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Gloria G. Chan
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Journal Articles

Clinical and Genomic Factors Are Predictive of Response and Prognostic of Progression-Free Survival in Patients with Waldenström Macroglobulinemia Treated with Ibrutinib

Jorge J. Castillo, MD, Joshua Gustine, MPH, Maria Demos, Andrew Keezer, BS, Kirsten Meid, MPH, Gloria G Chan, MS, Jiaji G Chen, Maria Luisa Guerrera, MD, Amanda Kofides, Manit Munshi, MS, Nicholas Tsakmaklis, Xia Liu, MD, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2823.
https://doi.org/10.1182/blood-2019-125069
Published: 2019
Journal Articles

CXCR4 Mutational Status Does Not Impact Outcomes in Patients with Waldenstrom Macroglobulinemia Treated with Proteasome Inhibitors

Jorge J. Castillo, MD, Joshua Gustine, MPH, Maria Demos, Andrew Keezer, BS, Kirsten Meid, MPH, Toni Dubeau, NP, Gloria G Chan, MS, Jiaji Chen, BS, Maria Luisa Guerrera, MD, Amanda Kofides, Manit Munshi, MS, Nicholas Tsakmaklis, Xia Liu, MD, Lian Xu, MS, Guang Yang, PhD, Zachary R Hunter, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2830.
https://doi.org/10.1182/blood-2019-122349
Published: 2019
Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 394.
https://doi.org/10.1182/blood-2019-130636
Published: 2019
Journal Articles

Mutated MYD88 Regulates HCK Pro-Survival Signaling through JunB in MYD88 Mutated B-Lymphoma Cells

Xia Liu, MD, Jiaji G Chen, Manit Munshi, MS, Lian Xu, MS, Amanda Kofides, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Kirsten Meid, MPH, Andrew Keezer, BS, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3778.
https://doi.org/10.1182/blood-2019-130885
Published: 2019
Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2018-99-117372
Published: 2018
Journal Articles

Genomic Analysis of Ibrutinib Resistance in Waldenstrom Macroglobulinemia

Cristina Jimenez, PhD, Gloria G Chan, MS, Lian Xu, MS, Nickolas Tsakmaklis, Jiaji G Chen, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Xia Liu, MD, Manit Munshi, MS, Joshua Gustine, MPH, Guang Yang, PhD, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Zachary R Hunter, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1372.
https://doi.org/10.1182/blood-2018-99-118819
Published: 2018
Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 40.
https://doi.org/10.1182/blood-2018-99-119171
Published: 2018
Journal Articles

Comprehensive Integration of Whole Genome, Transcriptome and Methylation Profiling Reveals Novel Gene Dysregulation Including IL15, SOCS6 and CARD11 Associated with MYD88 and CXCR4 Genotype Status in WM

Zachary R Hunter, PhD, Gloria G Chan, MS, Cristina Jimenez, PhD, Nickolas Tsakmaklis, Lian Xu, MS, Jiaji G Chen, Maria Demos, Amanda Kofides, Manit Munshi, MS, Maria Luisa Guerrera, MD, Xia Liu, MD, Guang Yang, PhD, Jorge J. Castillo, MD, Ari M Melnick, MD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1563.
https://doi.org/10.1182/blood-2018-99-119828
Published: 2018
Journal Articles

Alternative Mutations and Isoform Dysregulation in MYD88 in Waldenstrom's Macroglobulinemia

Amanda Kofides, Maria Demos, Nickolas Tsakmaklis, Lian Xu, MS, Xia Liu, MD, Christopher Patterson, Maria Luisa Guerrera, MD, Manit Munshi, MS, Guang Yang, PhD, Jiaji G Chen, Cristina Jimenez, PhD, Gloria G Chan, MS, Joshua Gustine, MPH, Jorge J. Castillo, MD, Steven P Treon, MD PhD FRCP, Zachary R Hunter, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1566.
https://doi.org/10.1182/blood-2018-99-119419
Published: 2018
Journal Articles

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

Jiaji G. Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G. Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G. Chan, Christopher J. Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J. Castillo, Zachary R. Hunter, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon, Guang Yang
Journal: Blood
Blood (2018) 131 (18): 2047–2059.
https://doi.org/10.1182/blood-2017-10-811752
Published: 2018
Includes: Supplemental data