenia after BCMA CAR-T Therapy in Multiple Myeloma

Maria Luisa Palacios-Berraquero, Paula Rodriguez-Marquez, Maria Erendira Calleja-Cervantes, Nerea Berastegui, Aintzane Zabaleta, Leire Burgos, Diego Alignani, Patxi San-Martin, Amaia Vilas-Zornoza, Saray Rodríguez Diaz, Susana Inogés, Ascensión López-Díaz De Cerio, Sofia Huerga, Luis-Esteban Tamariz-Amador, Jose J. Rifon, Ana Alfonso Pierola, Juan J Lasarte, Bruno Paiva, Mikel Hernaez, Paula Rodríguez-Otero, Jesús F. San-Miguel, Teresa Ezponda, Juan Roberto Rodriguez-Madoz, Felipe Prosper
Journal: Blood
Blood (2024) 144 (Supplement 1): 4798.
https://doi.org/10.1182/blood-2024-207990
Published: 2024
Journal Articles

Depletion of Mature B Cells and of Normal Plasma Cells (PC) behind the Higher Incidence of Infections after Anti-BCMA VS Anti-GPRC5D Bispecific Antibodies (bsAb) in Relapsed Refractory Multiple Myeloma (RRMM)

Tomas Jelinek, David Zihala, Aintzane Zabaleta, Ioannis V Kostopoulos, Ondrej Soucek, Ondrej Venglar, Cristina Moreno, Despina Fotiou, Eva Radova, Luis-Esteban Tamariz-Amador, Foteini Theodorakakou, Ludmila Muronova, Andrea Manubens, Ourania Tsitsilonis, Tereza Popkova, Lucie Broskevicova, Jana Mihalyova, Tereza Sevcikova, Jesús F. San-Miguel, Meletios Dimopoulos, Paula Rodríguez-Otero, Jakub Radocha, Efstathios Kastritis, Bruno Paiva, Roman Hajek
Journal: Blood
Blood (2024) 144 (Supplement 1): 1934.
https://doi.org/10.1182/blood-2024-205481
Published: 2024
Journal Articles

Forimtamig, a novel GPRC5D-targeting T-cell bispecific antibody with a 2+1 format, for the treatment of multiple myeloma

Jan Eckmann, Tanja Fauti, Marlene Biehl, Aintzane Zabaleta, Laura Blanco, Iva Lelios, Stefan Gottwald, Richard Rae, Stefanie Lechner, Christa Bayer, Quincy Dekempe, Franz Osl, Nadège Carrié, Sahar Kassem, Stefan Lorenz, Tony Christopeit, Alejandro Carpy, Alexander Bujotzek, Ann-Marie E. Bröske, Iryna Dekhtiarenko, Jan Attig, Leo Kunz, Floriana Cremasco, Roberto Adelfio, Georg Fertig, Stefan Dengl, Christian Gassner, Felix Bormann, Claudia Kirstenpfad, Thomas Emanuel Kraft, Sarah Diggelmann, Melanie Knobloch, Carina Hage, Romi Feddersen, Gordon Heidkamp, Thomas Pöschinger, Maud Lea Mayoux, Luise Bernasconi, Charles Dumontet, Felipe Prosper, Ludovic Martinet, Stephane Leclair, Wei Xu, Bruno Paiva, Christian Klein, Pablo Umaña
Journal: Blood
Blood blood.2024025987.
https://doi.org/10.1182/blood.2024025987
Published: 2024
Includes: Supplemental data
Journal Articles

Clinical Significance of Measurable Residual Disease (MRD) in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) Treated with Chimeric Antigen Receptor (CAR) T Cells and T-Cell Engagers (TCE)

Aintzane Zabaleta, Noemi Puig, Maria Teresa Cedena Romero, Jose J Perez, Cristina Moreno, Luis-Esteban Tamariz-Amador, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Lucia Lopez Corral, Beatriz Rey-Búa, Borja Puertas Martínez, Fatima Miras, Jose Sanchez-Pina, Nieves Lopez, Joaquin Martinez-Lopez, Maria Victoria Mateos, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 94.
https://doi.org/10.1182/blood-2023-185980
Published: 2023
Journal Articles

Sequential Scmultiomics of In Vivo CAR-T Cells Allows Characterization of Transcriptional Differences between Patients, and Identifies IL10 As a Potential Mechanism of Resistance to CAR-T Cells in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 3433.
https://doi.org/10.1182/blood-2023-182887
Published: 2023
Journal Articles

A CD38/CD28xCD3 Trispecific T-Cell Engager (TCE) As a Potentially Active Agent in Multiple Myeloma Patients Relapsed and/or Refractory (RRMM) to Anti-CD38 Monoclonal Antibodies (mAbs)

Aintzane Zabaleta, Laura Blanco, Peter Kim, Kamlesh Bisht, Hongfang Wang, Helgi J. Van de Velde, Marta Lasa, Luis-Esteban Tamariz-Amador, Paula Rodriguez Otero, Jesús San Miguel, Bruno Paiva, Esperanza Martín-Sánchez
Journal: Blood
Blood (2023) 142 (Supplement 1): 1921.
https://doi.org/10.1182/blood-2023-182150
Published: 2023
Journal Articles

A CD38/CD28xCD3 Trispecific T-Cell Engager (TCE) As a Potentially Active Agent for the Treatment of Older Patients with Acute Myeloid Leukemia (AML)

Aintzane Zabaleta, Esperanza Martín-Sánchez, Laura Blanco, Peter Kim, Kamlesh Bisht, Hongfang Wang, Helgi J. Van de Velde, Tomas Jelinek, Catia Simoes, Felipe Prosper, Jesus San-Miguel, David Martinez-Cuadron, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4178.
https://doi.org/10.1182/blood-2023-184797
Published: 2023
Journal Articles

Longitudinal Transcriptomic Analysis of CAR-T Cells at Single-Cell Level Allows the Identification of Molecular Mechanisms Promoting Long-Term CAR-T Cell Persistence in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2069.
https://doi.org/10.1182/blood-2023-182933
Published: 2023
Journal Articles

Deep Characterization of Immune Dysfunction in Patients with Multiple Myeloma (MM) and Identification of Cellular Biomarkers for Tailored Vaccination Strategies

Esperanza Martín-Sánchez, Camila Guerrero, Luis-Esteban Tamariz-Amador, Anastasiia Zherniakova, Aintzane Zabaleta, Catarina Maia, Laura Blanco, Maria-Antonia Fortuño, Carlos Grande, Andrea Manubens, Jose Maria Arguiñano, Clara Gomez, Ernesto Perez-Persona, Iñigo Olazabal, Itziar Oiartzabal, Carlos Panizo, Felipe Prosper, Jesús San Miguel, Paula Rodriguez Otero, Bruno Paiva, Basque-Navarre Association of Hematology and Hemotherapy Asovasna
Journal: Blood
Blood (2023) 142 (Supplement 1): 643.
https://doi.org/10.1182/blood-2023-181747
Published: 2023
Journal Articles

ARI0002h (Cesnicabtagene Autoleucel), an Academic Point-of-Care B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor (CAR) T-Cell Strategy: Activity and Safety after Fractionated Initial Therapy and Booster Dose in 60 Patients with Relapsed/Refractory Multiple Myeloma

Aina Oliver-Caldes, Veronica Gonzalez-Calle, Valentín Cabañas, Nieves Lopez-Muñoz, Paula Rodriguez Otero, Juan Luis Reguera, Marta Español-Rego, Susana Inoges, Aintzane Zabaleta, Lucia Lopez Corral, Beatriz Martin-Antonio, Lorena Perez-Amill, Bruno Paiva, Laura Rosiñol, Ascensión López-Díaz De Cerio, Sergio Navarro, Joan Cid, Natalia Tovar, Joaquin Saez-Peñataro, Miriam Lopez Parra, Eulalia Olesti, Elena Guillén, Sara Varea, Julio Delgado, Jose Maria Sanchez Pina, Anthony Battram, Marta Sonia Gonzalez Perez, Andres Sanchez Salinas, Valentin Ortiz-Maldonado, Felipe Prosper, Manel Juan, Joaquin Martinez Lopez, Jose Maria Moraleda, Maria Victoria Mateos, Mariona Pascal, Alvaro Urbano-Ispizua, Carlos Fernández de Larrea
Journal: Blood
Blood (2023) 142 (Supplement 1): 1026.
https://doi.org/10.1182/blood-2023-180828
Published: 2023
Journal Articles

Identification of Molecular Mechanisms Governing CAR-T Cell Response in MM Patients Using Single Cell Transcriptomics

Lorea Jordana-Urriza, Guillermo Serrano, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabañas, Almudena Navarro-Bailón, Aina Oliver-Caldes, Marta Español-Rego, Mariona Pascal, Manel Juan, Álvaro Urbano-Ispizua, Juan Luis Reguera, Jose Maria Moraleda, Maria-Victoria Mateos, Fermin Sanchez-Guijo, Ana Alfonso Pierola, José J. Rifón Roca, Paula Rodríguez-Otero, Carlos Fernandez de Larrea, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Juan Jose Lasarte, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Mikel Hernáez, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 7366–7368.
https://doi.org/10.1182/blood-2022-163082
Published: 2022
Journal Articles

RG6234: A Novel 2:1 GPRC5D T Cell Bispecific Antibody Exhibits Best in Class Potential for the Treatment of Multiple Myeloma As a Monotherapy and in Combination

Jan Eckmann, Tanja Fauti, Aintzane Zabaleta, Laura Blanco, Sahar Kassem, Nadege Carrié, Stefan Lorenz, Alejandro Carpy, Tony Christopeit, Georg Fertig, Luise Bernasconi, Marlene Biehl, Sarah Diggelmann, Melanie Knobloch, Maud Mayoux, Charles Dumontet, Bruno Paiva, Ludovic Martinet, Stéphane Leclair, Wei Xu, Christian Klein, Pablo Umaña
Journal: Blood
Blood (2022) 140 (Supplement 1): 2091–2092.
https://doi.org/10.1182/blood-2022-157485
Published: 2022
Journal Articles

CAR-T Related Cytopenia Profile in Relapsed/Refractory Multiple Myeloma: Results of Patients Treated with ARI0002h, an Academic BCMA-Directed CAR-T Cell

Aina Oliver-Caldes, Luis Gerardo Rodríguez-Lobato, Veronica Gonzalez-Calle, Natalia Tovar, Valentin Cabañas, Paula Rodríguez-Otero, Juan Luis Reguera, Marta Español-Rego, Beatriz Martin-Antonio, Aintzane Zabaleta, Marta Lasa, Susana Inogés, Ascensión López-Diaz de Cerio, Bruno Paiva, Sara Varea, Joaquin Saez-Peñataro, Manel Juan, Laura Rosiñol, Felipe Prosper, Jose M. Moraleda, Álvaro Urbano-Ispizua, Mariona Pascal, Maria-Victoria Mateos, Carlos Fernandez de Larrea
Journal: Blood
Blood (2022) 140 (Supplement 1): 10347–10349.
https://doi.org/10.1182/blood-2022-166525
Published: 2022
Journal Articles

BCMA CAR-T Cell Phenotype and Functionality Is Affected By Disease Stage of Multiple Myeloma Patients

Angel Martin-Mallo, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Aintzane Zabaleta, Diego Alignani, Paula Rodríguez-Márquez, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jauregui, Cristina Calviño, Maria Luisa Palacios-Berraquero, Candela Ceballos, Jorge Illarramendi Esteban, Diana Gisell Gabaldon Limas, Maria Cruz Viguria, Ana Margarita Redondo, Manel Juan, Álvaro Urbano-Ispizua, Carlos Fernandez de Larrea, Paula Rodríguez-Otero, Jose J. Rifon Roca, Ana Alfonso Pierola, Teresa Lozano, Juan Jose Lasarte, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 12708–12710.
https://doi.org/10.1182/blood-2022-163149
Published: 2022
Journal Articles

Correlative Biological Studies Related to the Response, Peak and Persistence of ARI0002h, an Academic BCMA-Directed CAR-T Cell, with Fractionated Initial Infusion and Booster Dose for Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)

Aina Oliver-Caldés, Marta Español-Rego, Aintzane Zabaleta, Susana Inogés, Ascensión López-Diaz de Cerio, Veronica Gonzalez-Calle, Valentin Cabañas, Beatriz Martin-Antonio, Lorena Pérez-Amill, Juan Luis Reguera, Juan Roberto Rodriguez-Madoz, Paula Rodríguez-Otero, Daniel Benítez-Ribas, Mari-Pau Mena, Marta Lasa, Luis Gerardo Rodríguez-Lobato, Azucena González, Laura Rosinol, Jose Maria Moraleda, Felipe Prósper, Álvaro Urbano-Ispizua, Maria-Victoria Mateos, Manel Juan, Bruno Paiva, Mariona Pascal, Carlos Fernandez de Larrea
Journal: Blood
Blood (2021) 138 (Supplement 1): 552.
https://doi.org/10.1182/blood-2021-148281
Published: 2021
Journal Articles

Immunologic Characterization of Coronavirus Disease 2019 (COVID-19) Patients with Hematological Cancer: Biologic and Clinical Significance

Catarina Maia, Esperanza Martín-Sánchez, Juan José Garcés, Ascensión López-Diaz de Cerio, Susana Inogés, MD PhD, Manuel Landecho, Belen Gil-Alzugaray, Cristina Pérez Ruiz, Cirino Botta, MDPhD, Aintzane Zabaleta, PhD, Felix Alegre, MD, César Rincón, Laura Blanco, Sarai Sarvide, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Cristina Moreno, Monica Olid, Andrés Blanco, Josepmaria Argemi, Bruno Paiva, PhD, Jose-Ramon Yuste
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-136969
Published: 2020
Journal Articles

Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma

Cristina Perez, Cirino Botta, Aintzane Zabaleta, Noemi Puig, Maria-Teresa Cedena, Ibai Goicoechea, Daniel Alameda, Edurne San José-Eneriz, Juana Merino, Paula Rodríguez-Otero, Catarina Maia, Diego Alignani, Patricia Maiso, Irene Manrique, David Lara-Astiaso, Amaia Vilas-Zornoza, Sarai Sarvide, Caterina Riillo, Marco Rossi, Laura Rosiñol, Albert Oriol, María-Jesús Blanchard, Rafael Rios, Anna Sureda, Jesus Martin, Rafael Martinez, Joan Bargay, Javier de la Rubia, Miguel-Teodoro Hernandez, Joaquin Martinez-Lopez, Alberto Orfao, Xabier Agirre, Felipe Prosper, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Blade, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2020) 136 (2): 199–209.
https://doi.org/10.1182/blood.2019004537
Published: 2020
Includes: Supplemental data
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

Detailed Phenotypic, Molecular and Functional Profiling of Myeloid Derived Suppressor Cells (MDSCs) in the Tumor Immune Microenvironment (TIME) of Multiple Myeloma (MM)

Cristina Pérez Ruiz, Aintzane Zabaleta, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Juana Merino, Diego Alignani, PhD, Sonia Garate, Ibai Goicoechea, PhD, David Lara-Astiaso, PhD, Sarai Sarvide, Cirino Botta, MD, Joaquin Martinez Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Laura Rosinol, MD PhD, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Joan Bladé, MD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4436.
https://doi.org/10.1182/blood-2018-99-111102
Published: 2018