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Stephan M Tirier
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Journal Articles

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Seufert, Lukas John, Stephan M. Tirier, Katharina Bauer, Anja Baumann, Jennifer Rohleder, Umair Munawar, Leo Rasche, K. Martin Kortüm, Nicola Giesen, Philipp Reichert, Stefanie Huhn, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S. Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2023) 142 (19): 1633–1646.
https://doi.org/10.1182/blood.2023019758
Published: 2023
Includes: Supplemental data
Journal Articles

Single-Cell Multi-Omics Reveal Longitudinal Dynamics of Clonal Architecture and Microenvironment Interactions in Relapsed-Refractory Myeloma

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Lander, Lukas John, Stephan M Tirier, Katharina Bauer, Anja Baumann, Umair Munawar, Leo Rasche, Martin Kortuem, Nicola Giesen, Stefanie Huhn, Carsten Mueller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2022) 140 (Supplement 1): 9987–9988.
https://doi.org/10.1182/blood-2022-166105
Published: 2022
Journal Articles

Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome

Simon Steiger, Raphael Lutz, Nina Prokoph, Subarna Palit, Stephan M Tirier, Philipp Reichert, Anja Baumann, Nadine Hefner, Sabrina Schumacher, Dominik Vonficht, Florian Grünschläger, Alexandra M Poos, Lukas John, Laleh Haghverdi, Jan-Philipp Mallm, Elias K Mai, Mirco Friedrich, Katharina Kriegsmann, Mohamed H.S. Awwad, Anna Jauch, Uta Bertsch, Diana Tichy, Carsten Müller-Tidow, Roland Schroers, Hans Salwender, Britta Besemer, Roland Fenk, Katja Weisel, Hartmut Goldschmidt, Stefanie Huhn, Michael Hundemer, Karsten Rippe, Simon Haas, Niels Weinhold, Marc S Raab
Journal: Blood
Blood (2022) 140 (Supplement 1): 2083–2085.
https://doi.org/10.1182/blood-2022-168685
Published: 2022
Journal Articles

The Spatial Heterogeneity in Newly Diagnosed Multiple Myeloma Patients - from Sub-Clonal Architecture to the Immune Microenvironment

Lukas John, Alexandra Poos, Stephan M Tirier, Jan-Philipp Mallm, Nina Prokoph, Alexander Brobeil, Raphael Lutz, Sabrina Schumacher, Simon Steiger, Katharina Bauer, Anja Baumann, Christoph Rehnitz, Carsten Müller-Tidow, Hartmut Goldschmidt, Stefanie Huhn, Karsten Rippe, Marc-Steffen Raab, Sandra Sauer, Niels Weinhold
Journal: Blood
Blood (2021) 138 (Supplement 1): 729.
https://doi.org/10.1182/blood-2021-150937
Published: 2021
Journal Articles

Dissecting Heterogeneity of Tumor Cells and Their Microenvironment in Refractory Multiple Myeloma

Stephan M Tirier, PhD, Jan-Philipp Mallm, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Alexandra M Poos, PhD, Katharina Bauer, Anja Baumann, Lukas John, MD, Jing Xu, PhD, Lara Klett, MSc, Carsten Müller-Tidow, MD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Niels Weinhold, PhD, Oliver Stegle, PhD, Karsten Rippe, PhD, Marc S. Raab, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 571.
https://doi.org/10.1182/blood-2019-128625
Published: 2019
Journal Articles

A Comprehensive Analysis of Single-Cell Chromatin Accessibility and Gene Expression Identifies Intra-Tumor Heterogeneity and Molecular Treatment Responses in Relapsed/Refractory Multiple Myeloma

Alexandra M Poos, PhD, Jan-Philipp Mallm, PhD, Stephan M Tirier, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Katharina Bauer, Anja Baumann, Lukas John, MD, Isabelle Lander, BSc, Jing Xu, PhD, Moritz Przybilla, BSc, Anja Kunze, PhD, Carsten Mueller-Tidow, MD, Benedikt Brors, PhD, Oliver Stegle, PhD, Hartmut Goldschmidt, MD, Karsten Rippe, PhD, Marc S Raab, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 575.
https://doi.org/10.1182/blood-2019-130051
Published: 2019