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Journal Articles

Modeling Clonal Hematopoiesis Due to Chromosome 13q Deletion in Human Hematopoietic Stem Cells

Gordon Gaa Lam Wong, Blair Gage, Mahmoud El-Maklizi, Ash Hagerman, Gregory Kent, Hyerin Kim, Nathan Mbong, Liqing Jin, Olga Gan, Clinton Robbins, Gordon Keller, Robert J Vanner, Eric Richard Lechman, John Edgar Dick
Journal: Blood
Blood (2024) 144 (Supplement 1): 946.
https://doi.org/10.1182/blood-2024-206253
Published: 2024
Journal Articles

Somatic TET2 Mutations Prime the Immune System for Response to Immune Checkpoint Blockade

Robert Vanner, Andy G.X. Zeng, Michelle Chan-Seng-Yue, Suraj Bansal, Elisa Donato, Liqing Jin, Sofia Genta, Enrique Sanz Garcia, Steven M. Chan, Andreas Trumpp, John E. Dick
Journal: Blood
Blood (2023) 142 (Supplement 1): 2689.
https://doi.org/10.1182/blood-2023-177740
Published: 2023
Journal Articles

Investigation of CD83 As a Novel Human Hematopoietic Stem Cell Inflammatory Activation Marker

Murtaza S. Nagree, Andy G.X. Zeng, Angelica Varesi, Isabel N.X. Lim, Sayyam Shah, Hyerin Kim, Liqing Jin, Mason Boulanger, John E. Dick, Stephanie Z. Xie
Journal: Blood
Blood (2023) 142 (Supplement 1): 4067.
https://doi.org/10.1182/blood-2023-187737
Published: 2023
Journal Articles

Discovery of a New Human Hematopoietic Stem Cell Involved with Aging That Retains Memory of Immune Activation

Andy G.X. Zeng, Murtaza S Nagree, Alexander Murison, Isabel Lim, Sayyam Shah, Alicia Aguilar-Navarro, Joana Araújo, Darrien Parris, Jessica L McLeod, Liqing Jin, Elvin Wagenblast, Eugenia Flores-Figueroa, John E. Dick, Stephanie Z Xie
Journal: Blood
Blood (2022) 140 (Supplement 1): 2218–2219.
https://doi.org/10.1182/blood-2022-170303
Published: 2022
Journal Articles

Uncovering Distinct Metabolic Properties of Relapse and Relapse-Fated Clones in B-Cell Acute Lymphoblastic Leukemia

Sabrina A Smith, Laura Garcia Prat, Mohsen Hosseini, Liqing Jin, Nathan Mbong, Monica Doedens, Jessica McLeod, Julie A. Reisz, Rebecca Wilkerson, Angelo D'Alessandro, Steven M. Chan, Courtney L Jones, John E. Dick
Journal: Blood
Blood (2022) 140 (Supplement 1): 5905–5906.
https://doi.org/10.1182/blood-2022-162652
Published: 2022
Journal Articles

A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells in Vitro and In Vivo

Lucas C M Arruda, Liqing Jin, Melanie Lambert, Laura Sanchez Rivera, Renato Alvez, Tales Rocha de Moura, Carsten Mim, Rebecca Axelsson-Robertson, John E. Dick, Jonas Mattsson, Bjorn Onfelt, Mattias Carlsten, Michael Uhlin
Journal: Blood
Blood (2021) 138 (Supplement 1): 2861.
https://doi.org/10.1182/blood-2021-145278
Published: 2021
Journal Articles

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Liberalis Debraj Boila, Liqing Jin, Alex Murison, Subham K. Bandyopadhyay, Subhadeep Ghosh, Siva Sai Naga Anurag Muddineni, Andy G.X. Zeng, Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Nathan Mbong, Olga I. Gan, Andrea Arruda, Wasim Shaikh, Anwesha Bose, Satyaki Bhowmik, Sayan Chakraborty, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Journal: Blood
Blood (2021) 138 (Supplement 1): 25.
https://doi.org/10.1182/blood-2021-145491
Published: 2021
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

Sirpαfc Treatment Targets Human Acute Myeloid Leukemia Stem Cells

Oleksandr Galkin, PhD, Jessica McLeod, BSc, James A Kennedy, MD PhD, Liqing Jin, MD, Nathan Mbong, Mark Wong, PhD, Bob Uger, PhD, Mark D. Minden, MD PhD, Jayne S Danska, PhD, Jean C.Y. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3906.
https://doi.org/10.1182/blood-2019-131018
Published: 2019
Journal Articles

A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1

Liqing Jin, MD, Nathan Mbong, Stanley W.K. Ng, PhD, Jean C.Y. Wang, MD, Mark D. Minden, MD PhD, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, MD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3940.
https://doi.org/10.1182/blood-2019-128450
Published: 2019
Journal Articles

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Stanley W.K. Ng, Stephanie Zhi-Juan Xie, PhD, Elvin Wagenblast, PhD, Naoya Takayama, MD PhD, Liqing Jin, MD, Nathan Mbong, Alex Murison, Schoof E Erwin, Amanda Mitchell, PhD, Peter Van Galen, PhD, Mathieu Lupien, PhD, Mark D. Minden, MD PhD, Jean C.Y. Wang, MD PhD, Peter W. Zandstra, PhD, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2018-99-114314
Published: 2018
Journal Articles

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

Jenny M. Ho, MD, Stephanie M. Dobson, Jessica McLeod, Liqing Jin, MD PhD, Stanley W.K. Ng, MSc, Amanda Mitchell, PhD, Liran I. Shlush, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1705.
https://doi.org/10.1182/blood.V128.22.1705.1705
Published: 2016
Journal Articles

AGS62P1, a Novel Anti-FLT3 Antibody Drug Conjugate, Employing Site Specific Conjugation, Demonstrates Preclinical Anti-Tumor Efficacy in AML Tumor and Patient Derived Xenografts

Nandini Rudra-Ganguly, PhD, Christine Lowe, Cyrus Virata, Monica Leavitt, Liqing Jin, MD, Brian Mendelsohn, PhD, Josh Snyder, Hector Aviña, Chunying Zhang, Deanna L Russell, Michael Mattie, PhD, Peng Yang, PhD, Baljinder Randhawa, Gao Liu, Faisal Malik, Misty Vest, Joseph D Abad, Christopher C Kemball, PhD, René Hubert, PhD, Sher Karki, PhD, Banmeet Anand, PhD, Zili An, MD, Jeanette Grant, PhD, John E. Dick, PhD, Fernando Doñate, PhD, Kendall Morrison, PhD, Pia Challita-Eid, PhD, Ingrid B Joseph, DVM, PhD, Daniel S. Pereira, PhD, David R. Stover, PhD
Journal: Blood
Blood (2015) 126 (23): 3806.
https://doi.org/10.1182/blood.V126.23.3806.3806
Published: 2015
Journal Articles

Engraftment Patterns in NOD. SCID Mice Predict Outcome in Human AML

James A. Kennedy, MDPhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Liqing Jin, MD, Stanley Wai-Kwong Ng, BASc, Liran I. Shlush, MDPhD, Sasan Zandi, MDPhD, Jessica McLeod, BSc, Andreea C. Popescu, BSc, Nathan Mbong, BSc, Andrea Arruda, MSc, Mark D Minden, MDPhD, John E. Dick, PhD, Jean C.Y. Wang, MDPhD
Journal: Blood
Blood (2014) 124 (21): 16.
https://doi.org/10.1182/blood.V124.21.16.16
Published: 2014
Journal Articles

Blockade Of CD47 Using SIRPαFc: Role Of The Fc Region In Anti-Leukemic Activity and Tolerability

Robert A. Uger, PhD, Xinli Pang, MD, PhD, Mark Wong, PhD, Violetta House, Karen Dodge, Stephane Viau, Noel T. Vigo, Debbie Tam, Tran Truong, Liqing Jin, MD, Andrei V. Malko, Jenny Ho, MD, Tatiana K. Prasolava, PhD, Jayne S. Danska, PhD, Jean C.Y. Wang, MD PhD, Penka S. Petrova, PhD
Journal: Blood
Blood (2013) 122 (21): 3935.
https://doi.org/10.1182/blood.V122.21.3935.3935
Published: 2013
Journal Articles

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Tino Schenk, PhD, Stefanie Göllner, PhD, Weihsu Claire Chen, PhD, Louise Howell, BSc, Liqing Jin, MD, Katja Hebestreit, Hans-Ulrich Klein, PhD, Alan K Burnett, MD, Ken I. Mills, PhD, FRCPath, Laurence Marton, MD, Robert Casero, Jr., PhD, Patrick Woster, PhD, Martin Dugas, MD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Carsten Müller-Tidow, MD, Kevin Petrie, PhD, Arthur Zelent, PhD
Journal: Blood
Blood (2011) 118 (21): 224.
https://doi.org/10.1182/blood.V118.21.224.224
Published: 2011
Journal Articles

Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRPα

Alexandre P.A. Theocharides, MD, Liqing Jin, MD, Po-Yan Cheng, Armando G. Poeppl, Tatiana K. Prasolava, PhD, Mark D. Minden, MD, PhD, John E. Dick, PhD, Jayne S. Danska, PhD, Jean C.Y. Wang, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 499.
https://doi.org/10.1182/blood.V116.21.499.499
Published: 2010
Journal Articles

CD47-Sirpα Interaction Modulates Homing and Engraftment of Human Acute Myeloid Leukemia Stem Cells in Mice.

Alexandre PA Theocharides, MD, Liqing Jin, MD, Armando G Poeppl, Tatiana K Prasolava, PhD, Olga I Gan, PhD, Mark D Minden, MD, PhD, Jayne S Danska, PhD, John E Dick, PhD, Jean CY Wang, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 476.
https://doi.org/10.1182/blood.V114.22.476.476
Published: 2009
Journal Articles

CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells.

Richard B. Lock, PhD, Liqing Jin, PhD, Erwin M. Lee, PhD, Hayley S. Ramshaw, PhD, Sam Busfield, PhD, Armando G. Peoppl, BSc, Lucy Wilkinson, BSc, Mark A. Guthridge, PhD, Andrew Boyd, PhD, David Gearing, PhD, Gino Vairo, PhD, Angel Lopez, MD, PhD, John E. Dick, PhD
Journal: Blood
Blood (2007) 110 (11): 161.
https://doi.org/10.1182/blood.V110.11.161.161
Published: 2007
Journal Articles

Radiotherapy Post Autologous Stem Cell Transplantation in Patients with Lymphoma Not Reached Complete Response.

Naibai Chang, Xichun Gu, Ling Zhu, Jianping Wei, Shengming Zhao, Liqing Jin
Journal: Blood
Blood (2005) 106 (11): 5473.
https://doi.org/10.1182/blood.V106.11.5473.5473
Published: 2005