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Zachary Hunter
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Journal Articles

IgM-MM is predominantly a pre–germinal center disorder and has a distinct genomic and transcriptomic signature from WM

CME Brief Report
Abdul Hamid Bazarbachi, Hervé Avet-Loiseau, Raphael Szalat, Anil Aktas Samur, Zachary Hunter, Masood Shammas, Jill Corre, Mariateresa Fulciniti, Kenneth C. Anderson, Giovanni Parmigiani, Steven P. Treon, Mohamad Mohty, Nikhil C. Munshi, Mehmet Kemal Samur
Journal: Blood
Blood (2021) 138 (20): 1980–1985.
https://doi.org/10.1182/blood.2021011452
Published: 2021
Includes: Supplemental data
Journal Articles

The Genomic Landscape of MYD88 Wild-Type WaldenströM's Macroglobulinemia Ischaracterized By Somatic Mutations in TBL1XR1, the CBM Complex, and NFKB2

Zachary Hunter, PhD, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Lian Xu, Gloria Chan, MS, Jiaji Chen, BS, Manit Munshi, MS, Xia Liu, MD, Joshua Gustine, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD, Guang Yang, PhD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 4011.
https://doi.org/10.1182/blood.V130.Suppl_1.4011.4011
Published: 2017
Journal Articles

Ibrutinib Discontinuation in Waldenström Macroglobulinemia: Etiologies, Outcomes, and IgM Rebound

Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Lian Xu, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 802.
https://doi.org/10.1182/blood.V130.Suppl_1.802.802
Published: 2017
Journal Articles

BTK Cys481Ser Mutation Drives Ibrutinib Resistance through ERK1/2 Hyperactivation, and Can Confer a Protective Effect on Bystander Waldenstrom's Macroglobulinemia and ABC DLBCL Cells through Paracrine Mediated Pro-Survival Signaling

Jiaji Chen, BS, Xia Liu, MD, Manit Munshi, MS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 803.
https://doi.org/10.1182/blood.V130.Suppl_1.803.803
Published: 2017
Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 719.
https://doi.org/10.1182/blood.V130.Suppl_1.719.719
Published: 2017
Journal Articles

PAK4 Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldestrostom Macroglobulinemia

Na Li, MD, Mariateresa Fulciniti, PhD, Michael A Lopez, BS, Tommaso Perini, MD, Raphael Szalat, MD, Subodh Kumar, PhD, Mehmet Kemal Samur, PhD, Lian Xu, Yan Xu, MD, William Senapedis, PhD, Erkan Baloglu, Stefania Oliva, MD, Masood A. Shammas, PhD, Zachary Hunter, PhD, Kenneth C Anderson, MD, Steven P Treon, MDPhDFRCP, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 648.
https://doi.org/10.1182/blood.V130.Suppl_1.648.648
Published: 2017
Journal Articles

Mutated MYD88 Activates the BCR Component SYK and Provides a Rationale Therapeutic Target in Waldenstrom's Macroglobulinemia

Manit Munshi, MS, Xia Liu, MD, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2539.
https://doi.org/10.1182/blood.V130.Suppl_1.2539.2539
Published: 2017
Journal Articles

Long-Term Follow-up of Previously Treated Patients Who Received Ibrutinib for Symptomatic Waldenstrom's Macroglobulinemia: Update of Pivotal Clinical Trial

Steven P Treon, MDPhDFRCP, Kirsten Meid, MPH, Joshua Gustine, Kurt S. Bantilan, MPH, Toni Dubeau, NP, Patricia Severns, NP, Guang Yang, PhD, Lian Xu, Christopher Patterson, MAcc, Irene M Ghobrial, MD, Jacob Laubach, MD, Zachary Hunter, PhD, Jorge J. Castillo, MD, Maria L. Palomba, MD, Ranjana H. Advani, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2766.
https://doi.org/10.1182/blood.V130.Suppl_1.2766.2766
Published: 2017
Journal Articles

Ibrutinib Is Highly Active As First Line Therapy in Symptomatic Waldenstrom's Macroglobulinemia

Steven P Treon, MDPhDFRCP, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Christopher Patterson, MAcc, Lian Xu, Guang Yang, PhD, Xia Liu, MD, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Manit Munshi, MS, Nickolas Tsakmaklis, BA, Gloria Chan, MS, Andrew J Yee, MD, Noopur Raje, MD, Elizabeth O'Donnell, MD, Zachary Hunter, PhD, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2767.
https://doi.org/10.1182/blood.V130.Suppl_1.2767.2767
Published: 2017
Journal Articles

Dysregulation of MYD88 Regulatory Isoforms in Waldenstrom's Macroglobulinemia

Amanda Kofides, BS, Maria Demos, BS, Nickolas Tsakmaklis, BA, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Jiaji Chen, BS, Christopher Patterson, MAcc, Maria Luisa Guerrera, MD, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4967.
https://doi.org/10.1182/blood.V130.Suppl_1.4967.4967
Published: 2017
Journal Articles

TP53 mutations Are Associated with Mutated MYD88 and CXCR4, and Confer an Adverse Outcome in Waldenström Macroglobulinemia

Joshua Gustine, Kirsten Meid, MPH, Patricia Severns, NP, Toni Dubeau, NP, Nickolas Tsakmaklis, BA, Christopher Patterson, MAcc, Guang Yang, PhD, Xia Liu, MD, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Manit Munshi, MS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Jorge J. Castillo, MD, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Lian Xu
Journal: Blood
Blood (2017) 130 (Supplement 1): 5140.
https://doi.org/10.1182/blood.V130.Suppl_1.5140.5140
Published: 2017
Journal Articles

Somatic Variants Associated with MDS/AML Are Present in MYD88 Mutated Waldenstrom's Macroglobulinemia

Gloria Chan, MS, Joshua Gustine, Nickolas Tsakmaklis, BA, Lian Xu, Amanda Kofides, BS, Maria Demos, BS, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4983.
https://doi.org/10.1182/blood.V130.Suppl_1.4983.4983
Published: 2017
Journal Articles

Characterization of Chromosome 6q Deletions in MYD88 Mutant and Wild-Type Waldenström's Macroglobulinemia

Maria Luisa Guerrera, MD, Nickolas Tsakmaklis, BA, Lian Xu, Guang Yang, PhD, Maria Demos, BS, Gloria Chan, MS, Amanda Kofides, BS, Robert Manning, Xia Liu, MD, Jiaji Chen, BS, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Toni Dubeau, NP, Joshua Gustine, Ruben D. Carrasco, MD PhD, Luca Arcaini, MD, Marzia Varettoni, MD, Mario Cazzola, MD, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4984.
https://doi.org/10.1182/blood.V130.Suppl_1.4984.4984
Published: 2017
Journal Articles

Modeling Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia in Transgenic Mice Using Human MYD88 L256P Mutated Protein

Tomasz Sewastianik, MSc,PhD, Maria Luisa Guerrera, MD, Meng Jiang, MD, Peter S. Dennis, Jianjun Zhao, MD, Guang Yang, PhD, Zachary Hunter, PhD, Geraldine S. Pinkus, Petr Jarolim, MD PhD, Wong Kwok-Kin, MD PhD, Steven P Treon, MDPhDFRCP, Ruben D. Carrasco, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2510.
https://doi.org/10.1182/blood.V130.Suppl_1.2510.2510
Published: 2017
Journal Articles

Abnormal Splicing Patterns and Novel Intron Retentions Affect Genes Regulating Splicing, NF-Kb, ERK1/2, and TP53 in Waldenstrom's Macroglobulinemia

Zachary Hunter, PhD, Nickolas Tsakmaklis, BA, Lian Xu, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Gloria Chan, MS, Manit Munshi, MS, Xia Liu, MD, Joshua Gustine, Kirsten Meid, MPH, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD, Guang Yang, PhD, Nikhil Munshi, MD, Kenneth C Anderson, MD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 3812.
https://doi.org/10.1182/blood.V130.Suppl_1.3812.3812
Published: 2017
Journal Articles

MYD88 Mutation Status Impacts Overall Survival and Risk of Histological Transformation in Waldenstrom's Macroglobulinemia

Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD, Joshua Gustine, Kirsten Meid, MPH, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Robert Manning, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Jiaji Chen, BS, Gloria Chan, MS, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4006.
https://doi.org/10.1182/blood.V130.Suppl_1.4006.4006
Published: 2017
Journal Articles

Mutated MYD88 Homozygosity Is Increased in Previously Treated Patients with Waldenstrom's Macroglobulinemia, and Associates with CXCR4 Mutation Status and Ibrutinib Exposure

Nickolas Tsakmaklis, BA, Lian Xu, Robert Manning, Guang Yang, PhD, Xia Liu, MD, Jiaji Chen, BS, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Maria Luisa Guerrera, MD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1462.
https://doi.org/10.1182/blood.V130.Suppl_1.1462.1462
Published: 2017
Journal Articles

Aberrant HCK Survival Signaling By Mutated MYD88 Requires PAX5 in Waldenstrom's Macroglobulinemia and ABC DLBCL Cells

Xia Liu, MD, Jiaji Chen, BS, Manit Munshi, MS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1199.
https://doi.org/10.1182/blood.V130.Suppl_1.1199.1199
Published: 2017
Journal Articles

Differential Diagnosis of Suspected MYD88 Wild-Type Waldenstrom's Macroglobulinemia Includes Other Malignant and Non-Malignant IgM Secreting Entities, Including Frequent Cases of IgM Myeloma

Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD, Joshua Gustine, Kirsten Meid, MPH, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Robert Manning, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Jiaji Chen, BS, Gloria Chan, MS, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4385.
https://doi.org/10.1182/blood.V130.Suppl_1.4385.4385
Published: 2017
Journal Articles

Molecular Basis of Ibrutinib Resistance in Waldenstrom's Macroglobulinemia

Lian Xu, Nicholas Tsakmaklis, Guang Yang, PhD, Jiaji G Chen, Xia Liu, MD, Jie Chen, PhD, Maria Demos, Christopher J Patterson, MFA, Toni Dubeau, NP, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Ranjana H Advani, MD, Maria Lia Palomba, MD, Richard R. Furman, MD, Zachary Hunter, PhD, Steven P Treon, MD PhD
Journal: Blood
Blood (2016) 128 (22): 756.
https://doi.org/10.1182/blood.V128.22.756.756
Published: 2016