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Journal Articles

RRMM and Post-BCMA Treated Subjects from the CC-220-MM-001 Study Show Increased Genomic Aberrations Associated with High-Risk and Significant Dysfunction in CD4+ T-Cell Compartment Compared to NDMM Subjects

Michael Amatangelo, Erin Flynt, Nicholas Stong, Maria Ortiz, Pradipta Ray, Maria Wang, Niels W.C.J. van de Donk, Sagar Lonial, Aparna Raval, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4665.
https://doi.org/10.1182/blood-2023-178912
Published: 2023
Journal Articles

BAY 94-9027 Provides Safe and Effective Long-Term Prophylaxis in Pediatric Patients: Results from the PROTECT VIII Kids Extension Study

Sanjay Ahuja, MD, Kathelijn Fischer, Tina Biss, Monika Maas Enriquez, Maria-Elisa Mancuso, MacGregor Steele, MD FRCPC, Maria Wang, Gili Kenet
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-140303
Published: 2020
Journal Articles

Leveraging gene expression subgroups to classify DLBCL patients and select for clinical benefit from a novel agent

Alberto Risueño, Patrick R. Hagner, Fadi Towfic, Celia Fontanillo, Amira Djebbari, Joel S. Parker, Clifton P. Drew, Grzegorz S. Nowakowski, Matthew J. Maurer, James R. Cerhan, Xin Wei, Yan Ren, Chung-Wein Lee, Suzana Couto, Maria Wang, Michael Pourdehnad, Anita K. Gandhi, Matthew W. B. Trotter
Journal: Blood
Blood (2020) 135 (13): 1008–1018.
https://doi.org/10.1182/blood.2019002414
Published: 2020
Includes: Supplemental data
Journal Articles

Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier

Clinical Trials & Observations
Cecilia Carpio, Reda Bouabdallah, Loïc Ysebaert, Juan-Manuel Sancho, Gilles Salles, Raul Cordoba, Antonio Pinto, Mecide Gharibo, Drew Rasco, Carlos Panizo, Jose A. Lopez-Martin, Armando Santoro, Antonio Salar, Silvia Damian, Alejandro Martin, Gregor Verhoef, Eric Van den Neste, Maria Wang, Suzana Couto, Soraya Carrancio, Andrew Weng, Xuehai Wang, Frank Schmitz, Xin Wei, Kristen Hege, Matthew W. B. Trotter, Alberto Risueño, Tonia J. Buchholz, Patrick R. Hagner, Anita K. Gandhi, Michael Pourdehnad, Vincent Ribrag
Journal: Blood
Blood (2020) 135 (13): 996–1007.
https://doi.org/10.1182/blood.2019002395
Published: 2020
Includes: Supplemental data
Journal Articles

Prognostic Molecular Stratification in Relapsed/Refractory Multiple Myeloma - Results of the Pomalidomide Mukseven (NCT02406222) Biomarker Trial

James Croft, MBBS, BSc, Andrew Hall, Amy L Sherborne, PhD, Katrina Walker, Sidra Ellis, Kim Sharp, Amy Price, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Louise Flanagan, PhD, Mamta Garg, MD FRCP, FRCPath, Suzana Couto, Maria Wang, Kevin Boyd, MB BS, BSc, MRCP, FRCPath, PhD, William E Pierceall, PhD, Anjan Thakurta, Gordon Cook, Sarah R Brown, PhD MSc, BSc, Martin F. Kaiser
Journal: Blood
Blood (2019) 134 (Supplement_1): 4327.
https://doi.org/10.1182/blood-2019-123640
Published: 2019
Journal Articles

Profiling the Immune Tumor Microenvironment of Newly Diagnosed Diffuse Large B Cell Lymphoma Identifies Three Major Immune Infiltration Patterns

C. Chris Huang, PhD, Yumi Nakayama, PhD, Matthew Stokes, PhD, Fadi Towfic, PhD, chung-Wein Lee, Yan Ren, Mathieu Marella, PhD, Maria Wang, Patrick R. Hagner, PhD, Suzana Couto, Kathryn Newhall, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 2797.
https://doi.org/10.1182/blood-2019-123691
Published: 2019
Journal Articles

Higher Expression of Nuclear Cereblon in Bone Marrow Biopsies of Patients with Multiple Myeloma Treated with Imids in the HOVON-87/Nmsg-18 Trial Is Associated with Longer PFS and OS

Ruth Wester, M Duin, King Hong Lam, MD PhD, Suzana Couto, Yan Ren, Maria Wang, Bronno Van Der Holt, PhD, Berna Berna Beverloo, PhD, Heleen Visser-Wisselaar, Alex Nigg, Anjan Thakurta, Sonja Zweegman, Annemiek Broyl, MD PhD, Pieter Sonneveld
Journal: Blood
Blood (2019) 134 (Supplement_1): 3071.
https://doi.org/10.1182/blood-2019-128584
Published: 2019
Journal Articles

Translational and Clinical Evidence of a Differentiated Profile for the Novel CELMoD, Iberdomide (CC-220)

Sagar Lonial, Michael Amatangelo, Rakesh Popat, Monique C. Minnema, Jeffrey A. Zonder, Jeremy Larsen, Albert Oriol Rocafiguera, Erica L. Campagnaro, MD, Paula Rodriguez Otero, Ashraf Z. Badros, David S. Siegel, Sundar Jagannath, Sara Bringhen, Mercedes Gironella, Martin F. Kaiser, Gordon Cook, Barbara Gamberi, Pieter Sonneveld, Tuong Vi Nguyen, Min S. Chen, Trevor Homan, Chad C. Bjorklund, Maria Wang, William E. Pierceall, Amine Bensmaine, Anjan Thakurta, Teresa Peluso, Niels W. C. J. Van De Donk
Journal: Blood
Blood (2019) 134 (Supplement_1): 3119.
https://doi.org/10.1182/blood-2019-124298
Published: 2019
Journal Articles

Higher Expression of Nuclear Cereblon in Bone Marrow Biopsies of Patients with Multiple Myeloma Included in the HOVON-87/Nmsg-18 Trial May be Associated with Longer PFS and OS

Ruth Wester, King Hong Lam, MD PhD, Mark van Duin, PhD, Suzana Couto, Yan Ren, Maria Wang, PhD, Bronno van der Holt, Berna Beverloo, PhD, Heleen Visser-Wisselaar, Alex Nigg, Max Qian, Anjan Thakurta, PhD, Annemiek Broyl, MD PhD, Sonja Zweegman, MD PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3052.
https://doi.org/10.1182/blood.V130.Suppl_1.3052.3052
Published: 2017
Journal Articles

Roar: A Phase Ib Trial of Oral Azacitidine (CC-486) in Combination with Lenalidomide and Dexamethasone (Rd) for Patients with Relapsed and/or Refractory (R/R) Multiple Myeloma Who Have Failed a Prior Lenalidomide-Containing Regimen

Anna Kalff, MBBS, FRACP, FRCPA, Kate Reed, Tiffany T. Khong, PhD, Sridurga Mithraprabhu, PhD, Malarmathy Ramachandran, John Reynolds, Krystal Bergin, Anjan Thakurta, PhD, Maria Wang, PhD, Andrew Spencer, Roberto Guzman, Suzana Cuoto, Yan Ren, MD
Journal: Blood
Blood (2016) 128 (22): 2121.
https://doi.org/10.1182/blood.V128.22.2121.2121
Published: 2016
Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Journal: Blood
Blood (2015) 126 (6): 779–789.
https://doi.org/10.1182/blood-2015-02-628669
Published: 2015
Includes: Supplemental data
Journal Articles

Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets

Kartik Sehgal, Rituparna Das, Lin Zhang, Rakesh Verma, Yanhong Deng, Mehmet Kocoglu, Juan Vasquez, Srinivas Koduru, Yan Ren, Maria Wang, Suzana Couto, Mike Breider, Donna Hansel, Stuart Seropian, Dennis Cooper, Anjan Thakurta, Xiaopan Yao, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Journal: Blood
Blood (2015) 125 (26): 4042–4051.
https://doi.org/10.1182/blood-2014-11-611426
Published: 2015
Includes: Supplemental data
Journal Articles

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Patrick Hagner, PhD, Maria Wang, PhD, Suzana Couto, PhD, Mike Breider, DVM, PhD DACVP, Celia Fontanillo, PhD, Matthew Trotter, PhD, Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Heather K Raymon, PhD, Rama Krishna Narla, PhD, Leo Barnes, PhD, Michelle Waldman, MS, Tom Daniel, MD, Anke Klippel, PhD, Michael Pourdehnad, MD, Anjan Thakurta, PhD, Rajesh Chopra, MD, PhD, Anita K. Gandhi, PhD
Journal: Blood
Blood (2014) 124 (21): 3035.
https://doi.org/10.1182/blood.V124.21.3035.3035
Published: 2014
Journal Articles

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs ® Immunomodulatory Compounds

Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Patrick R Hagner, PhD, Anita K. Gandhi, PhD, Maria Wang, PhD, Michael D Amatangelo, PhD, Ling Lu, BS, Huisheng Wang, MS, Mike Breider, DVM, PhD DACVP, Yan Ren, MS, Antonia Lopez-Girona, PhD, Anjan Thakurta, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4700.
https://doi.org/10.1182/blood.V124.21.4700.4700
Published: 2014
Journal Articles

Dual-Color CRBN/CD138 Immunohistochemistry Assay for Measuring Cereblon Protein in Samples from Patients with Multiple Myeloma

Yan Ren, MS, Maria Wang, PhD, Suzanne Couta, DVM, PhD DACVP, Donna Hansel, MD, Karen Miller, BS, Antonia Lopez-Girona, PhD, Chad C Bjorklund, PhD, Anita K. Gandhi, PhD, Anjan Thakurta, PhD, Rajesh Chopra, MD PhD, Michael Breider, DVM, PhD DACVP
Journal: Blood
Blood (2014) 124 (21): 6021.
https://doi.org/10.1182/blood.V124.21.6021.6021
Published: 2014
Journal Articles

Bleeding Phenotype with Various Bay 94-9027 Dosing Regimens: Subanalyses from the Protect VIII Study

Lisa N. Boggio, Walter Hong, Maria Wang, M. Elaine Eyster, MD, Lisa A. Michaels
Journal: Blood
Blood (2014) 124 (21): 1526.
https://doi.org/10.1182/blood.V124.21.1526.1526
Published: 2014
Journal Articles

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy

Hua-Xin Gao, Ph.D., Shawn Anderson, Cigall Kadoch, Ph.D., Mekhala Maiti, Ph.D., Lingjing Chen, Ph.D., Dong-Han Yao, Gerd Melkus, Ph.D., Maria Wang, Ph.D., Yan Ren, Ph.D., Michael Breider, Ph.D., Carla Heise, PhD, Clifford A. Lowell, MD, PhD, Colin Collins, Ph.D., James L. Rubenstein, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 374.
https://doi.org/10.1182/blood.V122.21.374.374
Published: 2013
Journal Articles

Lenalidomide Efficacy in Activated B-Cell-Like Subtype Diffuse Large B-Cell Lymphoma Is Dependent Upon IRF4 and Cereblon Expression

Ling-Hua Zhang, PhD, Jolanta Kosek, BA, Maria Wang, Ph.D., Carla Heise, PhD, Peter H Schafer, PhD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3287.
https://doi.org/10.1182/blood.V120.21.3287.3287
Published: 2012
Journal Articles

Reduction in Initial Length of Stay with Rivaroxaban Single-Drug Regimen versus LMWH-VKA Standard of Care: Findings from the EINSTEIN Trial Program

Bonno van Bellen, MD, Martin Prins, MD, PhD, Luke Bamber, Maria Wang, Anthonie WA Lensing
Journal: Blood
Blood (2012) 120 (21): 3419.
https://doi.org/10.1182/blood.V120.21.3419.3419
Published: 2012
Journal Articles

Patient-Reported Treatment Satisfaction with Oral Rivaroxaban Versus Standard Therapy in the Treatment of Acute Symptomatic Pulmonary Embolism

Martin Prins, MD, PhD, Luke Bamber, Stefan Cano, Maria Wang, Anthonie WA Lensing, Rupert Bauersachs
Journal: Blood
Blood (2012) 120 (21): 1163.
https://doi.org/10.1182/blood.V120.21.1163.1163
Published: 2012