1-20 of 51
Joshua Gustine
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Quantitative MYD88 L265P Analysis Represents a Powerful Tool for Assessing Disease Response and Evaluating Clinical Trial Performance in Waldenstrom's Macroglobulinemia

Nickolas Tsakmaklis, Zachary R Hunter, Xia Liu, Amanda Kofides, Shirong Liu, Alexa G Canning, Kris Richardson, Maria Luisa Guerrera, Christopher J Patterson, Kirsten Meid, Timothy P. White, Megan Little, Katherine Stockman, Joshua Gustine, Catherine A. Flynn, Andrew R. Branagan, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 211.
https://doi.org/10.1182/blood-2023-190520
Published: 2023
Journal Articles

Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications

Zachary R Hunter, Maria Luisa Guerrera, Ruben D. Carrasco, Nickolas Tsakmaklis, Kris Richardson, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Tomasz Sewastianik, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 756.
https://doi.org/10.1182/blood-2023-190685
Published: 2023
Journal Articles

The ERK1/2 Regulator WNK2 Shows Novel Alternative Splicing Aberrations That Support Tumor Growth in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Xia Liu, Eugenio Morelli, Kris Richardson, Nickolas Tsakmaklis, Amanda Kofides, Manit Munshi, Shirong Liu, Guang Yang, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Alessandra Trojani, Alessandra Tedeschi, Roberto Cairoli, Tomasz Sewastianik, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C Munshi, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2022) 140 (Supplement 1): 1549–1550.
https://doi.org/10.1182/blood-2022-169863
Published: 2022
Journal Articles

Identification of Robust Predictors for Ibrutinib Response By Multi-Omic Genomics in MYD88 Mutated Waldenstrom's Macroglobulinemia

Kris Richardson, Jorge J. Castillo, Shayna Sarosiek, Andrew R. Branagan, Catherine A. Flynn, Kirsten Meid, Carly Leventoff, Timothy P White, Megan Little, Joshua Gustine, Xia Liu, Amanda Kofides, Shirong Liu, Alexa Canning, Julie Wolf, Katherine Kacena, Christopher J Patterson, Maria Luisa Guerrera, Nickolas Tsakmaklis, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2022) 140 (Supplement 1): 3541–3542.
https://doi.org/10.1182/blood-2022-170254
Published: 2022
Journal Articles

Multi-Omic Analysis of 253 Untreated Patients with Waldenström's Macroglobulinemia Reveals Clinically and Genomically Distinct Disease Subtypes and a Model for Disease Progression

Zachary R Hunter, Nickolas Tsakmaklis, Kris Richardson, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Alexa Canning, Manit Munshi, Shayna Sarosiek, Catherine A. Flynn, Andrew R. Branagan, Lian Xu, Guang Yang, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Kenneth C. Anderson, Nikhil C Munshi, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1740–1741.
https://doi.org/10.1182/blood-2022-170412
Published: 2022
Journal Articles

Pirtobrutinib (LOXO-305) Is Active and Overcomes ERK Related Pro-Survival Signaling in Ibrutinib Resistant, BTK Cys481 Mutant Expressing WM and ABC DLBCL Lymphoma Cells Driven By Activating MYD88 Mutations

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Joshua Gustine, Shayna Sarosiek, Catherine A Flynn, Kirsten Meid, Timothy P White, Carly Leventoff, Christopher J Patterson, Andrew R. Branagan, Prafulla Gokhale, Michael J Poitras, Zachary R Hunter, Maria Luisa Guerrera, Jorge J. Castillo, Guang Yang, Steven P Treon
Journal: Blood
Blood (2021) 138 (Supplement 1): 2261.
https://doi.org/10.1182/blood-2021-153856
Published: 2021
Journal Articles

A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Zachary R Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Jinhua Wang, Sara J Buhrlage, Nathanael S Gray, Nikhil C. Munshi, Kenneth C. Anderson, Guang Yang, Steven P Treon
Journal: Blood
Blood (2021) 138 (Supplement 1): 3512.
https://doi.org/10.1182/blood-2021-153610
Published: 2021
Journal Articles

The ERK1/2 Regulator WNK2 Shows Differential Expression and Isoform Usage, Primarily Driven By Aberrant Methylation, in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Guang Yang, Xia Liu, Nickolas Tsakmaklis, Maria G Demos, Amanda Kofides, Manit Munshi, Lian Xu, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Kirsten Meid, Joshua Gustine, Tomasz Sewastianik, Ruben D. Carrasco, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2021) 138 (Supplement 1): 2692.
https://doi.org/10.1182/blood-2021-154160
Published: 2021
Journal Articles

Predictive Factors of Overall Survival in Patients with Relapsed AL Amyloidosis Treated with Single Agent Daratumumab

Raphael Szalat, Joshua Gustine, John Mark Sloan, Vaishali Sanchorawala
Journal: Blood
Blood (2021) 138 (Supplement 1): 2734.
https://doi.org/10.1182/blood-2021-144980
Published: 2021
Journal Articles

Dose Reductions Related to Adverse Effects in Patients with Waldenström Macroglobulinemia Treated with the BTK-Inhibitor Ibrutinib

Shayna Sarosiek, Joshua Gustine, Catherine A Flynn, Carly Leventoff, Timothy P White, Kirsten Meid, Steven P Treon, Jorge J. Castillo
Journal: Blood
Blood (2021) 138 (Supplement 1): 3529.
https://doi.org/10.1182/blood-2021-154284
Published: 2021
Journal Articles

Clinical and Genomic Factors Are Predictive of Response and Prognostic of Progression-Free Survival in Patients with Waldenström Macroglobulinemia Treated with Ibrutinib

Jorge J. Castillo, MD, Joshua Gustine, MPH, Maria Demos, Andrew Keezer, BS, Kirsten Meid, MPH, Gloria G Chan, MS, Jiaji G Chen, Maria Luisa Guerrera, MD, Amanda Kofides, Manit Munshi, MS, Nicholas Tsakmaklis, Xia Liu, MD, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2823.
https://doi.org/10.1182/blood-2019-125069
Published: 2019
Journal Articles

CXCR4 Mutational Status Does Not Impact Outcomes in Patients with Waldenstrom Macroglobulinemia Treated with Proteasome Inhibitors

Jorge J. Castillo, MD, Joshua Gustine, MPH, Maria Demos, Andrew Keezer, BS, Kirsten Meid, MPH, Toni Dubeau, NP, Gloria G Chan, MS, Jiaji Chen, BS, Maria Luisa Guerrera, MD, Amanda Kofides, Manit Munshi, MS, Nicholas Tsakmaklis, Xia Liu, MD, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2830.
https://doi.org/10.1182/blood-2019-122349
Published: 2019
Journal Articles

Ibrutinib Dose Reduction Does Not Affect Progression-Free Survival in Patients with Waldenstrom Macroglobulinemia

Jorge J. Castillo, MD, Joshua Gustine, MPH, Andrew Keezer, BS, Kirsten Meid, MPH, Toni Dubeau, NP, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1598.
https://doi.org/10.1182/blood-2018-99-111626
Published: 2018
Journal Articles

Alternative Mutations and Isoform Dysregulation in MYD88 in Waldenstrom's Macroglobulinemia

Amanda Kofides, Maria Demos, Nickolas Tsakmaklis, Lian Xu, MS, Xia Liu, MD, Christopher Patterson, Maria Luisa Guerrera, MD, Manit Munshi, MS, Guang Yang, PhD, Jiaji G Chen, Cristina Jimenez, PhD, Gloria G Chan, MS, Joshua Gustine, MPH, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Zachary R Hunter, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1566.
https://doi.org/10.1182/blood-2018-99-119419
Published: 2018
Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2018-99-117372
Published: 2018
Journal Articles

Deepening of Response after Completing Rituximab-Containing Primary Therapy in Patients with Waldenstrom Macroglobulinemia

Jorge J. Castillo, MD, Joshua Gustine, MPH, Toni Dubeau, NP, Kirsten Meid, MPH, Andrew Keezer, BS, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 2887.
https://doi.org/10.1182/blood-2018-99-110675
Published: 2018
Journal Articles

Multicenter Prospective Phase II Study of Venetoclax in Patients with Previously Treated Waldenstrom Macroglobulinemia

Jorge J. Castillo, MD, Joshua Gustine, MPH, Kirsten Meid, MPH, Toni Dubeau, NP, Andrew Keezer, BS, John N. Allan, MD, Richard R. Furman, MD, Tanya Siddiqi, MD, Ranjana Advani, MD, Jessica Lam, Zachary R Hunter, PhD, Guang Yang, PhD, Lian Xu, MS, Matthew S Davids, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 2888.
https://doi.org/10.1182/blood-2018-99-112325
Published: 2018
Journal Articles

Genomic Analysis of Ibrutinib Resistance in Waldenstrom Macroglobulinemia

Cristina Jimenez, PhD, Gloria G Chan, MS, Lian Xu, MS, Nickolas Tsakmaklis, Jiaji G Chen, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Xia Liu, MD, Manit Munshi, MS, Joshua Gustine, MPH, Guang Yang, PhD, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Zachary R Hunter, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1372.
https://doi.org/10.1182/blood-2018-99-118819
Published: 2018
Journal Articles

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

Jiaji G. Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G. Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G. Chan, Christopher J. Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J. Castillo, Zachary R. Hunter, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon, Guang Yang
Journal: Blood
Blood (2018) 131 (18): 2047–2059.
https://doi.org/10.1182/blood-2017-10-811752
Published: 2018
Includes: Supplemental data
Journal Articles

Acquired Von Willebrand Disease in Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, MD, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1088.
https://doi.org/10.1182/blood.V130.Suppl_1.1088.1088
Published: 2017