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Mikel Hernaez
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Journal Articles

An IFNγ-Mediated Immune Inflamed Microenvironment State in Multiple Myeloma with TP53 Loss That Can be Therapeutically Exploited

Marta Larrayoz, Elena Arriazu, Aintzane Zabaleta, Carmen Roncal, Ibon Tamayo, Diana Llopiz, Maddalen Jimenez, Carla Castro, Jon Celay, Carmen Vicente, Camila Guerrero, Sonia Sanz, Maria J Garcia-Barchino, Naroa Barrena, Noemi Puig, Maria Teresa Cedena Romero, Maria Jose Calasanz, Paula Rodríguez-Otero, Jesús F. San-Miguel, Mikel Hernaez, Xabier Agirre, Pablo Sarobe, Felipe Prosper, Bruno Paiva, Jose A. Martinez-Climent
Journal: Blood
Blood (2024) 144 (Supplement 1): 670.
https://doi.org/10.1182/blood-2024-194041
Published: 2024
Journal Articles

Unveiling ZMAT2 and SMARCD3 As Therapeutic Targets to Mitigate Aberrant Hematopoiesis in MDS

Aintzane Diaz-Mazkiaran, Jesús de la Fuente, Guillermo Serrano, Paula Garcia-Olloqui, Nerea Berastegui, Marina Ainciburu, Ana Alfonso Pierola, Amaia Vilas-Zornoza, Patxi San-Martin, Jose Maria Lamo-Espinosa, Mikel San-Julian, Pamela Acha, Tamara Jimenez, Antonieta Molero, Maria Julia Montoro, Francesc Sole, Maria Diez-Campelo, David Valcarcel, Irene Ganan-Gomez, Felipe Prosper, Mikel Hernaez, Teresa Ezponda
Journal: Blood
Blood (2024) 144 (Supplement 1): 879.
https://doi.org/10.1182/blood-2024-205305
Published: 2024
Journal Articles

Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional Analyses

Aleksandra Kurowska, Azari Bantan, Raghad Shuwaikan, Itziar Cenzano, Paula Aguirre-Ruiz, Estíbaliz Miranda, Leire Garate, Amaia Vilas-Zornoza, Patxi San-Martin, Marta Larrayoz, Nahia Gómez-Echarte, Beñat Ariceta, Daniel Soto Ortiz, Turki Sobahy, José Ignacio Martín-Subero, Vincenzo Lagani, Jesper Tegnér, Jose A. Martinez-Climent, Xabier Agirre, Mikel Hernáez Arrazola, Felipe Prosper, David Gomez-Cabrero
Journal: Blood
Blood (2024) 144 (Supplement 1): 1889.
https://doi.org/10.1182/blood-2024-209833
Published: 2024
Journal Articles

Molecular Mechanisms Promoting Long-Term Cytopenia after BCMA CAR-T Therapy in Multiple Myeloma

Maria Luisa Palacios-Berraquero, Paula Rodriguez-Marquez, Maria Erendira Calleja-Cervantes, Nerea Berastegui, Aintzane Zabaleta, Leire Burgos, Diego Alignani, Patxi San-Martin, Amaia Vilas-Zornoza, Saray Rodríguez Diaz, Susana Inogés, Ascensión López-Díaz De Cerio, Sofia Huerga, Luis-Esteban Tamariz-Amador, Jose J. Rifon, Ana Alfonso Pierola, Juan J Lasarte, Bruno Paiva, Mikel Hernaez, Paula Rodríguez-Otero, Jesús F. San-Miguel, Teresa Ezponda, Juan Roberto Rodriguez-Madoz, Felipe Prosper
Journal: Blood
Blood (2024) 144 (Supplement 1): 4798.
https://doi.org/10.1182/blood-2024-207990
Published: 2024
Journal Articles

Optimization of a Universal Allogeneic CAR-T Cells Combining CRISPR and Transposon-Based Technologies for Treatment of Acute Myeloid Leukemia

Candela Ceballos Bolaños, Cristina Calviño, Ana Alfonso Pierola, Patricia Jauregui, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Paula Rodríguez Márquez, Ángel Martin Mallo, Elena Iglesias, Gloria Abizanda, Saray Rodríguez Diaz, Rebeca Martínez Turrillas, Jorge Illarramendi Esteban, Ana Margarita Redondo, MC Viguria-Alegría, Carlos Panizo, Jose J. Rifon, Sara Villar, Juan J Lasarte, Susana Inogés, Ascensión López-Díaz De Cerio, Mikel Hernaez, Felipe Prosper, Juan Roberto Rodriguez-Madoz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3457.
https://doi.org/10.1182/blood-2023-189410
Published: 2023
Journal Articles

Longitudinal Transcriptomic Analysis of CAR-T Cells at Single-Cell Level Allows the Identification of Molecular Mechanisms Promoting Long-Term CAR-T Cell Persistence in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2069.
https://doi.org/10.1182/blood-2023-182933
Published: 2023
Journal Articles

Uncovering the Cis-Regulatory Program of Early Human B-Cell Commitment and Its Implications in the Pathogenesis of B-Cell Acute Lymphoblastic Leukemia

Nuria Planell, Xabier Martínez-de-Morentin, Daniel Mouzo, David Lara-Astiaso, Amaia Vilas-Zornoza, Patxi San-Martin, Diego Alignani, Bruno Paiva, Alberto Maillo, Aleksandra Kurowska, Arantxa Urdangarin, Peri Noori, Asier Ortega-Legarreta, Mikel Hernaez, Vincenzo Lagani, Narsis Kiani, Iñaki I. Martin Subero, Ricardo N. Ramírez, Jesper Tegner, Felipe Prosper, David Gomez-Cabrero
Journal: Blood
Blood (2023) 142 (Supplement 1): 4044.
https://doi.org/10.1182/blood-2023-185799
Published: 2023
Journal Articles

The Transcriptional Impact of 5q Deletion in MDS at Single Cell Resolution

Aintzane Diaz-Mazkiaran, Guillermo Serrano, Nerea Berastegui, Paula Garcia-Olloqui, Sofia Huerga, Ana Alfonso Pierola, Asier Ullate-Agote, Beñat Ariceta, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Jose Maria Lamo De Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Julia Montoro, Maria Diez-Campelo, David Valcarcel, Francesc Sole, Idoia Ochoa, Teresa Ezponda, Felipe Prosper, Mikel Hernaez
Journal: Blood
Blood (2023) 142 (Supplement 1): 1850.
https://doi.org/10.1182/blood-2023-186173
Published: 2023
Journal Articles

Light Chain Amyloidosis Plasma Cells Show Specific Chromatin Accessibility and Transcriptome

Beñat Ariceta, Alice Nevone, Itziar Cenzano, Ane Amundarain, Amaia Vilas-Zornoza, Leire Garate, Paula Aguirre-Ruiz, Estibaliz Miranda, Patxi San-Martin, Paolo Milani, Ramon Lecumberri Villamediana, Diego Alignani, Giovanni Palladini, Bruno Paiva, Jose Ignacio Martin-Subero, Giampaolo Merlini, Jesus San-Miguel, Mikel Hernaez, David Gomez-Cabrero, Xabier Agirre, Mario Nuvolone, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 4676.
https://doi.org/10.1182/blood-2023-185614
Published: 2023
Journal Articles

Comprehensive Characterization of the Bone Marrow Microenvironment Transcriptional Remodeling in the Progression from MGUS to Smoldering and Multiple Myeloma

Itziar Cenzano, Miguel Cocera, Azari Bantan, Marta Larrayoz, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Beñat Ariceta, Jin Ye, Diego Alignani, Aitziber Lopez, Aleksandra Kurowska, Fatimah AlSultan, Raghad Shuwaikan, Vincenzo Lagani, Jesper Tegner, Iñaki I. Martin Subero, Jose A. A Martinez-Climent, Xabier Agirre, Borja Saez-Ochoa, Bruno Paiva, Jesus San-Miguel, Mikel Hernaez, Isabel A Calvo, David Gomez-Cabrero, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 88.
https://doi.org/10.1182/blood-2023-178534
Published: 2023
Journal Articles

Sequential Scmultiomics of In Vivo CAR-T Cells Allows Characterization of Transcriptional Differences between Patients, and Identifies IL10 As a Potential Mechanism of Resistance to CAR-T Cells in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 3433.
https://doi.org/10.1182/blood-2023-182887
Published: 2023
Journal Articles

Identification of Molecular Mechanisms Governing CAR-T Cell Response in MM Patients Using Single Cell Transcriptomics

Lorea Jordana-Urriza, Guillermo Serrano, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabañas, Almudena Navarro-Bailón, Aina Oliver-Caldes, Marta Español-Rego, Mariona Pascal, Manel Juan, Álvaro Urbano-Ispizua, Juan Luis Reguera, Jose Maria Moraleda, Maria-Victoria Mateos, Fermin Sanchez-Guijo, Ana Alfonso Pierola, José J. Rifón Roca, Paula Rodríguez-Otero, Carlos Fernandez de Larrea, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Juan Jose Lasarte, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Mikel Hernáez, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 7366–7368.
https://doi.org/10.1182/blood-2022-163082
Published: 2022
Journal Articles

Characterization of Transcriptional Alterations Leading to Aberrant Myeloid Differentiation in Myelodysplastic Syndromes

Aintzane Diaz-Mazkiaran, Jesús De la Fuente, Guillermo Serrano, Paula Garcia-Olloqui, Nerea Berastegui, Marina Ainciburu, Ana Alfonso Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Jose Maria Lamo De Espinosa, Mikel San Julián, Pamela Acha, Francesc Solé, Tamara Jimenez, Félix López Cadenas, Maria Diez-Campelo, Antonieta Molero, Maria Julia Montoro, David Valcarcel, Teresa Ezponda, Mikel Hernáez, Felipe Prosper
Journal: Blood
Blood (2022) 140 (Supplement 1): 5852–5854.
https://doi.org/10.1182/blood-2022-166921
Published: 2022
Journal Articles

Single-Cell Transcriptomics Study of Human Hematopoietic Progenitors Reveals Alterations Associated with Aging and Myeloid Malignancies

Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Maria Lamo De Espinosa, Mikel San Julián, Tamara Jimenez, Felix López Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero Yordi, María Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, Gomez-Cabrero David, Maria Diez-Campelo, David Valcarcel, Mikel Hernáez, Juan P. Romero, Felipe Prosper
Journal: Blood
Blood (2021) 138 (Supplement 1): 1082.
https://doi.org/10.1182/blood-2021-153550
Published: 2021
Journal Articles

CAR Density Influences Antitumoral Efficacy of BCMA CAR-T Cells and Correlates with Clinical Outcome

Paula Rodriguez-Marquez, Maria Erendira Calleja-Cervantes, Guillermo Serrano, Maria Luisa Palacios-Berraquero, Diego Alignani, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Candela Ceballos, Angel Martin-Mallo, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jauregui, Cristina Calviño, Susana Inogés, Ascensión López-Diaz de Cerio, Aina Oliver-Caldés, Marta Español-Rego, Mariona Pascal, Beatriz Martin-Antonio, Manel Juan, Álvaro Urbano-Ispizua, Carlos Fernández De Larrea, Maria Cruz Viguria, Ana Margarita Redondo, Paula Rodríguez-Otero, Jose J. Rifon Roca, Ana Alfonso Pierola, Juan Jose Lasarte, Teresa Lozano, Bruno Paiva, Jesús F. San-Miguel, Mikel Hernáez, Juan Roberto Rodriguez-Madoz, Felipe Prósper
Journal: Blood
Blood (2021) 138 (Supplement 1): 735.
https://doi.org/10.1182/blood-2021-148578
Published: 2021