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Journal Articles

Preclinical Efficacy of the Investigational Orally Bioavailable Proteasome Inhibitor MLN9708 in Myeloma Bone Disease

Antonio Garcia-Gomez, Dalia Quwaider, Enrique M Ocio, MD, PhD, Laura San-Segundo, Teresa Paíno, Juan F Blanco, Allison J Berger, PhD, Atanasio Pandiella, MD, PhD, Jesús F San-Miguel, MD, PhD, Mercedes Garayoa
Journal: Blood
Blood (2012) 120 (21): 4014.
https://doi.org/10.1182/blood.V120.21.4014.4014
Published: 2012
Journal Articles

Epoxyketone-Based Proteasome Inhibitors Carfilzomib and Orally Bioavailable ONX 0912 Have Anti-Resorptive and Bone-Anabolic Activity in Addition to Anti-Myeloma Effects

Michelle A Hurchla, Antonio Garcia-Gomez, Mary C Hornick, Enrique M Ocio, Aixiao Li, Juan F Blanco, Lynne Collins, Christopher J Kirk, David Piwnica-Worms, Ravi Vij, MD, Michael H Tomasson, Atanasio Pandiella, Jesús F San Miguel, Mercedes Garayoa, Katherine N Weilbaecher
Journal: Blood
Blood (2011) 118 (21): 2906.
https://doi.org/10.1182/blood.V118.21.2906.2906
Published: 2011
Journal Articles

Biological and Clinical Significance of CD81 Expression by Clonal Plasma Cells in High-Risk Smoldering and Symptomatic Multiple Myeloma (MM) Patients,

Bruno Paiva, Norma C. Gutierrez, Xi Chen, María-Belén Vidriales, María-Angeles Montalbán, Laura Rosiñol, MD, Albert Oriol, Joaquín Martínez-López, MD, Maria Victoria Mateos, Lucía López-Corral, Elena Díaz-Rodríguez, Jose J. Perez, Elena Fernandez-Redondo, Felipe de Arriba, Luis Palomera, Enrique Bengoechea, María José Terol, MD, PhD, Raquel de Paz, Alejandro Martín, Jose Hernández, Alberto Orfao, MD, PhD, Juan José Lahuerta, Joan Blade, Atanasio Pandiella, Jesus F. San Miguel, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3936.
https://doi.org/10.1182/blood.V118.21.3936.3936
Published: 2011
Journal Articles

Reversibility of the Resistance to Lenalidomide and Pomalidomide and Absence of Cross-Resistance in a Murine Model of MM

Enrique M Ocio, Diego Fernández-Lázaro, Laura San-Segundo, Lorena González-Méndez, Montserrat Martín-Sánchez, Mercedes Garayoa, Teresa Paíno, Antonio Garcia-Gomez, Norma C. Gutierrez, Manuel Delgado, Juan C. Montero, Nuria Quintana, Jose Luis García, Atanasio Pandiella, Jesús F. San Miguel, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 134.
https://doi.org/10.1182/blood.V118.21.134.134
Published: 2011
Journal Articles

Antimyeloma Action of the Multikinase Inhibitor TG02

Stela Álvarez-Fernández, Susana Hernández-García, Xi Chen, Enrique M. Ocio, Jr., MD, PhD, Bruno Paiva, Kay R. Meshow, Lynn A. Cheatham, Francis Burrows, PhD, Jesús F. San Miguel, Sr., MD, PhD, Atanasio Pandiella, Sr., MD, PhD
Journal: Blood
Blood (2010) 116 (21): 4062.
https://doi.org/10.1182/blood.V116.21.4062.4062
Published: 2010
Journal Articles

A Novel Murine Model of Human Disseminated Multiple Myeloma with A Subcutaneous Human Bone Chip from an Adult Donor Confers Proliferative Advantage and Is Suitable for the In Vivo Evaluation of Novel Drugs

Enrique M. Ocio, Laura San-Segundo, Juan Blanco, Teresa Hernández-Iglesias, Diego Fernández-Lázaro, Teresa Paíno, Mercedes Garayoa, Enrique Álava, Fernando Jiménez-Barredo, Elena Díaz-Rodríguez, Atanasio Pandiella, J.F San Miguel
Journal: Blood
Blood (2010) 116 (21): 4077.
https://doi.org/10.1182/blood.V116.21.4077.4077
Published: 2010
Journal Articles

Development of 99mTcHYNIC-Tocilizumab as Imaging Agent In Multiple Myeloma

Eloísa Riva, MD, Victoria Calzada, BSc, Eugenia Gutiérrez, Marcelo Fernández, BSc, Natalia Oddone, BSc, María Moreno, PhD, Juan Benech, PhD, José A. Chabalgoity, PhD, Atanasio Pandiella, Sr., MD, PhD, Pablo Cabral, MSc
Journal: Blood
Blood (2010) 116 (21): 4081.
https://doi.org/10.1182/blood.V116.21.4081.4081
Published: 2010
Journal Articles

Acadesine Inhibits Proliferation and Induces Apoptosis In Multiple Myeloma Cells, and Synergizes with Standard of Care Antimyeloma Agents

Susana Hernández-García, Mercè de Frias, Clara Campàs, Bruno Paiva, Enrique M. Ocio, Jesús F. San Miguel, Sr., MD, PhD, Atanasio Pandiella, Sr., MD, PhD
Journal: Blood
Blood (2010) 116 (21): 5023.
https://doi.org/10.1182/blood.V116.21.5023.5023
Published: 2010
Journal Articles

Zalypsis Has Synergistic Effect When Combined with Bortezomib + Dexamethasone through Caspase Dependent and Mainly Independent Mechanisms and through A Potent Induction of DNA Damage

Enrique M. Ocio, Lorena González-Coco, Laura San-Segundo, Xi Chen, Teresa Hernández-Iglesias, Diego Fernández-Lázaro, Teresa Paíno, Mercedes Garayoa, Carmen Cuevas, Pablo Avilés, Enrique Álava, Atanasio Pandiella, J.F San Miguel
Journal: Blood
Blood (2010) 116 (21): 3003.
https://doi.org/10.1182/blood.V116.21.3003.3003
Published: 2010
Journal Articles

Dasatinib Promotes Osteoprogenitor Differentiation and Inhibition of Osteoclastogenesis: Rationale for Treatment of Myeloma Bone Disease.

Antonio Garcia-Gomez, Mercedes Garayoa, Enrique M. Ocio, Edvan Crusoe, Diego Fernández, Teresa Paíno, Laura San Segundo, Juan C. Montero, Stela Álvarez-Fernández, Juan F. Blanco, Fermin M. Sanchez-Guijo, Felix T. Garzon, Atanasio Pandiella, Jesús F. San-Miguel, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3834.
https://doi.org/10.1182/blood.V114.22.3834.3834
Published: 2009
Journal Articles

Zalypsis Possess Potent Antileukemic Effect through the Induction of a DNA Damage Response, Independently of the p53 Status.

Enrique Colado, Teresa Paíno, Enrique M Ocio, Patricia Maiso, Xi Chen, Stela Álvarez-Fernández, Jesús Martín-Sánchez, Lorena González, Laura San-Segundo, Mercedes Garayoa, Diego Fernández-Lázaro, Maria-Belén Vidriales, Carlos Galmarini, Pablo Avilés, Carmen Cuevas, Atanasio Pandiella, Jesús F. San-Miguel, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3792.
https://doi.org/10.1182/blood.V114.22.3792.3792
Published: 2009
Journal Articles

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks

Enrique M. Ocio, Patricia Maiso, Xi Chen, Mercedes Garayoa, Stela Álvarez-Fernández, Laura San-Segundo, David Vilanova, Lucía López-Corral, Juan C. Montero, Teresa Hernández-Iglesias, Enrique de Álava, Carlos Galmarini, Pablo Avilés, Carmen Cuevas, Jesús F. San-Miguel, Atanasio Pandiella
Journal: Blood
Blood (2009) 113 (16): 3781–3791.
https://doi.org/10.1182/blood-2008-09-177774
Published: 2009
Includes: Supplemental data
Journal Articles

Panobinostat (LBH589) a Promising New Partner for Combination with Doxorubicin in Acute Myeloid Leukemia.

Patricia Maiso, Enrique Colado, Enrique M Ocio, Mercedes Garayoa, Peter Atadja, Atanasio Pandiella, J. F. San Miguel, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1638.
https://doi.org/10.1182/blood.V112.11.1638.1638
Published: 2008
Journal Articles

DNA Double Strand Breaks Induction by Zalypsis, a Novel Marine Compound, Results in Potent Antimyeloma Activity

Enrique M Ocio, Patricia Maiso, Xi Chen, Mercedes Garayoa, Stela Álvarez-Fernández, Laura San-Segundo, David Vilanova, Lucía López-Corral, Juan Carlos Montero, Teresa Hernández-Iglesias, Enrique de Álava, Carlos Galmarini, Pablo Avilés, Carmen Cuevas, Atanasio Pandiella, J.F. San Miguel, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 245.
https://doi.org/10.1182/blood.V112.11.245.245
Published: 2008
Journal Articles

Antimyeloma Efficacy of Plitidepsin (Aplidin®): From Bench to the Bedside.

Enrique M. Ocio, Constantine Mitsiades, M. Victoria Mateos, Patricia Maiso, Faustino Mollinedo, Mercedes Garayoa, Consuelo Gajate, Joan Blade, Felipe Prosper, Juan José Lahuerta, Nicholas Mitsiades, Ciaran J. McMullan, Nikhil C. Munshi, Teru Hideshima, Dharminder Chauhan, Carmen Cuevas, Pablo Avilés, Glynn Faircloth, Paul G. Richardson, Atanasio Pandiella, Kenneth C. Anderson, J.F. San Miguel
Journal: Blood
Blood (2007) 110 (11): 1178.
https://doi.org/10.1182/blood.V110.11.1178.1178
Published: 2007
Journal Articles

Triple Combinations of the HDAC Inhibitor Panobinostat (LBH589) + Dexamethasone with Either Lenalidomide or Bortezomib Are Highly Effective in a Multiple Myeloma Mouse Model.

Enrique M. Ocio, MD, PhD, David Vilanova, BS, Laura San-Segundo, BS, Patricia Maiso, BS, PhD, Mercedes Garayoa, BS, PhD, Peter Atadja, Atanasio Pandiella, MD, PhD, J.F. San Miguel, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 1514.
https://doi.org/10.1182/blood.V110.11.1514.1514
Published: 2007
Journal Articles

The Activation of Fas Receptor by APO010, a Recombinant Form of Fas Ligand, Induces In Vitro and In Vivo Antimyeloma Activity.

Enrique M. Ocio, MD, PhD, Patricia Maiso, BS, PhD, Mercedes Garayoa, BS, PhD, Marc Dupuis, Atanasio Pandiella, MD, PhD, J.F. San Miguel, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 1515.
https://doi.org/10.1182/blood.V110.11.1515.1515
Published: 2007
Journal Articles

The IGF1-R Inhibitor AEW541 Is a Potent Anti-Myeloma Agent That Overcomes Drugs Resistance, and Has Synergistic Activity with Other New Drugs.

Patricia Maiso, Enrique M. Ocio, MD,PhD, Mercedes Garayoa, PhD, Mark A. Pearson, MD,PhD, Atanasio Pandiella, MD,PhD, J.F. San Miguel, MD,PhD
Journal: Blood
Blood (2006) 108 (11): 2599.
https://doi.org/10.1182/blood.V108.11.2599.2599
Published: 2006
Journal Articles

Role of c-Kit in Multiple Myeloma.

Juan Carlos Montero, PhD, J.F. San Miguel, Atanasio Pandiella, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 5047.
https://doi.org/10.1182/blood.V108.11.5047.5047
Published: 2006
Journal Articles

Proteasome Inhibitor Bortezomib Has Antitumour Activity Against Both CD34 Negative and CD34 Positive Acute Myeloid Leukemia Cells.

Enrique Colado, MD, Jesus Martin, MD, Maria-Belen Vidriales, MD,PhD, Atanasio Pandiella, MD,PhD, Dixie-Lee Esseltine, MD,FRCPC, Jose J. Perez, Enrique M. Ocio, MD,PhD, J.F. San Miguel, MD,PhD
Journal: Blood
Blood (2006) 108 (11): 1989.
https://doi.org/10.1182/blood.V108.11.1989.1989
Published: 2006