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Mark Rolfe
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Journal Articles

BMS-986458 a Potential First-in-Class, Highly Selective, Potent and Well Tolerated BCL6 Ligand Directed Degrader (LDD) Demonstrates Multi-Modal Anti-Tumor Efficacy for the Treatment of B-Cell Non-Hodgkin's Lymphoma

Lynda Groocock, Gauri Deb, Jinyi Zhu, Jim Gamez, Paola Castiglioni, Manuel Sanchez-Castillo, Justin Schumacher, Alicia Benitez Rondan, Diana Jankeel, Karla Martinez-Garcia, Scott Wood, Andy Christoforou, Carla Guarinos, Wei Zhang, Rama Krishna Narla, Christoph W. Zapf, Soraya Carrancio, Daniel W. Pierce, Mark Rolfe, Neil Bence, Antonia Lopez-Girona, Deborah S. Mortensen
Journal: Blood
Blood (2024) 144 (Supplement 1): 957.
https://doi.org/10.1182/blood-2024-210951
Published: 2024
Journal Articles

Synergistic Activity of BMS-986397, a First-in-Class a Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Targeting Casein Kinase 1α (CK1α), in Combination with Venetoclax and/or Azacitidine in Preclinical Models of Acute Myeloid Leukemia (AML)

Carmen Jimenez, Jose Francisco Lopez, Estela Garcia, Laura Diaz Regalado, Alejandro Panjkovich, Sophie Peng, Rama Krishna Narla, Noelia Purroy, Mark Rolfe, Daniel W. Pierce, Soraya Carrancio
Journal: Blood
Blood (2024) 144 (Supplement 1): 1395.
https://doi.org/10.1182/blood-2024-210023
Published: 2024
Journal Articles

Multi-Omics Integration to Elucidate the Cis-Regulatory Network Re-Wiring upon NSD2 Degradation in t(4;14) Multiple Myeloma

Bo Hu, Hardik Modi, Diana Jankeel, Jacob T. Edwards, Junfei Zhao, Chad C. Bjorklund, Gaurav Jain, Patrick R. Hagner, Maria Ortiz, Zhongying Mo, Celia Fontanillo, Christoph W. Zapf, Antonia Lopez-Girona, Neil Bence, Kai Wang, Anita K. Gandhi, Mark Rolfe, Deborah S. Mortensen, Lynda Groocock
Journal: Blood
Blood (2024) 144 (Supplement 1): 1881.
https://doi.org/10.1182/blood-2024-203621
Published: 2024
Journal Articles

BMS-986397, a First-in-Class Molecular Glue Degrader of Casein Kinase 1α (CK1α) for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS) Harboring Functional TP53

Carmen Jimenez, Sophie Peng, Rama Krishna Narla, Joshua Baughman, Scott Wood, Jean Lu, Noelia Purroy, Gina Yanochko, Mark Nagy, Gang Lu, Mark Rolfe, Daniel W. Pierce, Soraya Carrancio
Journal: Blood
Blood (2024) 144 (Supplement 1): 4142.
https://doi.org/10.1182/blood-2024-209924
Published: 2024
Journal Articles

Development of a ZBTB7A and Wiz Dual Degrading, HbF-Activating CELMoD™ for the Treatment of Sickle Cell Disease

Emily Rychak, Goldie Yuan Lam Lui, Cristhian Fimbres, Christine Kim Kang, Younguk Sun, Sophie Peng, Jingjing Deng, Sarah Franc, Eugene Ciccimaro, Kimberly Peacock, Minerva Tran, Andy Christoforou, Jinyi Zhu, Geraldine Polido, Barbra Pagarigan, Scott Johnson, Faye Wang, Paula Katavolos, Bonny Gaffney, Estela Garcia, France Landry, Fletcher Paddison, Petia Shipkova, Hannah Powers, Giorgio Tamò, August Dietrich, Soraya Carrancio, Radha Ramakrishnan, Karen Augustine, Rama Krishna Narla, Thomas Cummins, Mark Rolfe, Neil Bence, Antonia Lopez-Girona
Journal: Blood
Blood (2024) 144 (Supplement 1): 169.
https://doi.org/10.1182/blood-2024-203653
Published: 2024
Journal Articles

Elucidating the Molecular Mechanisms of Action of CC-99282, a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent, Via Genome-Wide CRISPR Screen in a Preclinical Model of Non-Hodgkin Lymphoma (NHL)

Zhongying Mo, Lynda Groocock, Scott Wood, Diana Jankeel, Preethi Janardhanan, Derek Mendy, Michael Angelo, In Sock Jang, Celia Fontanillo, Kai Wang, Mark Rolfe, Antonia Lopez-Girona
Journal: Blood
Blood (2022) 140 (Supplement 1): 8860–8861.
https://doi.org/10.1182/blood-2022-159393
Published: 2022
Journal Articles

CC-99282 is a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent with Enhanced Tumoricidal Activity in Preclinical Models of Lymphoma

Soraya Carrancio, Lynda Groocock, Preethi Janardhanan, Diana Jankeel, Ryan Galasso, Carla Guarinos, Rama K. Narla, Matthew Groza, Jim Leisten, Daniel W. Pierce, Mark Rolfe, Antonia Lopez-Girona
Journal: Blood
Blood (2021) 138 (Supplement 1): 1200.
https://doi.org/10.1182/blood-2021-148068
Published: 2021
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Gang Lu, Christine Surka, Chin-Chun Lu, In Sock Jang, PhD, Kai Wang, PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 405.
https://doi.org/10.1182/blood-2019-125492
Published: 2019
Journal Articles

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Ronan LE Moigne, PhD, Valeria Visconte, PhD, Bartlomiej Przychodzen, MSc, Mark Rolfe, PhD, Stevan Djakovic, PhD, Daniel Anderson, David Wustrow, PhD, Han-Jie Zhou, Steve Wong, PhD, Anjali Advani, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2015) 126 (23): 1350.
https://doi.org/10.1182/blood.V126.23.1350.1350
Published: 2015
Journal Articles

Pre-Clinical Activity of the Novel, First-in-Class p97 Inhibitor, CB-5083, in Multiple Myeloma

Blake T. Aftab, PhD, Daniel J Anderson, PhD, Ronan Le Moigne, PhD, Stevan Djakovic, PhD, Eugen Dhimolea, PhD, Megan Murnane, Emily King, Julie Rice, Steve Wong, Brajesh Kumar, PhD, Eduardo Valle, Mary-Kamala Menon, Szerenke Kiss von Soly, Jinhai Wang, PhD, Bing Yao, Ferdie Soriano, Martin Kampmann, PhD, Diego Alcost-Alvear, PhD, Marta Chesi, PhD, Leif Bergsagel, MD, F. Michael Yakes, PhD, Han-Jie Zhou, PhD, David Wustrow, PhD, Thomas G. Martin, MD, Jeffrey L. Wolf, Constantine S. Mitsiades, MD PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2014) 124 (21): 4701.
https://doi.org/10.1182/blood.V124.21.4701.4701
Published: 2014
Journal Articles

Inhibition of p97 with the First-in-Class Small Molecule CB-5083: A Novel Strategy for Acute Myeloid Leukemia Therapy

Rita Tohme, BS, Ronan Le Moigne, PhD, Bartlomiej P Przychodzen, Yingchun Han, MD, Mark Rolfe, PhD, Hetty E. Carraway, MD, Stevan Djakovic, PhD, Dan Anderson, PhD, David Wustrow, PhD, Han-Jie Zhou, PhD, Steve Wong, Kevin R. Kelly, MD, Yogen Saunthararajah, MD, Anjali S. Advani, MD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2014) 124 (21): 3766.
https://doi.org/10.1182/blood.V124.21.3766.3766
Published: 2014
Journal Articles

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy, Michael P. Thomas, Allison J. Berger, Lenny Dang, Lawrence R. Dick, James J. Garnsey, Erik Koenig, Steven P. Langston, Mark Manfredi, Usha Narayanan, Mark Rolfe, Louis M. Staudt, Teresa A. Soucy, Jie Yu, Julie Zhang, Joseph B. Bolen, Peter G. Smith
Journal: Blood
Blood (2010) 116 (9): 1515–1523.
https://doi.org/10.1182/blood-2010-03-272567
Published: 2010
Includes: Supplemental data
Journal Articles

In-Vitro and in-Vivo Evaluation of the Orally Active Proteasome Inhibitor MLN9708 in Hematological Models of Human Cancer.

Erik Kupperman, Edmund Lee, Yueying Cao, Bret Bannerman, Michael Fitzgerald, Allison J Berger, Jie Yu, Julie Zhang, Paul Hales, Frank Bruzzese, Jane Liu, Jonathan Blank, Khristofer Garcia, Christopher Tsu, Larry Dick, Paul Fleming, Li Yu, Mark G Manfredi, Mark Rolfe, Joseph Bolen
Journal: Blood
Blood (2009) 114 (22): 2709.
https://doi.org/10.1182/blood.V114.22.2709.2709
Published: 2009