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Journal Articles

Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma

Mara John, Moutaz Helal, Johannes Duell, Greta Mattavelli, Emilia Stanojkovska, Nazia Afrin, Alexander M. Leipold, Maximilian J. Steinhardt, Xiang Zhou, David Žihala, Anjana Anilkumar Sithara, Julia Mersi, Johannes M. Waldschmidt, Christine Riedhammer, Sofie-Katrin Kadel, Marietta Truger, Rudolf A. Werner, Claudia Haferlach, Hermann Einsele, Kai Kretzschmar, Tomáš Jelínek, Andreas Rosenwald, K. Martin Kortüm, Angela Riedel, Leo Rasche
Journal: Blood
Blood (2024) 144 (20): 2121–2135.
https://doi.org/10.1182/blood.2024024590
Published: 2024
Includes: Supplemental data
Journal Articles

Implementing Hifi Sequencing for Enhanced Genomic and Methylome Characterization in Multiple Myeloma

Seungbin Han, Nazia Afrin, Bas Tolhuis, Marietta Truger, Peter Raab, Umair Munawar, Cornelia Vogt, Shilpa Kurian, Silvia Nerreter, Xiang Zhou, Claudia Haferlach, Hermann Einsele, Johannes Waldschmidt, Leo Rasche, K. Martin Kortüm
Journal: Blood
Blood (2024) 144 (Supplement 1): 7490.
https://doi.org/10.1182/blood-2024-207422
Published: 2024
Journal Articles

Classic Anti-Myeloma Treatments Alter Circulating Immune Cell Subsets with Potential Implications for T Cell Immunotherapies in Multiple Myeloma

Xiang Zhou, Sarah Wiethe, Angelika Wolff, Max J Steinhardt, Nazia Afrin, Mara John, Christine Riedhammer, Xianghui Xiao, Umair Munawar, Julia Mersi, Seungbin Han, Johannes Waldschmidt, Angela Riedel, Max S. Topp, Johannes Duell, Hermann Einsele, K. Martin Kortüm, Leo Rasche
Journal: Blood
Blood (2024) 144 (Supplement 1): 4705.
https://doi.org/10.1182/blood-2024-203391
Published: 2024
Journal Articles

Sequential antigen loss and branching evolution in lymphoma after CD19- and CD20-targeted T-cell–redirecting therapy

Johannes Duell, Alexander M. Leipold, Silke Appenzeller, Viktoria Fuhr, Hilka Rauert-Wunderlich, Matteo Da Via, Oliver Dietrich, Christophe Toussaint, Fabian Imdahl, Florian Eisele, Nazia Afrin, Lars Grundheber, Hermann Einsele, Niels Weinhold, Andreas Rosenwald, Max S. Topp, Antoine-Emmanuel Saliba, Leo Rasche
Journal: Blood
Blood (2024) 143 (8): 685–696.
https://doi.org/10.1182/blood.2023021672
Published: 2024
Includes: Supplemental data
Journal Articles

The Impact of Treatment-Free Intervals on T-Cell Exhaustion and Clonotypic Diversity in Myeloma Patients Treated with BCMA Bispecific Antibodies

Florian Eisele, Nazia Afrin, Emilia Stanojkovska, Mara John, Moutaz Helal, Lars Grundheber, Philipp Weis, Christine Riedhammer, Sofie-Katrin Kadel, Max Steinhardt, Johannes Duell, Johannes M Waldschmidt, Hermann Einsele, Angela Riedel, K. Martin Kortüm, Leo Rasche
Journal: Blood
Blood (2023) 142 (Supplement 1): 1938.
https://doi.org/10.1182/blood-2023-189042
Published: 2023
Journal Articles

The T-Cell Metabolic Phenotype Is Dependent on Risk Status and Degree of PC Bone Marrow Infiltration in Multiple Myeloma

Mara John, Moutaz Helal, Lars Grundheber, Greta Mattavelli, Nazia Afrin, Xiang Zhou, Benedict Engel, Werner Schmitz, Emilia Stanojkovska, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Julia Mersi, Hermann Einsele, K. Martin Kortuem, Angela Riedel, Leo Rasche
Journal: Blood
Blood (2022) 140 (Supplement 1): 9959–9960.
https://doi.org/10.1182/blood-2022-168608
Published: 2022
Journal Articles

Spatial Transcriptomics Reveals a Multi Cellular Ecosystem in Extramedullary Multiple Myeloma

Moutaz Helal, Mara John, Emilia Stanojkovska, Greta Mattavelli, Lars Grundheber, Alexander Leipold, Nazia Afrin, Christine Riedhammer, Johannes Duell, Max Johannes Steinhardt, Julia Mersi, Hermann Einsele, Kai Kretzschmar, K. Martin Kortuem, Angela Riedel, Leo Rasche
Journal: Blood
Blood (2022) 140 (Supplement 1): 7060–7061.
https://doi.org/10.1182/blood-2022-168700
Published: 2022