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Journal Articles

Clinical Significance of Measurable Residual Disease (MRD) in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) Treated with Chimeric Antigen Receptor (CAR) T Cells and T-Cell Engagers (TCE)

Aintzane Zabaleta, Noemi Puig, Maria Teresa Cedena Romero, Jose J Perez, Cristina Moreno, Luis-Esteban Tamariz-Amador, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Lucia Lopez Corral, Beatriz Rey-Búa, Borja Puertas Martínez, Fatima Miras, Jose Sanchez-Pina, Nieves Lopez, Joaquin Martinez-Lopez, Maria Victoria Mateos, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 94.
https://doi.org/10.1182/blood-2023-185980
Published: 2023
Journal Articles

Biological and Clinical Significance of Undetectable Circulating Tumor Cells (CTCs) in Patients (Pts) with Multiple Myeloma (MM)

Juan-José Garcés, Rosalinda Termini, Esperanza Martín-Sánchez, Marta Lasa, Jose J Perez, Norma C. Gutierrez, Manuela Fernández, Maria Jose Calasanz, Laura Rosiñol, Miguel Teodoro Hernández Garcia, Albert Oriol, Anna Maria Sureda Balari, Albert Perez Montaña, Enrique M Ocio, Maria Casanova Espinosa, Felipe Prosper, Joaquin Martinez-Lopez, Jorge Labrador, Esther Gonzalez Garcia, Rafael Ríos, Fernando Escalante, Joan Bargay, Elena Cabezudo, Valentín Cabañas, Niels Weinhold, Aldo Roccaro, Herve Avet-Loiseau, Alberto Orfao, Joan Blade Creixenti, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Jesus San-Miguel, María T Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 646.
https://doi.org/10.1182/blood-2023-186411
Published: 2023
Journal Articles

Circulating Tumor Cells (CTCs) in Smoldering and Active Multiple Myeloma (MM): Mechanism of Egression, Clinical Significance and Therapeutic Endpoints

Juan-José Garcés, Noemi Puig, Rosalinda Termini, María Teresa Cedena, Cristina Moreno, José J Pérez, Diego Alignani, Sarvide Sarai, Albert Oriol, Esther González Garcia, Fernando Escalante, Anna Sureda, Felipe De Arriba, Rafael Rios, Jose Maria Moraleda, Mercedes Gironella, Miguel T Hernández, Juan Jose Joan Bargay, Luis Palomera, Alberto Orfao, Evangelos Terpos, Albert Pérez, Tomas Jelinek, Alexia Suárez, Hartmut Goldschmidt, Hervé Avet-Loiseau, Aldo M. Roccaro, Joaquin Martinez-Lopez, Juan Jose Lahuerta, Enrique Ocio, Laura Rosinol, Joan Bladé Creixenti, Maria-Victoria Mateos, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (Supplement 1): 76.
https://doi.org/10.1182/blood-2021-146535
Published: 2021
Journal Articles

Definition and Clinical Significance of the MGUS-like Phenotype: A Study in 5,114 Patients (Pts) with Monoclonal Gammopathies

Leire Burgos, Luis Esteban Tamariz-Amador, Noemí Puig, María Teresa Cedena, Tomas Jelinek, Sarah K Johnson, Paolo Milani, Lourdes Cordon, José J Pérez, Marta Lasa, Rosalinda Termini, Albert Oriol, Miguel-Teodoro Hernández, Luis Palomera, Rafael Martinez Martinez, Javier de la Rubia, Felipe De Arriba, Rafael Rios, Maria Esther González, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Isabel Krsnik, Albert Pérez, Veronica Gonzalez De La Calle, Paula Rodríguez-Otero, Vladimir Maisnar, Roman Hajek, Frits van Rhee, Victor H Jimenez-Zepeda, Giovanni Palladini, Paolo Milani, Alberto Orfao, Laura Rosinol, Joan Bladé Creixenti, Joaquín Martínez-López, Juan-José Lahuerta, Maria-Victoria Mateos, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (Supplement 1): 541.
https://doi.org/10.1182/blood-2021-150092
Published: 2021
Journal Articles

Discordances between Immunofixation (IFx) and Minimal Residual Disease (MRD) Assessment with Next-Generation Flow (NGF) and Sequencing (NGS) in Patients (Pts) with Multiple Myeloma (MM): Clinical and Pathogenic Significance

Sara Rodríguez, PhD, Ibai Goicoechea, PhD, Katerina Gemenetzi, Cirino Botta, MDPhD, Andreas Agathangelidis, PhD, Noemi Puig, MD PhD, María Teresa Cedena, MD, Alejandro Medina, MD, Rafael Valdés-Mas, Juan José Garcés, José J Pérez, Leire Burgos, María José Calasanz, PhD, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Sarvide Sarai, Felipe Prosper, MD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, Juan Jose Lahuerta, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, María-Victoria Mateos, MD PhD, Anastasia Chatzidimitriou, Jesus F. San-Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136258
Published: 2020
Journal Articles

Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma

Catarina Maia, Noemi Puig, Maria-Teresa Cedena, Ibai Goicoechea, Rafael Valdes-Mas, Iria Vazquez, Maria-Carmen Chillon, Paula Aguirre, Sarai Sarvide, Francisco Javier Gracia-Aznárez, Gorka Alkorta, Maria-Jose Calasanz, Ramon Garcia-Sanz, Marcos Gonzalez, Norma C. Gutierrez, Joaquin Martinez-Lopez, José J. Perez, Juana Merino, Cristina Moreno, Leire Burgos, Diego Alignani, Cirino Botta, Felipe Prosper, Sergio Matarraz, Alberto Orfao, Albert Oriol, Ana-Isabel Teruel, Raquel de Paz, Felipe de Arriba, Miguel T. Hernandez, Luis Palomera, Rafael Martinez, Laura Rosiñol, Maria-Victoria Mateos, Juan-Jose Lahuerta, Joan Blade, Jesus F. San Miguel, Bruno Paiva
Journal: Blood
Blood (2020) 135 (26): 2375–2387.
https://doi.org/10.1182/blood.2019003382
Published: 2020
Includes: Supplemental data
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

Qip-Mass Spectrometry in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Maria-Victoria Mateos, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Ramón García-Sanz, MD PhD, Enrique M. Ocio, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD, Jesus F. San-Miguel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 581.
https://doi.org/10.1182/blood-2019-127717
Published: 2019
Journal Articles

Heavy and Light Chain Monitoring in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Enrique M. Ocio, Ramón García-Sanz, MD PhD, Joan Bladé, MD PhD, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD, Maria-Victoria Mateos
Journal: Blood
Blood (2019) 134 (Supplement_1): 1852.
https://doi.org/10.1182/blood-2019-128655
Published: 2019
Journal Articles

Multidimensional Immunophenotyping Identifies Hallmarks of Systemic Light-Chain Amyloidosis (AL) and Maps the Disease in the Crossroad between MGUS and Multiple Myeloma (MM)

Noemi Puig, MD PhD, Bruno Paiva, MD PhD, Marta Lasa, Leire Burgos, José J Pérez, Juana Merino, Cristina Moreno, Maria-Belen Vidriales, MD, Dolores Gómez, María Teresa Cedena, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Javier De La Rubia, MD, José Enrique de la Puerta, Felipe De Arriba, PhD, Felipe Prosper, MD PhD, Joaquin Martinez Lopez, MD PhD, Quentin Lecrevisse, Javier Verde, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Alberto Orfao, MD PhD, Jesús F San-Miguel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3170.
https://doi.org/10.1182/blood-2018-99-119281
Published: 2018
Journal Articles

Immune Predictors of Response to Pembrolizumab Monotherapy As Consolidation in Multiple Myeloma Patients: Results of the GEM-Pembresid Clinical Trial

Enrique M. Ocio, MDPhD, Noemi Puig, MD PhD, Luis Corchete, José J Pérez, Julio Dávila, Teresa Paíno, Javier de la Rubia, Albert Oriol, MD, Jesús Martín, Felipe De Arriba, PhD, Joan Bladé, MD PhD, M Jesús Blanchard, Ramón García-Sanz, MD, Bruno Paiva, PhD, Juan-José Lahuerta, Jesus F. San Miguel, MD, Maria-Victoria Mateos, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1874.
https://doi.org/10.1182/blood.V130.Suppl_1.1874.1874
Published: 2017
Journal Articles

Peripheral Blood Analysis By Flow Cytometry for the Diagnosis of Type I Chronic Myelomonocytic Leukemia

Hae Tha Mya, MRCP, FRCPath, Maria Diez Campelo, MD PhD, Sandra Valle Herrero, MD, Agustin Díaz-Alvarez, MDPhD, Domingo Bustos, MD, Luis M Vaquero, MD, José J Pérez, Verónica González, MD, Jose M Bastida, MD, Alfonso Garcia-Coca, MD, Erik de Cabo, MD, Tomas Gonzalez, MD, Noemi Puig, MD PhD, Alejandro Martin-Sancho, MD PhD, Patricia Fernðndez, Julio Davila, MD, Ana Africa Martín López, MD, Marcos González, MD PhD, Consuelo Del Cañizo, MD PhD, Maria Belen Vidriales, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5248.
https://doi.org/10.1182/blood.V126.23.5248.5248
Published: 2015
Journal Articles

Next Generation Flow (NGF) for High Sensitive Detection of Minimal Residual Disease (MRD) in Multiple Myeloma (MM)

Juan A Flores-Montero, MD, Bruno Paiva, PhD, Luzalba Sanoja-Flores, M.Sc., Noemi Puig, MD PhD, Omar García, PhD, Sebastian Böttcher, MD PD, José J Pérez-Morán, Maria Belen Vidriales, MD PhD, Maria-Victoria Mateos, Ramon Garcia-Sanz, MD PhD, Cristina Jimenez, BsC, Marcos González, MD PhD, Joaquin Martinez-López, MD PhD, María Consuelo Cañizo, MD PhD, Jesus San Miguel, MD PhD, Brian Durie, MD, Jacques J.M. van Dongen, Alberto Orfao, MD PhD
Journal: Blood
Blood (2015) 126 (23): 367.
https://doi.org/10.1182/blood.V126.23.367.367
Published: 2015
Journal Articles

PD-1 and PD-L1 Are Overexpressed in the "Intermediate CD14+CD16+" and "Non Classical CD14lowCD16+" but Not in the "Classical CD14+CD16-" Monocytes in the Peripheral Blood of Chronic Myelomonocytic Leukemia

Hae Tha Mya, MRCP, FRCPath, Maria Diez Campelo, MD PhD, Sandra Valle Herrero, MD, Agustin Díaz-Alvarez, MDPhD, Domingo Bustos, MD, Luis M Vaquero, MD, José J Pérez, Verónica González, MD, Jose M Bastida, MD, Carlos Aguilar, MD, Abelardo Bárez, MD, Noemi Puig, MD PhD, Alejandro Martin-Sancho, MD PhD, María Jesús Garcia, Irene Aires, Sara Alonso, MD, Marcos González, MD PhD, Consuelo Del Cañizo, MD PhD, Maria Belen Vidriales, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1694.
https://doi.org/10.1182/blood.V126.23.1694.1694
Published: 2015
Journal Articles

The cellular origin and malignant transformation of Waldenström macroglobulinemia

Bruno Paiva, Luis A. Corchete, Maria-Belen Vidriales, Ramón García-Sanz, Jose J. Perez, Irene Aires-Mejia, Maria-Luz Sanchez, Paloma Barcena, Diego Alignani, Cristina Jimenez, Maria-Eugenia Sarasquete, María-Victoria Mateos, Enrique M. Ocio, Noemi Puig, Fernando Escalante, José Hernández, Rebeca Cuello, Alfonso García de Coca, Magdalena Sierra, Maria-Carmen Montes, Tomás J. González-López, Josefina Galende, Abelardo Bárez, José Alonso, Emilia Pardal, Alberto Orfao, Norma C. Gutierrez, Jesús F. San Miguel
Journal: Blood
Blood (2015) 125 (15): 2370–2380.
https://doi.org/10.1182/blood-2014-09-602565
Published: 2015
Includes: Supplemental data
Journal Articles

Whole Bone Marrow (BM) Immunophenotypic Profiling for the Identification of Newly Diagnosed Symptomatic Multiple Myeloma (MM) Patients with an MGUS-Like Signature Associated with Long-Term Disease Control (LTDC)

Bruno Paiva, María-Belén Vidriales, Jose J. Perez, María-Angeles Montalbán, Norma Gutierrez, Laura Rosiñol, MD, Joaquín Martínez-López, MD, María-Victoria Mateos, MD, PhD, Lourdes Cordon, Albert Oriol, Maria Jose Terol, MD, Maria Asuncion Echeveste, Raquel Paz, Felipe de Arriba, Luis Palomera, MD, Javier De La Rubia, MD, Joaquín Díaz-Mediavilla, Anna Sureda, MD, PhD, Ana Gorosquieta, Adrian Alegre, Alejandro Martín, Alberto Orfao, Juan-Jose Lahuerta, MD, Joan Blade, MD, Jesus F. San Miguel, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3949.
https://doi.org/10.1182/blood.V120.21.3949.3949
Published: 2012
Journal Articles

Multiparameter Flow Cytometry (MFC) Evaluation of Plasma Cell (PC) DNA Ploidy Status and Proliferative Rate in 595 Multiple Myeloma (MM) Patients (pts) Included in the Spanish GEM2000 and GEM2005<65years Trials: Clinical Value and Biological Insights,

Bruno Paiva, María-Belén Vidriales, María-Angeles Montalbán, Jose J. Perez, Norma C. Gutierrez, Laura Rosiñol, MD, Joaquín Martínez-López, MD, Maria Victoria Mateos, Lourdes Courdón, Albert Oriol, María José Terol, MD, PhD, Maria Asunción Etxebeste, Raquel de Paz, Felipe de Arriba, Luis Palomera, Javier De La Rubia, Joaquín Díaz-Mediavilla, Anna Sureda, MD, PhD, Ana Gorosquieta, Adrian Alegre, Alejandro Martín, Miguel T. Hernandez, Juan José Lahuerta, Joan Blade, Jesús F San Miguel, MD PhD
Journal: Blood
Blood (2011) 118 (21): 3938.
https://doi.org/10.1182/blood.V118.21.3938.3938
Published: 2011
Journal Articles

Biological and Clinical Significance of CD81 Expression by Clonal Plasma Cells in High-Risk Smoldering and Symptomatic Multiple Myeloma (MM) Patients,

Bruno Paiva, Norma C. Gutierrez, Xi Chen, María-Belén Vidriales, María-Angeles Montalbán, Laura Rosiñol, MD, Albert Oriol, Joaquín Martínez-López, MD, Maria Victoria Mateos, Lucía López-Corral, Elena Díaz-Rodríguez, Jose J. Perez, Elena Fernandez-Redondo, Felipe de Arriba, Luis Palomera, Enrique Bengoechea, María José Terol, MD, PhD, Raquel de Paz, Alejandro Martín, Jose Hernández, Alberto Orfao, MD, PhD, Juan José Lahuerta, Joan Blade, Atanasio Pandiella, Jesus F. San Miguel, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3936.
https://doi.org/10.1182/blood.V118.21.3936.3936
Published: 2011
Journal Articles

The clinical utility and prognostic value of multiparameter flow cytometry immunophenotyping in light-chain amyloidosis

Brief Report
Bruno Paiva, María-Belén Vídriales, José J. Pérez, María-Consuelo López-Berges, Ramón García-Sanz, Enrique M. Ocio, Natalia de las Heras, Rebeca Cuello, Alfonso García de Coca, Emilia Pardal, José Alonso, Magdalena Sierra, Abelardo Bárez, José Hernández, Lissbett Suárez, Josefina Galende, María-Victoria Mateos, Jesús F. San Miguel
Journal: Blood
Blood (2011) 117 (13): 3613–3616.
https://doi.org/10.1182/blood-2010-12-324665
Published: 2011
Includes: Supplemental data
Journal Articles

Utility of Multiparameter Flow Cytometry Immunophenotypic Studies In Patients with Systemic Light Chain (AL) Amyloidosis

Bruno Paiva, María-Belén Vidriales, Jose J. Perez, Maria-Consuelo López-Berges, Ramón García-Sanz, Enrique M. Ocio, Rebeca Garcia, Alfonso Garcia de Coca, Emilia Pardal, Magdalena Sierra, Jose Hernández, Natalia de las Heras, Josefina Galende, Jose Maria Alonso, Abelardo Bárez, María-Victoria Mateos, Jesus F San Miguel
Journal: Blood
Blood (2010) 116 (21): 4051.
https://doi.org/10.1182/blood.V116.21.4051.4051
Published: 2010