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Han-Jie Zhou
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Journal Articles

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Ronan LE Moigne, PhD, Valeria Visconte, PhD, Bartlomiej Przychodzen, MSc, Mark Rolfe, PhD, Stevan Djakovic, PhD, Daniel Anderson, David Wustrow, PhD, Han-Jie Zhou, Steve Wong, PhD, Anjali Advani, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2015) 126 (23): 1350.
https://doi.org/10.1182/blood.V126.23.1350.1350
Published: 2015
Journal Articles

Pre-Clinical Activity of the Novel, First-in-Class p97 Inhibitor, CB-5083, in Multiple Myeloma

Blake T. Aftab, PhD, Daniel J Anderson, PhD, Ronan Le Moigne, PhD, Stevan Djakovic, PhD, Eugen Dhimolea, PhD, Megan Murnane, Emily King, Julie Rice, Steve Wong, Brajesh Kumar, PhD, Eduardo Valle, Mary-Kamala Menon, Szerenke Kiss von Soly, Jinhai Wang, PhD, Bing Yao, Ferdie Soriano, Martin Kampmann, PhD, Diego Alcost-Alvear, PhD, Marta Chesi, PhD, Leif Bergsagel, MD, F. Michael Yakes, PhD, Han-Jie Zhou, PhD, David Wustrow, PhD, Thomas G. Martin, MD, Jeffrey L. Wolf, Constantine S. Mitsiades, MD PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2014) 124 (21): 4701.
https://doi.org/10.1182/blood.V124.21.4701.4701
Published: 2014
Journal Articles

Inhibition of p97 with the First-in-Class Small Molecule CB-5083: A Novel Strategy for Acute Myeloid Leukemia Therapy

Rita Tohme, BS, Ronan Le Moigne, PhD, Bartlomiej P Przychodzen, Yingchun Han, MD, Mark Rolfe, PhD, Hetty E. Carraway, MD, Stevan Djakovic, PhD, Dan Anderson, PhD, David Wustrow, PhD, Han-Jie Zhou, PhD, Steve Wong, Kevin R. Kelly, MD, Yogen Saunthararajah, MD, Anjali S. Advani, MD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2014) 124 (21): 3766.
https://doi.org/10.1182/blood.V124.21.3766.3766
Published: 2014
Journal Articles

Dose Intensive Administration of PR-047, a Novel Orally Bioavailable Inhibitor of the 20S Proteasome, Is Well Tolerated in Experimental Animals.

Tony Muchamuel, Shirin Kapur, PhD, Christopher J Kirk, Ph.D, Jing Jiang, M.D., Susan Lee, Mark K Bennett, PhD, Evan Lewis, Jinfu Yang, Mouhannad Jumaa, Eileen Ring, Pasit Phiasivongsa, Han-Jie Zhou, PhD, Zhengping Wang
Journal: Blood
Blood (2009) 114 (22): 4910.
https://doi.org/10.1182/blood.V114.22.4910.4910
Published: 2009
Journal Articles

Preclinical Pharmacology and in Vitro Characterization of PR-047, An Oral Inhibitor of the 20S Proteasome

Tony Muchamuel, Monette Aujay, Mark K Bennett, PhD, Maya Dajee, Susan Demo, PhD, Christopher J Kirk, Ph.D, Ying Fang, Jing Jiang, M.D., Evan Lewis, Yan Lu, Guy Laidig, Francesco Parlati, PhD, Jamie Shields, Congcong m Sun, Jinfu Yang, Han-Jie Zhou, PhD
Journal: Blood
Blood (2008) 112 (11): 3671.
https://doi.org/10.1182/blood.V112.11.3671.3671
Published: 2008
Journal Articles

Anti-Tumor Activity of Immunoproteasome Selective Inhibitors.

Francesco Parlati, Monette Aujay, Siv Lise Bedringaas, Susan Demo, Bjorn Gjertsen, Eileen Goldstein, Jing Jiang, Christopher Kirk, Guy Laidig, James Lorens, Yan Lu, David Micklem, Paulina Ruurs, Kevin Shenk, Catherine Sylvain, Congcong Sun, Tina Woo, Han-Jie Zhou, Mark Bennett
Journal: Blood
Blood (2007) 110 (11): 1599.
https://doi.org/10.1182/blood.V110.11.1599.1599
Published: 2007
Journal Articles

Immunoproteasome-Selective Keto-Epoxide Inhibitors: Potential Therapeutic Agents for the Treatment of Hematological Disorders.

Francesco Parlati, PhD, Monette A. Aujay, B.S., Susan D. Demo, Ph.D., Eileen D. Goldstein, B.S., Jing Jiang, B.S., Christopher J. Kirk, Ph.D., Guy J. Laidig, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Kevin D. Shenk, M.S., Catherine Sylvain, Ph.D., Congcong M. Sun, M.S., Tina M. Woo, B.S., Han-Jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 4392.
https://doi.org/10.1182/blood.V108.11.4392.4392
Published: 2006
Journal Articles

Pharmacologic Evaluation of Orally Bioavailable Inhibitors of the 20S Proteasome.

Christopher J. Kirk, PhD, Monette A. Aujay, B.S., Mark Ho, B.S., Jing Jiang, B.S., Guy J. Laidig, Ph.D., Evan R. Lewis, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Tina M. Woo, B.S., Congcong M. Sun, M.S., Catherine Sylvain, Ph.D., Jinfu Yang, Ph.D., Han-jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3581.
https://doi.org/10.1182/blood.V108.11.3581.3581
Published: 2006