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Journal Articles

Mutations in CRBN and Other Cereblon Pathway Genes Are Only Associated with Acquired Resistance to Immunomodulatory Drugs in a Subset of Patients and Cell Line Models

Amy Barber, PhD, John R Jones, MD, Harvey Che, Yann-Vai Le Bihan, Niels Weinhold, PhD, Cody Ashby, PhD, Brian A Walker, PhD, Christopher P. Wardell, PhD MSc, BSc, Hannah Wang, PhD, Martin F. Kaiser, MD FRCP, FRCPath, Graham H Jackson, MD MA, MB BS, FRCP, FRCPath, Faith E. Davies, Rajesh Chopra, MD, Gareth Morgan, MD PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath

Blood (2020) 136 (Supplement 1): 6–7.

https://doi.org/10.1182/blood-2020-140024

Published: 2020

Journal Articles

CC-122 Exhibits Potent Anti-Lymphoma Activity in Combination with Obinutuzumab through Cell Autonomous and Antibody Dependent Cell Mediated Cytotoxicity

Hsiling Chiu, Patrick Hagner, PhD, Michael Pourdehnad, MD, Thomas Daniel, Rajesh Chopra, Anke Klippel, Christian Klein, PhD, Anjan Thakurta, Anita K. Gandhi, PhD

Blood (2015) 126 (23): 4007.

https://doi.org/10.1182/blood.V126.23.4007.4007

Published: 2015

Journal Articles

A Novel Approach to QTc Studies: Assessing Cardiac Safety of the mTOR Kinase Inhibitor CC-223 within the Dose-Escalation/Expansion Study

Robert B Kleiman, Rajesh Chopra, de Haan Hans, Kristen Hege, Angela J James, Xiaomin Wang, Xiaoling Wu, Edward O'Mara

Blood (2015) 126 (23): 5555.

https://doi.org/10.1182/blood.V126.23.5555.5555

Published: 2015

Journal Articles

CC-122 Expands Activated and Memory CD4 and CD8 T Cells In Vivo and Induces T Cell Activation Ex Vivo in Subjects with Relapsed or Refractory Diffuse Large B Cell Lymphoma and Multiple Myeloma

Blood (2015) 126 (23): 2704.

https://doi.org/10.1182/blood.V126.23.2704.2704

Published: 2015

Journal Articles

Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity

Blood (2015) 126 (23): 821.

https://doi.org/10.1182/blood.V126.23.821.821

Published: 2015

Journal Articles

in Philadelphia-Chromosome-Negative Acute Lymphoblastic Leukemia, Late Relapses Are Not Uncommon, Occur Mostly in Patients at Standard Risk and Have a Relatively Favorable Outcome. Results of the International ALL Trial: MRC Ukallxii/ECOG E2993

Chezi Ganzel, Wang Xin Victoria, Adele K. Fielding, MB, BS, PhD, Jacob M. Rowe, MD, Susan M Richards, PhD, Georgina Buck, Rajesh Chopra, PhD, I. Jill Durrant, David Marks, MD PhD, Ian M. Franklin, MD, Andrew K McMilan, Mark R Litzow, MD, Elisabeth Paietta, PhD, Selina Luger, MD, Peter H Wiernik, Dan Douer, MD, Hillard M. Lazarus, MD, Martin S Tallman, MD, Anthony H. Goldstone, FRCP, FRCPath

Blood (2015) 126 (23): 795.

https://doi.org/10.1182/blood.V126.23.795.795

Published: 2015

Journal Articles

Resistance to Lenalidomide in Multiple Myeloma Is Associated with a Switch in Gene Expression Profile

Michael D. Amatangelo, PhD, Paola Neri, MD PhD, Maria Ortiz, PhD, Chad C. Bjorklund, Anita K. Gandhi, PhD, Anke Klippel, Nizar J Bahlis, MD, Tom Daniel, Rajesh Chopra, MBBS, PhD, Matthew Trotter, Anjan Thakurta

Blood (2015) 126 (23): 1789.

https://doi.org/10.1182/blood.V126.23.1789.1789

Published: 2015

Journal Articles

IMiD® Immunomodulatory Agents Promote Apoptosis in Multiple Myeloma Cells through Induction of TRAIL Expression

Michael D. Amatangelo, PhD, Chad C. Bjorklund, Anita K. Gandhi, PhD, Anke Klippel, Tom Daniel, Rajesh Chopra, MBBS, PhD, Matthew Trotter, Anjan Thakurta

Blood (2015) 126 (23): 5355.

https://doi.org/10.1182/blood.V126.23.5355.5355

Published: 2015

Journal Articles

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1

Jason Ear, Haigen Huang, Tianna Wilson, Zahra Tehrani, Anne Lindgren, Victoria Sung, Abderrahmane Laadem, Thomas O. Daniel, Rajesh Chopra, Shuo Lin

Blood (2015) 126 (7): 880–890.

https://doi.org/10.1182/blood-2015-01-622522

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Blood (2015) 126 (6): 779–789.

https://doi.org/10.1182/blood-2015-02-628669

Published: 2015

Includes: Supplemental data

Journal Articles

Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds

Kathryn Lagrue, Alex Carisey, David J. Morgan, Rajesh Chopra, Daniel M. Davis

Blood (2015) 126 (1): 50–60.

https://doi.org/10.1182/blood-2015-01-625004

Published: 2015

Includes: Supplemental data

Journal Articles

CC-122 Has Robust Anti-Proliferative Activity in a Primary Chronic Lymphocytic Leukemia (CLL) Co-Culture Model and Is Superior to Lenalidomide

Jemma Blocksidge, Mark Glenn, Anita K. Gandhi, PhD, Anke Klippel, PhD, Michael Pourdehnad, MD, Rajesh Chopra, MD PhD, Nagesh Kalakonda

Blood (2014) 124 (21): 4682.

https://doi.org/10.1182/blood.V124.21.4682.4682

Published: 2014

Journal Articles

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs ® Immunomodulatory Compounds

Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Patrick R Hagner, PhD, Anita K. Gandhi, PhD, Maria Wang, PhD, Michael D Amatangelo, PhD, Ling Lu, BS, Huisheng Wang, MS, Mike Breider, DVM, PhD DACVP, Yan Ren, MS, Antonia Lopez-Girona, PhD, Anjan Thakurta, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD

Blood (2014) 124 (21): 4700.

https://doi.org/10.1182/blood.V124.21.4700.4700

Published: 2014

Journal Articles

Dual-Color CRBN/CD138 Immunohistochemistry Assay for Measuring Cereblon Protein in Samples from Patients with Multiple Myeloma

Yan Ren, MS, Maria Wang, PhD, Suzanne Couta, DVM, PhD DACVP, Donna Hansel, MD, Karen Miller, BS, Antonia Lopez-Girona, PhD, Chad C Bjorklund, PhD, Anita K. Gandhi, PhD, Anjan Thakurta, PhD, Rajesh Chopra, MD PhD, Michael Breider, DVM, PhD DACVP

Blood (2014) 124 (21): 6021.

https://doi.org/10.1182/blood.V124.21.6021.6021

Published: 2014

Journal Articles

CC-122 Degrades the Lymphoid Transcription Factor Aiolos (IKZF3) By Modulating Cereblon and Shows Clinical Activity in a Phase Ib Study of Subjects with Relapsed or Refractory Non-Hodgkin’s Lymphoma and Multiple Myeloma

Vincent Ribrag, MD, Silvia Damien, MD, Mecide Gharibo, MD, Mercede Gironella, MD, Armando Santoro, MD, Drew W Rasco, MD, William Edenfield, MD, Xin Wei, PhD, Angela James, PhD, Patrick Hagner, PhD, Anita K. Gandhi, PhD, Rajesh Chopra, MD PhD, Jorge F. DiMartino, MD PhD, Michael Pourdehnad, MD, Anne-Marie Stoppa, MD

Blood (2014) 124 (21): 3500.

https://doi.org/10.1182/blood.V124.21.3500.3500

Published: 2014

Journal Articles

Lenalidomide Promotes Degradation of Casein Kinase 1a (CK1a) through Cereblon: Implications for the Efficacy of Lenalidomide in MDS and AML

Paul Hollenbach, Ling Lu, BS, Anita K. Gandhi, PhD, Rajesh Chopra, MD PhD, Kyle J MacBeth, PhD

Blood (2014) 124 (21): 3606.

https://doi.org/10.1182/blood.V124.21.3606.3606

Published: 2014

Journal Articles

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Patrick Hagner, PhD, Maria Wang, PhD, Suzana Couto, PhD, Mike Breider, DVM, PhD DACVP, Celia Fontanillo, PhD, Matthew Trotter, PhD, Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Heather K Raymon, PhD, Rama Krishna Narla, PhD, Leo Barnes, PhD, Michelle Waldman, MS, Tom Daniel, MD, Anke Klippel, PhD, Michael Pourdehnad, MD, Anjan Thakurta, PhD, Rajesh Chopra, MD, PhD, Anita K. Gandhi, PhD

Blood (2014) 124 (21): 3035.

https://doi.org/10.1182/blood.V124.21.3035.3035

Published: 2014

Journal Articles

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Courtney G. Havens, PhD, Chad Bjorklund, PhD, Jian Kang, BS, Maria Ortiz, PhD, Celia Fontanillo, PhD, Michael Amatangelo, PhD, Ling Lu, BS, Paola E. Neri, MD PhD, Antonia Lopez-Girona, PhD, Nizar J. Bahlis, MD, Anjan Thakurta, PhD, Mathew Trotter, MD, Anita K. Gandhi, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD

Blood (2014) 124 (21): 3432.

https://doi.org/10.1182/blood.V124.21.3432.3432

Published: 2014

Journal Articles

Absence Of Mutation In Cereblon (CRBN) and DNA Damage Binding Protein 1 (DDB1) Genes In Myeloma Cells and Patients and Its Clinical Significance

Anjan Thakurta, PhD, Anita K Gandhi, PhD, Michelle Waldman, MS, Chad C. Bjorklund, Ph.D., Suzanne Lentzsch, MD, PhD, Stephen A Schey, MD, Yolanda Calle, PhD, Rajani Chelliah, BSc, MSc, Robert Z. Orlowski, M.D., Ph.D, Anup Madan, PhD, Yuhong Ning, Derek Mendy, B.S., Antonia Lopez-Girona, PhD, Peter H Schafer, PhD, Herve Avet-Loiseau, MD, Rajesh Chopra, MD

Blood (2013) 122 (21): 3139.

https://doi.org/10.1182/blood.V122.21.3139.3139

Published: 2013

Journal Articles

Target Engagement, Pathway Inhibition, and Efficacy Of The Bruton’s Tyrosine Kinase (Btk) Inhibitor CC-292

Blood (2013) 122 (21): 4169.

https://doi.org/10.1182/blood.V122.21.4169.4169

Published: 2013

NARROW

Mutations in CRBN and Other Cereblon Pathway Genes Are Only Associated with Acquired Resistance to Immunomodulatory Drugs in a Subset of Patients and Cell Line Models

CC-122 Exhibits Potent Anti-Lymphoma Activity in Combination with Obinutuzumab through Cell Autonomous and Antibody Dependent Cell Mediated Cytotoxicity

A Novel Approach to QTc Studies: Assessing Cardiac Safety of the mTOR Kinase Inhibitor CC-223 within the Dose-Escalation/Expansion Study

CC-122 Expands Activated and Memory CD4 and CD8 T Cells In Vivo and Induces T Cell Activation Ex Vivo in Subjects with Relapsed or Refractory Diffuse Large B Cell Lymphoma and Multiple Myeloma

Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity

in Philadelphia-Chromosome-Negative Acute Lymphoblastic Leukemia, Late Relapses Are Not Uncommon, Occur Mostly in Patients at Standard Risk and Have a Relatively Favorable Outcome. Results of the International ALL Trial: MRC Ukallxii/ECOG E2993

Resistance to Lenalidomide in Multiple Myeloma Is Associated with a Switch in Gene Expression Profile

IMiD® Immunomodulatory Agents Promote Apoptosis in Multiple Myeloma Cells through Induction of TRAIL Expression

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds

CC-122 Has Robust Anti-Proliferative Activity in a Primary Chronic Lymphocytic Leukemia (CLL) Co-Culture Model and Is Superior to Lenalidomide

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs ® Immunomodulatory Compounds

Dual-Color CRBN/CD138 Immunohistochemistry Assay for Measuring Cereblon Protein in Samples from Patients with Multiple Myeloma

CC-122 Degrades the Lymphoid Transcription Factor Aiolos (IKZF3) By Modulating Cereblon and Shows Clinical Activity in a Phase Ib Study of Subjects with Relapsed or Refractory Non-Hodgkin’s Lymphoma and Multiple Myeloma

Lenalidomide Promotes Degradation of Casein Kinase 1a (CK1a) through Cereblon: Implications for the Efficacy of Lenalidomide in MDS and AML

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Absence Of Mutation In Cereblon (CRBN) and DNA Damage Binding Protein 1 (DDB1) Genes In Myeloma Cells and Patients and Its Clinical Significance

Target Engagement, Pathway Inhibition, and Efficacy Of The Bruton’s Tyrosine Kinase (Btk) Inhibitor CC-292

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American Society of Hematology

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American Society of Hematology

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