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Francesco Parlati
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Journal Articles

Metabolomic, Proteomic and Genomic Profiling Identifies Biomarakers of Sensitivity to Glutaminase Inhibitor CB-839 in Multiple Myeloma

Andrew L MacKinnon, PhD, Mark Bennett, PhD, Matt Gross, B.S., Julie Janes, M.S., Weiqin Li, PhD, Mirna Rodriquez, B.S., Tracy Wang, BS, Winter Zhang, B.S., Francesco Parlati, PhD
Journal: Blood
Blood (2015) 126 (23): 1802.
https://doi.org/10.1182/blood.V126.23.1802.1802
Published: 2015
Journal Articles

Biomarkers of Response to the Glutaminase Inhibitor CB-839 in Multiple Myeloma Cells

Andrew Mackinnon, PhD, Mark Bennett, PhD, Mirna Rodriguez, BS, Francesco Parlati, PhD
Journal: Blood
Blood (2014) 124 (21): 3429.
https://doi.org/10.1182/blood.V124.21.3429.3429
Published: 2014
Journal Articles

Glutaminase Inhibitor CB-839 Synergizes with Pomalidomide in Preclinical Multiple Myeloma Models

Francesco Parlati, PhD, Mathew Gross, BS, Julie Janes, MS, Evan Lewis, PhD, Andy MacKinnon, PhD, Mirna Rodriguez, BS, Peter Shwonek, BS, Mark Bennett, PhD
Journal: Blood
Blood (2014) 124 (21): 4720.
https://doi.org/10.1182/blood.V124.21.4720.4720
Published: 2014
Journal Articles

Antitumor Activity Of The Glutaminase Inhibitor CB-839 In Hematological Malignances

Francesco Parlati, PhD, Shoshana Bromley-Dulfano, BS, Susan Demo, PhD, Julie Janes, MS, Matt Gross, BS, Evan Lewis, PhD, Andy MacKinnon, PhD, Mirna Rodriguez, BS, Jinfu Yang, PhD, Frances Zhao, MS, Mark Bennett, PhD
Journal: Blood
Blood (2013) 122 (21): 4226.
https://doi.org/10.1182/blood.V122.21.4226.4226
Published: 2013
Journal Articles

Selective inhibition of CDK4/CDK6 sensitizes bone marrow myeloma cells for killing by proteasome inhibitors carfilzomib and PR-047 through cell cycle-dependent expression of pro-apoptotic Noxa and Bim.

Maurizio Di Liberto, PhD, Xiangao Huang, PhD, Rediet Zewdu, B.S., Francesco Parlati, PhD, Monette Aujay, B.S., Ruben Niesvizky, MD, Selina Chen-Kiang, PhD
Journal: Blood
Blood (2009) 114 (22): 2854.
https://doi.org/10.1182/blood.V114.22.2854.2854
Published: 2009
Journal Articles

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

Francesco Parlati, Susan J. Lee, Monette Aujay, Erika Suzuki, Konstantin Levitsky, James B. Lorens, David R. Micklem, Paulina Ruurs, Catherine Sylvain, Yan Lu, Kevin D. Shenk, Mark K. Bennett
Journal: Blood
Blood (2009) 114 (16): 3439–3447.
https://doi.org/10.1182/blood-2009-05-223677
Published: 2009
Includes: Supplemental data
Journal Articles

Non-Proteasomal Targets of Proteasome Inhibitors Bortezomib and Carfilzomib

Shirin Arastu-Kapur, Kevin Shenk, Francesco Parlati, Mark K Bennett
Journal: Blood
Blood (2008) 112 (11): 2657.
https://doi.org/10.1182/blood.V112.11.2657.2657
Published: 2008
Journal Articles

Induction of Sustained Early G1 Arrest by Selective Inhibition of CDK4 and CDK6 Primes Myeloma Cells for Synergistic Killing by Proteasome Inhibitors Carfilzomib and PR-047

Xiangao Huang, PhD, Kathryn Bailey, Maurizio Di Liberto, PhD, Francesco Parlati, PhD, Ruben Niesvizky, MD, Susan Demo, PhD, Selina Chen-Kiang, PhD
Journal: Blood
Blood (2008) 112 (11): 3670.
https://doi.org/10.1182/blood.V112.11.3670.3670
Published: 2008
Journal Articles

Preclinical Pharmacology and in Vitro Characterization of PR-047, An Oral Inhibitor of the 20S Proteasome

Tony Muchamuel, Monette Aujay, Mark K Bennett, PhD, Maya Dajee, Susan Demo, PhD, Christopher J Kirk, Ph.D, Ying Fang, Jing Jiang, M.D., Evan Lewis, Yan Lu, Guy Laidig, Francesco Parlati, PhD, Jamie Shields, Congcong m Sun, Jinfu Yang, Han-Jie Zhou, PhD
Journal: Blood
Blood (2008) 112 (11): 3671.
https://doi.org/10.1182/blood.V112.11.3671.3671
Published: 2008
Journal Articles

Anti-Tumor Activity of Immunoproteasome Selective Inhibitors.

Francesco Parlati, Monette Aujay, Siv Lise Bedringaas, Susan Demo, Bjorn Gjertsen, Eileen Goldstein, Jing Jiang, Christopher Kirk, Guy Laidig, James Lorens, Yan Lu, David Micklem, Paulina Ruurs, Kevin Shenk, Catherine Sylvain, Congcong Sun, Tina Woo, Han-Jie Zhou, Mark Bennett
Journal: Blood
Blood (2007) 110 (11): 1599.
https://doi.org/10.1182/blood.V110.11.1599.1599
Published: 2007
Journal Articles

Identification of Peptide Epoxy-Ketone Proteasome Inhibitors with Differential Active Site Selectivity.

Susan D. Demo, PhD, Monette A. Aujay, BS, Eileen Goldstein, BS, Guy J. Laidig, PhD, Francesco Parlati, PhD, Yan Lu, PhD, Kevin D. Shenk, BS, Congcong M. Sun, MS, Catherine Sylvain, PhD, Tina M. Woo, BS, Hanjie Zhou, PhD, Mark K. Bennett, PhD
Journal: Blood
Blood (2006) 108 (11): 4398.
https://doi.org/10.1182/blood.V108.11.4398.4398
Published: 2006
Journal Articles

Immunoproteasome-Selective Keto-Epoxide Inhibitors: Potential Therapeutic Agents for the Treatment of Hematological Disorders.

Francesco Parlati, PhD, Monette A. Aujay, B.S., Susan D. Demo, Ph.D., Eileen D. Goldstein, B.S., Jing Jiang, B.S., Christopher J. Kirk, Ph.D., Guy J. Laidig, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Kevin D. Shenk, M.S., Catherine Sylvain, Ph.D., Congcong M. Sun, M.S., Tina M. Woo, B.S., Han-Jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 4392.
https://doi.org/10.1182/blood.V108.11.4392.4392
Published: 2006
Journal Articles

Biochemical and Cellular Characterization of the Novel Proteasome Inhibitor PR-171.

Susan D. Demo, PhD, Tonia J. Buchholz, MS, Guy J. Laidig, PhD, Francesco Parlati, PhD, Kevin D. Shenk, BS, Mark S. Smyth, PhD, Carol M. Sullivan, BA, Congcong M. Sun, MS, Marcy K. Vallone, BS, Tina Woo, BS, Mark K. Bennett, PhD
Journal: Blood
Blood (2005) 106 (11): 1588.
https://doi.org/10.1182/blood.V106.11.1588.1588
Published: 2005