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Daniela Bellarosa
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Journal Articles

Tagraxofusp Shows Promising Anti-Tumoral Efficacy in Preclinical in Vitro Models of Myelofibrosis, Both As a Single Agent and in Combination with Janus Kinase Inhibitors

Maria Luisa Iannitto, Diego Bisignano, Alessio Fiascarelli, Simone Talucci, Sonia Zicari, Francesco Belli, Alessandro Bressan, Christopher Brooks, Daniela Bellarosa, Monica Binaschi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6329.
https://doi.org/10.1182/blood-2023-178864
Published: 2023
Journal Articles

MEN1703-Mediated PIM Kinases Inhibition Impairs Protumoral and Immunosuppressive Phenotype and Functions of Macrophages in Classical Hodgkin Lymphoma

Maciej Szydlowski, Filip Garbicz, Ewa Kurtz, Justyna Żurańska, Michał Seweryn, Michał Pawlak, Patryk Górniak, Kamil Sokół, Anna Szumera-Ciećkiewicz, Monika Kawecka, Daria Owczarek, Beata Puton, Monika Prochorec-Sobieszek, Daniela Bellarosa, Michał Kurlapski, Jan Zaucha, Paweł Wołkow, Przemyslaw Juszczynski
Journal: Blood
Blood (2022) 140 (Supplement 1): 6441–6442.
https://doi.org/10.1182/blood-2022-156894
Published: 2022
Journal Articles

Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703

Filip Garbicz, Sonia Debek, Anna Szumera-Ciećkiewicz, Joanna Barankiewicz, Dorota Komar, Michał Pawlak, Aleksandra Matrejek, Thorsten Stuehmer, Aleksander Salomon-Perzynski, Agata Malenda, Julia Ostrowska, Julia Dudkiewicz, Krzysztof Brzózka, Tomasz Rzymski, Daniela Bellarosa, Ewa Lech-Marańda, Monika Prochorec-Sobieszek, Zofia Pilch, Dominika Nowis, Jakub Golab, Helen Tanton, Teru Hideshima, David M. Dorfman, Irena Misiewicz-Krzeminska, Tomasz Sewastianik, Ruben D. Carrasco, Maciej Szydlowski, Przemyslaw Juszczynski
Journal: Blood
Blood (2022) 140 (Supplement 1): 4189–4190.
https://doi.org/10.1182/blood-2022-168770
Published: 2022
Journal Articles

PIM Kinases Regulate Super-Enhancer-Dependent Gene Expression in Diffuse Large B-Cell Lymphoma

Sonia Debek, Dorota Komar, Filip Garbicz, Aleksandra Matrejek, Michał Pawlak, Ewa Jabłońska, Maciej Szydlowski, Magdalena Skrzypczak, Sylwia Radomska, Daniela Bellarosa, Nazli Serin, Malgorzata Bajor, Bjoern Chapuy, Przemyslaw Juszczynski
Journal: Blood
Blood (2022) 140 (Supplement 1): 3044–3045.
https://doi.org/10.1182/blood-2022-167734
Published: 2022
Journal Articles

PIM Inhibition By SEL24/MEN1703 Combines Synergistically with Gilteritinib in FLT3-ITD Preclinical Models of Acute Myeloid Leukemia

Daniela Bellarosa, Sonia Zicari, Giuseppe Merlino, Alessio Fiascarelli, Diego Bisignano, Francesco Belli, Clelia Irrissuto, Simone Talucci, Maria Luisa Iannitto, Mario Bigioni, Alessandro Bressan, Krzysztof Brzózka, Gabriel Ghiaur, Monica Binaschi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3090–3091.
https://doi.org/10.1182/blood-2022-168491
Published: 2022
Journal Articles

SEL24/MEN1703 Inhibits PIM/FLT3 Downstream Target in Acute Myeloid Leukemia (AML) Patients: Results of the Pharmacodynamics (PD) Assay and Genomic Profiling in the First-in-Human Diamond-01 Trial

Alessandro Paoli, Daniela Bellarosa, Alessandro Bressan, Francesco Bertolini, Scott R. Solomon, Pau Montesinos, Sudipto Mukherjee, Stephen A Strickland, Giovanni Marconi, Armando Santoro, Roland B. Walter, Rachel J. Cook, Maria Calbacho, Susana Vives, Salman Fazal, Farhad Ravandi, Krzysztof Brzozka, Tomasz Rzymski, Milena Mazan, Simone Baldini, Niccolò Ravenni, Monica Binaschi, Dirk Laurent, Andrea Pellacani
Journal: Blood
Blood (2021) 138 (Supplement 1): 3436.
https://doi.org/10.1182/blood-2021-150277
Published: 2021
Journal Articles

SEL24/MEN1703 Provides PIM/FLT3 Downstream Pathway Inhibition in Acute Myeloid Leukemia (AML) Blast Cells: Results of the Pharmacodynamics (PD) Assay in the Dose Escalation Part of First-in-Human Diamond Trial

Andrea Massimiliano Tomirotti, PhD, Daniela Bellarosa, Scott R. Solomon, MD, Aziz Nazha, MD, Stephen A Strickland, MD MSCI, Roland P Walter, MDPhD, Farhad Ravandi, MBBS, Krzysztof Brzózka, PhD, Milena Mazan, PhD, Simone Baldini, MD, Massimiliano Salerno, Monica Binaschi, PhD, Dirk Laurent, MD, Andrea Pellacani, PhD MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136936
Published: 2020
Journal Articles

First in Human Study of SEL24/MEN1703, First in Class, Orally Available Dual PIM/FLT3 Kinase Inhibitor, in Patients with Acute Myeloid Leukemia

Scott R. Solomon, MD, Aziz Nazha, MD, Stephen A. Strickland, MD, Roland B. Walter, MD PhD MS, Ilaria Valimberti, Alessia Tagliavini, Paolo Mazzei, Caterina Fiesoli, Simona Scartoni, Daniela Bellarosa, Monica Binaschi, PhD, Pawel Chrom, MD PhD, Simone Baldini, MD, Krzysztof Brzózka, PhD, Angela Capriati, Andrea Pellacani, PhD MD, Farhad Ravandi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3920.
https://doi.org/10.1182/blood-2019-125878
Published: 2019
Journal Articles

Identification of a Pharmacodynamic Biomarker for SEL24/MEN1703, a First-in-Class Dual PIM/FLT3 Kinase Inhibitor for Acute Myeloid Leukemia, and Its Implementation in the First-in-Human Study CLI24-001

Andrea Tomirotti, PhD, Giuseppe Merlino, Alessio Fiascarelli, PhD, Simone Baldini, MD, Alessia Tagliavini, Elisa Borella, Milena Mazan, PhD, Krzysztof Brzózka, PhD, Alessandro Bressan, Andrea Pellacani, PhD MD, Massimiliano Salerno, Monica Binaschi, PhD, Daniela Bellarosa
Journal: Blood
Blood (2019) 134 (Supplement_1): 5087.
https://doi.org/10.1182/blood-2019-124800
Published: 2019
Journal Articles

MEN1112/OBT357, an Anti Bst1/CD157 Humanized Antibody Inducing Acute Myelogenous Leukemia (AML) Blast Depletion in an Autologous Ex Vivo Assay: A Potential New Targeted Therapy for AML

Adriano Venditti, MD, Francesco Buccisano, Luca Maurillo, MD, Maria Ilaria Del Principe, MD, Andrea Coppola, Patrizia Palomba, Roberto Arriga, Daniela Bellarosa, Alessandro Bressan, Keith Wilson, Stefano Manzini, Angela Capriati, MD PhD, Cecilia Simonelli, MD, Monica Binaschi, Sergio Amadori, MD, Giuseppe Sconocchia
Journal: Blood
Blood (2015) 126 (23): 788.
https://doi.org/10.1182/blood.V126.23.788.788
Published: 2015
Journal Articles

Targeting and Depletion of Acute Myeloid Leukemia Blasts By MEN1112, a Novel Humanized Defucosylated Monoclonal Antibodies with Specificity for Bst1/CD157 Antigen

Adriano Venditti, Francesco Buccisano, Luca Maurillo, Maria Ilaria Del Principe, Andrea Coppola, Patrizia Palomba, Anna Aureli, Roberto Arriga, Daniela Bellarosa, Alessandro Bressan, Stefano Manzini, Cecilia Simonelli, Monica Binaschi, Sergio Amadori, Giuseppe Sconocchia
Journal: Blood
Blood (2014) 124 (21): 2235.
https://doi.org/10.1182/blood.V124.21.2235.2235
Published: 2014