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Torsten Steinbrunn
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Journal Articles

Functional Genomics Studies Decipher the Genetic Perturbations and Unravel Mechanisms of Response/Resistance upon Mutant-Specific KRAS Inhibition in Multiple Myeloma

Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Phaik Ju Teoh, Lisa Leypoldt, Brian Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2024) 144 (Supplement 1): 3286.
https://doi.org/10.1182/blood-2024-211598
Published: 2024
Journal Articles

Integrated Molecular Landscape of Lesions in Cereblon and Its Pathway in Myeloma Patients: Insights into Mechanisms of Relapse from IMiD-Based Treatments

Lisa B Leypoldt, Torsten Steinbrunn, Phaik Ju Teoh, Ricardo De Matos Simoes, Ryosuke Shirasaki, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 3321.
https://doi.org/10.1182/blood-2023-180033
Published: 2023
Journal Articles

Platelet Subpopulations and Distinct Platelet Function Defects after Hematopoietic Stem Cell Transplantation in Mice and Humans

Kristina Mott, Lukas Johannes Weiss, Margret Droste, Maria Drayss, Sabrina Kraus, Torsten Steinbrunn, Harald Schulze
Journal: Blood
Blood (2023) 142 (Supplement 1): 348.
https://doi.org/10.1182/blood-2023-180641
Published: 2023
Journal Articles

Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance

Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Rin Mizuno, Takeru Sugihara, Phaik Ju Teoh, Lisa B Leypoldt, Mariko Kaji, Jeffrey Sorrell, Brian J Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 4186.
https://doi.org/10.1182/blood-2023-182476
Published: 2023
Journal Articles

Functional Characterization of Genes Residing in Chromosomal Regions with “High-Risk” Lesions in Multiple Myeloma

Phaik Ju Teoh, Ricardo De Matos Simoes, Tae-Hoon Chung, Torsten Steinbrunn, Lisa B Leypoldt, Olga Dashevsky, Francisca Vazquez, Wee-Joo Chng, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 3293.
https://doi.org/10.1182/blood-2023-190050
Published: 2023
Journal Articles

Immune Checkpoint CD200/CD200R Decreases T Cell-Mediated Cytotoxicity Via Dok2 and Is Regulated By P53 in Multiple Myeloma

Pooja Shah, Thorsten Stuehmer, Larissa Haertle, Daniela Bruennert, Umair Munawar, Ellen Leich, Sabrina Kraus, Michael Hudecek, Manik Chatterjee, Andreas Schlosser, Martin Kortuem, Ralf C Bargou, Hermann Einsele, Friederike Berberich-Siebelt, Torsten Steinbrunn
Journal: Blood
Blood (2022) 140 (Supplement 1): 7076–7077.
https://doi.org/10.1182/blood-2022-166283
Published: 2022
Journal Articles

CD200 Expression on Multiple Myeloma Cells Induces Attenuation of T Cell-Mediated Cytotoxicity Via DOK2

Pooja Shah, Thorsten Stuehmer, Daniela Bruennert, Umair Munawar, Ellen Leich, Sabrina Kraus, Michael Hudecek, Manik Chatterjee, Andreas Schlosser, Ralf C Bargou, Hermann Einsele, Friederike Berberich-Siebelt, Torsten Steinbrunn
Journal: Blood
Blood (2021) 138 (Supplement 1): 1587.
https://doi.org/10.1182/blood-2021-153741
Published: 2021
Journal Articles

Adhesion-Mediated Multiple Myeloma (MM) Disease Progression: Junctional Adhesion Molecule a Enhances Angiogenesis and Multiple Myeloma Dissemination and Predicts Poor Survival

Antonio Giovanni Solimando, MD, Matteo Claudio Da Via', MD, Patrizia Leone, Giorgio Croci, Paola Borrelli, Paula Tabares Gaviria, Andreas Brandl, PhD, Giuseppe Di Lernia, Francesco Paolo Bianchi, Silvio Tafuri, Umair Munawar, MSc, Torsten Steinbrunn, Alessandra Balduini, MD, Assunta Melaccio, Hilka Rauert-Wunderlich, Katharina Schmiedgen, Hannah Manz, Paolo Ditonno, Roberto Ria, MD, Erik Henke, Carolina Terragna, Wolfram Klapper, Nora Trinks, Ulrich Terpitz, Giacomo Corleone, Leo Rasche, MD, Andreas Rosenwald, MD, Martin Kortuem, Michele Cavo, Domenico Ribatti, MD, Vito Racanelli, Hermann Einsele, MD, Angelo Vacca, MD PhD, Andreas Beilhack, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 855.
https://doi.org/10.1182/blood-2019-126674
Published: 2019
Journal Articles

Activated Ral and Mutated RAS Are Independent Drivers of Multiple Myeloma Cell Survival.

Marcel Seibold, Thorsten Stuehmer, Anja Mottok, Claus J Scholz, Manik Chatterjee, Ellen Leich, Martin Kortüm, Andreas Schlosser, Hermann Einsele, Andreas Rosenwald, Ralf C Bargou, Torsten Steinbrunn
Journal: Blood
Blood (2018) 132 (Supplement 1): 3217.
https://doi.org/10.1182/blood-2018-99-119804
Published: 2018
Journal Articles

Focusing PI and IMiD Resistance in Multiple Myeloma: Impact of DNA Methylation

Larissa Haertle, PhD, Max Bittrich, MD, Ramya Potabattula, PhD, Matteo Claudio Da Via', MD, Umair Munawar, MS, BS, Yanira Ruiz-Heredia, Cornelia Vogt, Torsten Steinbrunn, Andoni Garitano-Trojaola, PhD, Thorsten Stuehmer, Joaquin Martinez Lopez, MD PhD, Hermann Einsele, MD, Thomas Haaf, MD PhD, K. Martin Kortüm, MD, Santiago Barrio Garcia, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 404.
https://doi.org/10.1182/blood-2018-99-118944
Published: 2018
Journal Articles

RAL Mediates Multiple Myeloma Cell Survival Independently of Oncogenic RAS

Marcel Seibold, Thorsten Stuehmer, Nadine Kremer, Anja Mottok, MD PhD, Claus J Scholz, Daniela Bruennert, Manik Chatterjee, Ellen Leich, Andreas Schlosser, Andreas Rosenwald, Hermann Einsele, Ralf C Bargou, Torsten Steinbrunn
Journal: Blood
Blood (2017) 130 (Supplement 1): 4406.
https://doi.org/10.1182/blood.V130.Suppl_1.4406.4406
Published: 2017
Journal Articles

Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival

Torsten Steinbrunn, Thorsten Stühmer, Stefan Gattenlöhner, Andreas Rosenwald, Anja Mottok, Christian Unzicker, Hermann Einsele, Manik Chatterjee, Ralf C. Bargou
Journal: Blood
Blood (2011) 117 (6): 1998–2004.
https://doi.org/10.1182/blood-2010-05-284422
Published: 2011
Includes: Supplemental data
Journal Articles

Analysis of PKB/Akt-Signaling and Oncogenic Ras in Multiple Myeloma.

Torsten Steinbrunn, Thorsten Stühmer, Manik Chatterjee, Stefan Gattenlöhner, Ralf C Bargou
Journal: Blood
Blood (2009) 114 (22): 831.
https://doi.org/10.1182/blood.V114.22.831.831
Published: 2009
Journal Articles

Effects of Integrin-Linked Kinase (ILK) Inhibitor QLT0267 on Multiple Myeloma Cells and Evaluation of ILK as a Therapeutic Target in Multiple Myeloma.

Thorsten Stühmer, PhD, Torsten Steinbrunn, MD, Evelyn Grella, Ralf C. Bargou, MD PhD
Journal: Blood
Blood (2007) 110 (11): 3529.
https://doi.org/10.1182/blood.V110.11.3529.3529
Published: 2007