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Journal Articles

Optimized Inhibition of GM-CSF in Preclinical Models of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

Evandro D. Bezerra, Reona Sakemura, James Girsch, Carli M. Stewart, Gunjan A Awatramani, Claudia Manriquez-Roman, Kendall J. Schick, Ismail Can, Ekene J. Ogbodo, Erin E. Tapper, Elizabeth L. Siegler, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Susan L. Slager, Sameer A. Parikh, Neil E. Kay, Cameron Durrant, Omar Ahmed, Dale Chappell, Michelle J. Cox, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2777.
https://doi.org/10.1182/blood-2021-149859
Published: 2021
Journal Articles

A Phase 2/3 Randomized, Placebo-Controlled, Open-Label, Multi-Center Trial of Lenzilumab to Improve the Safety and Efficacy of CAR-T Cell Therapy in Adults with Relapsed or Refractory Large B-Cell Lymphoma (The SHIELD Study)

Saad S. Kenderian, Cameron Durrant, Dale Chappell, Omar Ahmed, Adrian Kilcoyne
Journal: Blood
Blood (2021) 138 (Supplement 1): 1758.
https://doi.org/10.1182/blood-2021-153987
Published: 2021
Journal Articles

Phase 1 study of lenzilumab, a recombinant anti–human GM-CSF antibody, for chronic myelomonocytic leukemia

Clinical Trials & Observations
Mrinal M. Patnaik, David A. Sallman, Abhishek A. Mangaonkar, Rachel Heuer, Jeffery Hirvela, Darci Zblewski, Aref Al-Kali, Moritz Binder, Maria E. Balasis, Hannah Newman, Christopher Letson, Traci L. Kruer, Naseema Gangat, Rami S. Komrokji, Ayalew Tefferi, Adrian Lo, Ted Shih, Cameron Durrant, Alan F. List, Eric Padron
Journal: Blood
Blood (2020) 136 (7): 909–913.
https://doi.org/10.1182/blood.2019004352
Published: 2020
Includes: Supplemental data
Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3868.
https://doi.org/10.1182/blood-2019-129349
Published: 2019
Journal Articles

A Phase 1 Study of Lenzilumab, a humaneered recombinant Anti-Human Granulocyte-Macrophage Colony- Stimulating Factor (anti-hGM-CSF) Antibody, for Chronic Myelomonocytic Leukemia (CMML)

Mrinal M Patnaik, MDMBBS, David A Sallman, MD, Abhishek A Mangaonkar, MBBS, Rachel Heuer, Jeffery Hirvela, Darci Zblewski, APRN, C-NP, Aref Al-Kali, MD, Deanna Kanne, Rahil Ismail, Rami S. Komrokji, MD, Adrian Lo, Maria E Balasis, Cameron Durrant, Dale Chappell, Omar Ahmed, Alan F. List, MD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4234.
https://doi.org/10.1182/blood-2019-131181
Published: 2019
Journal Articles

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Rosalie M. Sterner, Reona Sakemura, Michelle J. Cox, Nan Yang, Roman H. Khadka, Cynthia L. Forsman, Michael J. Hansen, Fang Jin, Katayoun Ayasoufi, Mehrdad Hefazi, Kendall J. Schick, Denise K. Walters, Omar Ahmed, Dale Chappell, Tarek Sahmoud, Cameron Durrant, Wendy K. Nevala, Mrinal M. Patnaik, Larry R. Pease, Karen E. Hedin, Neil E. Kay, Aaron J. Johnson, Saad S. Kenderian
Journal: Blood
Blood (2019) 133 (7): 697–709.
https://doi.org/10.1182/blood-2018-10-881722
Published: 2019
Includes: Supplemental data
Journal Articles

GM-CSF Blockade during Chimeric Antigen Receptor T Cell Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance Their Effector Functions

Rosalie M. Sterner, Reona Sakemura, MD PhD, Nan Yang, MD, Michelle J. Cox, Roman H. Khadka, Cynthia L. Forsman, PhD, Michael J. Hansen, Fang Jin, Katayoun Ayasoufi, Mehrdad Hefazi, MD, Baustin M. Welch, Kendall J. Schick, Denise K Walters, PhD, German Martinez, Omar Ahmed, Tarek Sahmoud, Cameron Durrant, Wendy K. Nevala, Mrinal M. Patnaik, MDMBBS, Stephen J. Russell, MD PhD, Larry Pease, Neil E. Kay, MD, Karen E. Hedin, Aaron J. Johnson, Saad S. Kenderian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 961.
https://doi.org/10.1182/blood-2018-99-111766
Published: 2018