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Journal Articles

The genomic landscape of Waldenström macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis

Zachary R. Hunter, Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert J. Manning, Christina Tripsas, Christopher J. Patterson, Patricia Sheehy, Steven P. Treon

Blood (2014) 123 (11): 1637–1646.

https://doi.org/10.1182/blood-2013-09-525808

Published: 2014

Includes: Supplemental data

Journal Articles

Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström's Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance

Lian Xu, Zachary Hunter, Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Sandra Kanan, NP, Jiaji G Chen, Neil I Lindeman, MD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 3024.

https://doi.org/10.1182/blood.V122.21.3024.3024

Published: 2013

Journal Articles

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Yangsheng Zhou, MD, Lian Xu, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Zachary Hunter, Sara Buhrlage, Ph.D, Nathanael S Gray, PhD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4255.

https://doi.org/10.1182/blood.V122.21.4255.4255

Published: 2013

Journal Articles

A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia

Guang Yang, Yangsheng Zhou, Xia Liu, Lian Xu, Yang Cao, Robert J. Manning, Christopher J. Patterson, Sara J. Buhrlage, Nathanael Gray, Yu-Tzu Tai, Kenneth C. Anderson, Zachary R. Hunter, Steven P. Treon

Blood (2013) 122 (7): 1222–1232.

https://doi.org/10.1182/blood-2012-12-475111

Published: 2013

Journal Articles

MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction

Blood (2013) 121 (11): 2051–2058.

https://doi.org/10.1182/blood-2012-09-454355

Published: 2013

Journal Articles

MYD88 L265P Promotes Survival of Waldenstrom's Macroglobulinemia Cells by Activation of Bruton's Tyrosine Kinase

Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Yang Cao, MD, Christopher J Patterson, Yu-Tzu Tai, PhD, Kenneth C. Anderson, Zachary Hunter, Steven P. Treon, M.D., Ph.D.

Blood (2012) 120 (21): 897.

https://doi.org/10.1182/blood.V120.21.897.897

Published: 2012

Journal Articles

Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom's Macroglobinemia.

Yang Cao, MD, Lian Xu, Xia Liu, MD, Yangsheng Zhou, MD, Guang Yang, MD, Christopher J Patterson, Steven Peter Treon, MD, MA, PhD, Zachary Hunter

Blood (2012) 120 (21): 2715.

https://doi.org/10.1182/blood.V120.21.2715.2715

Published: 2012

Journal Articles

A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas

Lian Xu, Aliyah R. Sohani, MD, Luca Arcaini, MD, Zachary Hunter, Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christopher J Patterson, Leukothea Ioakimidis, Christina Tripsas, Geraldine S. Pinkus, MD, Nancy Lee Harris, MD, Scott J. Rodig, MD, PhD, Steven Treon, MD, PhD

Blood (2011) 118 (21): 261.

https://doi.org/10.1182/blood.V118.21.261.261

Published: 2011

Journal Articles

Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenström's Macroglobulinemia

Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Guang Yang, PhD, Yang Cao, MD, Zachary Hunter, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 86.

https://doi.org/10.1182/blood.V118.21.86.86

Published: 2011

Journal Articles

MicroRNA-21 and −155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia,

Yang Cao, MD, Zachary Hunter, Yangsheng Zhou, MD, Xia Liu, MD, Guang Yang, PhD, Lian Xu, Christopher Patterson, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 3957.

https://doi.org/10.1182/blood.V118.21.3957.3957

Published: 2011

Journal Articles

Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia

Zachary Hunter, Lian Xu, Yangsheng Zhou, MD, Guang Yang, PhD, Xia Liu, MD, Yang Cao, MD, Christina Hanzis, Patricia Sheehy, NP, Robert Manning, Christopher J Patterson, Jason M Laramie, PhD, Donald A Skifter, PhD, Stephen E Lincoln, PhD, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 434.

https://doi.org/10.1182/blood.V118.21.434.434

Published: 2011

Journal Articles

Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia

Steven P Treon, MD, PhD, Lian Xu, Yangsheng Zhou, MD, Xia Liu, MD, Guang Yang, PhD, Yang Cao, MD, Christina Hanzis, Patricia Sheehy, NP, Robert Manning, Christopher J Patterson, Jason M Laramie, PhD, Donald A Skifter, PhD, Stephen E Lincoln, PhD, Zachary Hunter

Blood (2011) 118 (21): 300.

https://doi.org/10.1182/blood.V118.21.300.300

Published: 2011

Journal Articles

Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-κβ and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobulinemia

Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Zachary Hunter, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 597.

https://doi.org/10.1182/blood.V118.21.597.597

Published: 2011

Journal Articles

Involvement of Ets Factor Spi-B and Id2 In Waldenström's Macroglobulinemia

Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Zachary Hunter, Jenny Sun, MD, Guang Yang, MD, Bryan Ciccarelli, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 129.

https://doi.org/10.1182/blood.V116.21.129.129

Published: 2010

Journal Articles

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Zachary Hunter, Yang Cao, MD, Megan Lewicki, Jenny Sun, MD, Hsiuyi Tseng, Christina Hanzis, Philip Brodsky, Robert Manning, Lian Xu, Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Jingrui Jiang, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 1912.

https://doi.org/10.1182/blood.V116.21.1912.1912

Published: 2010

Journal Articles

Involvement of Lipogenic Pathway In 5-Azacytidine-Induced Cytotoxicity In Waldenstrom's Macroglobulinemia

Lian Xu, Christopher Patterson, Jenny Sun, MD, Guang Yang, MD, Yangsheng Zhou, MD, Zachary Hunter, Bryan Ciccarelli, Robert Manning, Xia Liu, MD, Yang Cao, MD, Hsiuyi Tseng, Leukothea Ioakimidis, Christina Hanzis, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 2991.

https://doi.org/10.1182/blood.V116.21.2991.2991

Published: 2010

Journal Articles

The Rituximab and IVIG Related IgM Flare In Waldenstrom's Macroglobulinemia Is Associated with Monocytic Activation of Fcgriia Signaling, and Triggering of IL-6 Release by the PI3K/AKT and MAPK Pathways

Guang Yang, MD, Lian Xu, Zachary Hunter, Xia Liu, MD, Yang Cao, MD, Jingrui Jiang, Hsiuyi Tseng, Yangsheng Zhou, MD, Leukothea Ioakimidis, Christina Hanzis, Patricia Sheehy, NP, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 2870.

https://doi.org/10.1182/blood.V116.21.2870.2870

Published: 2010

Journal Articles

The IgM Flare Following Rituximab and IVIG Administration in Waldenstrom's Macroglobulinemia Is Related to IL-6 Production by Bystander Immune Cells, Possibly through Stimulation of the Fcgriia Receptor.

Guang Yang, PhD, Ping Gong, Thea Ioakimidis, MS, Lian Xu, Zachary Hunter, Jenny Sun, MD, Bryan Ciccarelli, Yangsheng Zhou, MD, PhD, Xia Liu, Hsiuyi Tseng, Yang Cao, Robert Manning, Megan Lewicki, Christina Hanzis, Patricia Sheehy, NP, Christopher J Patterson, Steven Treon, MD, PhD

Blood (2009) 114 (22): 761.

https://doi.org/10.1182/blood.V114.22.761.761

Published: 2009

Journal Articles

Histone Deacetylase Inhibitors Demonstrate Significant Preclinical Activity as Single Agents, and in Combination with Bortezomib in Waldenstrom's Macroglobulinemia.

Blood (2009) 114 (22): 4785.

https://doi.org/10.1182/blood.V114.22.4785.4785

Published: 2009

Journal Articles

Patients with Waldenstrom's Macroglobulinemia Are Often Hypoferremic That Is Refractory to Oral Iron Repletion and Responsive to Parental Iron Infusions, and Demonstrate Elevated Levels of Hepcidin.

Bryan Ciccarelli, Christopher J Patterson, Zachary Hunter, Christina Hanzis, Thea Ioakimidis, MS, Robert Manning, Guang Yang, PhD, Ping Gong, Lian Xu, Yangsheng Zhou, MD, PhD, Jenny Sun, MD, Xia Liu, Hsiuyi Tseng, Yang Cao, Patricia Sheehy, NP, Steven Treon, MD, PhD

Blood (2009) 114 (22): 2952.

https://doi.org/10.1182/blood.V114.22.2952.2952

Published: 2009

NARROW

The genomic landscape of Waldenström macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis

Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström's Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia

MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction

MYD88 L265P Promotes Survival of Waldenstrom's Macroglobulinemia Cells by Activation of Bruton's Tyrosine Kinase

Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom's Macroglobinemia.

A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas

Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenström's Macroglobulinemia

MicroRNA-21 and −155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia,

Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia

Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia

Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-κβ and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobulinemia

Involvement of Ets Factor Spi-B and Id2 In Waldenström's Macroglobulinemia

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Involvement of Lipogenic Pathway In 5-Azacytidine-Induced Cytotoxicity In Waldenstrom's Macroglobulinemia

The Rituximab and IVIG Related IgM Flare In Waldenstrom's Macroglobulinemia Is Associated with Monocytic Activation of Fcgriia Signaling, and Triggering of IL-6 Release by the PI3K/AKT and MAPK Pathways

The IgM Flare Following Rituximab and IVIG Administration in Waldenstrom's Macroglobulinemia Is Related to IL-6 Production by Bystander Immune Cells, Possibly through Stimulation of the Fcgriia Receptor.

Histone Deacetylase Inhibitors Demonstrate Significant Preclinical Activity as Single Agents, and in Combination with Bortezomib in Waldenstrom's Macroglobulinemia.

Patients with Waldenstrom's Macroglobulinemia Are Often Hypoferremic That Is Refractory to Oral Iron Repletion and Responsive to Parental Iron Infusions, and Demonstrate Elevated Levels of Hepcidin.

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American Society of Hematology

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American Society of Hematology

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