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Nicola Giesen
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Journal Articles

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Seufert, Lukas John, Stephan M. Tirier, Katharina Bauer, Anja Baumann, Jennifer Rohleder, Umair Munawar, Leo Rasche, K. Martin Kortüm, Nicola Giesen, Philipp Reichert, Stefanie Huhn, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S. Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2023) 142 (19): 1633–1646.
https://doi.org/10.1182/blood.2023019758
Published: 2023
Includes: Supplemental data
Journal Articles

A phase 2 clinical trial of combined BRAF/MEK inhibition for BRAF V600E -mutated multiple myeloma

Clinical Trials & Observations Brief Report
Nicola Giesen, Manik Chatterjee, Christof Scheid, Alexandra M. Poos, Britta Besemer, Kaya Miah, Axel Benner, Nicole Becker, Thomas Moehler, Ivana Metzler, Cyrus Khandanpour, Andrea Seidel-Glaetzer, Karolin Trautmann-Grill, K. Martin Kortüm, Carsten Müller-Tidow, Gunhild Mechtersheimer, Benjamin Goeppert, Albrecht Stenzinger, Niels Weinhold, Hartmut Goldschmidt, Katja Weisel, Marc S. Raab
Journal: Blood
Blood (2023) 141 (14): 1685–1690.
https://doi.org/10.1182/blood.2022017789
Published: 2023
Includes: Supplemental data
Journal Articles

Single-Cell Multi-Omics Reveal Longitudinal Dynamics of Clonal Architecture and Microenvironment Interactions in Relapsed-Refractory Myeloma

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Lander, Lukas John, Stephan M Tirier, Katharina Bauer, Anja Baumann, Umair Munawar, Leo Rasche, Martin Kortuem, Nicola Giesen, Stefanie Huhn, Carsten Mueller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2022) 140 (Supplement 1): 9987–9988.
https://doi.org/10.1182/blood-2022-166105
Published: 2022
Journal Articles

Prediction of Early Death and Severe Infections during Novel Agent-Based Induction Therapy in Newly-Diagnosed Multiple Myeloma: An Intergroup Analysis from the German Speaking Myeloma Multicenter Group, the Dutch-Belgian Cooperative Trial Group for Hematology Oncology Foundation and the European Myeloma Network

Elias K Mai, Thomas Hielscher, Uta Bertsch, Hans Salwender, Sonja Zweegman, Markus Munder, Lucia Pantani, Peter Brossart, Meral Beksac, Igor Wolfgang Blau, Marc-Steffen Raab, Jan Dürig, Nicola Giesen, Britta Besemer, Roland Fenk, Peter Reimer, Bronno van der Holt, Mathias Haenel, Ivana v. Metzler, Ullrich Graeven, Mario Boccadoro, Christof Scheid, Meletios A. Dimopoulos, Katja Weisel, Michele Cavo, Pieter Sonneveld, Hartmut Goldschmidt
Journal: Blood
Blood (2021) 138 (Supplement 1): 3792.
https://doi.org/10.1182/blood-2021-145289
Published: 2021
Journal Articles

Impact of Novel Therapies on CD4-T-Cell-Numbers and Infectious Complications in Patients with Relapsed/Refractory Multiple Myeloma

Lukas John, Kaya Miah, Axel Benner, Elias K Mai, MD, Katharina Kriegsmann, MD, Michael Hundemer, MD, Carsten Mueller-Tidow, MD, Karin Jordan, MD, Hartmut Goldschmidt, MD, Marc S. Raab, MD, Nicola Giesen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-136686
Published: 2020
Journal Articles

Comprehensive Comparison of Early Relapse and End-Stage Relapsed Refractory Multiple Myeloma

Alexandra M Poos, PhD, Nicola Giesen, MD, Calogerina Catalano, PhD, Nagarajan Paramasivam, PhD, Daniel Huebschmann, MDPhD, Lukas John, Anja Baumann, Jason Hochhaus, Carsten Mueller-Tidow, MD, Sandra Sauer, MD, Stefanie Huhn, PhD, Matthias Schlesner, PhD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Marc S. Raab, MD, Niels Weinhold, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-141611
Published: 2020
Journal Articles

Safety and Preliminary Efficacy Results from a Phase II Study Evaluating Combined BRAF and MEK Inhibition in Relapsed/Refractory Multiple Myeloma (rrMM) Patients with Activating BRAF V600E Mutations: The GMMG-Birma Trial

Marc S. Raab, MD, Nicola Giesen, MD, Christof Scheid, MD, Britta Besemer, Kaya Miah, Axel Benner, Ivana Metzler, MD, Cyrus Khandanpour, PD, MD, Andrea Seidel-Glaetzer, Karolin Trautmann-Grill, MD, Gunhild Mechtersheimer, Benjamin Goeppert, Albrecht Stenzinger, Hartmut Goldschmidt, MD, Katja Weisel, MD, Manik Chatterjee
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-142600
Published: 2020
Journal Articles

Dissecting Heterogeneity of Tumor Cells and Their Microenvironment in Refractory Multiple Myeloma

Stephan M Tirier, PhD, Jan-Philipp Mallm, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Alexandra M Poos, PhD, Katharina Bauer, Anja Baumann, Lukas John, MD, Jing Xu, PhD, Lara Klett, MSc, Carsten Müller-Tidow, MD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Niels Weinhold, PhD, Oliver Stegle, PhD, Karsten Rippe, PhD, Marc S. Raab, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 571.
https://doi.org/10.1182/blood-2019-128625
Published: 2019
Journal Articles

A Comprehensive Analysis of Single-Cell Chromatin Accessibility and Gene Expression Identifies Intra-Tumor Heterogeneity and Molecular Treatment Responses in Relapsed/Refractory Multiple Myeloma

Alexandra M Poos, PhD, Jan-Philipp Mallm, PhD, Stephan M Tirier, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Katharina Bauer, Anja Baumann, Lukas John, MD, Isabelle Lander, BSc, Jing Xu, PhD, Moritz Przybilla, BSc, Anja Kunze, PhD, Carsten Mueller-Tidow, MD, Benedikt Brors, PhD, Oliver Stegle, PhD, Hartmut Goldschmidt, MD, Karsten Rippe, PhD, Marc S Raab, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 575.
https://doi.org/10.1182/blood-2019-130051
Published: 2019
Journal Articles

Biallelic Inactivation of Multiple Tumor Suppressors Is Associated with Early Relapse after Stem Cell Transplant in Newly Diagnosed Myeloma

Niels Weinhold, PhD, Jing Xu, PhD, Martina Fröhlich, PhD, Alexandra M Poos, PhD, Lukas John, MD, Carsten Müller-Tidow, MD, Sandra Sauer, MD, Stefanie Huhn, PhD, Dirk Hose, MD, Anja Seckinger, Kari Hemminki, MD PhD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Nicola Giesen, MD, Marc S Raab, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1783.
https://doi.org/10.1182/blood-2019-131195
Published: 2019
Journal Articles

Mechanisms of Proteasome Inhibitor Resistance Selected By Clonal Evolution in Multiple Myeloma

Larissa Haertle, PhD, Santiago Barrio, PhD, Michal Simicek, PhD, Umair Munawar, MSc, Ricardo Sanchez, PhD MD, Max Bittrich, MD, Matteo DaVia, MD, Cornelia Vogt, MSc, Nicola Giesen, MD, Andoni Garitano-Trojaola, PhD, Silvia Nerreter, Thorsten Stuehmer, PhD, Marc S. Raab, MD, Joaquin Martinez Lopez, MD PhD, Roman Hajek, MD, Hermann Einsele, MD, Leo Rasche, MD, Thomas Haaf, MD, Martin Kortüm, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4349.
https://doi.org/10.1182/blood-2019-130847
Published: 2019