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Journal Articles

Identification a Novel Molecular Mechanism Underlying the Anti-CD38-Based Treatment Resistance in Multiple Myeloma Patients

Sophia Adamia, Daisuke Ogiya, Evdoxia Hatjiharissi, Michael P. Chu, Zuzana Chyra, Kenneth Wen, Yu-Tzu Tai, David M. Dorfman, Teru Hideshima, Kenneth C. Anderson

Blood (2022) 140 (Supplement 1): 2081–2082.

https://doi.org/10.1182/blood-2022-169943

Published: 2022

Journal Articles

Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703

Blood (2022) 140 (Supplement 1): 4189–4190.

https://doi.org/10.1182/blood-2022-168770

Published: 2022

Journal Articles

Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma

Sophia Adamia, Zuzana Chyra, Morgan O'Keefe, Shruti Bhatt, Kenneth Wen, Geoffrey G Fell, Yu-Tzu Tai, Anthony G. Letai, Ivane Abiatari, David M. Dorfman, Teru Hideshima, Kenneth C. Anderson

Blood (2021) 138 (Supplement 1): 2688.

https://doi.org/10.1182/blood-2021-152986

Published: 2021

Journal Articles

miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms

Blood (2021) 137 (14): 1905–1919.

https://doi.org/10.1182/blood.2020009088

Published: 2021

Includes: Supplemental data

Journal Articles

Impact of Sickle Cell Trait on Morbidity and Mortality from Sars-Cov-2 Infection

Lauren E. Merz, MDMSc, Kavita Mistry, MD PhD, Revital Freedman, PhD, Katherine L Jolley, Hae Soo Park, David M. Dorfman, MD PhD, Donna S. Neuberg, ScD, Maureen Achebe, MD MPH

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-142835

Published: 2020

Journal Articles

Aberrant RHAMM Splicing in Multiple Myeloma (MM) and Its Implications for Immunotherapy

Daisuke Ogiya, MD PhD, Lisa Müller, Sigitas J Verselis, PhD, Heiner Schaal, PhD, Ivane Abiatari, MD, Ana M Stenstrom, Catherine A Nicholas, John F Daley, Michael P. Chu, David M. Dorfman, MD PhD, Linda M. Pilarski, PhD, Teru Hideshima, MD PhD, Kenneth C. Anderson, MD, Sophia Adamia, PhD

Blood (2019) 134 (Supplement_1): 1804.

https://doi.org/10.1182/blood-2019-131775

Published: 2019

Journal Articles

Altered Genomic and Epigenetic Profiling of Myeloma Bone Marrow Stromal Cells Identifies Targets for Current and Future Immunotherapeutic Approaches

Sophia Adamia, PhD, Daisuke Ogiya, MD PhD, Ivane Abiatari, MD, Sigitas J Verselis, PhD, Michael P. Chu, David M. Dorfman, MD PhD, Linda M. Pilarski, PhD, Teru Hideshima, MD PhD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 3079.

https://doi.org/10.1182/blood-2019-131243

Published: 2019

Journal Articles

Myeloma Heterogeneity within Its Complex Immune Ecosystem

Jana Jakubikova, PhD, Danka Cholujova, PhD, Gabor Beke, PhD, Zachary R Hunter, PhD, Teru Hideshima, MD PhD, Merav Leiba, MD, Krzysztof Jamroziak, MD PhD, Paul G. Richardson, MD, Eftathios Kastritis, David M. Dorfman, MD PhD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 4354.

https://doi.org/10.1182/blood-2019-132193

Published: 2019

Journal Articles

High-Dimensional Heterogeneity of Waldenström Macroglobulinemia within Its Immune Tumor Microenvironment

Jana Jakubikova, PhD, Danka Cholujova, PhD, Gabor Beke, PhD, Zachary R Hunter, PhD, Teru Hideshima, MD PhD, Ludmila Flores, Merav Leiba, MD, Paul G. Richardson, MD, Eftathios Kastritis, David M. Dorfman, MD PhD, Steven P Treon, MD PhD FRCP, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 3975.

https://doi.org/10.1182/blood-2019-130011

Published: 2019

Journal Articles

Dissecting the Epigenetic Landscape of Smoldering, Newly Diagnosed and Relapsed Multiple Myeloma Revealed IRAK3 As a Marker of Disease Progression

Mahshid Rahmat, PhD, Nicholas Haradhvala, BA, Romanos Sklavenitis-Pistofidis, MD, Jihye Park, PhD, Daisy Huynh, MS, Mark Bustoros, MD, Brianna Berrios, BS, Mairead Reidy, PhD, Adriana Perilla-Glen, Bradley Rivotto, BS, Kalvis Hornburg, BA, David M. Dorfman, MD, PhD, Jonathan D. Licht, MD, Gad Getz, PhD, Irene M. Ghobrial, MD

Blood (2018) 132 (Supplement 1): 3896.

https://doi.org/10.1182/blood-2018-99-115046

Published: 2018

Journal Articles

Circulating Myeloid-Derived Suppressor Cells Reflect Mycosis Fungoides/Sezary Syndrome Disease Stage and Response to Treatment

Christopher B. Hergott, MD PhD, Graham Dudley, M.S., David M. Dorfman, MD, PhD

Blood (2018) 132 (Supplement 1): 4127.

https://doi.org/10.1182/blood-2018-99-120344

Published: 2018

Journal Articles

Leukemic-phase progression of aleukemic mast cell leukemia

Sanjay S. Patel, David M. Dorfman

Blood (2018) 131 (21): 2406.

https://doi.org/10.1182/blood-2018-02-831388

Published: 2018

Journal Articles

T-Cell Lymphoma Patient-Derived Xenografts and Newly Developed Cell Lines Recapitulate Aspects of Disease Biology and Represent Novel Tools for Preclinical Drug Development

Blood (2016) 128 (22): 3015.

https://doi.org/10.1182/blood.V128.22.3015.3015

Published: 2016

Journal Articles

FLT3 Splice Variant (FLT3Va) As a Potential Immunotherapeutic Target in Patients with Acute Myeloid Leukemia (AML)

Sophia Adamia, PhD, Jeffrey Nemeth, PhD, Shruti Bhatt, PhD, Sarah R Walker, Natalie I Voeks, William Lento, PhD, Ricardo M. Attar, Ilene Galinsky, MSN, ANPc, David A Frank, MD PhD, Martha Wadleigh, MD, Anthony Letai, MD PhD, David P. Steensma, MD, David M. Weinstock, MD, Daniel J. DeAngelo, MD PhD, David M. Dorfman, MD PhD, Richard M. Stone, MD, James D Griffin, MD

Blood (2016) 128 (22): 1681.

https://doi.org/10.1182/blood.V128.22.1681.1681

Published: 2016

Journal Articles

Microrna-138 Regulates Osteogenic Differentiation and Its Inhibition Presents a Novel Therapeutic Line to Prevent Bone Lytic Lesions in Multiple Myeloma

Shokichi Tsukamoto, MD PhD, Karma Salem, MD, Salomon Manier, MD, Michaela R. Reagan, PhD, Daisy Huynh, BS, MS, Adriana Perilla-Glen, MBA, Antonio Sacco, BS, Oksana Zavidij, PhD, Mahshid Rahmat, PhD, Satoshi Takagi, PhD, Yawara Kawano, MD PhD, Katsutoshi Kokubun, PhD, Charlotte Albæk Thrue, MSc, Andreas Petri, PhD MSc, David M. Dorfman, MD PhD, Aldo M. Roccaro, MD PhD, Marzia Capelletti, PhD MMSc, Sakari Kauppinen, PhD, Irene M. Ghobrial, MD

Blood (2016) 128 (22): 4483.

https://doi.org/10.1182/blood.V128.22.4483.4483

Published: 2016

Journal Articles

Differential Expression of Enhancer of Zeste Homolog 2 (EZH2) Protein in Low and High Grade B-Cell Non-Hodgkin Lymphomas and Differential Regulation of EZH2 Expression By p-ERK and MYC in High Grade B Cell Lymphomas

Xuejun Tian, MD/PhD, Ali Shahsafaei, David M. Dorfman, MD PhD

Blood (2015) 126 (23): 2660.

https://doi.org/10.1182/blood.V126.23.2660.2660

Published: 2015

Journal Articles

Characterization of the Role of Regulatory T Cells (Tregs) in Inducing Progression of Multiple Myeloma

Yawara Kawano, MDPhD, Michele Moschetta, MD, Katsutoshi Kokubun, PhD, Pavlo Lukyanchykov, MD, Esilida Sula Karreci, MD, Salomon Manier, MD, Shokichi Tsukamoto, MD PhD, Satoshi Takagi, PhD, Jiantao Shi, Michaela R. Reagan, PhD, Daisy Huynh, BS, MS, Antonio Sacco, BS, David M. Dorfman, MD PhD, Marta Chesi, PhD, Peter Leif Bergsagel, MD PhD, Aldo M Roccaro, MD PhD, Jamil Azzi, MD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 502.

https://doi.org/10.1182/blood.V126.23.502.502

Published: 2015

Journal Articles

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

Mark A. Murakami, MD MA, Alexandra N. Christodoulou, M.S., Amanda L Christie, B.S., Tiffany DeSouza, B.S., Abner Louissaint, Jr., MD PhD, Una Vojinovic, B.S., Raphael Koch, MD, Loretta S. Li, MD, Scott P. Kallgren, PhD, Prakash Rao, PhD, Johannes Köster, PhD, Raga Vadhi, M.S., Eilene Duberow, B.S., Elizabeth A. Morgan, MD, Hongjun Wang, Samia S. Ahmed, Katharine L. Majewski, Marina Konopleva, MD PhD, Jerome Tamburini, MD, PhD, Alejandro Gutierrez, MD, Michelle Kelliher, PhD, Julia Etchin, PhD, Irmela Jeremias, MD, Andrew P. Weng, MD PhD, Andrew L Kung, MD PhD, Andrew A Lane, MD PhD, Francine Garnache-Ottou, PhD, Shai Izraeli, MD Prof, Eric Jacobsen, MD, Ilene Galinsky, ANP, Richard M. Stone, MD, Marian H. Harris, MD PhD, David M. Dorfman, MD PhD, Jon C Aster, MDPhD, Henry Long, PhD, Lewis B. Silverman, MD, David M Weinstock, MD

Blood (2015) 126 (23): 3252.

https://doi.org/10.1182/blood.V126.23.3252.3252

Published: 2015

Journal Articles

B and T-Cell Lymphoma Patient-Derived Xenografts Recapitulate Aspects of Disease Biology and Progression and Represent Novel Tools for Preclinical Drug Development

Blood (2015) 126 (23): 4001.

https://doi.org/10.1182/blood.V126.23.4001.4001

Published: 2015

Journal Articles

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

Aline Renneville, Peter Van Galen, Matthew C. Canver, Marie McConkey, John M. Krill-Burger, David M. Dorfman, Edward B. Holson, Bradley E. Bernstein, Stuart H. Orkin, Daniel E. Bauer, Benjamin L. Ebert

Blood (2015) 126 (16): 1930–1939.

https://doi.org/10.1182/blood-2015-06-649087

Published: 2015

Includes: Supplemental data

NARROW

Identification a Novel Molecular Mechanism Underlying the Anti-CD38-Based Treatment Resistance in Multiple Myeloma Patients

Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703

Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma

miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms

Impact of Sickle Cell Trait on Morbidity and Mortality from Sars-Cov-2 Infection

Aberrant RHAMM Splicing in Multiple Myeloma (MM) and Its Implications for Immunotherapy

Altered Genomic and Epigenetic Profiling of Myeloma Bone Marrow Stromal Cells Identifies Targets for Current and Future Immunotherapeutic Approaches

Myeloma Heterogeneity within Its Complex Immune Ecosystem

High-Dimensional Heterogeneity of Waldenström Macroglobulinemia within Its Immune Tumor Microenvironment

Dissecting the Epigenetic Landscape of Smoldering, Newly Diagnosed and Relapsed Multiple Myeloma Revealed IRAK3 As a Marker of Disease Progression

Circulating Myeloid-Derived Suppressor Cells Reflect Mycosis Fungoides/Sezary Syndrome Disease Stage and Response to Treatment

Leukemic-phase progression of aleukemic mast cell leukemia

T-Cell Lymphoma Patient-Derived Xenografts and Newly Developed Cell Lines Recapitulate Aspects of Disease Biology and Represent Novel Tools for Preclinical Drug Development

FLT3 Splice Variant (FLT3Va) As a Potential Immunotherapeutic Target in Patients with Acute Myeloid Leukemia (AML)

Microrna-138 Regulates Osteogenic Differentiation and Its Inhibition Presents a Novel Therapeutic Line to Prevent Bone Lytic Lesions in Multiple Myeloma

Differential Expression of Enhancer of Zeste Homolog 2 (EZH2) Protein in Low and High Grade B-Cell Non-Hodgkin Lymphomas and Differential Regulation of EZH2 Expression By p-ERK and MYC in High Grade B Cell Lymphomas

Characterization of the Role of Regulatory T Cells (Tregs) in Inducing Progression of Multiple Myeloma

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

B and T-Cell Lymphoma Patient-Derived Xenografts Recapitulate Aspects of Disease Biology and Progression and Represent Novel Tools for Preclinical Drug Development

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

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American Society of Hematology

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American Society of Hematology

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