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Elizabeth Witten
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Journal Articles

Impaired Response to Oxidative DNA Damage Underlies Genomic Instability in B-Cell Leukemia Driven By RPS15 Mutation

Marwan Kwok, Catherine Gutierrez, Neil Ruthen, Peyton Waddicor, Tamara Ouspenskaia, Christina Curran, Doris Fu, Binyamin Knisbacher, Anat Biran, Adi Nagler, Aviv Liani, Sarah Chen, Gregory Lazarian, Elizabeth Witten, Gabriela Brunsting Hoffmann, Emma Lin, Lucas Pomerance, Shuqiang Li, Lili Wang, Kenneth J. Livak, Donna S. Neuberg, Gad Getz, Elisa Ten Hacken, Catherine J. Wu
Journal: Blood
Blood (2024) 144 (Supplement 1): 758.
https://doi.org/10.1182/blood-2024-202115
Published: 2024
Journal Articles

Immuno-Genetic Changes Underlie Response to Immune Checkpoint Blockade Therapy in Richter's Syndrome Mouse Models

Elisa Ten Hacken, Gabriela Brunsting Hoffmann, Kayla Cruz, Erin Michelle Parry, Elizabeth Witten, Donna S. Neuberg, Gordon J Freeman, Catherine J. Wu
Journal: Blood
Blood (2022) 140 (Supplement 1): 1538–1539.
https://doi.org/10.1182/blood-2022-160465
Published: 2022
Journal Articles

B Cell-Restricted Depletion of Dnmt3a Activates Notch Signaling and Causes Chronic Lymphocytic Leukemia

Shanye Yin, Anat Biran, Helene Kretzmer, Elisa Ten Hacken, Salma Parvin, Fabienne Lucas, Mohamed Uduman, Catherine Gutierrez, Nathan J Dangle, Leah Billington, Fara Regis, Laura Z. Rassenti, Arman W. Mohammad, Mei Zheng, Elizabeth Witten, Thomas J. Kipps, Jon C. Aster, Andreas Gnirke, Donna S. Neuberg, Anthony G. Letai, Lili Wang, Ruben D. Carrasco, Alexander Meissner, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 249.
https://doi.org/10.1182/blood-2021-150789
Published: 2021
Journal Articles

Dissecting Richter's Syndrome in a Multiplexed CRISPR-Based Mouse Model Reveals Key Changes in MYC, Interferon and BCR Signaling Underlying Transformation

Elisa Ten Hacken, Shanye Yin, Tomasz Sewastianik, Livius Penter, Neil Ruthen, Michaela Gruber, Erin Michelle Parry, Romain Guieze, Robert A. Redd, Mohamed Uduman, Shuqiang Li, Jackson Southard, Maria Hernandez-Sanchez, Salma Parvin, Fen Zhu, Gabriela Brunsting Hoffmann, Elizabeth Witten, Kenneth J. Livak, Matthew S. Davids, Anthony G. Letai, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 251.
https://doi.org/10.1182/blood-2021-148614
Published: 2021
Journal Articles

RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Catherine Gutierrez, Tamara Ouspenskaia, PhD, Doris Fu, Peyton Waddicor, B.S., Anat Biran, PhD, Aviv Liani, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Elizabeth Witten, Fara Faye Regis, BS, Heather Joyal, Leah Billington, BA, Fabienne Lucas, MDPhD, Mei Zheng, Blake Tye, PhD, Maria Hernandez-Sanchez, PhD, Miguel Quijada Álamo, MSc, Shuqiang Li, PhD, Binyamin A. Knisbacher, PhD, Ziao Lin, BS, Aziz Al'Khafaji, PhD, Lili Wang, MDPhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Florence Cymbalista, MD PhD, Gad Getz, PhD, Stirling Churchman, PhD, Ruben D. Carrasco, MD PhD, Sichen Shao, PhD, Aviv Regev, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-138900
Published: 2020
Journal Articles

IKZF3 Overexpression Phenocopies Gain-of-Function Mutation in Chronic Lymphocytic Leukemia

Shanye Yin, PhD, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Satyen Gohil, BSc, MBBS, MRCP, FRCPath, Shuqiang Li, PhD, Laura Z. Rassenti, PhD, Leah Billington, BA, Elizabeth Witten, Teddy Huang, BS, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Fanny Baran-Marszak, MD PhD, Thomas J. Kipps, MD PhD, Florence Cymbalista, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9.
https://doi.org/10.1182/blood-2020-137085
Published: 2020
Journal Articles

Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome

Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Robert A. Redd, MS, Geoffrey Fell, MS, Mohamed Uduman, PhD, Michaela Gruber, MD PhD, Shanye Yin, PhD, Kendell Clement, PhD, Erin Michelle Parry, MD PhD, Shuqiang Li, PhD, Maria Hernandez-Sanchez, PhD, Leah Billington, BA, Elizabeth Witten, Kaitlyn J Baranowski, Lili Wang, MDPhD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-137130
Published: 2020
Journal Articles

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Gregory Lazarian, PharmD, Shanye Yin, PhD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, MSc,PhD, Alba Font-tello, PhD, Heather Joyal, Elizabeth Witten, Mei Zheng, Christopher J. Ott, PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 848.
https://doi.org/10.1182/blood-2019-123963
Published: 2019