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Journal Articles

Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-Atpase ( PSMC ) Gene Family Transmit Proteasome Inhibitor Resistance in Multiple Myeloma By Impacting the ADP/ATP Binding Pocket

Larissa Haertle, Hipolito Nicolas Cuesta Hernandez, Natalia Sofia Buenache, Michal Simicek, Renata Snaurova, Inmaculada Rapado, Nerea Martinez, Nieves López-Muñoz, Jose Maria Sanchez-Pina, Rafael Colmenares, Margarita Sanchez-Beato, Miguel Angel Piris, Ivan Plaza Menacho, Mehmet Kemal Samur, Nikhil C Munshi, Rosa Ayala, K. Martin Kortuem, Santiago Barrio, Joaquin Martinez-Lopez
Journal: Blood
Blood (2022) 140 (Supplement 1): 4318–4319.
https://doi.org/10.1182/blood-2022-158763
Published: 2022
Journal Articles

Impact of ABCB1 Promoter Methylation on PI-Resistance in Multiple Myeloma

Seungbin Han, Larissa Haertle, Lenka Besse, Chien-Yun Lee, Xiang Zhou, Umair Munawar, Andrej Besse, Miriam Kull, Max Bittrich, Max Johannes Steinhardt, Julia Mersi, Eva Teufel, Silvia Nerreter, Cornelia Vogt, Sophia Danhof, Jan Krönke, Niels Weinhold, Marc S Raab, Thomas Haaf, Christoph Driessen, Hermann Einsele, Leo Rasche, Bernhard Küster, Martin Kortuem
Journal: Blood
Blood (2022) 140 (Supplement 1): 12462–12463.
https://doi.org/10.1182/blood-2022-168694
Published: 2022
Journal Articles

The T-Cell Metabolic Phenotype Is Dependent on Risk Status and Degree of PC Bone Marrow Infiltration in Multiple Myeloma

Mara John, Moutaz Helal, Lars Grundheber, Greta Mattavelli, Nazia Afrin, Xiang Zhou, Benedict Engel, Werner Schmitz, Emilia Stanojkovska, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Julia Mersi, Hermann Einsele, K. Martin Kortuem, Angela Riedel, Leo Rasche
Journal: Blood
Blood (2022) 140 (Supplement 1): 9959–9960.
https://doi.org/10.1182/blood-2022-168608
Published: 2022
Journal Articles

Immune Checkpoint CD200/CD200R Decreases T Cell-Mediated Cytotoxicity Via Dok2 and Is Regulated By P53 in Multiple Myeloma

Pooja Shah, Thorsten Stuehmer, Larissa Haertle, Daniela Bruennert, Umair Munawar, Ellen Leich, Sabrina Kraus, Michael Hudecek, Manik Chatterjee, Andreas Schlosser, Martin Kortuem, Ralf C Bargou, Hermann Einsele, Friederike Berberich-Siebelt, Torsten Steinbrunn
Journal: Blood
Blood (2022) 140 (Supplement 1): 7076–7077.
https://doi.org/10.1182/blood-2022-166283
Published: 2022
Journal Articles

Spatial Transcriptomics Reveals a Multi Cellular Ecosystem in Extramedullary Multiple Myeloma

Moutaz Helal, Mara John, Emilia Stanojkovska, Greta Mattavelli, Lars Grundheber, Alexander Leipold, Nazia Afrin, Christine Riedhammer, Johannes Duell, Max Johannes Steinhardt, Julia Mersi, Hermann Einsele, Kai Kretzschmar, K. Martin Kortuem, Angela Riedel, Leo Rasche
Journal: Blood
Blood (2022) 140 (Supplement 1): 7060–7061.
https://doi.org/10.1182/blood-2022-168700
Published: 2022
Journal Articles

Single-Agent Belantamab Mafodotin in Patients with Relapsed or Refractory Multiple Myeloma: Final Analysis of the DREAMM-2 Trial

Ajay K. Nooka, Adam Cohen, Hans C. Lee, Ashraf Z. Badros, Attaya Suvannasankha, Natalie Callander, Al-Ola Abdallah, Suzanne Trudel, Ajai Chari, Edward Libby, Maria Chaudhry, Malin Hultcrantz, Martin Kortuem, Paul G. Richardson, Rakesh Popat, Douglas W. Sborov, Shawn Hakim, Eric Lewis, Bharat Bhushan, Boris Gorsh, Ira Gupta, Joanna Opalinska, Sagar Lonial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7301–7303.
https://doi.org/10.1182/blood-2022-164877
Published: 2022
Journal Articles

Real-World Treatment Patterns of Patients Initiating Third-Line Therapy in Relapsed or Refractory Multiple Myeloma in Europe

Moritz Lehne, K. Martin Kortuem, Elena Zamagni, Tim d'Estrube, Soham Shukla, Evi Zhuleku, Marco Ghiani, Maya Hanna, Ulf Maywald, Thomas Wilke, Sue Perera
Journal: Blood
Blood (2022) 140 (Supplement 1): 12485–12486.
https://doi.org/10.1182/blood-2022-163586
Published: 2022
Journal Articles

Multiomic Analysis of CD38 Expression Levels in 209 Untreated and Daratumumab-Resistant Patients

Max Johannes Steinhardt, Patrick Eiring, Umair Munawar, Larissa Haertle, Seungbin Han, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Julia Mersi, Max Bittrich, Sophia Danhof, Marietta Truger, Thomas Haaf, Santiago Barrio, Xiang Zhou, Joaquín Martínez-López, Claudia Haferlach, Michael Hudecek, Hermann Einsele, Leo Rasche, Markus Sauer, K. Martin Kortuem
Journal: Blood
Blood (2022) 140 (Supplement 1): 4230–4231.
https://doi.org/10.1182/blood-2022-169255
Published: 2022
Journal Articles

Impaired Death Receptor Signaling Mediates Cross-Resistance to Immunotherapy in MM

Umair Munawar, Xiang Zhou, Sabrina Prommersberger, Max Johannes Steinhardt, Julia Mersi, Max Bittrich, Silvia Nerreter, Cornelia Vogt, Eva Teufel, Seungbin Han, Larissa Haertle, Patrick Eiring, Nicole Banholzer, Sophia Danhof, Adrián Fernández-Martín, Marietta Truger, Santiago Barrio, Miguel Gallardo, Antonio Valeri, Eva Castellano, Peter Raab, Claudia Haferlach, Markus Sauer, Michael Hudecek, Joaquin Martinez-Lopez, Hermann Einsele, Leo Rasche, Martin Kortuem
Journal: Blood
Blood (2022) 140 (Supplement 1): 4226–4227.
https://doi.org/10.1182/blood-2022-168702
Published: 2022
Journal Articles

Single-Cell Multi-Omics Reveal Longitudinal Dynamics of Clonal Architecture and Microenvironment Interactions in Relapsed-Refractory Myeloma

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Lander, Lukas John, Stephan M Tirier, Katharina Bauer, Anja Baumann, Umair Munawar, Leo Rasche, Martin Kortuem, Nicola Giesen, Stefanie Huhn, Carsten Mueller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2022) 140 (Supplement 1): 9987–9988.
https://doi.org/10.1182/blood-2022-166105
Published: 2022
Journal Articles

Advanced Risk Stratification in Multiple Myeloma Beyond Traditional FISH: The First Prospective Real-World Evidence for SKY92 Gene Expression Profiling

Xiang Zhou, Annika Hofmann, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Marietta Truger, Benedict Engel, Anastasia Barcic, Jessica Peter, Christine Riedhammer, Max Johannes Steinhardt, Xianghui Xiao, Hannah Hornburger, Seungbin Han, Larissa Haertle, Umair Munawar, Julia Mersi, Claudia Haferlach, Hermann Einsele, Leo Rasche, K. Martin Kortuem
Journal: Blood
Blood (2022) 140 (Supplement 1): 4273–4274.
https://doi.org/10.1182/blood-2022-163848
Published: 2022
Journal Articles

Pseudoprogression and Sarcoidosis-like Phenomena after CART-Cells and Bispecific Antibodies in Multiple Myeloma

Alexander Leipold, Rudolf Werner, Johannes Duell, Pius Jung, Mara John, Emilia Stanojkovska, Xiang Zhou, Anna Ruckdeschel, Oliver Dietrich, Fabian Imdahl, Tobias Krammer, Andreas Buck, Julia Mersi, Hermann Einsele, K. Martin Kortuem, Antoine-Emmanuel Saliba, Leo Rasche
Journal: Blood
Blood (2022) 140 (Supplement 1): 10020–10021.
https://doi.org/10.1182/blood-2022-168836
Published: 2022
Journal Articles

Phase 1b Results for Subcutaneous Talquetamab Plus Daratumumab in Patients with Relapsed/Refractory Multiple Myeloma

Ajai Chari, Parameswaran Hari, Nizar J. Bahlis, Maria-Victoria Mateos, Niels W.C.J. van de Donk, Bhagirathbhai Dholaria, Alfred L. Garfall, Hartmut Goldschmidt, K. Martin Kortuem, Amrita Y. Krishnan, Thomas Martin, Daniel Morillo Giles, Albert Oriol, Donna E. Reece, Cesar Rodriguez, Paula Rodriguez-Otero, Jesús F. San-Miguel, Saad Z. Usmani, Raluca I. Verona, Shun Xin Wang Lin, Thomas J. Prior, Mark Wade, Brendan M. Weiss, Jenna D. Goldberg, Elham Askari
Journal: Blood
Blood (2021) 138 (Supplement 1): 161.
https://doi.org/10.1182/blood-2021-148813
Published: 2021
Journal Articles

High-Dose Carfilzomib Recaptures Response in Relapsed/Refractory Multiple Myeloma Resistant to Low-Dose Carfilzomib By Co-Inhibiting β2 Subunit of Proteasome Complex: The First in Human Evidence

Xiang Zhou, Andrej Besse, Jessica Peter, Max Mendez Lopez, Larissa Haertle, Umair Munawar, Seungbin Han, Elmer Maurits, Herman S. Overkleeft, Hermann Einsele, Christoph Driessen, Martin Kortuem, Lenka Besse, Leo Rasche
Journal: Blood
Blood (2021) 138 (Supplement 1): 818.
https://doi.org/10.1182/blood-2021-147170
Published: 2021
Journal Articles

Is PFS the Right Endpoint to Assess Outcome of Maintenance Studies in Multiple Myeloma? Results of a Patient Survey Highlight Quality-of-Life As an Equally Important Outcome Measure

Anna Fleischer, Larissa Heimeshoff, Johannes Allgaier, Karin Jordan, Götz Gelbrich, Rüdiger Pryss, Johannes Schobel, Hermann Einsele, Martin Kortuem, Imad Maatouk, Niels Weinhold, Leo Rasche
Journal: Blood
Blood (2021) 138 (Supplement 1): 836.
https://doi.org/10.1182/blood-2021-152648
Published: 2021
Journal Articles

FISH and WGS in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma - WGS Will Affect Future Treatment Decisions

Marietta Truger, Stephan Hutter, Manja Meggendorfer, K. Martin Kortuem, Niroshan Nadarajah, Wencke Walter, Constance Baer, Leo Rasche, Wolfgang Kern, Torsten Haferlach, Hermann Einsele, Claudia Haferlach
Journal: Blood
Blood (2021) 138 (Supplement 1): 397.
https://doi.org/10.1182/blood-2021-152412
Published: 2021
Journal Articles

Real-World Experience with Minimal Residual Disease Testing with Next Generation Flow Cytometry and Functional Imaging in Multiple Myeloma

David Böckle, MD, Paula Tabares Gaviria, Xiang Zhou, MD, Janin Messerschmidt, MD, Lukas Scheller, Maximilian Johannes Steinhardt, MD, Elena Seebacher, Maria Ulbrich, Anke Heidemeier, MD, Andreas Buck, MD, Hermann Einsele, MD, Andreas Beilhack, MD, Martin Kortuem, MD, Leo Rasche, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-140772
Published: 2020
Journal Articles

Adhesion-Mediated Multiple Myeloma (MM) Disease Progression: Junctional Adhesion Molecule a Enhances Angiogenesis and Multiple Myeloma Dissemination and Predicts Poor Survival

Antonio Giovanni Solimando, MD, Matteo Claudio Da Via', MD, Patrizia Leone, Giorgio Croci, Paola Borrelli, Paula Tabares Gaviria, Andreas Brandl, PhD, Giuseppe Di Lernia, Francesco Paolo Bianchi, Silvio Tafuri, Umair Munawar, MSc, Torsten Steinbrunn, Alessandra Balduini, MD, Assunta Melaccio, Hilka Rauert-Wunderlich, Katharina Schmiedgen, Hannah Manz, Paolo Ditonno, Roberto Ria, MD, Erik Henke, Carolina Terragna, Wolfram Klapper, Nora Trinks, Ulrich Terpitz, Giacomo Corleone, Leo Rasche, MD, Andreas Rosenwald, MD, Martin Kortuem, Michele Cavo, Domenico Ribatti, MD, Vito Racanelli, Hermann Einsele, MD, Angelo Vacca, MD PhD, Andreas Beilhack, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 855.
https://doi.org/10.1182/blood-2019-126674
Published: 2019
Journal Articles

Targeted Sequencing of Relapsed/Refractory Myeloma Patients Identifies an Enrichment of Mutations in Cereblon and MAPK Pathways

Elias Karl Mai, MD, K. Martin Kortuem, MD, Nur Hanafiah, Santiago Barrio, Laura Ann Bruins, Maximilian Merz, MD, Jing Xu, Koenuel Pashayeva, MD, Yuan-Xiao Zhu, Chang-Xin Shi, PhD, R. Alexander Stewart, Patrick Jedlowski, Mindaugas Andrulis, MD, Anna Jauch, Prof., Jens Hillengass, MD, Hartmut Goldschmidt, MD, P. Leif Bergsagel, MD PhD, Esteban Braggio, PhD, A. Keith Stewart, MD, Marc Steffen Raab, MD PhD
Journal: Blood
Blood (2015) 126 (23): 723.
https://doi.org/10.1182/blood.V126.23.723.723
Published: 2015
Journal Articles

Targeted Genomic Mutation Panel (M 3 P) Results from 504 Multiple Myeloma (MM) Patients

K Martin Kortuem, Esteban Braggio, Pieter Sonneveld, MD PhD, Laura Ann Bruins, Santiago Barrio, Davine Hofste op Bruinink, Mark vanDuin, Elias Karl Mai, MD, Nur Hanafiah, Hartmut Goldschmidt, MD, Sanchin Pathangey, Yanira Ruiz Heredia, Inmaculada Rapado, Beatriz Sanchez-Vega, Stefan Knop, Leo Rasche, Christian Langer, Miriam Kull, Lars Bullinger, Monika Engelhardt, Joaquin Martinez-Lopez, Hermann Einsele, Marc S. Raab, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 1795.
https://doi.org/10.1182/blood.V126.23.1795.1795
Published: 2015