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Journal Articles

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Seufert, Lukas John, Stephan M. Tirier, Katharina Bauer, Anja Baumann, Jennifer Rohleder, Umair Munawar, Leo Rasche, K. Martin Kortüm, Nicola Giesen, Philipp Reichert, Stefanie Huhn, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S. Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2023) 142 (19): 1633–1646.
https://doi.org/10.1182/blood.2023019758
Published: 2023
Includes: Supplemental data
Journal Articles

Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome

Simon Steiger, Raphael Lutz, Nina Prokoph, Subarna Palit, Stephan M Tirier, Philipp Reichert, Anja Baumann, Nadine Hefner, Sabrina Schumacher, Dominik Vonficht, Florian Grünschläger, Alexandra M Poos, Lukas John, Laleh Haghverdi, Jan-Philipp Mallm, Elias K Mai, Mirco Friedrich, Katharina Kriegsmann, Mohamed H.S. Awwad, Anna Jauch, Uta Bertsch, Diana Tichy, Carsten Müller-Tidow, Roland Schroers, Hans Salwender, Britta Besemer, Roland Fenk, Katja Weisel, Hartmut Goldschmidt, Stefanie Huhn, Michael Hundemer, Karsten Rippe, Simon Haas, Niels Weinhold, Marc S Raab
Journal: Blood
Blood (2022) 140 (Supplement 1): 2083–2085.
https://doi.org/10.1182/blood-2022-168685
Published: 2022
Journal Articles

Single-Cell Multi-Omics Reveal Longitudinal Dynamics of Clonal Architecture and Microenvironment Interactions in Relapsed-Refractory Myeloma

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Lander, Lukas John, Stephan M Tirier, Katharina Bauer, Anja Baumann, Umair Munawar, Leo Rasche, Martin Kortuem, Nicola Giesen, Stefanie Huhn, Carsten Mueller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2022) 140 (Supplement 1): 9987–9988.
https://doi.org/10.1182/blood-2022-166105
Published: 2022
Journal Articles

The Spatial Heterogeneity in Newly Diagnosed Multiple Myeloma Patients - from Sub-Clonal Architecture to the Immune Microenvironment

Lukas John, Alexandra Poos, Stephan M Tirier, Jan-Philipp Mallm, Nina Prokoph, Alexander Brobeil, Raphael Lutz, Sabrina Schumacher, Simon Steiger, Katharina Bauer, Anja Baumann, Christoph Rehnitz, Carsten Müller-Tidow, Hartmut Goldschmidt, Stefanie Huhn, Karsten Rippe, Marc-Steffen Raab, Sandra Sauer, Niels Weinhold
Journal: Blood
Blood (2021) 138 (Supplement 1): 729.
https://doi.org/10.1182/blood-2021-150937
Published: 2021
Journal Articles

Targeting PI3K-AKT-mTOR Signaling in Multiple Myeloma Mesenchymal Stem Cells Mediates Antiproliferative Effect on Myeloma Cells

Luca Heinmann, Helal Mohammed Mohammed Ahmed Noman, Klara Möllers, Subbaiah Chary Nimmagadda, Kaiyan Sun, Daria Frank, Hanna Korab, Lanying Wei, Anja Baumann, Alexandra Poos, Marc-Steffen Raab, Georg Lenz, Cyrus Khandanpour
Journal: Blood
Blood (2021) 138 (Supplement 1): 1600.
https://doi.org/10.1182/blood-2021-150413
Published: 2021
Journal Articles

Comprehensive Comparison of Early Relapse and End-Stage Relapsed Refractory Multiple Myeloma

Alexandra M Poos, PhD, Nicola Giesen, MD, Calogerina Catalano, PhD, Nagarajan Paramasivam, PhD, Daniel Huebschmann, MDPhD, Lukas John, Anja Baumann, Jason Hochhaus, Carsten Mueller-Tidow, MD, Sandra Sauer, MD, Stefanie Huhn, PhD, Matthias Schlesner, PhD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Marc S. Raab, MD, Niels Weinhold, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-141611
Published: 2020
Journal Articles

Dissecting Heterogeneity of Tumor Cells and Their Microenvironment in Refractory Multiple Myeloma

Stephan M Tirier, PhD, Jan-Philipp Mallm, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Alexandra M Poos, PhD, Katharina Bauer, Anja Baumann, Lukas John, MD, Jing Xu, PhD, Lara Klett, MSc, Carsten Müller-Tidow, MD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Niels Weinhold, PhD, Oliver Stegle, PhD, Karsten Rippe, PhD, Marc S. Raab, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 571.
https://doi.org/10.1182/blood-2019-128625
Published: 2019
Journal Articles

A Comprehensive Analysis of Single-Cell Chromatin Accessibility and Gene Expression Identifies Intra-Tumor Heterogeneity and Molecular Treatment Responses in Relapsed/Refractory Multiple Myeloma

Alexandra M Poos, PhD, Jan-Philipp Mallm, PhD, Stephan M Tirier, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Katharina Bauer, Anja Baumann, Lukas John, MD, Isabelle Lander, BSc, Jing Xu, PhD, Moritz Przybilla, BSc, Anja Kunze, PhD, Carsten Mueller-Tidow, MD, Benedikt Brors, PhD, Oliver Stegle, PhD, Hartmut Goldschmidt, MD, Karsten Rippe, PhD, Marc S Raab, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 575.
https://doi.org/10.1182/blood-2019-130051
Published: 2019
Journal Articles

Preclinical Evaluation of Hdp-101, a Novel Anti-BCMA Antibody-Drug Conjugate, in Multiple Myeloma

Jonathan Ko, Christian Breunig, Vianiuhini Figueroa, Nicola Lehners, MD, Anja Baumann, Aniko Pálfi, Christoph Müller, Christian Lutz, Torsten Hechler, Michael Kulke, Carsten Müller-Tidow, Hartmut Goldschmidt, MD, Andreas Pahl, Marc S Raab, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3070.
https://doi.org/10.1182/blood.V130.Suppl_1.3070.3070
Published: 2017
Journal Articles

Substantially Improved Outcome of Adult Burkitt Non-Hodgkin Lymphoma and Leukemia Patients with Rituximab and a Short-Intensive Chemotherapy; Report of a Large Prospective Multicenter Trial

Dieter Hoelzer, MD, Jan Walewski, Hartmut Döhner, MD, Mathias Schmid, MD, Wolfgang Hiddemann, MD, PhD, Anja Baumann, MD, Hubert Serve, Prof. Dr. med., Ulrich Dührsen, Andreas Hüttmann, Eckhard Thiel, Jolanta Dengler, MD, Michael Kneba, MD, Markus Schuler, MD, Ingo Schmidt-Wolf, MD, Joachim Beck, MD, Bernd Hertenstein, Albrecht Reichle, Katarzyna Domanska-Czyz, Rainer Fietkau, MD, Heinz-August Horst, MD, Harald Rieder, MD, Stefan Schwartz, MD, Thomas Burmeister, MD, Nicola Goekbuget, MD
Journal: Blood
Blood (2012) 120 (21): 667.
https://doi.org/10.1182/blood.V120.21.667.667
Published: 2012
Journal Articles

PEG-Asparaginase Intensification In Adult Acute Lymphoblastic Leukemia (ALL): Significant Improvement of Outcome with Moderate Increase of Liver Toxicity In the German Multicenter Study Group for Adult ALL (GMALL) Study 07/2003

Nicola Goekbuget, MD, Anja Baumann, MD, Joachim Beck, MD, Monika Brueggemann, MD, Helmut Diedrich, MD, Andreas Huettmann, MD, Lothar Leimer, MD, Stefan Zewen, MD, Martin Mohren, MD, Albrecht Reichle, MD, Markus Schaich, MD, Kerstin Schaefer-Eckart, MD, Marc Schmalzing, MD, Mathias Schmid, MD, Hubert Serve, MD, Reingard Stuhlmann, MD, Theis H Terwey, MD, Dieter Hoelzer, MD
Journal: Blood
Blood (2010) 116 (21): 494.
https://doi.org/10.1182/blood.V116.21.494.494
Published: 2010
Journal Articles

PEG-Asparaginase in Adult Acute Lymphoblastic Leukemia (ALL): Efficacy and Feasibility Analysis with Increasing Dose Levels

Nicola Goekbuget, MD, Anja Baumann, MD, Joachim Beck, MD, Joachim Boos, MD, PhD, Monika Brueggemann, MD, PhD, Helmut Diedrich, MD, Andreas Hüttmann, MD, Lothar Leimer, MD, Thomas Lipp, MD, Ralph Naumann, MD, PhD, Martin Mohren, MD, Albrecht Reichle, MD, PhD, Kerstin Schäfer-Eckart, MD, Marc Schmalzing, MD, Mathias Schmid, MD, PhD, Norbert Schmitz, MD, PhD, Theis Therwey, MD, Dieter Hoelzer, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 302.
https://doi.org/10.1182/blood.V112.11.302.302
Published: 2008
Journal Articles

General Condition and Early Complications Have in Addition to Disease- Specific Factors a Significant Impact on Outcome - Prognostic Factors Revisited in 1657 Adult ALL Patients (15–55 years).

Nicola Goekbuget, MD, Renate Arnold, MD, PhD, Anja Baumann, MD, Joachim Beck, MD, Helmut Diedrich, MD, Mathias Freund, MD, PhD, Andreas Hüttmann, MD, PhD, Michael Kneba, MD, PhD, Karl Anton Kreuzer, MD, Lothar Leimer, MD, Thomas Lipp, MD, Dorle Messerer, Ralph Naumann, MD, PhD, Albrecht Reichle, MD, PhD, Harald Rieder, MD, PhD, Kerstin Schäfer-Eckart, MD, Marc Schmalzing, MD, Mathias Schmid, MD, PhD, Norbert Schmitz, MD, PhD, Hubert Serve, MD, PhD, Matthias Stelljes, MD, Eckhard Thiel, MD, PhD, Dieter Hoelzer, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1927.
https://doi.org/10.1182/blood.V112.11.1927.1927
Published: 2008