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Journal Articles

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Yujia Xu, Min Xu, Jiefei Tong, Xiaowen Tang, Jinhao Chen, Xuehan Chen, Zubin Zhang, Biyin Cao, A. Keith Stewart, Michael F. Moran, Depei Wu, Xinliang Mao

Blood (2021) 137 (11): 1478–1490.

https://doi.org/10.1182/blood.2020005199

Published: 2021

Includes: Supplemental data

Journal Articles

PCT3, a Combination of Active Steroidal Saponins from the Paris Forrestii (Takht.) H. Li, Displays Potent Activity Against Acute Myeloid Leukemia By Suppressing the PBX1/RNF6/AKT/mTOR Signaling Pathway

Qin Lu, MD, Yunjing Zheng, MD, Yuehu Wang, PhD, Jian Pan, PhD, Xinliang Mao, MD PhD, Shaoyan Hu, MD PhD

Blood (2017) 130 (Supplement 1): 2533.

https://doi.org/10.1182/blood.V130.Suppl_1.2533.2533

Published: 2017

Journal Articles

Ikaros Family Zinc Finger 1 Mutation Is a Poor Prognosis Factor of Adult B Cell Acute Lymphoblastic Leukemia

Shanhao Tang, Hongjie Shen, Xinliang Mao, MD PhD, Haiping Dai, Xiaming Zhu, Shengli Xue, Zixuan Ding, Jing Lu, Depei Wu, MD, XiaoWen Tang, MD

Blood (2017) 130 (Supplement 1): 5117.

https://doi.org/10.1182/blood.V130.Suppl_1.5117.5117

Published: 2017

Journal Articles

Low-Dose Decitabine Combined with Modified Bucy Is More Effective Conditioning Regimen for High-Risk Patients with Acute Myeloid Leukaemia/Myelodysplastic Syndrome

Xiaowen Tang, MD, Jing Cao, Xiaojing Shi, Ling Ge, Aining Sun, PhD, Xiaming Zhu, Huiying Qiu, Zhengming Jin, Miao Miao, Chengcheng Fu, Xiao Ma, Feng Chen, Shengli Xue, Yue Han, MD, Mengxing Xue, Xinliang Mao, PhD, Depei Wu, MD PhD

Blood (2016) 128 (22): 5750.

https://doi.org/10.1182/blood.V128.22.5750.5750

Published: 2016

Journal Articles

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice

Zubin Zhang, Jiefei Tong, Xiaowen Tang, Jiaxiang Juan, Biyin Cao, Rose Hurren, Guodong Chen, Paul Taylor, Xin Xu, Chang-xin Shi, Juan Du, Jian Hou, Guanghui Wang, Depei Wu, A. Keith Stewart, Aaron D. Schimmer, Michael F. Moran, Xinliang Mao

Blood (2016) 127 (13): 1676–1686.

https://doi.org/10.1182/blood-2015-07-658203

Published: 2016

Includes: Supplemental data

Journal Articles

A Novel PI3K Inhibitor Identified By a High Throughput Virtual Screen Displays Potent Activity Against Multiple Myeloma

Biyin Cao, MD PhD, Jingyu Zhu, PhD, Man Wang, Yang Yu, Huixin Qi, Kunkun Han, Zubin Zhang, Yuanying Zeng, MD, Chunhua Qiao, PhD, Hongjian Zhang, PhD, Tingjun Hou, PhD, Xinliang Mao, PhD

Blood (2014) 124 (21): 4722.

https://doi.org/10.1182/blood.V124.21.4722.4722

Published: 2014

Journal Articles

Loss of Autophagy Leads to Megakaryocytes Differentiation Failure and Defective Platelets Function

Yan Cao, BS, Jinyang Cai, MS, Xin Li, BS, Yixuan Fang, BS, Suping Zhang, MD PhD, Na Yuan, BS, Xinliang Mao, MD PhD, Jianrong Wang, PhD

Blood (2014) 124 (21): 4148.

https://doi.org/10.1182/blood.V124.21.4148.4148

Published: 2014

Journal Articles

Autophagy Collaborates with Ubiquitination to Down-Regulate Oncoprotein E2A/Pbx1 in B Cell Acute Lymphoblastic Leukemia

Suping Zhang, MD PhD, Lin Song, BS, Na Yuan, BS, Weiwei Lin, MS, Yan Cao, BS, Fei Xu, MS, Yixuan Fang, BS, Zheng Wang, BS, Xin Li, BS, Zhijian Wang, MS, Jinyang Cai, MS, Wenli Zhao, MD PhD, Shaoyan Hu, MD PhD, Suning Chen, MD PhD, Xinliang Mao, MD PhD, Jianrong Wang, PhD

Blood (2014) 124 (21): 5276.

https://doi.org/10.1182/blood.V124.21.5276.5276

Published: 2014

Journal Articles

Bafilomycin A1 Targets Both Autophagy and Apoptosis Pathways in Pediatric t(1;19) Pre-B Acute Lymphoblastic Leukemia Cells

Na Yuan, BS, Lin Song, BS, Suping Zhang, MD PhD, Weiwei Lin, MS, Yan Cao, BS, Fei Xu, MS, Yixuan Fang, BS, Zheng Wang, BS, Zhijian Wang, MS, Xin Li, BS, Jinyang Cai, MS, Yi Zhang, PhD, Wenli Zhao, MD PhD, Shaoyan Hu, MD PhD, Suning Chen, MD PhD, Xinliang Mao, MD PhD, Jianrong Wang, PhD

Blood (2014) 124 (21): 3699.

https://doi.org/10.1182/blood.V124.21.3699.3699

Published: 2014

Journal Articles

Targeting The PI3K/AKT Pathway To Inhibit Platelet Activation and Thrombus Formation

Wenxiu Yi, BS, Wei Li, MS, Lijie Ren, MS, Xinliang Mao, MD, PhD, Li Zhu, MD, PhD

Blood (2013) 122 (21): 3513.

https://doi.org/10.1182/blood.V122.21.3513.3513

Published: 2013

Journal Articles

The Proteasomal Inhibitor Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity.

Biyin Cao, MD, PhD, Mingyun Shen, Mr., Depei Wu, Jianhong Du, MD, Jingyu Zhu, Suning Chen, Aining Sun, Xiaowen Tang, MD, PhD, Zhuan Xu, Yan Kong, MD. PhD, Xinliang Mao, MD, PhD

Blood (2012) 120 (21): 2449.

https://doi.org/10.1182/blood.V120.21.2449.2449

Published: 2012

Journal Articles

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway

Xinliang Mao, Biyin Cao, Tabitha E. Wood, Rose Hurren, Jiefei Tong, Xiaoming Wang, Wenjie Wang, Jie Li, Yueping Jin, Wenxian Sun, Paul A. Spagnuolo, Neil MacLean, Michael F. Moran, Alessandro Datti, Jeffery Wrana, Robert A. Batey, Aaron D. Schimmer

Blood (2011) 117 (6): 1986–1997.

https://doi.org/10.1182/blood-2010-05-284810

Published: 2011

Includes: Supplemental data

Journal Articles

Clioquinol Arrests Cell Cycle at G1 Phase and Triggers Intrinsic Apoptosis In Myeloma and Leukemia Cells by Inhibiting Histone Deacetylases

Biyin Cao, Tingjun Hou, PhD, Suning Chen, Depei Wu, Aining Sun, Huiying Qiu, Wenjie Wang, Aaron Schimmer, MD, PhD, Xinliang Mao, MD, PhD

Blood (2010) 116 (21): 1836.

https://doi.org/10.1182/blood.V116.21.1836.1836

Published: 2010

Journal Articles

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

Blood (2010) 115 (11): 2251–2259.

https://doi.org/10.1182/blood-2009-07-231191

Published: 2010

Includes: Supplemental data

Journal Articles

A Small Molecule Inhibitor of D-Cyclin Transactivation Displays Preclinical Efficacy in Myeloma and Leukemia.

Xinliang Mao, MD, PhD, Tabitha E Wood, PhD, Rose Hurren, Jiefei Tong, PhD, Xiaoming Wang, Paul A. Spagnuolo, PhD, Neil MacLean, Michael F. Moran, PhD, Alessandro Datti, Jeff Wrana, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD

Blood (2009) 114 (22): 2036.

https://doi.org/10.1182/blood.V114.22.2036.2036

Published: 2009

Journal Articles

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

Rodger E. Tiedemann, Jessica Schmidt, Jonathan J. Keats, Chang-Xin Shi, Yuan Xiao Zhu, Stephen E. Palmer, Xinliang Mao, Aaron D. Schimmer, A. Keith Stewart

Blood (2009) 113 (17): 4027–4037.

https://doi.org/10.1182/blood-2008-09-179796

Published: 2009

Includes: Supplemental data

Journal Articles

A Novel Chromene-Based Pan-PI3 Kinase Inhibitor Displays Preclinical Activity in Leukemia and Myeloma.

Xinliang Mao, MD, PhD, Tabitha W. Wood, PhD, Xiaoming Wang, PhD, Johnathan St-Germain, BSc, Michael F. Moran, PhD, Alessandro Datti, PhD, Jeff Wrana, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD

Blood (2008) 112 (11): 1605.

https://doi.org/10.1182/blood.V112.11.1605.1605

Published: 2008

Journal Articles

Identification of a Potent Natural Triterpenoid Inhibitor of Proteosome Chymotrypsin-Like Activity and NF-κB with Specific Anti-Myeloma Activity in Vitr o and in Vivo

Rodger E. Tiedemann, MBChB, PhD, FRACP, FRCPA, Jonathan J Keats, PhD, Jessica Schmidt, BS, Chang-Xin Shi, Yuan X Zhu, PhD, Xinliang Mao, MD, PhD, Aaron D. Schimmer, Keith Stewart, MD

Blood (2008) 112 (11): 3679.

https://doi.org/10.1182/blood.V112.11.3679.3679

Published: 2008

Journal Articles

A Novel Non-Competitive Chemical Proteasome Inhibitor Displays Preclinical Activity in Myeloma and Leukemia.

Xiaoming Li, PhD, Tabitha E Wood, PhD, Remco Sprangers, PhD, Xinliang Mao, PhD, Xiaoming Wang, PhD, Yi Zhang, BSc, David Rose, PhD, Robert A. Batey, PhD, Lewis E. Kay, PhD, Aaron D. Schimmer, MD, PhD

Blood (2008) 112 (11): 1711.

https://doi.org/10.1182/blood.V112.11.1711.1711

Published: 2008

Journal Articles

Cyproheptadine displays preclinical activity in myeloma and leukemia

Blood (2008) 112 (3): 760–769.

https://doi.org/10.1182/blood-2008-02-142687

Published: 2008

Includes: Supplemental data

NARROW

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

PCT3, a Combination of Active Steroidal Saponins from the Paris Forrestii (Takht.) H. Li, Displays Potent Activity Against Acute Myeloid Leukemia By Suppressing the PBX1/RNF6/AKT/mTOR Signaling Pathway

Ikaros Family Zinc Finger 1 Mutation Is a Poor Prognosis Factor of Adult B Cell Acute Lymphoblastic Leukemia

Low-Dose Decitabine Combined with Modified Bucy Is More Effective Conditioning Regimen for High-Risk Patients with Acute Myeloid Leukaemia/Myelodysplastic Syndrome

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice

A Novel PI3K Inhibitor Identified By a High Throughput Virtual Screen Displays Potent Activity Against Multiple Myeloma

Loss of Autophagy Leads to Megakaryocytes Differentiation Failure and Defective Platelets Function

Autophagy Collaborates with Ubiquitination to Down-Regulate Oncoprotein E2A/Pbx1 in B Cell Acute Lymphoblastic Leukemia

Bafilomycin A1 Targets Both Autophagy and Apoptosis Pathways in Pediatric t(1;19) Pre-B Acute Lymphoblastic Leukemia Cells

Targeting The PI3K/AKT Pathway To Inhibit Platelet Activation and Thrombus Formation

The Proteasomal Inhibitor Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity.

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway

Clioquinol Arrests Cell Cycle at G1 Phase and Triggers Intrinsic Apoptosis In Myeloma and Leukemia Cells by Inhibiting Histone Deacetylases

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

A Small Molecule Inhibitor of D-Cyclin Transactivation Displays Preclinical Efficacy in Myeloma and Leukemia.

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

A Novel Chromene-Based Pan-PI3 Kinase Inhibitor Displays Preclinical Activity in Leukemia and Myeloma.

Identification of a Potent Natural Triterpenoid Inhibitor of Proteosome Chymotrypsin-Like Activity and NF-κB with Specific Anti-Myeloma Activity in Vitr o and in Vivo

A Novel Non-Competitive Chemical Proteasome Inhibitor Displays Preclinical Activity in Myeloma and Leukemia.

Cyproheptadine displays preclinical activity in myeloma and leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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