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Huihui Tang
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Journal Articles

Functional Genomics Studies Decipher the Genetic Perturbations and Unravel Mechanisms of Response/Resistance upon Mutant-Specific KRAS Inhibition in Multiple Myeloma

Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Phaik Ju Teoh, Lisa Leypoldt, Brian Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2024) 144 (Supplement 1): 3286.
https://doi.org/10.1182/blood-2024-211598
Published: 2024
Journal Articles

Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance

Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Rin Mizuno, Takeru Sugihara, Phaik Ju Teoh, Lisa B Leypoldt, Mariko Kaji, Jeffrey Sorrell, Brian J Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 4186.
https://doi.org/10.1182/blood-2023-182476
Published: 2023
Journal Articles

Functional Oncogenomic and Immune Response Landscape for Genes Recurrently Mutated in Myeloma

Ricardo De Matos Simoes, Benjamin G Barwick, Ryosuke Shirasaki, Olga Dashevsky, Sara Gandolfi, Huihui Tang, Brian Glassner, Richard W.J. Groen, Daniel Auclair, Aedin Culhane, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 1589.
https://doi.org/10.1182/blood-2021-154359
Published: 2021
Journal Articles

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Shizuka Yamano, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Huihui Tang, PhD, Vikas Gupta, MD PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-143117
Published: 2020
Journal Articles

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Huihui Tang, PhD, Shizuka Yamano, Benjamin G Barwick, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Sondra L. Downey-Kopyscinski, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Dhvanir Kansara, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Vikas Gupta, MD PhD, Aedin Culhane, PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-142580
Published: 2020
Journal Articles

Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms

Olga Dashevsky, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Sara Gandolfi, MD, Huihui Tang, PhD, Sondra L. Downey-Kopyscinski, PhD, Megan Bariteau, B.Sc., Jeffrey Sorrell, BA, Brian Glassner, PhD, John Doench, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36.
https://doi.org/10.1182/blood-2020-142651
Published: 2020
Journal Articles

Functional Characterization of Genes Driving Enhanced Biological Aggressiveness of Myeloma Cells: Identification of Novel and Understudied "Drivers" of Myeloma

Huihui Tang, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Sara Gandolfi, MD, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 313.
https://doi.org/10.1182/blood-2019-128919
Published: 2019
Journal Articles

Functional Interactions between Transcription Factors Involved in Myeloma Pathogenesis - Biological and Therapeutic Implications

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Huihui Tang, PhD, Brian Glassner, PhD, Olga Dashevsky, PhD, Minasri Borah, Megan Bariteau, B.Sc., Richard Groen, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 315.
https://doi.org/10.1182/blood-2019-127502
Published: 2019
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3197.
https://doi.org/10.1182/blood-2018-99-118712
Published: 2018
Journal Articles

CRISPR Activation Screen for HDAC Inhibitor Resistance

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3958.
https://doi.org/10.1182/blood-2018-99-119044
Published: 2018
Journal Articles

Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Megan Bariteau, BSc, Jonathan D. Licht, MD, Brian Glassner, PhD, Richard WJ Groen, PhD, Joan Levy, PhD, Daniel Auclair, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 189.
https://doi.org/10.1182/blood-2018-189
Published: 2018
Journal Articles

Systematic Characterization of the "Resistome" of Tumor Cells Against Panels of Small Molecule Inhibitors — Application in the Context of Inhibitors of Transcriptional Cyclin-Dependent Kinases (tCDKs) and Implications for Future "Individualized" Clinical Applications

Ryosuke Shirasaki, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Tinghu Zhang, PhD, Megan Bariteau, Jeffrey Sorrell, BA, Nicholas P Kwiatkowski, PhD, Nathanael Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3343.
https://doi.org/10.1182/blood.V130.Suppl_1.3343.3343
Published: 2017
Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Paul Hengeveld, Johanna Bruggenthies, Eugen Dhimolea, PhD, Huihui Tang, PhD, Megan Bariteau, Andrew Aguirre, MD PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Brian Glassner, PhD, Christopher J. Ott, PhD, Dennis Buckley, Nicholas P Kwiatkowski, PhD, Jonathan D. Licht, MD, Nathanael Gray, PhD, Joshua Dempster, PhD, Richard WJ Groen, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1212.
https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212
Published: 2017
Journal Articles

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Geoffrey M. Matthews, PhD, Ricardo De Matos Simoes, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Paul J. Hengeveld, B.Sc., Megan A. Bariteau, BSc, Brian Glassner, PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Sara Gandolfi, MD, Pallavi Awate, MSc, Huihui Tang, PhD, Franciska Vazquez, PhD, Aedin Culhane, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 119.
https://doi.org/10.1182/blood.V128.22.119.119
Published: 2016