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Nickolas Tsakmaklis
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Journal Articles

Establishment of a Novel Waldenström's Macroglobulinemia (WM) Cell Line Bcwm.2 with Del6q and Unique MYD88 S243N , LYN I297N , SPI1 Q227E Mutations and That Shows Robust In Vivo Engraftment in SCID NOD Mice

Shirong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M Soroko, Johany Penailillo, Alexa G Canning, Yang Cao, Guang Yang, Lian Xu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 5834.
https://doi.org/10.1182/blood-2024-211381
Published: 2024
Journal Articles

Pacritinib Effectively Inhibits Pro-Survival Signaling and Overcomes BTK Cys481Ser -Mediated Resistance in MYD88-Mutated B-Cell Malignancies

Shirong Liu, Amanda Kofides, Xia Liu, Hao Sun, Alexa G Canning, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Kirsten Meid, Prafulla C. Gokhale, John M Hatcher, Jorge J. Castillo, Shayna R Sarosiek, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 5830.
https://doi.org/10.1182/blood-2024-211285
Published: 2024
Journal Articles

Correlation between Familial Waldenström Macroglobulinemia Clusters Withclinical Features, Complications, and Outcomes in 1000 Patients: A Single-Center Retrospective Cohort Study

Andres Ramirez, Jorge J. Castillo, Nickolas Tsakmaklis, Zachary R Hunter, Maria Luisa Guerrera, Catherine A. Flynn, Shayna R Sarosiek, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 6322.
https://doi.org/10.1182/blood-2024-193524
Published: 2024
Journal Articles

Two-Year Follow-up after Ibrutinib and Venetoclax in Symptomatic, Treatment-Naive Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, Shayna R Sarosiek, Andrew R. Branagan, Gottfried von Keudell, Catherine A. Flynn, Andres Ramirez-Gamero, Nina S Budano, Alexandra N. Eurell, Kirsten Meid, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Christopher J Patterson, Zachary R Hunter, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 1647.
https://doi.org/10.1182/blood-2024-198376
Published: 2024
Journal Articles

Development and Evaluation of a Multiplex Digital PCR Assay for Detecting CXCR4 S338X Mutations in Waldenstrom's Macroglobulinemia

Nickolas Tsakmaklis, Zachary R Hunter, Amanda Kofides, Xia Liu, Shirong Liu, Hao Sun, Abigail Peachey, Maria Luisa Guerrera, Christopher J Patterson, Joshua Gustine, Andrew R. Branagan, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 6194.
https://doi.org/10.1182/blood-2024-211703
Published: 2024
Journal Articles

Development and Characterization of Novel Dual HCK/BTK Bifunctional Protacs That Potently Inhibit Kinase Function and Demonstrate Robust in Vitro and In Vivo Degradation of Targets for the Treatment of MYD88-Mutated B-Cell Malignancies

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Dominic Pizzarella, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 834.
https://doi.org/10.1182/blood-2024-211103
Published: 2024
Journal Articles

Single-Cell RNA Analysis of Bone Marrow Mononuclear Cells Reveals Abnormal Activation of T Cells and Monocytes, and Identifies CD35 As a Novel Biomarker and Therapeutic Target in Waldenstrom Macroglobulinemia

Hao Sun, Xia Liu, Maria Luisa Guerrera, Nickolas Tsakmaklis, Amanda Kofides, Andres Felipe Ramirez Gamero, Catherine A. Flynn, Christopher J Patterson, Mu Hao, Lugui Qiu, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Shirong Liu, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 743.
https://doi.org/10.1182/blood-2024-211488
Published: 2024
Journal Articles

Analysis of Alternative Splicing in Waldenstrom's Macroglobulinemia Reveals Novel Targets, Insights into IgM Production and Improved Gene Level Expression Estimates

Zachary R Hunter, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Abigail Peachey, Andres Felipe Ramirez Gamero, John M Hatcher, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C. Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 2986.
https://doi.org/10.1182/blood-2024-212123
Published: 2024
Journal Articles

Discovery of Undocumented, Cancer-Specific and Pro-Inflammatory Isoforms of WNK2 That Are Highly Expressed in MYD88 Mutated Waldenström's Macroglobulinemia and Represent Novel Therapeutic Targets.

Maria Luisa Guerrera, Xia Liu, John M Hatcher, Nickolas Tsakmaklis, Amanda Kofides, Abigail Peachey, Hao Sun, Shirong Liu, Christopher J Patterson, Eugenio Morelli, Jorge J. Castillo, Shayna R Sarosiek, Catherine A. Flynn, Kirsten Meid, Andrew R. Branagan, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C. Munshi, Steven P. Treon, Zachary R Hunter
Journal: Blood
Blood (2024) 144 (Supplement 1): 2972.
https://doi.org/10.1182/blood-2024-211759
Published: 2024
Journal Articles

Multi-Omic Analysis Identifies Deletions in Chr17p and High ROR1 Expression, but Not TP53 Mutations As Predictors of Overall Survival in Patients with Untreated Waldenstrom's Macroglobulinemia (WM)

Zachary R Hunter, Andres Felipe Ramirez Gamero, Maria Luisa Guerrera, Nickolas Tsakmaklis, Amanda Kofides, Xia Liu, Shirong Liu, Abigail Peachey, Hao Sun, Catherine A. Flynn, Kirsten Meid, Joshua Gutine, Christopher J Patterson, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 2968.
https://doi.org/10.1182/blood-2024-211664
Published: 2024
Journal Articles

A Phase II Study of Pirtobrutinib and Venetoclax in Previously Treated Patients with Waldenström Macroglobulinemia: An Interim Analysis

Jorge J. Castillo, Shayna R Sarosiek, Andrew R. Branagan, Gottfried von Keudell, Catherine A. Flynn, Nina S Budano, Alexandra N. Eurell, Kirsten Meid, Andres Ramirez-Gamero, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Christopher J Patterson, Zachary R Hunter, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 3011.
https://doi.org/10.1182/blood-2024-198297
Published: 2024
Journal Articles

Genomic Evolution By Serial Single-Cell Sequencing Identifies High Tumor Expression of LYN As a Promoter of Resistance in Waldenstrom's Macroglobulinemia Undergoing Ibrutinib Monotherapy

Hao Sun, Romanos Sklavenitis-Pistofidis, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Andres Felipe Ramirez Gamero, Catherine A. Flynn, Christopher J Patterson, Mu Hao, Lu-Gui Qiu, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Shirong Liu, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 4338.
https://doi.org/10.1182/blood-2024-211597
Published: 2024
Journal Articles

Development and Characterization of a Novel Bifunctional Protac Jh-XIII-05-1 That Shows Potent IRAK1 and IRAK4 Kinase Inhibition and Target Degradation and Is Highly Active in MYD88 Mutated B-Cell Lymphoma Cells Alone and in Combination with BTK- and BCL2- Inhibitors

John M Hatcher, Shirong Liu, Amanda Kofides, Alexa G Canning, Dominic Pizzarella, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 4359.
https://doi.org/10.1182/blood-2024-211804
Published: 2024
Journal Articles

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 3298.
https://doi.org/10.1182/blood-2023-190369
Published: 2023
Journal Articles

Quantitative MYD88 L265P Analysis Represents a Powerful Tool for Assessing Disease Response and Evaluating Clinical Trial Performance in Waldenstrom's Macroglobulinemia

Nickolas Tsakmaklis, Zachary R Hunter, Xia Liu, Amanda Kofides, Shirong Liu, Alexa G Canning, Kris Richardson, Maria Luisa Guerrera, Christopher J Patterson, Kirsten Meid, Timothy P. White, Megan Little, Katherine Stockman, Joshua Gustine, Catherine A. Flynn, Andrew R. Branagan, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 211.
https://doi.org/10.1182/blood-2023-190520
Published: 2023
Journal Articles

Ibrutinib and Venetoclax in Symptomatic, Treatment-Naive Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, Shayna R Sarosiek, Andrew R. Branagan, Catherine A. Flynn, Megan Little, Katherine Stockman, Timothy P. White, Alexandra N. Eurell, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Kirsten Meid, Christopher J Patterson, Zachary R Hunter, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 1661.
https://doi.org/10.1182/blood-2023-174375
Published: 2023
Journal Articles

Single-Cell RNA Sequencing Reveals Hypo-Responsiveness of T and NK Cells to Interferon Stimulation As an Immune Hallmark in Asymptomatic Waldenstrom's Macroglobulinemia

Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Daniel L. Mallory, Ting Wu, Michelle P. Aranha, Junko Tsuji, Nicholas J Haradhvala, Elizabeth D. Lightbody, Katherine Towle, Laura Hevenor, Nickolas Tsakmaklis, Xiyue Wang, Alexa G Canning, Christine-Ivy Liacos, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Steven P Treon, Gady Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 2026.
https://doi.org/10.1182/blood-2023-186470
Published: 2023
Journal Articles

Early Subclones Showing Aberrant Co-Expression of Stem Cell, T Cell and Myeloid Genes Can be Detected By Flow Cytometry in MYD88 Mutated Waldenström's Macroglobulinemia Patients

Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Nickolas Tsakmaklis, Kris Richardson, Shirong Liu, Christopher J Patterson, Catherine A. Flynn, Kirsten Meid, Nikhil C Munshi, Kenneth C. Anderson, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2023) 142 (Supplement 1): 1952.
https://doi.org/10.1182/blood-2023-190942
Published: 2023
Journal Articles

Changes in Methylation and Chromatin Accessibility Underlie Subtype Classification and Disease Evolution in Waldenström's Macroglobulinemia

Zachary R Hunter, Nickolas Tsakmaklis, Kris Richardson, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Ari M Melnick, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 755.
https://doi.org/10.1182/blood-2023-190825
Published: 2023
Journal Articles

Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications

Zachary R Hunter, Maria Luisa Guerrera, Ruben D. Carrasco, Nickolas Tsakmaklis, Kris Richardson, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Tomasz Sewastianik, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 756.
https://doi.org/10.1182/blood-2023-190685
Published: 2023