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Zachary Hunter
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Journal Articles

High VGPR/CR rates with pirtobrutinib plus venetoclax in previously treated Waldenström macroglobulinemia: Results from a multicenter phase II study

Free
Jorge Castillo, Gottfried von Keudell, Andrew Branagan, Alberto Guijosa, Hannah Chory, Margaret Kobs, Nina Budano, Julia Nguyen, Alexandra Eurell, Kirsten Meid, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Christopher Patterson, Zachary Hunter, Steven Treon, Shayna Sarosiek
Journal: Blood
Blood (2025) 146 (Supplement 1): 225.
https://doi.org/10.1182/blood-2025-225
Published: 2025
Journal Articles

Double-hit alterations of TP53 identify ultra high-risk disease in previously treated, MYD88 mutated waldenstrom macroglobulinemia.

Free
Nickolas Tsakmaklis, Alberto Guijosa, Andres Ramirez, Amanda Kofides, Abigail Peachey, Xia Liu, Hao Sun, Maria Luisa Guerrera, Christopher Patterson, Andrew Branagan, Shayna Sarosiek, Jorge Castillo, Zachary Hunter, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 224.
https://doi.org/10.1182/blood-2025-224
Published: 2025
Journal Articles

Deep responses following treatment with loncastuximab tesirine (WM-NET1 trial) in patients with Relapsed/Refractory including those withhigh-risk, TP53-altered Waldenström macroglobulinemia.

Free
Shayna Sarosiek, Mary Kwok, Prashant Kapoor, Hannah Chory, Nina Budano, Julia Nguyen, Alexandra Eurell, Kirsten Meid, Alberto Guijosa, Nickolas Tsakmaklis, Zachary Hunter, Andrew Branagan, Steven Treon, Jorge Castillo
Journal: Blood
Blood (2025) 146 (Supplement 1): 581.
https://doi.org/10.1182/blood-2025-581
Published: 2025
Journal Articles

Novel mechanistic insights for IRAK1 and IRAK4 signaling provide a framework for the development of dual IRAK1 and IRAK4 protacs for MYD88 mutated lymphomas.

Free
Xia Liu, Shirong Liu, Amanda Kofides, Dominic Pizzarella, Jinhua Wang, Sara Buhrlage, Nickolas Tsakmaklis, Abigail Peachey, Alberto Guijosa, Hao Sun, Maria Luisa Guerrera, Christopher Patterson, Shayna Sarosiek, Jorge Castillo, Zachary Hunter, John Hatcher, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5324.
https://doi.org/10.1182/blood-2025-5324
Published: 2025
Journal Articles

Venetoclax or pirtobrutinib in relapsed/refractory Waldenström macroglobulinemia: Clinical and molecular predictors and sequencing implications

Free
Alberto Guijosa, Nickolas Tsakmaklis, Margaret Kobs, Nina Budano, Julia Nguyen, Alexandra Eurell, Maria Luisa Guerrera, Gottfried von Keudell, Andrew Branagan, Zachary Hunter, Steven Treon, Shayna Sarosiek, Jorge Castillo
Journal: Blood
Blood (2025) 146 (Supplement 1): 3577.
https://doi.org/10.1182/blood-2025-3577
Published: 2025
Journal Articles

Discovery of an undocumented pattern of intron retention that is abundant in healthy B-cells and circumvented in Waldenstrom's macroglobulinemia impacting genes driving cellular growth and survival

Free
Zachary Hunter, Amanda Kofides, Abigail Peachey, Nickolas Tsakmaklis, Maria Luisa Guerrera, Xia Liu, Shirong Liu, Hao Sun, Alberto Guijosa, John Hatcher, Dominic Pizzarella, Christopher Patterson, Andrew Branagan, Shayna Sarosiek, Jorge Castillo, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 3544.
https://doi.org/10.1182/blood-2025-3544
Published: 2025
Journal Articles

Regulatory network analysis identifies changes in ahr, TFAP4, and AP-1 transcription factors as top drivers of symptomatic disease progression in Waldenstrom's macroglobulinemia.

Free
Zachary Hunter, Derrick DeConti, Brian Lawney, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Hao Sun, Dominic Pizzarella, Abigail Peachey, Alberto Guijosa, John Hatcher, Kirsten Meid, Christopher Patterson, Torsten Steinbrunn, Constantine Mitsiades, John Quackenbush, Andrew Branagan, Shayna Sarosiek, Jorge Castillo, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 3543.
https://doi.org/10.1182/blood-2025-3543
Published: 2025
Journal Articles

Mass spectrometry demonstrates very frequent multi-clonality in familial Waldenström macroglobulinemia and shows distinct IgM profiles across IgM-related disorders.

Free
Alberto Guijosa, Nickolas Tsakmaklis, Abigail Peachey, Nicholas Paciaroni, Nina Budano, Julia Nguyen, Kirsten Meid, Maria Luisa Guerrera, Christopher Patterson, Andrew Branagan, Shayna Sarosiek, Zachary Hunter, Jorge Castillo, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5392.
https://doi.org/10.1182/blood-2025-5392
Published: 2025
Journal Articles

Final report of a phase II study of ibrutinib and venetoclax in previously untreated Waldenström macroglobulinemia

Free
Jorge Castillo, Andrew Branagan, Gottfried von Keudell, Alberto Guijosa, Nina Budano, Julia Nguyen, Alexandra Eurell, Kirsten Meid, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Nickolas Tsakmaklis, Zachary Hunter, Steven Treon, Shayna Sarosiek
Journal: Blood
Blood (2025) 146 (Supplement 1): 1794.
https://doi.org/10.1182/blood-2025-1794
Published: 2025
Journal Articles

LOX1 expression identifies a population of polymorphonuclear myeloid-derived suppressor cells that are highly enriched in bone marrow samples of treatment-Naïve and BTKi-Relapsed/Refractory WM patients and show constitutive activation of BTK

Free
Maria Luisa Guerrera, Abigail Peachey, Xia Liu, Dominic Pizzarella, Amanda Kofides, Nickolas Tsakmaklis, Hao Sun, Shirong Liu, Alberto Guijosa, John Hatcher, Christopher Patterson, Nina Budano, Julia Nguyen, Kirsten Meid, Andrew Branagan, Jorge Castillo, Shayna Sarosiek, Samir Parekh, Zachary Hunter, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5731.
https://doi.org/10.1182/blood-2025-5731
Published: 2025
Journal Articles

Zanubrutinib and pirtobrutinib (ZAP) but not ibrutinib and pirtobrutinib (IAP) show synergistic tumor cell killing and suppression of BTK and downstream signaling in MYD88 mutated lymphoma cells.

Free
Dominic Pizzarella, Amanda Kofides, Xia Liu, John Hatcher, Alberto Guijosa, Nickolas Tsakmaklis, Abigail Peachey, Jinhua Wang, Maria Luisa Guerrera, Christopher Patterson, Zachary Hunter, Hao Sun, Shayna Sarosiek, Jorge Castillo, Sara Buhrlage, Sirano Dhe-Paganon, Steven Treon, Shirong Liu
Journal: Blood
Blood (2025) 146 (Supplement 1): 7453.
https://doi.org/10.1182/blood-2025-7453
Published: 2025
Journal Articles

CD20 (MS4A1) mutations are strongly associated with prior chemoimmunotherapy exposure in Waldenström macroglobulinemia and have predicted functional consequences for the development of CD20-directed cellular therapies.

Free
Alberto Guijosa, Nickolas Tsakmaklis, Sirano Dhe-Paganon, John Hatcher, Andres Ramirez, Dominic Pizzarella, Amanda Kofides, Abigail Peachey, Shirong Liu, Hao Sun, Xia Liu, Maria Luisa Guerrera, Andrew Branagan, Gottfried von Keudell, Shayna Sarosiek, Jorge Castillo, Zachary Hunter, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 3611.
https://doi.org/10.1182/blood-2025-3611
Published: 2025
Journal Articles

Diverse signaling and vulnerabilities accompany distinct BTK mutations associated with clinical resistance to COVALENT, non-COVALENT and protacs targeting BTK in MYD88 mutated lymphomas.

Free
Shirong Liu, Xia Liu, Amanda Kofides, John Hatcher, Nickolas Tsakmaklis, Abigail Peachey, Dominic Pizzarella, Alberto Guijosa, Jinhua Wang, Maria Luisa Guerrera, Christopher Patterson, Zachary Hunter, Shayna Sarosiek, Jorge Castillo, Sara Buhrlage, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 2171.
https://doi.org/10.1182/blood-2025-2171
Published: 2025
Journal Articles

Development of novel MZB1-directed HLA-dependent CAR T cell and CAR enhancer therapy in MM and other B-cell malignancies

Free
Elena Maroto Martin, Marina He, Radia Khan, Taha Rakhshandehroo, Jian Cui, Yingjie Zhao, Victoria Rivet, Jessica Encinas Mayoral, Sara Kolhatkar, Roberto García-Vicente, María Linares, Mubin Tarannum, Zachary Hunter, Steven Treon, Kenneth Anderson, Rizwan Romee, Mehmet Samur, Mariateresa Fulciniti, Mohammad Rashidian, Jianzhu Chen, Nikhil Munshi
Journal: Blood
Blood (2025) 146 (Supplement 1): 2332.
https://doi.org/10.1182/blood-2025-2332
Published: 2025
Journal Articles

IgM-MM is predominantly a pre–germinal center disorder and has a distinct genomic and transcriptomic signature from WM

Free
CME Brief Report
Abdul Hamid Bazarbachi, Hervé Avet-Loiseau, Raphael Szalat, Anil Aktas Samur, Zachary Hunter, Masood Shammas, Jill Corre, Mariateresa Fulciniti, Kenneth C. Anderson, Giovanni Parmigiani, Steven P. Treon, Mohamad Mohty, Nikhil C. Munshi, Mehmet Kemal Samur
Journal: Blood
Blood (2021) 138 (20): 1980–1985.
https://doi.org/10.1182/blood.2021011452
Published: 2021
Includes: Supplemental data
Journal Articles

Abnormal Splicing Patterns and Novel Intron Retentions Affect Genes Regulating Splicing, NF-Kb, ERK1/2, and TP53 in Waldenstrom's Macroglobulinemia

Free
Zachary Hunter, PhD, Nickolas Tsakmaklis, BA, Lian Xu, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Gloria Chan, MS, Manit Munshi, MS, Xia Liu, MD, Joshua Gustine, Kirsten Meid, MPH, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD, Guang Yang, PhD, Nikhil Munshi, MD, Kenneth C Anderson, MD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 3812.
https://doi.org/10.1182/blood.V130.Suppl_1.3812.3812
Published: 2017
Journal Articles

Aberrant HCK Survival Signaling By Mutated MYD88 Requires PAX5 in Waldenstrom's Macroglobulinemia and ABC DLBCL Cells

Free
Xia Liu, MD, Jiaji Chen, BS, Manit Munshi, MS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1199.
https://doi.org/10.1182/blood.V130.Suppl_1.1199.1199
Published: 2017
Journal Articles

Dysregulation of MYD88 Regulatory Isoforms in Waldenstrom's Macroglobulinemia

Free
Amanda Kofides, BS, Maria Demos, BS, Nickolas Tsakmaklis, BA, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Jiaji Chen, BS, Christopher Patterson, MAcc, Maria Luisa Guerrera, MD, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4967.
https://doi.org/10.1182/blood.V130.Suppl_1.4967.4967
Published: 2017
Journal Articles

TP53 mutations Are Associated with Mutated MYD88 and CXCR4, and Confer an Adverse Outcome in Waldenström Macroglobulinemia

Free
Joshua Gustine, Kirsten Meid, MPH, Patricia Severns, NP, Toni Dubeau, NP, Nickolas Tsakmaklis, BA, Christopher Patterson, MAcc, Guang Yang, PhD, Xia Liu, MD, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Manit Munshi, MS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Jorge J. Castillo, MD, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Lian Xu
Journal: Blood
Blood (2017) 130 (Supplement 1): 5140.
https://doi.org/10.1182/blood.V130.Suppl_1.5140.5140
Published: 2017
Journal Articles

MYD88 Mutation Status Impacts Overall Survival and Risk of Histological Transformation in Waldenstrom's Macroglobulinemia

Free
Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD, Joshua Gustine, Kirsten Meid, MPH, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Robert Manning, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Jiaji Chen, BS, Gloria Chan, MS, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4006.
https://doi.org/10.1182/blood.V130.Suppl_1.4006.4006
Published: 2017