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Diana Cirstea
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Journal Articles

Previous HDM/ASCT Adversely Impacts PFS with BCMA-Directed CAR T-Cell Therapy in Multiple Myeloma

Joshua Gustine, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Marcela Maus, Matthew J. Frigault, Noopur Raje
Journal: Blood
Blood (2024) 144 (Supplement 1): 79.
https://doi.org/10.1182/blood-2024-212135
Published: 2024
Journal Articles

Biological Correlatives of Efficacy and Toxicity of BCMA Targeting CAR T Cell Therapy in a Real-World Setting

Charlotte Graham, Aiyana Parker, Xiaomeng Sun, Nicholas J. Haradhvala, Maria Dolaher, Kevin Lindell, Deshea Harris, Won-Ho Lee, Kiana J Graham, Hannah K Nolan, Viktoria Blumenberg, David J Bozym, Alex Li, Hana Cho, Estelle Emmanuel-Alejandro, Arienne R Annati, Julianne Marie Gildea, Alexis Barselau, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Noopur Raje, Gad Getz, Mark B Leick, Matthew Frigault, Kathleen Gallagher, Marcela V Maus
Journal: Blood
Blood (2024) 144 (Supplement 1): 7126.
https://doi.org/10.1182/blood-2024-194895
Published: 2024
Journal Articles

Outcomes of Patients By High-Risk Cytogenetic Abnormalities in a Phase II Study of Isatuximab, Weekly Carfilzomib, Lenalidomide, Dexamethasone in Newly Diagnosed, Multiple Myeloma (The SKylaRk Trial) Who Deferred Transplant

Elizabeth K. O'Donnell, Clifton C. Mo, Omar Nadeem, Jacob Laubach, Jacalyn Rosenblatt, Nikhil C. Munshi, Shonali Midha, Diana Cirstea, Paul G. Richardson, Noopur Raje, Andrew J. Yee
Journal: Blood
Blood (2024) 144 (Supplement 1): 4747.
https://doi.org/10.1182/blood-2024-201768
Published: 2024
Journal Articles

Clonal Hematopoiesis of Indeterminate Potential Does Not Impact Overall Survival in Multiple Myeloma

Farah Rexha, Joshua Gustine, Ryan Han, Rie Nakamoto-Matsubara, Cristina Panaroni, Rajib Shome, Valentina Nardi, Andrew R. Branagan, Diana Cirstea, Andrew J. Yee, Noopur Raje
Journal: Blood
Blood (2024) 144 (Supplement 1): 3339.
https://doi.org/10.1182/blood-2024-211622
Published: 2024
Journal Articles

Immune Profiling and Responses of Smoldering Multiple Myeloma Patients Treated in a Phase Ib Study of Pvx-410 Vaccine Targeting XBP1/CD138/CS1 Antigens, and Citarinostat, a Histone Deacetylase Inhibitor (HDACi) with and without Lenalidomide

Diana Cirstea, Rajib Shome, Joseph James Connolly, Emilie Duvallet, Amanda N. R. Joyce, Victor Moyo, Kathleen Lively, Gina Basinsky, Andrew J. Yee, Cristiana Costa Chase, Ehsan Malek, Ruben Niesvizky, Paul G. Richardson, Noopur S. Raje
Journal: Blood
Blood (2023) 142 (Supplement 1): 2017.
https://doi.org/10.1182/blood-2023-189332
Published: 2023
Journal Articles

A Phase II Study of Isatuximab, Once Weekly Carfilzomib, Lenalidomide, Dexamethasone, in Newly Diagnosed, Transplant-Eligible Multiple Myeloma (The SKylaRk Trial)

Elizabeth K. O'Donnell, Clifton C. Mo, Andrew J. Yee, Omar Nadeem, Andrew R. Branagan, Jacob Laubach, Jacalyn Rosenblatt, Nora Horick, Paul G. Richardson, Noopur Raje, Diana Cirstea
Journal: Blood
Blood (2023) 142 (Supplement 1): 4671.
https://doi.org/10.1182/blood-2023-181019
Published: 2023
Journal Articles

Use of Cilta-Cel CAR T Cells Following Previous Use of a BCMA-Directed CAR T-Cell Product in Heavily Treated Patients with Relapsed/Refractory Multiple Myeloma: A Single Institution Case Series

Narsis Attar, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Matthew J. Frigault, Noopur Raje
Journal: Blood
Blood (2023) 142 (Supplement 1): 6924.
https://doi.org/10.1182/blood-2023-182212
Published: 2023
Journal Articles

With Equal Access, African Americans with Non-del17p Multiple Myeloma Have Superior Overall Survival, but del17p Still Carries Poor Prognosis across Race: A VA Study

Anusha Munjuluri, MSc, Nathanael Fillmore, PhD, Diana Cirstea, MD, Hassan Yameen, MD, Sarvari Venkata Yellapragada, MD, Ifeorah Chizoba, MPH, Nhan Do, MD, Mary Brophy, MD MPH, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4388.
https://doi.org/10.1182/blood-2019-131247
Published: 2019
Journal Articles

With equal access, African American patients have superior survival compared to white patients with multiple myeloma: a VA study

Clinical Trials & Observations
Nathanael R. Fillmore, Sarvari V. Yellapragada, Chizoba Ifeorah, Ansh Mehta, Diana Cirstea, Paul S. White, Gustavo Rivero, Andrew Zimolzak, Saiju Pyarajan, Nhan Do, Mary Brophy, Nikhil C. Munshi
Journal: Blood
Blood (2019) 133 (24): 2615–2618.
https://doi.org/10.1182/blood.2019000406
Published: 2019
Journal Articles

Treatment Disparities in Minority Groups with Multiple Myeloma at a Large Safety-Net Hospital

Michael Dennis, MD, Diana Cirstea, MD, Asaf Maoz, MD, Adam Lerner, MD, Ami K. Patel, MD, Shayna Sarosiek, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4864.
https://doi.org/10.1182/blood-2018-99-118472
Published: 2018
Journal Articles

Opioid Use Is NOT Associated with in-Hospital Mortality Among Patients with Sickle CELL Disease in the United States: Findings from the National Inpatient Sample

Oladimeji Akinola Akinboro, MBBS, Stanley Nwabudike, MD, Camille Edwards, MD, Diana Cirstea, MD, Nana Oduraa Addo-Tabiri, MD PhD, Michael Voisine, MD, Hassan Yameen, MD, Adetola A. Kassim, MD MS
Journal: Blood
Blood (2018) 132 (Supplement 1): 315.
https://doi.org/10.1182/blood-2018-99-115573
Published: 2018
Journal Articles

p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma

Clinical Trials & Observations
Teru Hideshima, Francesca Cottini, Yoshihisa Nozawa, Hyuk-Soo Seo, Hiroto Ohguchi, Mehmet K. Samur, Diana Cirstea, Naoya Mimura, Yoshikazu Iwasawa, Paul G. Richardson, Nikhil C. Munshi, Dharminder Chauhan, Walter Massefski, Teruhiro Utsugi, Sirano Dhe-Paganon, Kenneth C. Anderson
Journal: Blood
Blood (2017) 129 (10): 1308–1319.
https://doi.org/10.1182/blood-2016-09-738500
Published: 2017
Includes: Supplemental data
Journal Articles

Role Of Decorin In Multiple Myeloma (MM) Bone Marrow Microenvironment

Neeharika Nemani, Loredana Santo, Homare Eda, Diana Cirstea, Yuko Mishima, Chirayu Patel, Noopur Raje, MD
Journal: Blood
Blood (2013) 122 (21): 1851.
https://doi.org/10.1182/blood.V122.21.1851.1851
Published: 2013
Journal Articles

AVL-292, a Bruton's Tyrosine Kinase Inhibitor Impacts Bone Resorption by Abrogating Osteoclast Sealing Zone Formation in Multiple Myeloma

Homare Eda, Loredana Santo, Diana Cirstea, Andrew J. Yee, Anuj Mahindra, Tyler Scullen, Neeharika Nemani, Yuko Mishima, Erica Evans, Juswinder Singh, Wes Westlin, Noopur Raje
Journal: Blood
Blood (2012) 120 (21): 1822.
https://doi.org/10.1182/blood.V120.21.1822.1822
Published: 2012
Journal Articles

Role of Selective HDAC6 Inhibition On Multiple Myeloma Bone Disease

Loredana Santo, Diana Cirstea, Bin Wang, Tso-Pang Yao, Joy Y. Wu, Peter Waterman, Derrick Jeon, Mary Bouxsein, Leeann Louis, Sutada Lotinun, Roland Baron, Homare Eda, Neeharika Nemani, Anuj Mahindra, Andrew J. Yee, Teru Hideshima, Kenneth C. Anderson, Simon S Jones, Noopur Raje, MD
Journal: Blood
Blood (2012) 120 (21): 328.
https://doi.org/10.1182/blood.V120.21.328.328
Published: 2012
Journal Articles

TAS-117, a Novel Selective Akt Inhibitor Demonstrates Significant Growth Inhibition in Multiple Myeloma Cells in Vitro and in Vivo

Naoya Mimura, Hiroto Ohguchi, Diana Cirstea, MD, Francesca Cottini, Gullu Topal Gorgun, PhD, Jiro Minami, Rikio Suzuki, Toshiyasu Shimomura, PhD, Teruhiro Utsugi, PhD, Teru Hideshima, MD, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2012) 120 (21): 942.
https://doi.org/10.1182/blood.V120.21.942.942
Published: 2012
Journal Articles

Increased Sclerostin Secretion in Multiple Myeloma Plays a Central Role in Osteolytic Bone Disease

Homare Eda, Loredana Santo, Diana Cirstea, Andrew J. Yee, Anuj Mahindra, Tyler Scullen, Neeharika Nemani, Yuko Mishima, Sonia Vallet, Noopur Raje
Journal: Blood
Blood (2012) 120 (21): 3989.
https://doi.org/10.1182/blood.V120.21.3989.3989
Published: 2012
Journal Articles

Mutational Profiling of Multiple Myeloma Bone Marrow Aspirates As a Clinical Tool for Personalized Treatment of Myeloma

Anuj Mahindra, MD, Dora Dias-Santagata, Ph.D., Darrell Borger, Ph.D., Loredana Santo, Tyler A. Scullen, Andrew Yee, Homare Eda, Diana Cirstea, Anthony John Iafrate, M.D., Ph.D., Noopur Raje, MD
Journal: Blood
Blood (2012) 120 (21): 3990.
https://doi.org/10.1182/blood.V120.21.3990.3990
Published: 2012
Journal Articles

Rational Combination Treatment of a Novel Selective mTOR Kinase Inhibitor AZD8055 with IGF-1R Inhibitors in Multiple Myeloma

Diana Cirstea, Teru Hideshima, MD, PhD, Loredana Santo, Homare Eda, Tyler A. Scullen, Neeharika Nemani, Anuj Mahindra, Andrew Yee, Yiguo Hu, Naoya Mimura, Jiro Minami, Hiroto Ohguchi, Rikio Suzuki, Francesca Cottini, Sylvie M Guichard, Kenneth C. Anderson, Noopur Raje
Journal: Blood
Blood (2012) 120 (21): 4023.
https://doi.org/10.1182/blood.V120.21.4023.4023
Published: 2012
Journal Articles

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Naoya Mimura, Mariateresa Fulciniti, Gullu Gorgun, Yu-Tzu Tai, Diana Cirstea, Loredana Santo, Yiguo Hu, Claire Fabre, Jiro Minami, Hiroto Ohguchi, Tanyel Kiziltepe, Hiroshi Ikeda, Yutaka Kawano, Maureen French, Martina Blumenthal, Victor Tam, Nathalie L. Kertesz, Uriel M. Malyankar, Mark Hokenson, Tuan Pham, Qingping Zeng, John B. Patterson, Paul G. Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2012) 119 (24): 5772–5781.
https://doi.org/10.1182/blood-2011-07-366633
Published: 2012
Includes: Supplemental data