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Journal Articles

Cyclin D1 Induces Global Epigenetic and Transcriptional Changes in Multiple Myeloma with t(11;14)(q13;q32)

Huihuang Yan, Suganti Shivaram, Hongwei Tang, Hans Anderson, Shulan Tian, Michael D Howe, Abiola Bolarinwa, Cinthya Zepeda Mendoza, Stacey Lehman, Leif Bergsagel, Esteban Braggio, Rafael Fonseca, Shaji Kumar, Francesco Maura, Linda B. Baughn
Journal: Blood
Blood (2024) 144 (Supplement 1): 6822.
https://doi.org/10.1182/blood-2024-208503
Published: 2024
Journal Articles

Serum Immunoglobulins Are an Independent Prognostic Marker of Time to First Therapy in Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) and Monoclonal B-Cell Lymphocytosis (MBL)

Yuan Yao, Kari G. Rabe, Cristine Allmer, Geffen Kleinstern, Nicholas J. Boddicker, Shulan Tian, Laura A. Bruins, Daniel R. O'Brien, Aaron D. Norman, Huihuang Yan, Timothy G. Call, Paul J. Hampel, Yucai Wang, Eli Muchtar, Saad S. Kenderian, Neil E. Kay, Celine M. Vachon, James R. Cerhan, Susan L. Slager, Esteban Braggio, Sameer A. Parikh
Journal: Blood
Blood (2024) 144 (Supplement 1): 4616.
https://doi.org/10.1182/blood-2024-194925
Published: 2024
Journal Articles

Targeting Aberrant DLK1 Re-Expression in ASXL1 -Mutant Chronic Myelomonocytic Leukemia with BRD4 / p300-Directed Epigenetic Small Molecule Therapy

Terra L. Lasho, Jenna A. Fernandez, Jeong-Heon Lee, Linh D. Pham, Huihuang Yan, Christy Finke, Abhishek A. Mangaonkar, Aref Al-Kali, Naseema Gangat, Joseph Collard, Claes Wahlestedt, Mrinal M. Patnaik, Moritz Binder
Journal: Blood
Blood (2024) 144 (Supplement 1): 3197.
https://doi.org/10.1182/blood-2024-204070
Published: 2024
Journal Articles

The Role of NOXA in Venetoclax Treatment Response in Multiple Myeloma

Suganti Shivaram, Huihuang Yan, Hongwei Tang, Hans M. Anderson, Marcella Kaddoura, J Erin Wiedmeier-Nutor, Shulan Tian, Michael D Howe, Abiola Bolarinwa, Cinthya Zepeda Mendoza, Vikas A Gupta, Stacey Lehman, Constantine S Mitsiades, P. Leif Bergsagel, Esteban Braggio, Lawrence H. Boise, Rafael Fonseca, Francesco Maura, Shaji Kumar, Linda B. Baughn
Journal: Blood
Blood (2024) 144 (Supplement 1): 4635.
https://doi.org/10.1182/blood-2024-205385
Published: 2024
Journal Articles

Prediction of outcomes for high-count monoclonal B lymphocytosis using an epigenetic and immunogenetic signature

Brief Report
Salma B. Abdelbaky, Brian Giacopelli, Kari G. Rabe, Kyoko Yamaguchi, Yue-Zhong Wu, Huihuang Yan, Tait D. Shanafelt, Sameer A. Parikh, Wei Ding, Paul J. Hampel, Sochilt Brown, James R. Cerhan, Celine M. Vachon, Neil E. Kay, Curtis A. Hanson, Alexander S. Parker, Esteban Braggio, Susan L. Slager, Christopher C. Oakes
Journal: Blood
Blood (2024) 143 (17): 1752–1757.
https://doi.org/10.1182/blood.2023022180
Published: 2024
Includes: Supplemental data
Journal Articles

PD-1 Expression in Lymphoma Cells Mediates Cellular Proliferation By Engaging Phosphatase SHP-1/SHP-2

Sutapa Sinha, Tammy Price-Troska, Shulan Tian, R. Leo Sakemura, Huihuang Yan, Justin Boysen, Zhiquan Wang, Xiaosheng Wu, Rong He, Min Shi, Yucai Wang, Eric W Klee, Sameer A. Parikh, Paul J Hampel, Timothy G. Call, Jose F. Leis, Tait D. Shanafelt, Stephen M Ansell, Saad S. Kenderian, Neil E. Kay, Wei Ding
Journal: Blood
Blood (2023) 142 (Supplement 1): 3261.
https://doi.org/10.1182/blood-2023-177755
Published: 2023
Journal Articles

Variation in the Immune Tumor Microenvironment in Relation to Self-Reported Race in Individuals with Multiple Myeloma

Neeraj Sharma, Hongwei Tang, Huihuang Yan, Shulan Tian, Suganti Shivaram, Taxiarchis Kourelis, Shaji K Kumar, Linda B. Baughn
Journal: Blood
Blood (2022) 140 (Supplement 1): 4209–4210.
https://doi.org/10.1182/blood-2022-166744
Published: 2022
Journal Articles

Utilization of a Targeted Next Generation Sequencing Assay to Identify Copy Number Alterations in Chronic Lymphocytic Leukemia and Monoclonal B-Cell Lymphocytosis

Julia E. Wiedmeier, Chantal McCabe, Daniel R. O'Brien, Nicholas J. Boddicker, Rosalie Griffin Waller, Cecilia Bonolo De Campos, James R. Cerhan, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, Daniel L. Van Dyke, Susan L. Slager, Esteban Braggio
Journal: Blood
Blood (2021) 138 (Supplement 1): 4677.
https://doi.org/10.1182/blood-2021-153001
Published: 2021
Journal Articles

TP53 Aberrations and Outcomes in MBL and Untreated CLL

Rosalie Griffin Waller, Julia E. Wiedmeier, Nicholas J. Boddicker, Geffen Kleinstern, Cecilia Bonolo De Campos, Daniel L. Van Dyke, Huihuang Yan, Celine M. Vachon, Daniel R. O'Brien, Cristine Allmer, Kari G. Rabe, James R. Cerhan, Timothy G. Call, Sameer A. Parikh, Neil E. Kay, Esteban Braggio, Susan L. Slager
Journal: Blood
Blood (2021) 138 (Supplement 1): 2618.
https://doi.org/10.1182/blood-2021-153602
Published: 2021
Journal Articles

B Cell Receptor Signaling Drives APOBEC3 Expression Via Direct Enhancer Regulation in Chronic Lymphocytic Leukemia B Cells

Zhiquan Wang, Huihuang Yan, Justin C. Boysen, Charla R. Secreto, Esteban Braggio, Susan L. Slager, Sameer A. Parikh, Neil E. Kay
Journal: Blood
Blood (2021) 138 (Supplement 1): 3313.
https://doi.org/10.1182/blood-2021-153214
Published: 2021
Journal Articles

Targeting Aberrant Chromatin in Chronic Lymphocytic Leukemia

Zhiquan Wang, PhD, Justin C. Boysen, Huihuang Yan, PhD, Charla R. Secreto, Sameer A. Parikh, MD, Saad S. Kenderian, MB, ChB, Wei Ding, MD PhD, Esteban Braggio, PhD, Susan L. Slager, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140309
Published: 2020
Journal Articles

Identification of a Novel Role for PD-1 Signaling in Promotion Tumor Proliferation in B-Cell Lymphoma

Sutapa Sinha, PhD, Wei Ding, MD PhD, Tammy Price-Troska, BS, Reona Sakemura, MDPhD, Shulan Tian, MS, PhD, Charla R. Secreto, Xiaosheng Wu, MD, Timothy G. Call, MD, Rong He, MD, Sameer A. Parikh, MD, Yucai Wang, MDPhD, Jose F. Leis, MD PhD, Huihuang Yan, PhD, Karen Rech, MD, Amber B. Koehler, PA-C, MS, Daniel L. Van Dyke, PhD, Minetta C. Liu, MD, Susan L. Slager, PhD, Esteban Braggio, PhD, Stephen M. Ansell, MD PhD, Saad S. Kenderian, MB, ChB, Neil E. Kay, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–12.
https://doi.org/10.1182/blood-2020-136550
Published: 2020
Journal Articles

Genomic Profiling Reveals Molecular Heterogeneity in Patients with Richter's Syndrome (RS) and Progressive Chronic Lymphocytic Leukemia (CLL)

Shulan Tian, MS, PhD, Hanyin Wang, MD, Timothy G. Call, MD, Eric W. Klee, PhD, Minetta C. Liu, MD, Erik Jessen, PhD, Sameer A. Parikh, MD, Yucai Wang, MDPhD, Saad S. Kenderian, MB, ChB, Jose F. Leis, MD PhD, Min Shi, MDPhD, Eli Muchtar, MD, Daniel L. Van Dyke, PhD, Amber B. Koehler, PA-C, MS, Neil E. Kay, MD, Susan L. Slager, PhD, Esteban Braggio, PhD, Huihuang Yan, PhD, Wei Ding, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-138397
Published: 2020
Journal Articles

Distinct Gene Expression Signatures in Patients with Richter's Syndrome and Chronic Lymphocytic Leukemia with Prior Exposure to Ibrutinib

Hanyin Wang, MD, Shulan Tian, MS, PhD, Qing Zhao, Wendy Blumenschein, Jennifer H. Yearley, PhD, Charla R. Secreto, Sutapa Sinha, PhD, Timothy G. Call, MD, Yucai Wang, MDPhD, Sameer A. Parikh, MD, Saad S. Kenderian, MB, ChB, Rong He, MD, Jose F. Leis, MD PhD, Min Shi, MDPhD, Neil E. Kay, MD, Susan L. Slager, PhD, Esteban Braggio, PhD, Huihuang Yan, PhD, Wei Ding, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136172
Published: 2020
Journal Articles

Tumor Mutational Load and Germline Polygenic Risk Score Predicts Time-to-First Treatment in Chronic Lymphocytic Leukemia (CLL) and High-Count Monoclonal B Cell Lymphocytosis (MBL)

Geffen Kleinstern, PhD, Daniel R O'Brien, Brian Kabat, B.S., Kari G Rabe, Aaron D. Norman, Huihuang Yan, PhD, Celine M. Vachon, PhD, Shulan Tian, MS, PhD, Timothy G. Call, MD, Sameer A. Parikh, MD, Jose F. Leis, MD PhD, Wei Ding, MD PhD, James R. Cerhan, MD PhD, Neil E. Kay, MD, Esteban Braggio, PhD, Susan L. Slager, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 852.
https://doi.org/10.1182/blood-2019-124346
Published: 2019
Journal Articles

Recurrent MSC E116K mutations in ALK-negative anaplastic large cell lymphoma

Rebecca A. Luchtel, Michael T. Zimmermann, Guangzhen Hu, Surendra Dasari, Manli Jiang, Naoki Oishi, Hailey K. Jacobs, Yu Zeng, Tanya Hundal, Karen L. Rech, Rhett P. Ketterling, Jeong-Heon Lee, Bruce W. Eckloff, Huihuang Yan, Krutika S. Gaonkar, Shulan Tian, Zhenqing Ye, Marshall E. Kadin, Jagmohan Sidhu, Liuyan Jiang, Jesse Voss, Brian K. Link, Sergei I. Syrbu, Fabio Facchetti, N. Nora Bennani, Susan L. Slager, Tamas Ordog, Jean-Pierre Kocher, James R. Cerhan, Stephen M. Ansell, Andrew L. Feldman
Journal: Blood
Blood (2019) 133 (26): 2776–2789.
https://doi.org/10.1182/blood.2019000626
Published: 2019
Includes: Supplemental data
Journal Articles

PD-1 Overexpression in Richter's Transformation (RT) and Aggressive Chronic Lymphocytic Leukemia (CLL) after Progression on Ibrutinib Increases Bcl-2 Expression Via Akt/mTOR Pathway

Sutapa Sinha, PhD, Tammy Price-Troska, BS, Shulan Tian, MS, PhD, Charla R Secreto, Xiaosheng Wu, MD, Timothy G. Call, MD, Rong He, MD, Sameer A. Parikh, MD, Saad S. Kenderian, MD, Jose F. Leis, MD PhD, Huihuang Yan, PhD, Karen L Rech, MD, Minetta C Liu, MD, Stephen M. Ansell, MD PhD, Neil E. Kay, MD, Wei Ding, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 586.
https://doi.org/10.1182/blood-2018-99-112575
Published: 2018
Journal Articles

Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL

Clinical Trials & Observations
Wei Ding, Betsy R. LaPlant, Timothy G. Call, Sameer A. Parikh, Jose F. Leis, Rong He, Tait D. Shanafelt, Sutapa Sinha, Jennifer Le-Rademacher, Andrew L. Feldman, Thomas M. Habermann, Thomas E. Witzig, Gregory A. Wiseman, Yi Lin, Erik Asmus, Grzegorz S. Nowakowski, Michael J. Conte, Deborah A. Bowen, Casey N. Aitken, Daniel L. Van Dyke, Patricia T. Greipp, Xin Liu, Xiaosheng Wu, Henan Zhang, Charla R. Secreto, Shulan Tian, Esteban Braggio, Linda E. Wellik, Ivana Micallef, David S. Viswanatha, Huihuang Yan, Asher A. Chanan-Khan, Neil E. Kay, Haidong Dong, Stephen M. Ansell
Journal: Blood
Blood (2017) 129 (26): 3419–3427.
https://doi.org/10.1182/blood-2017-02-765685
Published: 2017
Includes: Supplemental data
Journal Articles

PD-1 Blockade with Pembrolizumab in Relapsed CLL Including Richter's Transformation: An Updated Report from a Phase 2 Trial (MC1485)

Wei Ding, MD PhD, Jennifer Le-Rademacher, PhD, Timothy G. Call, MD, Sameer A. Parikh, MD, Jose F. Leis, MD PhD, Tait D. Shanafelt, MD, Rong He, MD, Thomas M. Habermann, MD, Yi Lin, MD PhD, Betsy R. Laplant, MS, Andrew L Feldman, MD, Thomas E. Witzig, MD, Asher A. Chanan-Khan, MD, Erik Asmus, Daniel L. Van Dyke, PhD, Michael J Conte, PA-C, Deborah A. Bowen, APRN, CNP, Sutapa Sinha, PhD, Henan Zhang, MD, Xin Liu, Charla R Secreto, Shulan Tian, Esteban Braggio, PhD, Ivana Micallef, MD, Huihuang Yan, Ph. D, Neil E. Kay, MD, Haidong Dong, MD PhD, Stephen M Ansell, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 4392.
https://doi.org/10.1182/blood.V128.22.4392.4392
Published: 2016
Journal Articles

Novel Mutations in NOTCH and Altered Wnt/β-Catenin Pathway Indicate a Role of Embryonic Signals in the Pathogenesis of T-Cell Prolymphocytic Leukemia

Henan Zhang, MD, Shulan Tian, Esteban Braggio, PhD, Andrew L Feldman, MD, Rhett P. Ketterling, MD, Rong He, MD, Timothy G. Call, MD, Thomas E. Witzig, MD, Sameer A. Parikh, MD, Yi Lin, MD PhD, Charla R Secreto, Emma I Andersson, MSc, Satu Mustjoki, MD PhD, Alexandra Schrader, Marco Herling, MD PhD, Huihuang Yan, Ph. D, Wei Ding, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4103.
https://doi.org/10.1182/blood.V128.22.4103.4103
Published: 2016