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Journal Articles

The ERK1/2 Regulator WNK2 Shows Novel Alternative Splicing Aberrations That Support Tumor Growth in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Xia Liu, Eugenio Morelli, Kris Richardson, Nickolas Tsakmaklis, Amanda Kofides, Manit Munshi, Shirong Liu, Guang Yang, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Alessandra Trojani, Alessandra Tedeschi, Roberto Cairoli, Tomasz Sewastianik, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C Munshi, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2022) 140 (Supplement 1): 1549–1550.
https://doi.org/10.1182/blood-2022-169863
Published: 2022
Journal Articles

Ibrutinib and Venetoclax in Previously Untreated Waldenström Macroglobulinemia

Jorge J. Castillo, Shayna Sarosiek, Andrew R. Branagan, David J. Sermer, Catherine A. Flynn, Carly Leventoff, Megan Little, Timothy P White, Kirsten Meid, Alexa Canning, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Manit Munshi, Nicholas Tsakmaklis, Christopher J Patterson, Zachary R Hunter, Steven P Treon
Journal: Blood
Blood (2022) 140 (Supplement 1): 564–565.
https://doi.org/10.1182/blood-2022-155610
Published: 2022
Journal Articles

Multi-Omic Analysis of 253 Untreated Patients with Waldenström's Macroglobulinemia Reveals Clinically and Genomically Distinct Disease Subtypes and a Model for Disease Progression

Zachary R Hunter, Nickolas Tsakmaklis, Kris Richardson, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Alexa Canning, Manit Munshi, Shayna Sarosiek, Catherine A. Flynn, Andrew R. Branagan, Lian Xu, Guang Yang, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Kenneth C. Anderson, Nikhil C Munshi, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1740–1741.
https://doi.org/10.1182/blood-2022-170412
Published: 2022
Journal Articles

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTK Cys481 ibrutinib resistance

Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G. Chen, Nicholas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Lian Xu, Zachary R. Hunter, Jinwei Che, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Nikhil C. Munshi, Kenneth C. Anderson, Michael Cameron, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon
Journal: Blood
Blood (2021) 138 (20): 1966–1979.
https://doi.org/10.1182/blood.2021011405
Published: 2021
Includes: Supplemental data
Journal Articles

A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Zachary R Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Jinhua Wang, Sara J Buhrlage, Nathanael S Gray, Nikhil C. Munshi, Kenneth C. Anderson, Guang Yang, Steven P Treon
Journal: Blood
Blood (2021) 138 (Supplement 1): 3512.
https://doi.org/10.1182/blood-2021-153610
Published: 2021
Journal Articles

The ERK1/2 Regulator WNK2 Shows Differential Expression and Isoform Usage, Primarily Driven By Aberrant Methylation, in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Guang Yang, Xia Liu, Nickolas Tsakmaklis, Maria G Demos, Amanda Kofides, Manit Munshi, Lian Xu, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Kirsten Meid, Joshua Gustine, Tomasz Sewastianik, Ruben D. Carrasco, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2021) 138 (Supplement 1): 2692.
https://doi.org/10.1182/blood-2021-154160
Published: 2021
Journal Articles

Pirtobrutinib (LOXO-305) Is Active and Overcomes ERK Related Pro-Survival Signaling in Ibrutinib Resistant, BTK Cys481 Mutant Expressing WM and ABC DLBCL Lymphoma Cells Driven By Activating MYD88 Mutations

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Joshua Gustine, Shayna Sarosiek, Catherine A Flynn, Kirsten Meid, Timothy P White, Carly Leventoff, Christopher J Patterson, Andrew R. Branagan, Prafulla Gokhale, Michael J Poitras, Zachary R Hunter, Maria Luisa Guerrera, Jorge J. Castillo, Guang Yang, Steven P Treon
Journal: Blood
Blood (2021) 138 (Supplement 1): 2261.
https://doi.org/10.1182/blood-2021-153856
Published: 2021
Journal Articles

Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia

Clinical Trials & Observations Brief Report
Steven P. Treon, Kirsten Meid, Zachary R. Hunter, Catherine A. Flynn, Shayna R. Sarosiek, Carly R. Leventoff, Timothy P. White, Yang Cao, Aldo M. Roccaro, Antonio Sacco, Maria G. Demos, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Lian Xu, Christopher J. Patterson, Manit Munshi, Nicholas Tsakmaklis, Guang Yang, Irene M. Ghobrial, Andrew R. Branagan, Jorge J. Castillo
Journal: Blood
Blood (2021) 138 (17): 1535–1539.
https://doi.org/10.1182/blood.2021012953
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical and Genomic Factors Are Predictive of Response and Prognostic of Progression-Free Survival in Patients with Waldenström Macroglobulinemia Treated with Ibrutinib

Jorge J. Castillo, MD, Joshua Gustine, MPH, Maria Demos, Andrew Keezer, BS, Kirsten Meid, MPH, Gloria G Chan, MS, Jiaji G Chen, Maria Luisa Guerrera, MD, Amanda Kofides, Manit Munshi, MS, Nicholas Tsakmaklis, Xia Liu, MD, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2823.
https://doi.org/10.1182/blood-2019-125069
Published: 2019
Journal Articles

CXCR4 Mutational Status Does Not Impact Outcomes in Patients with Waldenstrom Macroglobulinemia Treated with Proteasome Inhibitors

Jorge J. Castillo, MD, Joshua Gustine, MPH, Maria Demos, Andrew Keezer, BS, Kirsten Meid, MPH, Toni Dubeau, NP, Gloria G Chan, MS, Jiaji Chen, BS, Maria Luisa Guerrera, MD, Amanda Kofides, Manit Munshi, MS, Nicholas Tsakmaklis, Xia Liu, MD, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2830.
https://doi.org/10.1182/blood-2019-122349
Published: 2019
Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 394.
https://doi.org/10.1182/blood-2019-130636
Published: 2019
Journal Articles

Mutated MYD88 Regulates HCK Pro-Survival Signaling through JunB in MYD88 Mutated B-Lymphoma Cells

Xia Liu, MD, Jiaji G Chen, Manit Munshi, MS, Lian Xu, MS, Amanda Kofides, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Kirsten Meid, MPH, Andrew Keezer, BS, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3778.
https://doi.org/10.1182/blood-2019-130885
Published: 2019
Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2018-99-117372
Published: 2018
Journal Articles

Genomic Analysis of Ibrutinib Resistance in Waldenstrom Macroglobulinemia

Cristina Jimenez, PhD, Gloria G Chan, MS, Lian Xu, MS, Nickolas Tsakmaklis, Jiaji G Chen, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Xia Liu, MD, Manit Munshi, MS, Joshua Gustine, MPH, Guang Yang, PhD, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Zachary R Hunter, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1372.
https://doi.org/10.1182/blood-2018-99-118819
Published: 2018
Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 40.
https://doi.org/10.1182/blood-2018-99-119171
Published: 2018
Journal Articles

Comprehensive Integration of Whole Genome, Transcriptome and Methylation Profiling Reveals Novel Gene Dysregulation Including IL15, SOCS6 and CARD11 Associated with MYD88 and CXCR4 Genotype Status in WM

Zachary R Hunter, PhD, Gloria G Chan, MS, Cristina Jimenez, PhD, Nickolas Tsakmaklis, Lian Xu, MS, Jiaji G Chen, Maria Demos, Amanda Kofides, Manit Munshi, MS, Maria Luisa Guerrera, MD, Xia Liu, MD, Guang Yang, PhD, Jorge J. Castillo, MD, Ari M Melnick, MD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1563.
https://doi.org/10.1182/blood-2018-99-119828
Published: 2018
Journal Articles

Alternative Mutations and Isoform Dysregulation in MYD88 in Waldenstrom's Macroglobulinemia

Amanda Kofides, Maria Demos, Nickolas Tsakmaklis, Lian Xu, MS, Xia Liu, MD, Christopher Patterson, Maria Luisa Guerrera, MD, Manit Munshi, MS, Guang Yang, PhD, Jiaji G Chen, Cristina Jimenez, PhD, Gloria G Chan, MS, Joshua Gustine, MPH, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Zachary R Hunter, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1566.
https://doi.org/10.1182/blood-2018-99-119419
Published: 2018
Journal Articles

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

Jiaji G. Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G. Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G. Chan, Christopher J. Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J. Castillo, Zachary R. Hunter, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon, Guang Yang
Journal: Blood
Blood (2018) 131 (18): 2047–2059.
https://doi.org/10.1182/blood-2017-10-811752
Published: 2018
Includes: Supplemental data
Journal Articles

The Genomic Landscape of MYD88 Wild-Type WaldenströM's Macroglobulinemia Ischaracterized By Somatic Mutations in TBL1XR1, the CBM Complex, and NFKB2

Zachary Hunter, PhD, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Lian Xu, Gloria Chan, MS, Jiaji Chen, BS, Manit Munshi, MS, Xia Liu, MD, Joshua Gustine, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD, Guang Yang, PhD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 4011.
https://doi.org/10.1182/blood.V130.Suppl_1.4011.4011
Published: 2017
Journal Articles

BTK Cys481Ser Mutation Drives Ibrutinib Resistance through ERK1/2 Hyperactivation, and Can Confer a Protective Effect on Bystander Waldenstrom's Macroglobulinemia and ABC DLBCL Cells through Paracrine Mediated Pro-Survival Signaling

Jiaji Chen, BS, Xia Liu, MD, Manit Munshi, MS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 803.
https://doi.org/10.1182/blood.V130.Suppl_1.803.803
Published: 2017