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Journal Articles

BMS-986397, a First-in-Class Molecular Glue Degrader of Casein Kinase 1α (CK1α) for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS) Harboring Functional TP53

Carmen Jimenez, Sophie Peng, Rama Krishna Narla, Joshua Baughman, Scott Wood, Jean Lu, Noelia Purroy, Gina Yanochko, Mark Nagy, Gang Lu, Mark Rolfe, Daniel W. Pierce, Soraya Carrancio
Journal: Blood
Blood (2024) 144 (Supplement 1): 4142.
https://doi.org/10.1182/blood-2024-209924
Published: 2024
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Antonia Lopez-Girona, Courtney G. Havens, Gang Lu, Emily Rychak, Derek Mendy, Bonny Gaffney, Christine Surka, Chin-Chun Lu, Mary Matyskiela, Gody Khambatta, Lilly Wong, Joshua Hansen, Daniel W. Pierce, Brian E. Cathers, James Carmichael
Journal: Blood
Blood (2019) 134 (Supplement_1): 1812.
https://doi.org/10.1182/blood-2019-124338
Published: 2019
Journal Articles

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Gang Lu, Christine Surka, Chin-Chun Lu, In Sock Jang, PhD, Kai Wang, PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 405.
https://doi.org/10.1182/blood-2019-125492
Published: 2019
Journal Articles

CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)

Antonia Lopez-Girona, Gang Lu, Emily Rychak, Derek Mendy, Chin-Chun Lu, Irit Rappley, Celia Fontanillo, Brian E. Cathers, Thomas O. Daniel, Joshua Hansen
Journal: Blood
Blood (2019) 134 (Supplement_1): 2703.
https://doi.org/10.1182/blood-2019-127892
Published: 2019
Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Journal: Blood
Blood (2015) 126 (6): 779–789.
https://doi.org/10.1182/blood-2015-02-628669
Published: 2015
Includes: Supplemental data
Journal Articles

Genome-Wide Abnormality Patterns of B-Lineage Acute Lymphoblastic Leukemia in Adults in Comparison with Pediatric Cases

Bai-Yan Wang, MD, PhD, Yuan-Fang Liu, MD, PhD, Jing-Yan Tang, MD, Zhao-Hui Gu, PhD, Wei-Na Zhang, MD, Zi-Guan Zhang, B.S., Qiang Wang, MD, Bing Chen, MD, PhD, Sheng-Yue Wang, PhD, Yong-Mei Zhu, M.S., Jun-Min Li, MD, PhD, Jin Wang, Yun Bai, PhD, Gang Lu, M.S., Min-Jun Yang, PhD, Jin-Li Zhang, M.S., Jing-Yi Shi, PhD, Kan-Kan Wang, PhD, Chun-Ming Pan, M.S., Jing Lu, B.S., Lu Jiang, PhD, Yang Li, MD, Chun-Jun Zhao, B.S., Jing Chen, MD, PhD, Long-Jun Gu, MD, Jian-Qing Mi, MD, PhD, Ben-Shang Li, MD, PhD, Zhu Chen, MD, PhD, Sai-Juan Chen, MD, PhD
Journal: Blood
Blood (2014) 124 (21): 3786.
https://doi.org/10.1182/blood.V124.21.3786.3786
Published: 2014
Journal Articles

Disruption of the Ikaros-Mediated Gene Expression Program in Multiple Myeloma with Immunomodulatory Agents

Christopher J. Ott, Gang Lu, Jaime Reyes, Charles Y. Lin, William G. Kaelin, MD, James E. Bradner
Journal: Blood
Blood (2014) 124 (21): 420.
https://doi.org/10.1182/blood.V124.21.420.420
Published: 2014