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Journal Articles

Results of the promise study from ~30,000 individuals screened for monoclonal gammopathies

Free
Sabine Allam, Sungjae Kim, Jean-Baptiste Alberge, Habib El-Khoury, Floris Chabrun, Jacqueline Perry, Katherine Padgett, Julia Colchie, Joseph Flinn, Grace Fleming, Rachel Choi, Kaitlin Bondi, Ciara Murphy, Sofia Wallin, Luca Bertamini, David Lee, Derek Troske, Dhananjay Sakrikar, David Barnidge, Stephen Harding, David Cordas Dos Santos, Romanos Sklavenitis-Pistofidis, Meletios Dimopoulos, Efstathios Kastritis, Irit Avivi, Wenlong Chen, Maureen Joffe, Elizabeth Karlson, Elizabeth O'Donnell, Omar Nadeem, Lorenzo Trippa, Catherine Marinac, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 403.
https://doi.org/10.1182/blood-2025-403
Published: 2025
Journal Articles

Risk factors and prevalence of monoclonal gammopathy of undetermined significance (MGUS) by duffy genotype

Free
Lauren Merz, Sabine Allam, Sungjae Kim, Jean-Baptiste Alberge, Jacqueline Perry, David Lee, Katherine Padgett, Julia Colchie, Omar Nadeem, Irene Ghobrial, Paul Richardson
Journal: Blood
Blood (2025) 146 (Supplement 1): 4578.
https://doi.org/10.1182/blood-2025-4578
Published: 2025
Journal Articles

Characterization of the plasma proteome of multiple myeloma and its precursor conditions and identification of a prognostic high-risk signature of progression

Free
Elizabeth Lightbody, D. R. Mani, Hasmik Keshishian, Romanos Sklavenitis-Pistofidis, Ankit Dutta, Esperanza Martin-Sanchez, Elise Rees, Christine-Ivy Liacos, Nayda Bidikian, Habib El-Khoury, Hadley Barr, Ting Wu, Junko Tsuji, Sarah Nersesian, Nang Kham Su, Cody Boehner, Michael Agius, Michelle Aranha, Sabrin Tahri, Laura Hevenor, Katherine Towle, Erica Horowitz, Jacqueline Perry, Maya Davis, Kelly Walsh, John Ready, Catherine Marinac, Kwee Yong, Gad Getz, Efstathios Kastritis, Meletios Dimopoulos, Bruno Paiva, Namrata Udeshi, Michael Gillette, Steven Carr, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 2168.
https://doi.org/10.1182/blood-2025-2168
Published: 2025
Journal Articles

Results of the Phase II d-PRISM study: Daratumumab in high-risk MGUS and low-risk smoldering myeloma

Free
Omar Nadeem, Michelle Aranha, Robert Redd, Michael Koontz, Jeffrey Matous, Andrew Yee, Jeffrey Zonder, Andrew Kin, Sophie Magidson, Elizabeth Lightbody, Ting Wu, Floris Chabrun, Jean-Baptiste Alberge, Ankit Dutta, Jacqueline Perry, Ashlee Sturtevant, Mahshid Rahmat, Junko Tsuji, Christine Davie, Caroline Ricciardi, Frances Arters, Marjorie Marto, Amy Goguen, Jacalyn Rosenblatt, Elizabeth O'Donnell, Jacob Laubach, Paul Richardson, Gad Getz, Lorenzo Trippa, Romanos Sklavenitis-Pistofidis, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 1533.
https://doi.org/10.1182/blood-2025-1533
Published: 2025
Journal Articles

Monoclonal gammopathy of indeterminate potential (MGIP) as a stable premalignant entity preceding hematologic malignancy

Free
Sungjae Kim, Sabine Allam, Yoshinobu Konishi, Floris Chabrun, Jean-Baptiste Alberge, Luca Bertamini, Habib El-Khoury, Junko Tsuji, Romanos Sklavenitis-Pistofidis, Rosa Toenges, Elizabeth Lightbody, Michael Timonian, Uday Aditya Sarkar, Michelle Aranha, Jacqueline Perry, Ting Wu, Grace Fleming, Joseph Flinn, Mendy Miller, Nikhil Munshi, Kenneth Anderson, Omar Nadeem, Catherine Marinac, Jennifer Brown, Paolo Ghia, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 582.
https://doi.org/10.1182/blood-2025-582
Published: 2025
Journal Articles

Spatial proteomics of the bone marrow reveals distinct Tumor–Immune niches in smoldering and relapsed myeloma and their remodeling in response to bispecific antibody and CAR-T therapy

Free
David Cordas Dos Santos, Kane Foster, Daniel Heilpern-Mallory, Sophia Schroeder, Yoshinobu Konishi, Maria-Theresa Silverio, Jacqueline Perry, Sophie Magidson, Diego Vieyra, Rocio Montes De Oca, Daniel Zangrando, Nina Lane, Adam Sperling, Eric Smith, Jacob Laubach, Elizabeth O'Donnell, Nikhil Munshi, Kenneth Anderson, Shonali Midha, Gad Getz, Omar Nadeem, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 3921.
https://doi.org/10.1182/blood-2025-3921
Published: 2025
Journal Articles

Spatial profiling of the bone marrow microenvironment in patients with IgM gammopathies reveals a T cell–Enriched tumor niche associated with asymptomatic waldenstrom macroglobulinemia progression

Free
David Cordas Dos Santos, Kane Foster, Daniel Heilpern-Mallory, Sophia Schroeder, Minhua Su, Vidhi Patel, Catherine Tobia, Mohammed Rahman, Jacqueline Perry, Daniel Zangrando, Nina Lane, Yoshinobu Konishi, Steven Treon, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 3559.
https://doi.org/10.1182/blood-2025-3559
Published: 2025
Journal Articles

Serum free light chains in a racially diverse population including African Americans and populations from South Africa

Available to Purchase
Luca Bertamini, Jean-Baptiste Alberge, David J. Lee, Habib El-Khoury, Sungjae Kim, Grace Fleming, Ciara Murphy, Julia Colchie, Maya I. Davis, Jacqueline Perry, Elizabeth D. Lightbody, Sabine Allam, Lindokuhle N. Goqwana, Vinitha Philip, Natalie Smyth, Dhananjay Sakrikar, Mark Perkins, Stephen Harding, Derek Troske, Gad Getz, Elizabeth W. Karlson, Nikhil Munshi, Kenneth C. Anderson, Lorenzo Trippa, Catherine R. Marinac, Wenlong C. Chen, Maureen Joffe, Irene M. Ghobrial
Journal: Blood
Blood (2025) 145 (8): 840–849.
https://doi.org/10.1182/blood.2024026078
Published: 2025
Includes: Supplemental data
Journal Articles

Landscape Assessment of the Perceptions of Distress and Symptom Burden in Patients with Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Multiple Myeloma (SMM)

Free
Elizabeth K. O'Donnell, Jennifer Carroll, Jacqueline Perry, Katherine Padgett, Vidhi Patel, Omar Nadeem, Areej El-Jawahri, Irene Ghobrial, Catherine R. Marinac
Journal: Blood
Blood (2024) 144 (Supplement 1): 6872.
https://doi.org/10.1182/blood-2024-201747
Published: 2024
Journal Articles

Novel Non-Coding Candidate Drivers of Multiple Myeloma Linked to Plasma Cell Tumor Biology and B Cell Development

Free
Jean-Baptiste Alberge, Ankit K. Dutta, Andrea Poletti, Oliver Priebe, Tim H.H. Coorens, Elizabeth D. Lightbody, Rosa Toenges, Xavi Loinaz, Sofia Wallin, Andrew Dunford, Cody J. Boehner, Erica M. Horowitz, Nang Kham Su, Hadley Barr, Laura Hevenor, Katherine Towle, Rashmika Beesam, Jenna D. Beckwith, Jacqueline Perry, David M. Cordas dos Santos, Luca Bertamini, Kirsten Kübler, Carolina Terragna, Elena Zamagni, Julian Hess, Romanos Sklavenitis-Pistofidis, Chip Stewart, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1894.
https://doi.org/10.1182/blood-2024-205523
Published: 2024
Journal Articles

A 1,000-Genome Map for Multiple Myeloma and Its Precursor Stages, and Its Impact on Clinical Outcome

Free
Jean-Baptiste Alberge, Ankit K. Dutta, Andrea Poletti, Tim H.H. Coorens, Elizabeth D. Lightbody, Rosa Toenges, Xavi Loinaz, Sofia Wallin, Andrew Dunford, Oliver Priebe, Cody J. Boehner, Erica M. Horowitz, Nang Kham Su, Hadley Barr, Laura Hevenor, Katherine Towle, Rashmika Beesam, Jenna D. Beckwith, Jacqueline Perry, David M. Cordas dos Santos, Luca Bertamini, Patricia Greipp, Kirsten Kübler, Peter F. Arndt, Carolina Terragna, Elena Zamagni, Julian Hess, Romanos Sklavenitis-Pistofidis, Chip Stewart, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1019.
https://doi.org/10.1182/blood-2024-203517
Published: 2024
Journal Articles

Single-Cell RNA Sequencing of Circulating Tumor Cells in Precursor Myeloma Patients Reveals Mechanisms of Disease Dissemination

Free
Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Danielle T. Firer, Junko Tsuji, Mike P. Agius, Ankit K. Dutta, Ting Wu, Hadley Barr, Sungjae Kim, Tim Coorens, Jean-Baptiste Alberge, Michelle P. Aranha, Nicholas J Haradhvala, Nang Kham Su, Cody J. Boehner, Kelly Walsh, Mahshid Rahmat, Yoshinobu Konishi, Laura Hevenor, Katherine Towle, Erica M. Horowitz, Jacqueline Perry, Grace Fleming, Habib El-Khoury, Michael Vinyard, Annie Cowan, Daniel Auclair, John E. Ready, Catherine R. Marinac, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 872.
https://doi.org/10.1182/blood-2023-189760
Published: 2023
Journal Articles

Understanding Patient Preferences for Intervention in Individuals with Precursor Multiple Myeloma: The Preference Study

Free
Catherine R. Marinac, Katelyn Downy, Irene M. Ghobrial, Jacqueline Perry, Brittany Fischer-Longden, Timothy R Rebbeck, Elizabeth K. O'Donnell, Omar Nadeem, Brian Egleston
Journal: Blood
Blood (2023) 142 (Supplement 1): 4775.
https://doi.org/10.1182/blood-2023-190035
Published: 2023
Journal Articles

Genome Sequencing to Discover Drivers of Clonal Expansion in Smoldering Multiple Myeloma

Free
Jean-Baptiste Alberge, Ankit K. Dutta, Elizabeth D. Lightbody, Andrea Poletti, Sofia Wallin, Andrew Dunford, Tim Coorens, Xavi Loinaz, Cody J. Boehner, Nang Kham Su, Laura Hevenor, Katherine Towle, Jacqueline Perry, Kirsten Kübler, Romanos Sklavenitis-Pistofidis, Julian Hess, Chip Stewart, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 4143.
https://doi.org/10.1182/blood-2023-184900
Published: 2023
Journal Articles

High-Throughput Plasma Proteomics to Define the Precursor Multiple Myeloma Proteome and Identify Candidate High-Risk Disease Biomarkers of Progression

Free
Elizabeth D. Lightbody, D. R. Mani, Hasmik Keshishian, Habib El-Khoury, Ankit K. Dutta, Hadley Barr, Namrata Udeshi, Luca Bertamini, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Katherine Towle, Grace Fleming, Christian Cea-Curry, Jacqueline Perry, Erica M. Horowitz, Maya Davis, Annie Cowan, Catherine R. Marinac, Michael Gillette, Steven A. Carr, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 334.
https://doi.org/10.1182/blood-2023-189091
Published: 2023
Journal Articles

Large-Scale Characterization and Functional Assessment of Adaptive Immunity in Patients with MGUS and SMM Reveals Significant Defects

Free
Michelle P. Aranha, Romanos Sklavenitis-Pistofidis, Yoshinobu Konishi, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Daniel L. Mallory, Michael P. Agius, Shohreh Varmeh, Nang Kham Su, Jacqueline Perry, Erica M. Horowitz, Maya Davis, Anna Justis, Radosław P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric Fischer, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 2548.
https://doi.org/10.1182/blood-2023-178062
Published: 2023
Journal Articles

High-Throughput Plasma Proteomic Profiling to Identify Candidate High-Risk Disease Biomarkers in Precursor Multiple Myeloma Patients

Free
Elizabeth D. Lightbody, Hasmik Keshishian, Habib El-Khoury, Ankit K. Dutta, Hadley Barr, Jes Barbagallo, Namrata Udeshi, Michael P. Agius, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Katherine Towle, Christian J. Cea-Curry, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna Cowan, Evan Mills, Marijana Rucevic, DR Mani, Daniel Auclair, Catherine R. Marinac, Michael A Gillette, Steven A Carr, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 4303–4304.
https://doi.org/10.1182/blood-2022-170346
Published: 2022
Journal Articles

Monitoring Plasma Cells and Clonal Emergence through Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma

Free
Ankit K. Dutta, Jean-Baptiste Alberge, Elizabeth D. Lightbody, Cody J. Boehner, Romanos Sklavenitis-Pistofidis, Amanda Cao, Tarek H. Mouhieddine, Anna Cowan, Nang Kham Su, Andrew Dunford, Erica Horowitz, Hadley Barr, Jenna B. Beckwith, Laura Hevenor, Jacqueline Perry, Ornkleaw Zepp, Thai Bui, Steven Gross, Omar Nadeem, Chip Stewart, Daniel Auclair, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 9927–9928.
https://doi.org/10.1182/blood-2022-169034
Published: 2022
Journal Articles

Single-Cell RNA-Sequencing of 245 Tumor Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveals Novel Insights into Malignant Plasma Cell Biology

Free
Junko Tsuji, Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Michael P. Agius, Mahshid Rahmat, Hadley Barr, Yoshinobu Konishi, Ankit K. Dutta, Nang Kham Su, Cody J. Boehner, Danielle T. Firer, Ting Wu, Michelle P. Aranha, Laura Hevenor, Erica Horowitz, Jacqueline Perry, François Aguet, Nicholas J. Haradhvala, Rebecca Boiarsky, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 254–255.
https://doi.org/10.1182/blood-2022-167325
Published: 2022
Journal Articles

Dysregulated Humoral and Cellular Response to Sars-Cov-2 Vaccination in Patients with MGUS and SMM

Free
Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Michelle P. Aranha, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Shohreh Varmeh, Daniel Heilpern-Mallory, Michael P. Agius, Nang Kham Su, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna V. Justis, Radoslaw P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric S. Fischer, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7158–7159.
https://doi.org/10.1182/blood-2022-167212
Published: 2022