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Michael P. Agius
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Journal Articles

Comprehensive Characterization of the Plasma Proteome of Multiple Myeloma and Its Precursor Conditions and Identification of a Proteomic Signature to Improve Risk Prediction of Disease Progression

Elizabeth D. Lightbody, D. R. Mani, Hasmik Keshishian, Namrata Udeshi, Romanos Sklavenitis-Pistofidis, Ankit K. Dutta, Ting Wu, Junko Tsuji, Habib El-Khoury, Hadley Barr, Sarah Nersesian, Nang Kham Su, Cody J. Boehner, Michael P. Agius, Michelle P. Aranha, Laura Hevenor, Katherine Towle, Grace Fleming, Christian Cea-Curry, Daniel Heilpern-Mallory, Erica M. Horowitz, Jacqueline F Perry, Maya Davis, Kelly Walsh, Annie Cowan, John E. Ready, Catherine R. Marinac, Gad Getz, Michael Gillette, Steven A. Carr, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1903.
https://doi.org/10.1182/blood-2024-209286
Published: 2024
Journal Articles

Single-Cell RNA-Sequencing of 6 Million Tumor and Immune Cells in 365 Patients with MGUS and SMM Demonstrates Complex Progressive Changes in Immune Cell Functionality with a Distinct Footprint on Tumor Cell Biology and Disease Control

Romanos Sklavenitis-Pistofidis, Ting Wu, Elizabeth D. Lightbody, Yoshinobu Konishi, Mahshid Rahmat, Michael P. Agius, Junko Tsuji, Jean-Baptiste Alberge, Michael Timonian, Ankit K. Dutta, Michelle P. Aranha, Nayda Bidikian, Hadley Barr, Nicholas J. Haradhvala, Moshe Sade-Feldman, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1895.
https://doi.org/10.1182/blood-2024-208837
Published: 2024
Journal Articles

Single-Cell Profiling of ~1.7 Million Plasma Cells across >250 Individuals Reveals Transcriptional Signatures of Progression and Clonal Expansion in Multiple Myeloma and Its Precursor Stages

Junko Tsuji, Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Ting Wu, Michael P. Agius, Danielle T. Firer, Mahshid Rahmat, Hadley Barr, Yoshinobu Konishi, Ankit K. Dutta, Jean-Baptiste Alberge, Nang Kham Su, Cody J. Boehner, Michelle P. Aranha, Laura Hevenor, Katherine Towle, Erica M. Horowitz, Maya Davis, Jacqueline F Perry, Francois Aguet, Ruitong Li, Sungjae Kim, Nicholas J. Haradhvala, Rebecca Boiarsky, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 4637.
https://doi.org/10.1182/blood-2024-206540
Published: 2024
Journal Articles

Pharmacological Targeting of IRF4 As a Therapeutic Strategy for Multiple Myeloma

Michael P. Agius, Laura Hevenor, N Connor Payne, Qi Liu, Hyuk-Soo Seo, Romanos Sklavenitis-Pistofidis, Daniel Heilpern-Mallory, Puspalata Bashyal, Michelle P. Aranha, Elizabeth D. Lightbody, Ralph Mazitschek, Sirano Dhe-Paganon, Jun Qi, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 155.
https://doi.org/10.1182/blood-2024-203381
Published: 2024
Journal Articles

Large-Scale Characterization and Functional Assessment of Adaptive Immunity in Patients with MGUS and SMM Reveals Significant Defects

Michelle P. Aranha, Romanos Sklavenitis-Pistofidis, Yoshinobu Konishi, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Daniel L. Mallory, Michael P. Agius, Shohreh Varmeh, Nang Kham Su, Jacqueline Perry, Erica M. Horowitz, Maya Davis, Anna Justis, Radosław P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric Fischer, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 2548.
https://doi.org/10.1182/blood-2023-178062
Published: 2023
Journal Articles

Single-Cell RNA Sequencing of Rare Circulating Tumor Cells in Precursor Myeloma Patients Reveals Molecular Underpinnings of Tumor Cell Circulation

Elizabeth D. Lightbody, Danielle T. Firer, Romanos Sklavenitis-Pistofidis, Junko Tsuji, Michael P. Agius, Ankit K. Dutta, Ting Wu, Hadley Barr, Mahshid Rahmat, Yoshinobu Konishi, Michelle P. Aranha, Michael Vinyard, Jean-Baptiste Alberge, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Habib El-Khoury, Katherine Towle, Christian J. Cea-Curry, Erica Horowitz, Jacqueline Perry, Anna Cowan, Anna V. Justis, Daniel Auclair, Catherine R. Marinac, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 602–603.
https://doi.org/10.1182/blood-2022-162851
Published: 2022
Journal Articles

High-Throughput Plasma Proteomic Profiling to Identify Candidate High-Risk Disease Biomarkers in Precursor Multiple Myeloma Patients

Elizabeth D. Lightbody, Hasmik Keshishian, Habib El-Khoury, Ankit K. Dutta, Hadley Barr, Jes Barbagallo, Namrata Udeshi, Michael P. Agius, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Katherine Towle, Christian J. Cea-Curry, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna Cowan, Evan Mills, Marijana Rucevic, DR Mani, Daniel Auclair, Catherine R. Marinac, Michael A Gillette, Steven A Carr, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 4303–4304.
https://doi.org/10.1182/blood-2022-170346
Published: 2022
Journal Articles

Dysregulated Humoral and Cellular Response to Sars-Cov-2 Vaccination in Patients with MGUS and SMM

Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Michelle P. Aranha, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Shohreh Varmeh, Daniel Heilpern-Mallory, Michael P. Agius, Nang Kham Su, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna V. Justis, Radoslaw P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric S. Fischer, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7158–7159.
https://doi.org/10.1182/blood-2022-167212
Published: 2022
Journal Articles

Single-Cell RNA-Sequencing of 245 Tumor Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveals Novel Insights into Malignant Plasma Cell Biology

Junko Tsuji, Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Michael P. Agius, Mahshid Rahmat, Hadley Barr, Yoshinobu Konishi, Ankit K. Dutta, Nang Kham Su, Cody J. Boehner, Danielle T. Firer, Ting Wu, Michelle P. Aranha, Laura Hevenor, Erica Horowitz, Jacqueline Perry, François Aguet, Nicholas J. Haradhvala, Rebecca Boiarsky, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 254–255.
https://doi.org/10.1182/blood-2022-167325
Published: 2022
Journal Articles

Identification of a Novel Epigenetic Mechanism of MYC Deregulation in Smoldering and Newly Diagnosed Multiple Myeloma Patients

Mahshid Rahmat, Kendell Clement, Romanos Sklavenitis-Pistofidis, Rohan Kodgule, Charles Fulco, Jean-Baptiste Alberge, Cody J. Boehner, Michael P. Agius, Elizabeth Morgan Kitzenberg, David Dorfman, Russell J. H. Ryan, Luca Pinello, Irene M. Ghobrial
Journal: Blood
Blood (2021) 138 (Supplement 1): 504.
https://doi.org/10.1182/blood-2021-150734
Published: 2021
Journal Articles

A High-Throughput Drug Screen Reveals a Novel Compound Class That Significantly Depletes IRF4 Expression in Multiple Myeloma

Elizabeth D. Lightbody, PhD, Mairead Reidy, PhD, Michael P. Agius, PhD, Salma El-Behaedi, BSc, Romanos Sklavenitis-Pistofidis, MD, Salomon Manier, MD PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5545.
https://doi.org/10.1182/blood-2019-130910
Published: 2019