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Journal Articles

Combination Interaction Effects of Ibrutinib with Variety Drugs in in Vitro Mesenchymal Stromal Cell System in Chronic Lymphocytic Leukemia

Weiguo Han, Connie Lesnick, Aisharya Bhattacharya, Sutapa Sinha, Zhiquan Wang, Sameer A. Parikh, Neil E. Kay
Journal: Blood
Blood (2024) 144 (Supplement 1): 6760.
https://doi.org/10.1182/blood-2024-203943
Published: 2024
Journal Articles

Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib

Noelia Purroy, Yuzhou Evelyn Tong, Camilla K. Lemvigh, Nicoletta Cieri, Shuqiang Li, Erin M. Parry, Wandi Zhang, Laura Z. Rassenti, Thomas J. Kipps, Susan L. Slager, Neil E. Kay, Connie Lesnick, Tait D. Shanafelt, Paolo Ghia, Lydia Scarfò, Kenneth J. Livak, Peter V. Kharchenko, Donna S. Neuberg, Lars Rønn Olsen, Jean Fan, Satyen H. Gohil, Catherine J. Wu
Journal: Blood
Blood (2022) 139 (14): 2252–2256.
https://doi.org/10.1182/blood.2021013926
Published: 2022
Includes: Supplemental data
Journal Articles

Targeted Deep Sequencing in Untreated Progressive CLL Helps to Better Dissect the Genomic Landscape and Shows Novel Associations between Mutations, Prognostic and Clinical Parameters: Data from E1912, a Randomized Phase III Study of the ECOG-ACRIN Cancer Research Group

Esteban Braggio, PhD, Victoria Wang, Laura Ann Bruins, BS, Santiago Barrio, PhD, Connie Lesnick, Jacqueline C. Barrientos, MD, Susan M. O'Brien, MD, Martin S. Tallman, MD, Mark R. Litzow, MD, Rafael Fonseca, MD, Neil E. Kay, MD, Tait D Shanafelt, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4288.
https://doi.org/10.1182/blood.V130.Suppl_1.4288.4288
Published: 2017
Journal Articles

Novel Associations Between Mutations, Prognostic and Clinical Parameters in Untreated Progressive CLL: Data from E1912, a Randomized Phase III Study of the ECOG-ACRIN Cancer Research Group

Esteban Braggio, PhD, Victoria X Wang, Santiago Garcia, PhD, Laura Ann Bruins, Connie Lesnick, Jacqueline C. Barrientos, MD, Susan M. O'Brien, MD, Martin S. Tallman, MD, Rafael Fonseca, MD, Neil E. Kay, MD, Tait D. Shanafelt, MD
Journal: Blood
Blood (2016) 128 (22): 4373.
https://doi.org/10.1182/blood.V128.22.4373.4373
Published: 2016
Journal Articles

Targeted Inhibition of Axl Primes Chronic Lymphocytic Leukemia B-Cells for Apoptosis: Synergistic/Additive Effects in Combination with Bruton Tyrosine Kinase Inhibitors

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Charla Secreto, Steven L. Warner, PhD, David J. Bearss, PhD, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 1946.
https://doi.org/10.1182/blood.V124.21.1946.1946
Published: 2014
Journal Articles

Activated Chronic Lymphocytic Leukemia B-Cells Preferentially Shed CD52 + Microvesicles, but Not CD19 + , and May Predict Therapeutic Outcome

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 1961.
https://doi.org/10.1182/blood.V124.21.1961.1961
Published: 2014
Journal Articles

The AKT Inhibitor MK2206 In Combination With Rituximab and Bendamustine Is Tolerable and Active In Relapsed Or Refractory Chronic Lymphocytic Leukemia: Results From a Phase 1 Study (NCCTG N1087 Alliance)

Wei Ding, MD, PhD, Tait D Shanafelt, MD, Clive S. Zent, MD, Jose F. Leis, MD, PhD, Betsy R. LaPlant, Timothy G. Call, MD, Curtis A Hanson, MD, Charles Erlichman, MD, Thomas M. Habermann, MD, Craig Reeder, MD, Daniel Nikcevich, Deborah Bowen, CNP, Michael J. Conte, PA-C, Justin Boysen, Charla Secreto, Connie Lesnick, M.Sc, Renee C. Tschumper, Diane F. Jelinek, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2013) 122 (21): 2882.
https://doi.org/10.1182/blood.V122.21.2882.2882
Published: 2013
Journal Articles

Novel Pharmacological Agents Differentially Modulate Cytokine Release On CLL B-Cell-Stromal Cell Co-Culture: Implications for Stromal Rescue of CLL B-Cells From Chemotherapy

Connie Lesnick, M.Sc, Asish K Ghosh, PhD, Betsy R. LaPlant, Wei Ding, MD, PhD, Neil E. Kay, MD, Tait D. Shanafelt, MD
Journal: Blood
Blood (2012) 120 (21): 3927.
https://doi.org/10.1182/blood.V120.21.3927.3927
Published: 2012
Journal Articles

Allosteric Akt Inhibitor MK2206 Synergizes with Bendamustine in Promoting the Apoptosis of Chronic Lymphocytic Leukemia Cells and Selectively Targets B-Cell Receptor Mediated Cytokine Production

Wei Ding, MD, PhD, Tait D. Shanafelt, MD, Connie Lesnick, M.Sc, Traci Sassoon, Charla Secreto, Charles Erlichman, MD, Jose Leis, MD, PhD, Timothy G. Call, MD, Deborah Bowen, CNP, Shaji K. Kumar, MD, Neil E. Kay, MD
Journal: Blood
Blood (2012) 120 (21): 3928.
https://doi.org/10.1182/blood.V120.21.3928.3928
Published: 2012
Journal Articles

Epigallocatechin-3-Gallate (EGCG) Modulates Cytokine Production When Leukemic CLL B-Cells and Marrow Stromal Cells Are Co-Cultured: Correlations with Clinical Activity in a Phase II Trial,

Connie Lesnick, Neil Kay, MD, Betsy R. LaPlant, Asish K Ghosh, PhD, Tait D. Shanafelt, MD
Journal: Blood
Blood (2011) 118 (21): 3882.
https://doi.org/10.1182/blood.V118.21.3882.3882
Published: 2011
Journal Articles

The Green Tea Extract EGCG Demonstrates Synergist Activity against CLL B-Cells When Combined with Fludarabine and Chlorambucil.

Connie Lesnick, Neil E. Kay, MD, Betsy LaPlant, Tait D. Shanafelt, M.D.,
Journal: Blood
Blood (2009) 114 (22): 3452.
https://doi.org/10.1182/blood.V114.22.3452.3452
Published: 2009