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Antonia Lopez-Girona
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Journal Articles

BMS-986458 a Potential First-in-Class, Highly Selective, Potent and Well Tolerated BCL6 Ligand Directed Degrader (LDD) Demonstrates Multi-Modal Anti-Tumor Efficacy for the Treatment of B-Cell Non-Hodgkin's Lymphoma

Lynda Groocock, Gauri Deb, Jinyi Zhu, Jim Gamez, Paola Castiglioni, Manuel Sanchez-Castillo, Justin Schumacher, Alicia Benitez Rondan, Diana Jankeel, Karla Martinez-Garcia, Scott Wood, Andy Christoforou, Carla Guarinos, Wei Zhang, Rama Krishna Narla, Christoph W. Zapf, Soraya Carrancio, Daniel W. Pierce, Mark Rolfe, Neil Bence, Antonia Lopez-Girona, Deborah S. Mortensen
Journal: Blood
Blood (2024) 144 (Supplement 1): 957.
https://doi.org/10.1182/blood-2024-210951
Published: 2024
Journal Articles

Multi-Omics Integration to Elucidate the Cis-Regulatory Network Re-Wiring upon NSD2 Degradation in t(4;14) Multiple Myeloma

Bo Hu, Hardik Modi, Diana Jankeel, Jacob T. Edwards, Junfei Zhao, Chad C. Bjorklund, Gaurav Jain, Patrick R. Hagner, Maria Ortiz, Zhongying Mo, Celia Fontanillo, Christoph W. Zapf, Antonia Lopez-Girona, Neil Bence, Kai Wang, Anita K. Gandhi, Mark Rolfe, Deborah S. Mortensen, Lynda Groocock
Journal: Blood
Blood (2024) 144 (Supplement 1): 1881.
https://doi.org/10.1182/blood-2024-203621
Published: 2024
Journal Articles

Development of a ZBTB7A and Wiz Dual Degrading, HbF-Activating CELMoD™ for the Treatment of Sickle Cell Disease

Emily Rychak, Goldie Yuan Lam Lui, Cristhian Fimbres, Christine Kim Kang, Younguk Sun, Sophie Peng, Jingjing Deng, Sarah Franc, Eugene Ciccimaro, Kimberly Peacock, Minerva Tran, Andy Christoforou, Jinyi Zhu, Geraldine Polido, Barbra Pagarigan, Scott Johnson, Faye Wang, Paula Katavolos, Bonny Gaffney, Estela Garcia, France Landry, Fletcher Paddison, Petia Shipkova, Hannah Powers, Giorgio Tamò, August Dietrich, Soraya Carrancio, Radha Ramakrishnan, Karen Augustine, Rama Krishna Narla, Thomas Cummins, Mark Rolfe, Neil Bence, Antonia Lopez-Girona
Journal: Blood
Blood (2024) 144 (Supplement 1): 169.
https://doi.org/10.1182/blood-2024-203653
Published: 2024
Journal Articles

Mezigdomide (CC-92480), a Novel Cereblon E3 Ligase Modulator, Induces Vulnerability of Multiple Myeloma Cells to T-Cell-Mediated Killing

Bonny Gaffney, Yu Shi, Petrus de Jong, Manuel Sanchez, Celia Fontanillo, Antonia Lopez-Girona, Isaac W. Boss, Antonina Kurtova, Soraya Carrancio, Lilly Wong, Daniel W. Pierce
Journal: Blood
Blood (2022) 140 (Supplement 1): 7108–7109.
https://doi.org/10.1182/blood-2022-157939
Published: 2022
Journal Articles

Elucidating the Molecular Mechanisms of Action of CC-99282, a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent, Via Genome-Wide CRISPR Screen in a Preclinical Model of Non-Hodgkin Lymphoma (NHL)

Zhongying Mo, Lynda Groocock, Scott Wood, Diana Jankeel, Preethi Janardhanan, Derek Mendy, Michael Angelo, In Sock Jang, Celia Fontanillo, Kai Wang, Mark Rolfe, Antonia Lopez-Girona
Journal: Blood
Blood (2022) 140 (Supplement 1): 8860–8861.
https://doi.org/10.1182/blood-2022-159393
Published: 2022
Journal Articles

CC-99282 is a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent with Enhanced Tumoricidal Activity in Preclinical Models of Lymphoma

Soraya Carrancio, Lynda Groocock, Preethi Janardhanan, Diana Jankeel, Ryan Galasso, Carla Guarinos, Rama K. Narla, Matthew Groza, Jim Leisten, Daniel W. Pierce, Mark Rolfe, Antonia Lopez-Girona
Journal: Blood
Blood (2021) 138 (Supplement 1): 1200.
https://doi.org/10.1182/blood-2021-148068
Published: 2021
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy

Nikolaos Ioannou, Patrick R. Hagner, Matt Stokes, Anita K. Gandhi, Benedetta Apollonio, Mariam Fanous, Despoina Papazoglou, Lesley-Ann Sutton, Richard Rosenquist, Rose-Marie Amini, Hsiling Chiu, Antonia Lopez-Girona, Preethi Janardhanan, Farrukh T. Awan, Jeffrey Jones, Neil E. Kay, Tait D. Shanafelt, Martin S. Tallman, Kostas Stamatopoulos, Piers E. M. Patten, Anna Vardi, Alan G. Ramsay
Journal: Blood
Blood (2021) 137 (2): 216–231.
https://doi.org/10.1182/blood.2020006073
Published: 2021
Includes: Supplemental data
Journal Articles

CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)

Antonia Lopez-Girona, Gang Lu, Emily Rychak, Derek Mendy, Chin-Chun Lu, Irit Rappley, Celia Fontanillo, Brian E. Cathers, Thomas O. Daniel, Joshua Hansen
Journal: Blood
Blood (2019) 134 (Supplement_1): 2703.
https://doi.org/10.1182/blood-2019-127892
Published: 2019
Journal Articles

CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Antonia Lopez-Girona, Courtney G. Havens, Gang Lu, Emily Rychak, Derek Mendy, Bonny Gaffney, Christine Surka, Chin-Chun Lu, Mary Matyskiela, Gody Khambatta, Lilly Wong, Joshua Hansen, Daniel W. Pierce, Brian E. Cathers, James Carmichael
Journal: Blood
Blood (2019) 134 (Supplement_1): 1812.
https://doi.org/10.1182/blood-2019-124338
Published: 2019
Journal Articles

CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

Lilly Wong, Rama Krishna Narla, Jim Leisten, Daniel Bauer, Matthew Groza, Bonny Gaffney, Courtney G. Havens, Justin Choi, Jack Houston, Antonia Lopez-Girona, Joshua Hansen, Brian E. Cathers, James Carmichael, Daniel W. Pierce
Journal: Blood
Blood (2019) 134 (Supplement_1): 1815.
https://doi.org/10.1182/blood-2019-124345
Published: 2019
Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Journal: Blood
Blood (2015) 126 (6): 779–789.
https://doi.org/10.1182/blood-2015-02-628669
Published: 2015
Includes: Supplemental data
Journal Articles

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs ® Immunomodulatory Compounds

Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Patrick R Hagner, PhD, Anita K. Gandhi, PhD, Maria Wang, PhD, Michael D Amatangelo, PhD, Ling Lu, BS, Huisheng Wang, MS, Mike Breider, DVM, PhD DACVP, Yan Ren, MS, Antonia Lopez-Girona, PhD, Anjan Thakurta, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4700.
https://doi.org/10.1182/blood.V124.21.4700.4700
Published: 2014
Journal Articles

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Courtney G. Havens, PhD, Chad Bjorklund, PhD, Jian Kang, BS, Maria Ortiz, PhD, Celia Fontanillo, PhD, Michael Amatangelo, PhD, Ling Lu, BS, Paola E. Neri, MD PhD, Antonia Lopez-Girona, PhD, Nizar J. Bahlis, MD, Anjan Thakurta, PhD, Mathew Trotter, MD, Anita K. Gandhi, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3432.
https://doi.org/10.1182/blood.V124.21.3432.3432
Published: 2014
Journal Articles

Dual-Color CRBN/CD138 Immunohistochemistry Assay for Measuring Cereblon Protein in Samples from Patients with Multiple Myeloma

Yan Ren, MS, Maria Wang, PhD, Suzanne Couta, DVM, PhD DACVP, Donna Hansel, MD, Karen Miller, BS, Antonia Lopez-Girona, PhD, Chad C Bjorklund, PhD, Anita K. Gandhi, PhD, Anjan Thakurta, PhD, Rajesh Chopra, MD PhD, Michael Breider, DVM, PhD DACVP
Journal: Blood
Blood (2014) 124 (21): 6021.
https://doi.org/10.1182/blood.V124.21.6021.6021
Published: 2014
Journal Articles

Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21 WAF1/Cip1 -dependent mechanism independent of functional p53

Jessie-F. Fecteau, Laura G. Corral, Emanuela M. Ghia, Svetlana Gaidarova, Diahnn Futalan, Ila Sri Bharati, Brian Cathers, Maria Schwaederlé, Bing Cui, Antonia Lopez-Girona, Davorka Messmer, Thomas J. Kipps
Journal: Blood
Blood (2014) 124 (10): 1637–1644.
https://doi.org/10.1182/blood-2014-03-559591
Published: 2014
Includes: Supplemental data
Journal Articles

The Novel mTOR Kinase Inhibitor CC-223 Demonstrates Significant Activity In In Vitro Models Of Multiple Myeloma (MM), Both As a Single Agent and In Combination With The Approved Agents, Dexamethasone, Lenalidomide and Pomalidomide

Emily Rychak, Ph.D., Derek Mendy, B.S., Karen Miller, B.S., Jim Leisten, B.S., Rama Krishna Narla, Ph.D., Heather K Raymon, Ph.D., Rajesh Chopra, M.D., Ph.D., Antonia Lopez-Girona, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 3160.
https://doi.org/10.1182/blood.V122.21.3160.3160
Published: 2013
Journal Articles

Lenalidomide Inhibits Proliferation Of Chronic Lymphocytic Leukemia Cells Via a Cereblon/p21 WAF1/Cip1 -Dependent Mechanism

Jessie-Farah Fecteau, Ph.D., Laura G Corral, Diahnn Futalan, Svetlana Gaidarova, MS, Ila Bharati, BS, Brian Cathers, PhD, Emanuela M. Ghia, PhD, Maria Schwaederlé, PharmaD, Antonia Lopez-Girona, Ph.D., Davorka Messmer, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4139.
https://doi.org/10.1182/blood.V122.21.4139.4139
Published: 2013
Journal Articles

Absence Of Mutation In Cereblon (CRBN) and DNA Damage Binding Protein 1 (DDB1) Genes In Myeloma Cells and Patients and Its Clinical Significance

Anjan Thakurta, PhD, Anita K Gandhi, PhD, Michelle Waldman, MS, Chad C. Bjorklund, Ph.D., Suzanne Lentzsch, MD, PhD, Stephen A Schey, MD, Yolanda Calle, PhD, Rajani Chelliah, BSc, MSc, Robert Z. Orlowski, M.D., Ph.D, Anup Madan, PhD, Yuhong Ning, Derek Mendy, B.S., Antonia Lopez-Girona, PhD, Peter H Schafer, PhD, Herve Avet-Loiseau, MD, Rajesh Chopra, MD
Journal: Blood
Blood (2013) 122 (21): 3139.
https://doi.org/10.1182/blood.V122.21.3139.3139
Published: 2013
Journal Articles

CC-122 Is a Novel Pleiotropic Pathway Modifier with Potent in Vitro Immunomodulatory and Anti-Angiogenic Properties and in Vivo Anti-Tumor Activity in Hematological Cancers.

Anita K Gandhi, PhD, Derek Mendy, BS, Anastasia Parton, BA, Lei Wu, MS, ECFMG, Jolanta Kosek, BA, Ling-Hua Zhang, PhD, Lori Capone, BS, Antonia Lopez-Girona, PhD, Peter H Schafer, PhD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2963.
https://doi.org/10.1182/blood.V120.21.2963.2963
Published: 2012