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Journal Articles

AO-176, a Highly Differentiated Clinical Stage Anti-CD47 Antibody, Exerts Potent Anti-Tumor Activity in Preclinical Models of Multiple Myeloma As a Single Agent and in Combination with Approved Therapeutics

William Casey Wilson, PhD, John Richards, PhD, Robyn J Puro, PhD, Gabriela Andrejeva, PhD, Ben J Capoccia, PhD, Mike J Donio, Ronald R Hiebsch, BS, Prabir Chakraborty, PhD, Victoria Sung, PhD, Daniel S Pereira, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-139655
Published: 2020
Journal Articles

Highly Differentiated Anti-CD47 Antibody, AO-176, Potently Inhibits Hematologic Malignancies Alone and in Combination

John Richards, PhD, Myriam N Bouchlaka, BS,PhD, Robyn J Puro, PhD, Ben J Capoccia, PhD, Ronald R Hiebsch, BS, Michael J Donio, BS, W. Casey Wilson, PhD, Prabir Chakraborty, PhD, Victoria Sung, PhD, Daniel S Pereira, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1844.
https://doi.org/10.1182/blood-2019-126298
Published: 2019
Journal Articles

GDF15 and Erythroferrone Mark Erythropoietic Response to ACE-011 (Sotatercept) in Thalassemia

Maciej W Garbowski, MD PhD, Olivier Hermine, MD PhD, Maria Domenica Cappellini, MD, Raffaella Origa, MD, Gian Luca Forni, MD, Ersi Voskaridou, MD, Frédéric Galactéros, MD PhD, Ali Taher, MD PhD, Jean Benoît Arlet, MD PhD, Jean-Antoine Ribeil, MD PhD, Giovanna Graziadei, MD, Chantal Brouzes, MD, Michaela Semeraro, MD PhD, Patricia Evans, PhD, Abderrahmane Laadem, MD, Dimana Miteva, PhD, Jun Zou, MD PhD, Tatiana Zinger, PhD, Martin Schwickart, PhD, Victoria Sung, PhD, John Porter, MA MD FRCP FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 3633.
https://doi.org/10.1182/blood-2018-99-111770
Published: 2018
Journal Articles

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1

Jason Ear, Haigen Huang, Tianna Wilson, Zahra Tehrani, Anne Lindgren, Victoria Sung, Abderrahmane Laadem, Thomas O. Daniel, Rajesh Chopra, Shuo Lin
Journal: Blood
Blood (2015) 126 (7): 880–890.
https://doi.org/10.1182/blood-2015-01-622522
Published: 2015
Includes: Multimedia, Supplemental data
Journal Articles

RAP-011 Efficiently Rescues Erythropoiesis In Zebrafish Models Of Diamond Blackfan Anemia

Jason Ear, Haigen Huang, Zahra Tehrani, Victoria Sung, PhD, Thomas Daniel, Rajesh Chopra, MD, Shuo Lin
Journal: Blood
Blood (2013) 122 (21): 3702.
https://doi.org/10.1182/blood.V122.21.3702.3702
Published: 2013
Journal Articles

Sotatercept, An Activin Receptor-2a Ligand Trap, Modulates Hepcidin Levels In Primary Human Hepatocytes

Mehnaz Malek, Carla Heise, PhD, Rajesh Chopra, PhD, Tom O Daniel, MD, PhD, Victoria Sung, PhD
Journal: Blood
Blood (2013) 122 (21): 3441.
https://doi.org/10.1182/blood.V122.21.3441.3441
Published: 2013
Journal Articles

A Phase 2a, Open-Label, Dose-Finding Study To Determine The Safety and Tolerability Of Sotatercept (ACE-011) In Adults With Beta (β)-Thalassemia: Interim Results

Maria-Domenica Cappellini, MD, John Porter, MD, Raffaella Origa, MD, Gian Luca Forni, MD, Adberrahmane Laadem, MD, Frédéric Galacteros, MD PhD, Dimana Miteva, PhD, Victoria Sung, PhD, Rajesh Chopra, MD, Jean-Benoît Arlet, MD, PhD, Jean-Antoine Ribeil, MD, PhD, Kenneth Klesczewski, PhD, Kenneth Attie, MD, Maciej Garbowski, MD, Olivier Hermine, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3448.
https://doi.org/10.1182/blood.V122.21.3448.3448
Published: 2013
Journal Articles

Sotatercept Promotes Differentiation and Survival Of Erythroid Progenitors By Blocking Inhibitory Effects Of TGFβ Superfamily Members

Soraya Carrancio, PhD, Jennifer A. Markovics, PhD, Piu Wong, PhD, Carla Heise, PhD, Tom O. Daniel, MD, PhD, Rajesh Chopra, MD, Victoria Sung, PhD
Journal: Blood
Blood (2013) 122 (21): 944.
https://doi.org/10.1182/blood.V122.21.944.944
Published: 2013
Journal Articles

Modulation of Activin Signaling by RAP-011 (ActRIIA-IgG1) Improve Anemia, Increases Hemoglobin Levels and Corrects Ineffective Erythropoiesis in β-Thalassemia

Michael Dussiot, Thiago Maciel, PhD, Aurelie Fricot, Joel Veiga, Etienne Paubelle, Emmanuel Payen, Yves Beuzard, MD, Jean-Antoine Ribeil, MD, PhD, Jean-Benoît Arlet, MD, Genevieve Courtois, PhD, Tom O Daniel, MD, PhD, Rajesh Chopra, MD, PhD, Victoria Sung, Ph.D., Olivier Hermine, MD, PhD, Ivan Cruz Moura, PhD
Journal: Blood
Blood (2012) 120 (21): 247.
https://doi.org/10.1182/blood.V120.21.247.247
Published: 2012
Journal Articles

Exposures and Erythropoietic Responses to Sotatercept (ACE-011) in Healthy Volunteers and Cancer Patients: Implications for Mechanism of Action

Nianhang Chen, Ph D, Adberrahmane Laadem, MD, Matthew L. Sherman, MD, Simon Zhou, PhD, Victoria Sung, PhD, Maria Palmisano, MD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3454.
https://doi.org/10.1182/blood.V120.21.3454.3454
Published: 2012
Journal Articles

Sotatercept, an Activin Receptor IIa Ligand Trap, Acts Through Bone Marrow Accessory Cells to Promote Late-Stage Erythropoiesis and a Rapid Induction of Red Blood Cell Number and Hemoglobin

Soraya Carrancio, PhD, Jennifer A Markovics, PhD, Piu Wong, PhD, Jim Leisten, Matthew C Groza, Heather K Raymon, Carla Heise, PhD, Rajesh Chopra, MD, PhD, Tom O Daniel, MD, PhD, Victoria Sung, PhD
Journal: Blood
Blood (2012) 120 (21): 372.
https://doi.org/10.1182/blood.V120.21.372.372
Published: 2012
Journal Articles

Amrubicin Targets Nuclear Matrix-Bound Topoisomerase II In Human Myeloid Leukemia Cells

Daniel J. Fernandes, Ph.D., D.Sc., Yoko Otake, M.S., Victoria Sung, Ph.D., Robert K Stuart, M.D.
Journal: Blood
Blood (2010) 116 (21): 1830.
https://doi.org/10.1182/blood.V116.21.1830.1830
Published: 2010