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Sara J Buhrlage
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Journal Articles

Development and Characterization of Novel Dual HCK/BTK Bifunctional Protacs That Potently Inhibit Kinase Function and Demonstrate Robust in Vitro and In Vivo Degradation of Targets for the Treatment of MYD88-Mutated B-Cell Malignancies

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Dominic Pizzarella, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 834.
https://doi.org/10.1182/blood-2024-211103
Published: 2024
Journal Articles

Development and Characterization of a Novel Bifunctional Protac Jh-XIII-05-1 That Shows Potent IRAK1 and IRAK4 Kinase Inhibition and Target Degradation and Is Highly Active in MYD88 Mutated B-Cell Lymphoma Cells Alone and in Combination with BTK- and BCL2- Inhibitors

John M Hatcher, Shirong Liu, Amanda Kofides, Alexa G Canning, Dominic Pizzarella, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 4359.
https://doi.org/10.1182/blood-2024-211804
Published: 2024
Journal Articles

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 3298.
https://doi.org/10.1182/blood-2023-190369
Published: 2023
Journal Articles

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTK Cys481 ibrutinib resistance

Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G. Chen, Nicholas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Lian Xu, Zachary R. Hunter, Jinwei Che, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Nikhil C. Munshi, Kenneth C. Anderson, Michael Cameron, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon
Journal: Blood
Blood (2021) 138 (20): 1966–1979.
https://doi.org/10.1182/blood.2021011405
Published: 2021
Includes: Supplemental data
Journal Articles

A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Zachary R Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Jinhua Wang, Sara J Buhrlage, Nathanael S Gray, Nikhil C. Munshi, Kenneth C. Anderson, Guang Yang, Steven P Treon
Journal: Blood
Blood (2021) 138 (Supplement 1): 3512.
https://doi.org/10.1182/blood-2021-153610
Published: 2021
Journal Articles

Blockade of Deubiquitylating Enzyme USP7 in Plasmacytoid Dendritic Cells Stimulates Anti-Myeloma Immunity

Arghya Ray, PhD, Ting DU, PhD, Yan Song, PhD, Sara J Buhrlage, PhD, Dharminder Chauhan, PhD, Kenneth Anderson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43.
https://doi.org/10.1182/blood-2020-138591
Published: 2020
Journal Articles

Targeting Oncoproteins with a Positive Selection Assay for Protein Degraders

Sagar Koduri, MD PhD, Adam C. Wang, B.S., Mette Ishoey, PhD, Joshiawa Paulk, Xiaoxi Liu, PhD, Isaac Harris, PhD, Jennifer Endress, B.S., Benjamin L. Lampson, MD PhD, Christopher J. Ott, PhD, James Bradner, MD, Jeffrey A. Medin, PhD, Sara J Buhrlage, PhD, William Kaelin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-141558
Published: 2020
Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 394.
https://doi.org/10.1182/blood-2019-130636
Published: 2019
Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2018-99-117372
Published: 2018
Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 40.
https://doi.org/10.1182/blood-2018-99-119171
Published: 2018
Journal Articles

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

Jiaji G. Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G. Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G. Chan, Christopher J. Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J. Castillo, Zachary R. Hunter, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon, Guang Yang
Journal: Blood
Blood (2018) 131 (18): 2047–2059.
https://doi.org/10.1182/blood-2017-10-811752
Published: 2018
Includes: Supplemental data
Journal Articles

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

Julie Marie Matthews, Shruti Bhatt, Matthew P. Patricelli, Tyzoon K. Nomanbhoy, Xiaoyu Jiang, Yasodha Natkunam, Andrew J. Gentles, Ezequiel Martinez, Daxing Zhu, Jennifer Rose Chapman, Elena Cortizas, Ragini Shyam, Shideh Chinichian, Ranjana Advani, Li Tan, Jianming Zhang, Hwan Geun Choi, Robert Tibshirani, Sara J. Buhrlage, Dita Gratzinger, Ramiro Verdun, Nathanael S. Gray, Izidore S. Lossos
Journal: Blood
Blood (2016) 128 (2): 239–248.
https://doi.org/10.1182/blood-2016-02-696856
Published: 2016
Includes: Supplemental data
Journal Articles

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Guang Yang, Sara J. Buhrlage, Li Tan, Xia Liu, Jie Chen, Lian Xu, Nicholas Tsakmaklis, Jiaji G. Chen, Christopher J. Patterson, Jennifer R. Brown, Jorge J. Castillo, Wei Zhang, Xiaofeng Zhang, Shuai Liu, Philip Cohen, Zachary R. Hunter, Nathanael Gray, Steven P. Treon
Journal: Blood
Blood (2016) 127 (25): 3237–3252.
https://doi.org/10.1182/blood-2016-01-695098
Published: 2016
Journal Articles

A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia

Guang Yang, Yangsheng Zhou, Xia Liu, Lian Xu, Yang Cao, Robert J. Manning, Christopher J. Patterson, Sara J. Buhrlage, Nathanael Gray, Yu-Tzu Tai, Kenneth C. Anderson, Zachary R. Hunter, Steven P. Treon
Journal: Blood
Blood (2013) 122 (7): 1222–1232.
https://doi.org/10.1182/blood-2012-12-475111
Published: 2013