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Celia Fontanillo
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Journal Articles

Multi-Omics Integration to Elucidate the Cis-Regulatory Network Re-Wiring upon NSD2 Degradation in t(4;14) Multiple Myeloma

Bo Hu, Hardik Modi, Diana Jankeel, Jacob T. Edwards, Junfei Zhao, Chad C. Bjorklund, Gaurav Jain, Patrick R. Hagner, Maria Ortiz, Zhongying Mo, Celia Fontanillo, Christoph W. Zapf, Antonia Lopez-Girona, Neil Bence, Kai Wang, Anita K. Gandhi, Mark Rolfe, Deborah S. Mortensen, Lynda Groocock
Journal: Blood
Blood (2024) 144 (Supplement 1): 1881.
https://doi.org/10.1182/blood-2024-203621
Published: 2024
Journal Articles

Mezigdomide (CC-92480), a Novel Cereblon E3 Ligase Modulator, Induces Vulnerability of Multiple Myeloma Cells to T-Cell-Mediated Killing

Bonny Gaffney, Yu Shi, Petrus de Jong, Manuel Sanchez, Celia Fontanillo, Antonia Lopez-Girona, Isaac W. Boss, Antonina Kurtova, Soraya Carrancio, Lilly Wong, Daniel W. Pierce
Journal: Blood
Blood (2022) 140 (Supplement 1): 7108–7109.
https://doi.org/10.1182/blood-2022-157939
Published: 2022
Journal Articles

Elucidating the Molecular Mechanisms of Action of CC-99282, a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent, Via Genome-Wide CRISPR Screen in a Preclinical Model of Non-Hodgkin Lymphoma (NHL)

Zhongying Mo, Lynda Groocock, Scott Wood, Diana Jankeel, Preethi Janardhanan, Derek Mendy, Michael Angelo, In Sock Jang, Celia Fontanillo, Kai Wang, Mark Rolfe, Antonia Lopez-Girona
Journal: Blood
Blood (2022) 140 (Supplement 1): 8860–8861.
https://doi.org/10.1182/blood-2022-159393
Published: 2022
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

Leveraging gene expression subgroups to classify DLBCL patients and select for clinical benefit from a novel agent

Alberto Risueño, Patrick R. Hagner, Fadi Towfic, Celia Fontanillo, Amira Djebbari, Joel S. Parker, Clifton P. Drew, Grzegorz S. Nowakowski, Matthew J. Maurer, James R. Cerhan, Xin Wei, Yan Ren, Chung-Wein Lee, Suzana Couto, Maria Wang, Michael Pourdehnad, Anita K. Gandhi, Matthew W. B. Trotter
Journal: Blood
Blood (2020) 135 (13): 1008–1018.
https://doi.org/10.1182/blood.2019002414
Published: 2020
Includes: Supplemental data
Journal Articles

CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)

Antonia Lopez-Girona, Gang Lu, Emily Rychak, Derek Mendy, Chin-Chun Lu, Irit Rappley, Celia Fontanillo, Brian E. Cathers, Thomas O. Daniel, Joshua Hansen
Journal: Blood
Blood (2019) 134 (Supplement_1): 2703.
https://doi.org/10.1182/blood-2019-127892
Published: 2019
Journal Articles

Discovery of an Immune-Driven Gene Expression Signature That Predicts for Clinical Benefit to CC-122 in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL)

Alberto Risueño, PhD, Patrick R. Hagner, PhD, Celia Fontanillo, PhD, Amira Djebbari, DSc, Joel S. Parker, PhD, Clifton P. Drew, PhD, Fadi Towfic, PhD, Michael Pourdehnad, MD, Anita K. Gandhi, PhD, Matthew Trotter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2830.
https://doi.org/10.1182/blood.V130.Suppl_1.2830.2830
Published: 2017
Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Journal: Blood
Blood (2015) 126 (6): 779–789.
https://doi.org/10.1182/blood-2015-02-628669
Published: 2015
Includes: Supplemental data
Journal Articles

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Patrick Hagner, PhD, Maria Wang, PhD, Suzana Couto, PhD, Mike Breider, DVM, PhD DACVP, Celia Fontanillo, PhD, Matthew Trotter, PhD, Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Heather K Raymon, PhD, Rama Krishna Narla, PhD, Leo Barnes, PhD, Michelle Waldman, MS, Tom Daniel, MD, Anke Klippel, PhD, Michael Pourdehnad, MD, Anjan Thakurta, PhD, Rajesh Chopra, MD, PhD, Anita K. Gandhi, PhD
Journal: Blood
Blood (2014) 124 (21): 3035.
https://doi.org/10.1182/blood.V124.21.3035.3035
Published: 2014
Journal Articles

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Courtney G. Havens, PhD, Chad Bjorklund, PhD, Jian Kang, BS, Maria Ortiz, PhD, Celia Fontanillo, PhD, Michael Amatangelo, PhD, Ling Lu, BS, Paola E. Neri, MD PhD, Antonia Lopez-Girona, PhD, Nizar J. Bahlis, MD, Anjan Thakurta, PhD, Mathew Trotter, MD, Anita K. Gandhi, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3432.
https://doi.org/10.1182/blood.V124.21.3432.3432
Published: 2014
Journal Articles

A High Number of Losses in 13q14 Chromosome Is Associated with a Worse Outcome and Biological Differences in Patients with B Chronic Lymphoid Leukemia.

José-Ángel Hernández, Ana-Eugenia Rodríguez, Marcos González, Rocío Benito, Celia Fontanillo, Virgilio Sandoval, Mercedes Romero, Guillermo Martín-Núñez, Alfonso García de Coca, Rosa Fisac, Josefina Galende, Isabel Recio, Francisco Ortuño, Juan-Luis García, Javier de las Rivas, Norma-Carmen Gutiérrez, Jesús-Maria Hernández, J.F. San Miguel
Journal: Blood
Blood (2008) 112 (11): 2073.
https://doi.org/10.1182/blood.V112.11.2073.2073
Published: 2008