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Journal Articles

A Phase II Study of Pirtobrutinib and Venetoclax in Previously Treated Patients with Waldenström Macroglobulinemia: An Interim Analysis

Jorge J. Castillo, Shayna R Sarosiek, Andrew R. Branagan, Gottfried von Keudell, Catherine A. Flynn, Nina S Budano, Alexandra N. Eurell, Kirsten Meid, Andres Ramirez-Gamero, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Christopher J Patterson, Zachary R Hunter, Steven P. Treon

Blood (2024) 144 (Supplement 1): 3011.

https://doi.org/10.1182/blood-2024-198297

Published: 2024

Journal Articles

Duration of Therapy in Patients with Waldenström Macroglobulinemia Undergoing Dose Reductions of First-Line Ibrutinib: A Real-World Analysis

Shayna R Sarosiek, Monika Salkar, Barnabie Agatep, Barton Jones, Michelle Pacia, Chadi Saifan, Shaffee Bacchus, Sudeep Karve, Jonas Paludo

Blood (2024) 144 (Supplement 1): 3728.

https://doi.org/10.1182/blood-2024-194639

Published: 2024

Journal Articles

Development and Characterization of Novel Dual HCK/BTK Bifunctional Protacs That Potently Inhibit Kinase Function and Demonstrate Robust in Vitro and In Vivo Degradation of Targets for the Treatment of MYD88-Mutated B-Cell Malignancies

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Dominic Pizzarella, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P. Treon

Blood (2024) 144 (Supplement 1): 834.

https://doi.org/10.1182/blood-2024-211103

Published: 2024

Journal Articles

Single-Cell RNA Analysis of Bone Marrow Mononuclear Cells Reveals Abnormal Activation of T Cells and Monocytes, and Identifies CD35 As a Novel Biomarker and Therapeutic Target in Waldenstrom Macroglobulinemia

Hao Sun, Xia Liu, Maria Luisa Guerrera, Nickolas Tsakmaklis, Amanda Kofides, Andres Felipe Ramirez Gamero, Catherine A. Flynn, Christopher J Patterson, Mu Hao, Lugui Qiu, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Shirong Liu, Steven P. Treon

Blood (2024) 144 (Supplement 1): 743.

https://doi.org/10.1182/blood-2024-211488

Published: 2024

Journal Articles

Analysis of Alternative Splicing in Waldenstrom's Macroglobulinemia Reveals Novel Targets, Insights into IgM Production and Improved Gene Level Expression Estimates

Zachary R Hunter, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Abigail Peachey, Andres Felipe Ramirez Gamero, John M Hatcher, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C. Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon

Blood (2024) 144 (Supplement 1): 2986.

https://doi.org/10.1182/blood-2024-212123

Published: 2024

Journal Articles

Genomic Evolution By Serial Single-Cell Sequencing Identifies High Tumor Expression of LYN As a Promoter of Resistance in Waldenstrom's Macroglobulinemia Undergoing Ibrutinib Monotherapy

Hao Sun, Romanos Sklavenitis-Pistofidis, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Andres Felipe Ramirez Gamero, Catherine A. Flynn, Christopher J Patterson, Mu Hao, Lu-Gui Qiu, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Shirong Liu, Steven P. Treon

Blood (2024) 144 (Supplement 1): 4338.

https://doi.org/10.1182/blood-2024-211597

Published: 2024

Journal Articles

Development and Characterization of a Novel Bifunctional Protac Jh-XIII-05-1 That Shows Potent IRAK1 and IRAK4 Kinase Inhibition and Target Degradation and Is Highly Active in MYD88 Mutated B-Cell Lymphoma Cells Alone and in Combination with BTK- and BCL2- Inhibitors

John M Hatcher, Shirong Liu, Amanda Kofides, Alexa G Canning, Dominic Pizzarella, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P. Treon

Blood (2024) 144 (Supplement 1): 4359.

https://doi.org/10.1182/blood-2024-211804

Published: 2024

Journal Articles

A Phase II Trial of Loncastuximab Tesirine in Patients with Previously Treated Waldenström Macroglobulinemia

Jorge J. Castillo, Steven P. Treon, Catherine A. Flynn, Andres Ramirez-Gamero, Nina S Budano, Alexandra N. Eurell, Kirsten Meid, Shayna R Sarosiek

Blood (2024) 144 (Supplement 1): 4404.

https://doi.org/10.1182/blood-2024-211573

Published: 2024

Journal Articles

Discovery of Undocumented, Cancer-Specific and Pro-Inflammatory Isoforms of WNK2 That Are Highly Expressed in MYD88 Mutated Waldenström's Macroglobulinemia and Represent Novel Therapeutic Targets.

Blood (2024) 144 (Supplement 1): 2972.

https://doi.org/10.1182/blood-2024-211759

Published: 2024

Journal Articles

Multi-Omic Analysis Identifies Deletions in Chr17p and High ROR1 Expression, but Not TP53 Mutations As Predictors of Overall Survival in Patients with Untreated Waldenstrom's Macroglobulinemia (WM)

Zachary R Hunter, Andres Felipe Ramirez Gamero, Maria Luisa Guerrera, Nickolas Tsakmaklis, Amanda Kofides, Xia Liu, Shirong Liu, Abigail Peachey, Hao Sun, Catherine A. Flynn, Kirsten Meid, Joshua Gutine, Christopher J Patterson, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon

Blood (2024) 144 (Supplement 1): 2968.

https://doi.org/10.1182/blood-2024-211664

Published: 2024

Journal Articles

Establishment of a Novel Waldenström's Macroglobulinemia (WM) Cell Line Bcwm.2 with Del6q and Unique MYD88 S243N , LYN I297N , SPI1 Q227E Mutations and That Shows Robust In Vivo Engraftment in SCID NOD Mice

Shirong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M Soroko, Johany Penailillo, Alexa G Canning, Yang Cao, Guang Yang, Lian Xu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Steven P. Treon

Blood (2024) 144 (Supplement 1): 5834.

https://doi.org/10.1182/blood-2024-211381

Published: 2024

Journal Articles

Pacritinib Effectively Inhibits Pro-Survival Signaling and Overcomes BTK Cys481Ser -Mediated Resistance in MYD88-Mutated B-Cell Malignancies

Shirong Liu, Amanda Kofides, Xia Liu, Hao Sun, Alexa G Canning, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Kirsten Meid, Prafulla C. Gokhale, John M Hatcher, Jorge J. Castillo, Shayna R Sarosiek, Steven P. Treon

Blood (2024) 144 (Supplement 1): 5830.

https://doi.org/10.1182/blood-2024-211285

Published: 2024

Journal Articles

A Phase 2 Trial Investigating Epcoritamab in Patients with Previously Treated Waldenstrom Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (WM-NET3)

Gottfried von Keudell, Emma K Logan, Robert A. Redd, Shayna R Sarosiek, Andrew R. Branagan, Larry D Anderson, Jr., Christopher Dittus, Steven P. Treon, Jorge J. Castillo

Blood (2024) 144 (Supplement 1): 6294.

https://doi.org/10.1182/blood-2024-206415

Published: 2024

Journal Articles

Correlation between Familial Waldenström Macroglobulinemia Clusters Withclinical Features, Complications, and Outcomes in 1000 Patients: A Single-Center Retrospective Cohort Study

Andres Ramirez, Jorge J. Castillo, Nickolas Tsakmaklis, Zachary R Hunter, Maria Luisa Guerrera, Catherine A. Flynn, Shayna R Sarosiek, Steven P. Treon

Blood (2024) 144 (Supplement 1): 6322.

https://doi.org/10.1182/blood-2024-193524

Published: 2024

Journal Articles

Two-Year Follow-up after Ibrutinib and Venetoclax in Symptomatic, Treatment-Naive Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, Shayna R Sarosiek, Andrew R. Branagan, Gottfried von Keudell, Catherine A. Flynn, Andres Ramirez-Gamero, Nina S Budano, Alexandra N. Eurell, Kirsten Meid, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Christopher J Patterson, Zachary R Hunter, Steven P. Treon

Blood (2024) 144 (Supplement 1): 1647.

https://doi.org/10.1182/blood-2024-198376

Published: 2024

Journal Articles

Development and Evaluation of a Multiplex Digital PCR Assay for Detecting CXCR4 S338X Mutations in Waldenstrom's Macroglobulinemia

Nickolas Tsakmaklis, Zachary R Hunter, Amanda Kofides, Xia Liu, Shirong Liu, Hao Sun, Abigail Peachey, Maria Luisa Guerrera, Christopher J Patterson, Joshua Gustine, Andrew R. Branagan, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon

Blood (2024) 144 (Supplement 1): 6194.

https://doi.org/10.1182/blood-2024-211703

Published: 2024

Journal Articles

Real-World Outcomes Following Dose Modifications of First-Line Ibrutinib in Patients with Waldenström Macroglobulinemia

Shayna R Sarosiek, Gottfried R. von Keudell, Jonas Paludo, Monika Salkar, Barnabie Agatep, Anjali Franco, Samuel Crawford, Michelle Pacia, Jorge J. Castillo

Blood (2023) 142 (Supplement 1): 3780.

https://doi.org/10.1182/blood-2023-181925

Published: 2023

Journal Articles

Pacritinib Blocks Key Pro-Survival Signaling Related to Mutated MYD88, Produces High Levels of Apoptosis and Overcomes Mutated BTK Cys481 Related BTK-Inhibitor Resistance

Shirong Liu, Amanda Kofides, Xia Liu, Alexa G Canning, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Kris Richardson, Catherine A. Flynn, Kirsten Meid, Megan Little, Katherine Stockman, Timothy P. White, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon

Blood (2023) 142 (Supplement 1): 3300.

https://doi.org/10.1182/blood-2023-190463

Published: 2023

Journal Articles

Novel Isoforms Identified By Isoseq Analysis Drive Expression Differences in Key Genes That Delineate the Subtypes of Waldenstrom's Macroglobulinemia

Kris Richardson, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Steven P Treon

Blood (2023) 142 (Supplement 1): 1946.

https://doi.org/10.1182/blood-2023-190631

Published: 2023

Journal Articles

Final Results of a Multicenter Pilot Study Evaluating Brentuximab Vedotin with Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (BV-CHEP) for the Treatment of Aggressive Adult T-Cell Leukemia/Lymphoma

Christopher Dittus, Matthew Weinstock, Jeffrey A. Barnes, Jose Sandoval-Sus, Natalie S. Grover, Anne Beaven, Xianming Tan, Areej El-Jawahri, Shayna R Sarosiek, John Mark Sloan

Blood (2023) 142 (Supplement 1): 1692.

https://doi.org/10.1182/blood-2023-173822

Published: 2023

NARROW

A Phase II Study of Pirtobrutinib and Venetoclax in Previously Treated Patients with Waldenström Macroglobulinemia: An Interim Analysis

Duration of Therapy in Patients with Waldenström Macroglobulinemia Undergoing Dose Reductions of First-Line Ibrutinib: A Real-World Analysis

Development and Characterization of Novel Dual HCK/BTK Bifunctional Protacs That Potently Inhibit Kinase Function and Demonstrate Robust in Vitro and In Vivo Degradation of Targets for the Treatment of MYD88-Mutated B-Cell Malignancies

Single-Cell RNA Analysis of Bone Marrow Mononuclear Cells Reveals Abnormal Activation of T Cells and Monocytes, and Identifies CD35 As a Novel Biomarker and Therapeutic Target in Waldenstrom Macroglobulinemia

Analysis of Alternative Splicing in Waldenstrom's Macroglobulinemia Reveals Novel Targets, Insights into IgM Production and Improved Gene Level Expression Estimates

Genomic Evolution By Serial Single-Cell Sequencing Identifies High Tumor Expression of LYN As a Promoter of Resistance in Waldenstrom's Macroglobulinemia Undergoing Ibrutinib Monotherapy

Development and Characterization of a Novel Bifunctional Protac Jh-XIII-05-1 That Shows Potent IRAK1 and IRAK4 Kinase Inhibition and Target Degradation and Is Highly Active in MYD88 Mutated B-Cell Lymphoma Cells Alone and in Combination with BTK- and BCL2- Inhibitors

A Phase II Trial of Loncastuximab Tesirine in Patients with Previously Treated Waldenström Macroglobulinemia

Discovery of Undocumented, Cancer-Specific and Pro-Inflammatory Isoforms of WNK2 That Are Highly Expressed in MYD88 Mutated Waldenström's Macroglobulinemia and Represent Novel Therapeutic Targets.

Multi-Omic Analysis Identifies Deletions in Chr17p and High ROR1 Expression, but Not TP53 Mutations As Predictors of Overall Survival in Patients with Untreated Waldenstrom's Macroglobulinemia (WM)

Establishment of a Novel Waldenström's Macroglobulinemia (WM) Cell Line Bcwm.2 with Del6q and Unique MYD88 S243N , LYN I297N , SPI1 Q227E Mutations and That Shows Robust In Vivo Engraftment in SCID NOD Mice

Pacritinib Effectively Inhibits Pro-Survival Signaling and Overcomes BTK Cys481Ser -Mediated Resistance in MYD88-Mutated B-Cell Malignancies

A Phase 2 Trial Investigating Epcoritamab in Patients with Previously Treated Waldenstrom Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (WM-NET3)

Correlation between Familial Waldenström Macroglobulinemia Clusters Withclinical Features, Complications, and Outcomes in 1000 Patients: A Single-Center Retrospective Cohort Study

Two-Year Follow-up after Ibrutinib and Venetoclax in Symptomatic, Treatment-Naive Patients with Waldenström Macroglobulinemia

Development and Evaluation of a Multiplex Digital PCR Assay for Detecting CXCR4 S338X Mutations in Waldenstrom's Macroglobulinemia

Real-World Outcomes Following Dose Modifications of First-Line Ibrutinib in Patients with Waldenström Macroglobulinemia

Pacritinib Blocks Key Pro-Survival Signaling Related to Mutated MYD88, Produces High Levels of Apoptosis and Overcomes Mutated BTK Cys481 Related BTK-Inhibitor Resistance

Novel Isoforms Identified By Isoseq Analysis Drive Expression Differences in Key Genes That Delineate the Subtypes of Waldenstrom's Macroglobulinemia

Final Results of a Multicenter Pilot Study Evaluating Brentuximab Vedotin with Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (BV-CHEP) for the Treatment of Aggressive Adult T-Cell Leukemia/Lymphoma

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American Society of Hematology

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American Society of Hematology

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