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Journal Articles

BCMA Mutational Screening Reveals Differential Cytotoxic Activity between T-Cell Engagers in Preclinical Co-Culture Models

Vinidhra Sridharan, Hsiling Chiu, Shirong Li, Chad C. Bjorklund, Anita K. Gandhi, Patrick R. Hagner
Journal: Blood
Blood (2024) 144 (Supplement 1): 4650.
https://doi.org/10.1182/blood-2024-211024
Published: 2024
Journal Articles

Mezigdomide Reverses T-Cell Exhaustion through Degradation of Aiolos/Ikaros and Reinvigoration of Cytokine Production Pathways

Hsiling Chiu, Junfei Zhao, Maria Ortiz Estevez, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 335.
https://doi.org/10.1182/blood-2023-189445
Published: 2023
Journal Articles

Investigation of the Synergistic Combination of a Novel Celmod (CC-99282) and BET Inhibitors in Preclinical DLBCL

Chih-Chao Hsu, Hsiling Chiu, Chad C. Bjorklund, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 5719.
https://doi.org/10.1182/blood-2023-189191
Published: 2023
Journal Articles

CC-92480 Enhances Cell-Autonomous Cytotoxicity through Blockade of G 2 /M Transition When Combined with Bortezomib/Dexamethasone in Pre-Clinical Multiple Myeloma

Chad C Bjorklund, Michael Amatangelo, Jian Kang, Hsiling Chiu, Archana Mukhopadhyay, Krista Wollerman, Michael Pourdehnad, Patrick Hagner, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 2669.
https://doi.org/10.1182/blood-2021-153907
Published: 2021
Journal Articles

Differential Effects of Iberdomide Versus Revlimid on Leukocyte Trafficking, Immune Activation and DLBCL Tumor Cell Killing

Yumi Nakayama, Hsiling Chiu, Rama K. Narla, Arvind Shakya, Jim Gamez, Isobelle Wall, Despoina Papazoglou, Benedetta Apollonio, Alan G. Ramsay, Patrick Hagner, Anita K Gandhi
Journal: Blood
Blood (2021) 138 (Supplement 1): 718.
https://doi.org/10.1182/blood-2021-153063
Published: 2021
Journal Articles

Pre-Clinical and Clinical Immunomodulatory Effects of Pomalidomide or CC-92480 in Combination with Bortezomib in Multiple Myeloma

Chad C Bjorklund, Michael Amatangelo, Hsiling Chiu, Jian Kang, Tiziana Civardi, Jessica Katz, Paulo Maciag, Patrick Hagner, Michael Pourdehnad, Nizar J. Bahlis, Paul G. Richardson, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 1613.
https://doi.org/10.1182/blood-2021-153994
Published: 2021
Journal Articles

Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy

Nikolaos Ioannou, Patrick R. Hagner, Matt Stokes, Anita K. Gandhi, Benedetta Apollonio, Mariam Fanous, Despoina Papazoglou, Lesley-Ann Sutton, Richard Rosenquist, Rose-Marie Amini, Hsiling Chiu, Antonia Lopez-Girona, Preethi Janardhanan, Farrukh T. Awan, Jeffrey Jones, Neil E. Kay, Tait D. Shanafelt, Martin S. Tallman, Kostas Stamatopoulos, Piers E. M. Patten, Anna Vardi, Alan G. Ramsay
Journal: Blood
Blood (2021) 137 (2): 216–231.
https://doi.org/10.1182/blood.2020006073
Published: 2021
Includes: Supplemental data
Journal Articles

Interactome of Aiolos/Ikaros in Diffuse Large B-Cell Lymphoma (DLBCL) Reveals Novel Combination of Cereblon Modulators (CELMoD) and Histone Deacetylase (HDAC) Inhibitors

Patrick R. Hagner, PhD, Hsiling Chiu, MS, Vivek S. Chopra, PhD, Martino S. Colombo, PhD, Nisha Patel, PhD, Maria Ortiz, Remco S. Loos, PhD, Fadi Towfic, PhD, Michelle Waldman, MS, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 306.
https://doi.org/10.1182/blood-2019-126681
Published: 2019
Journal Articles

Combination of Lenalidomide and Rituximab (R 2 ) Targets Immune Dysfunction in FL By Activating T and NK Cells Ex Vivo and Is Differentiated from Chemotherapy

Hsiling Chiu, Patrick R. Hagner, PhD, Preeti Trisal, Michelle Waldman, Chloe Cavanaugh, Anita K. Gandhi, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1531.
https://doi.org/10.1182/blood.V130.Suppl_1.1531.1531
Published: 2017
Journal Articles

CC-122 Exhibits Greater Preclinical Activity in Mantle Cell Lymphoma Than Lenalidomide through a Combination of Direct Cell-Autonomous and Increased Antibody Dependent Cell-Mediated Cytotoxicity

Patrick R. Hagner, Hsiling Chiu, Michelle F. Waldman, Anke Klippel, PhD, Michael Pourdehnad, Anita K. Gandhi, PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2016) 128 (22): 4188.
https://doi.org/10.1182/blood.V128.22.4188.4188
Published: 2016
Journal Articles

CC-220 Is a Potent Cereblon Modulating Agent That Displays Anti-Proliferative, Pro-Apoptotic and Immunomodulatory Activity on Sensitive and Resistant Multiple Myeloma Cell Lines

Chad C Bjorklund, PhD, Jian Kang, Ling Lu, Michael Amatangelo, PhD, Hsiling Chiu, Anita K. Gandhi, PhD, Michael Pourdehnad, MD, Anke Klippel, PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2016) 128 (22): 1591.
https://doi.org/10.1182/blood.V128.22.1591.1591
Published: 2016
Journal Articles

CC-122 Is a Cereblon Modulating Agent That Is Active in Lenalidomide-Resistant and Lenalidomide/Dexamethasone-Double-Resistant Multiple Myeloma Pre-Clinical Models

Chad C Bjorklund, PhD, Jian Kang, Ling Lu, Michael Amatangelo, PhD, Hsiling Chiu, Patrick Hagner, PhD, Anita K. Gandhi, PhD, Michael Pourdehnad, MD, Anke Klippel, PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2016) 128 (22): 1592.
https://doi.org/10.1182/blood.V128.22.1592.1592
Published: 2016
Journal Articles

CC-122 Exhibits Potent Anti-Lymphoma Activity in Combination with Obinutuzumab through Cell Autonomous and Antibody Dependent Cell Mediated Cytotoxicity

Hsiling Chiu, Patrick Hagner, PhD, Michael Pourdehnad, MD, Thomas Daniel, Rajesh Chopra, Anke Klippel, Christian Klein, PhD, Anjan Thakurta, Anita K. Gandhi, PhD
Journal: Blood
Blood (2015) 126 (23): 4007.
https://doi.org/10.1182/blood.V126.23.4007.4007
Published: 2015
Journal Articles

Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity

Patrick Hagner, PhD, Hsiling Chiu, Maria Ortiz-Estevez, Tsvetan Biyukov, Carrie Brachman, Marek Trneny, Luca Arcaini, Franck Morschhauser, MD, Antoine Thyss, Stephan Stilgenbauer, Noel Milpied, Reinhard Marks, Pellegrino Musto, Giovanni Martinelli, MD PhD, Carla Heise, Thomas Daniel, Rajesh Chopra, James Carmichael, Matthew Trotter, Anita K. Gandhi, PhD, Anjan Thakurta
Journal: Blood
Blood (2015) 126 (23): 821.
https://doi.org/10.1182/blood.V126.23.821.821
Published: 2015
Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Journal: Blood
Blood (2015) 126 (6): 779–789.
https://doi.org/10.1182/blood-2015-02-628669
Published: 2015
Includes: Supplemental data