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Journal Articles

PD-1 Expression in Lymphoma Cells Mediates Cellular Proliferation By Engaging Phosphatase SHP-1/SHP-2

Sutapa Sinha, Tammy Price-Troska, Shulan Tian, R. Leo Sakemura, Huihuang Yan, Justin Boysen, Zhiquan Wang, Xiaosheng Wu, Rong He, Min Shi, Yucai Wang, Eric W Klee, Sameer A. Parikh, Paul J Hampel, Timothy G. Call, Jose F. Leis, Tait D. Shanafelt, Stephen M Ansell, Saad S. Kenderian, Neil E. Kay, Wei Ding
Journal: Blood
Blood (2023) 142 (Supplement 1): 3261.
https://doi.org/10.1182/blood-2023-177755
Published: 2023
Journal Articles

Aberrant Heterochromatin Silences Immune Response Genes in Chronic Lymphocytic Leukemia

Zhiquan Wang, Olivia M. Depies, Sutapa Sinha, Weiguo Han, Sameer A. Parikh, Neil E. Kay
Journal: Blood
Blood (2023) 142 (Supplement 1): 3258.
https://doi.org/10.1182/blood-2023-182898
Published: 2023
Journal Articles

Beyond CLL Progression: Unveiling Th17 and Th2 T Cell Subsets As Predictors of Pembrolizumab Response in Richter's Transformation

Prajish Iyer, Lu Yang, Sutapa Sinha, Miles Del Busso, Zhi-Zhang Yang, Hyojin Kim, Charla Secreto, Yucai Wang, Neil E. Kay, Stephen M Ansell, Wei Ding, Lili Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1888.
https://doi.org/10.1182/blood-2023-181004
Published: 2023
Journal Articles

Identification of a Novel Role for PD-1 Signaling in Promotion Tumor Proliferation in B-Cell Lymphoma

Sutapa Sinha, PhD, Wei Ding, MD PhD, Tammy Price-Troska, BS, Reona Sakemura, MDPhD, Shulan Tian, MS, PhD, Charla R. Secreto, Xiaosheng Wu, MD, Timothy G. Call, MD, Rong He, MD, Sameer A. Parikh, MD, Yucai Wang, MDPhD, Jose F. Leis, MD PhD, Huihuang Yan, PhD, Karen Rech, MD, Amber B. Koehler, PA-C, MS, Daniel L. Van Dyke, PhD, Minetta C. Liu, MD, Susan L. Slager, PhD, Esteban Braggio, PhD, Stephen M. Ansell, MD PhD, Saad S. Kenderian, MB, ChB, Neil E. Kay, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–12.
https://doi.org/10.1182/blood-2020-136550
Published: 2020
Journal Articles

Pre-Existing T Cell Subsets Determine Anti-PD1 Blockade Response in Richter's Transformation

Prajish Iyer, PhD, Lu Yang, PhD, Zhi-Zhang Yang, PhD, Charla R. Secreto, Sutapa Sinha, PhD, Neil E. Kay, MD, Stephen M. Ansell, MD PhD, Lili Wang, MDPhD, Wei Ding, MD PhD, Hyojin Kim, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-138601
Published: 2020
Journal Articles

Distinct Gene Expression Signatures in Patients with Richter's Syndrome and Chronic Lymphocytic Leukemia with Prior Exposure to Ibrutinib

Hanyin Wang, MD, Shulan Tian, MS, PhD, Qing Zhao, Wendy Blumenschein, Jennifer H. Yearley, PhD, Charla R. Secreto, Sutapa Sinha, PhD, Timothy G. Call, MD, Yucai Wang, MDPhD, Sameer A. Parikh, MD, Saad S. Kenderian, MB, ChB, Rong He, MD, Jose F. Leis, MD PhD, Min Shi, MDPhD, Neil E. Kay, MD, Susan L. Slager, PhD, Esteban Braggio, PhD, Huihuang Yan, PhD, Wei Ding, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136172
Published: 2020
Journal Articles

Β-Catenin and Axl Receptor Tyrosine Kinase Modulation in CLL B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Drug Resistance

Sutapa Sinha, PhD, Charla R Secreto, Justin C. Boysen, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1739.
https://doi.org/10.1182/blood-2019-121772
Published: 2019
Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3868.
https://doi.org/10.1182/blood-2019-129349
Published: 2019
Journal Articles

PD-1 Overexpression in Richter's Transformation (RT) and Aggressive Chronic Lymphocytic Leukemia (CLL) after Progression on Ibrutinib Increases Bcl-2 Expression Via Akt/mTOR Pathway

Sutapa Sinha, PhD, Tammy Price-Troska, BS, Shulan Tian, MS, PhD, Charla R Secreto, Xiaosheng Wu, MD, Timothy G. Call, MD, Rong He, MD, Sameer A. Parikh, MD, Saad S. Kenderian, MD, Jose F. Leis, MD PhD, Huihuang Yan, PhD, Karen L Rech, MD, Minetta C Liu, MD, Stephen M. Ansell, MD PhD, Neil E. Kay, MD, Wei Ding, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 586.
https://doi.org/10.1182/blood-2018-99-112575
Published: 2018
Journal Articles

Axl-RTK Inhibition Modulates T Cell Functions and Synergizes with Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies

Reona Sakemura, MD PhD, Nan Yang, MD, Michelle J. Cox, Sutapa Sinha, PhD, Mehrdad Hefazi, MD, Michael J. Hansen, Kendall J. Schick, Cynthia L. Forsman, PhD, Justin C. Boysen, Renee C Tschumper, Elizabeth Juarez Diaz, BS, Lars Mouritsen, Jason M Foulks, PhD, Steven L. Warner, PhD, Sameer A. Parikh, MD, Wei Ding, MD PhD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 728.
https://doi.org/10.1182/blood-2018-99-112209
Published: 2018
Journal Articles

Size Matters: Identification of Larger Size CD19 Positive Extracellular Vesicles in Chronic Lymphocytic Leukemia That Inhibit Chimeric Antigen Receptor T Cell Functions

Cynthia L. Forsman, PhD, Reona Sakemura, MD PhD, Fabrice Lucien-Matteoni, PhD, Elizabeth Juarez-Diaz, B.S., Nan Yang, MD, Michelle J. Cox, Sutapa Sinha, PhD, Mehrdad Hefazi, MD, Kendall J. Schick, Justin C. Boysen, Sameer A. Parikh, MD, Hon Sing Leong, PhD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1865.
https://doi.org/10.1182/blood-2018-99-119484
Published: 2018
Journal Articles

Enhanced Expression of Beta-Catenin and Axl Receptor Tyrosine Kinase (RTK) in Chronic Lymphocytic Leukemia (CLL) B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Leukemic Cell Drug Resistance

Sutapa Sinha, PhD, Charla R Secreto, Justin C. Boysen, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3125.
https://doi.org/10.1182/blood-2018-99-110981
Published: 2018
Journal Articles

Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL

Clinical Trials & Observations
Wei Ding, Betsy R. LaPlant, Timothy G. Call, Sameer A. Parikh, Jose F. Leis, Rong He, Tait D. Shanafelt, Sutapa Sinha, Jennifer Le-Rademacher, Andrew L. Feldman, Thomas M. Habermann, Thomas E. Witzig, Gregory A. Wiseman, Yi Lin, Erik Asmus, Grzegorz S. Nowakowski, Michael J. Conte, Deborah A. Bowen, Casey N. Aitken, Daniel L. Van Dyke, Patricia T. Greipp, Xin Liu, Xiaosheng Wu, Henan Zhang, Charla R. Secreto, Shulan Tian, Esteban Braggio, Linda E. Wellik, Ivana Micallef, David S. Viswanatha, Huihuang Yan, Asher A. Chanan-Khan, Neil E. Kay, Haidong Dong, Stephen M. Ansell
Journal: Blood
Blood (2017) 129 (26): 3419–3427.
https://doi.org/10.1182/blood-2017-02-765685
Published: 2017
Includes: Supplemental data
Journal Articles

PD-1 Blockade with Pembrolizumab in Relapsed CLL Including Richter's Transformation: An Updated Report from a Phase 2 Trial (MC1485)

Wei Ding, MD PhD, Jennifer Le-Rademacher, PhD, Timothy G. Call, MD, Sameer A. Parikh, MD, Jose F. Leis, MD PhD, Tait D. Shanafelt, MD, Rong He, MD, Thomas M. Habermann, MD, Yi Lin, MD PhD, Betsy R. Laplant, MS, Andrew L Feldman, MD, Thomas E. Witzig, MD, Asher A. Chanan-Khan, MD, Erik Asmus, Daniel L. Van Dyke, PhD, Michael J Conte, PA-C, Deborah A. Bowen, APRN, CNP, Sutapa Sinha, PhD, Henan Zhang, MD, Xin Liu, Charla R Secreto, Shulan Tian, Esteban Braggio, PhD, Ivana Micallef, MD, Huihuang Yan, Ph. D, Neil E. Kay, MD, Haidong Dong, MD PhD, Stephen M Ansell, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 4392.
https://doi.org/10.1182/blood.V128.22.4392.4392
Published: 2016
Journal Articles

Sensitivity of Ibrutinib Exposed Chronic Lymphocytic Leukemia B-Cells to Inhibition of Axl Receptor Tyrosine Kinase

Sutapa Sinha, PhD, Justin C Boysen, Kari G. Chaffee, MS, Brian F Kabat, Susan L. Slager, PhD, Sameer A. Parikh, MD, Charla R Secreto, Tait D. Shanafelt, MD, Jose F. Leis, MD PhD, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2016) 128 (22): 2020.
https://doi.org/10.1182/blood.V128.22.2020.2020
Published: 2016
Journal Articles

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Guru P Maiti, PhD MSc, Sutapa Sinha, PhD, Justin C Boysen, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2016) 128 (22): 4363.
https://doi.org/10.1182/blood.V128.22.4363.4363
Published: 2016
Journal Articles

Targeted Inhibition of Axl Primes Chronic Lymphocytic Leukemia B-Cells for Apoptosis: Synergistic/Additive Effects in Combination with Bruton Tyrosine Kinase Inhibitors

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Charla Secreto, Steven L. Warner, PhD, David J. Bearss, PhD, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 1946.
https://doi.org/10.1182/blood.V124.21.1946.1946
Published: 2014
Journal Articles

Activated Chronic Lymphocytic Leukemia B-Cells Preferentially Shed CD52 + Microvesicles, but Not CD19 + , and May Predict Therapeutic Outcome

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 1961.
https://doi.org/10.1182/blood.V124.21.1961.1961
Published: 2014
Journal Articles

Axl Regulates Fibroblast Growth Factor Receptor Signaling in B-Cell Chronic Lymphocytic Leukemia: Dual Targeting in CLL Therapy

Sutapa Sinha, PhD, Justin Boysen, Charla Secreto, Steven L. Warner, PhD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 831.
https://doi.org/10.1182/blood.V124.21.831.831
Published: 2014