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Erik Koenig
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Journal Articles

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy

Clinical Trials & Observations
George Mulligan, David I. Lichter, Alessandra Di Bacco, Stephen J. Blakemore, Allison Berger, Erik Koenig, Hugues Bernard, William Trepicchio, Bin Li, Rachel Neuwirth, Nibedita Chattopadhyay, Joseph B. Bolen, Andrew J. Dorner, Helgi van de Velde, Deborah Ricci, Sundar Jagannath, James R. Berenson, Paul G. Richardson, Edward A. Stadtmauer, Robert Z. Orlowski, Sagar Lonial, Kenneth C. Anderson, Pieter Sonneveld, Jesús F. San Miguel, Dixie-Lee Esseltine, Matthew Schu
Journal: Blood
Blood (2014) 123 (5): 632–639.
https://doi.org/10.1182/blood-2013-05-504340
Published: 2014
Includes: Supplemental data
Journal Articles

Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

Michael Milhollen, Michael Thomas, Tary Traore, Usha Narayanan, Jessica Riceberg, Todd Sells, PhD, Ben Amidon, PhD, Mark Manfredi, PhD, Neil Bence, PhD, James Brownell, PhD, Larry Dick, PhD, Erik Koenig, James Gavin, Peter G Smith, PhD
Journal: Blood
Blood (2011) 118 (21): 1413.
https://doi.org/10.1182/blood.V118.21.1413.1413
Published: 2011
Journal Articles

Mutational Analysis of Tumor Samples From Patients with Relapsed or Refractory Multiple Myeloma (MM) Highlights the Prevalence of RAS/RAF Pathway Activation and Demonstrates Previously Unreported Mutations in Known Cancer Genes

George Mulligan, PhD, David I Lichter, MS, Alessandra Di Bacco, PhD, Stephen J Blakemore, PhD, Allison Berger, PhD, Erik Koenig, Hugues Bernard, William L. Trepicchio, PhD, Bin Li, PhD, Sagar Lonial, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Pieter Sonneveld, MD, PhD, Jesús F San Miguel, MD PhD, Dixie-Lee Esseltine, MD, FRCPC, Matthew Schu, MS
Journal: Blood
Blood (2011) 118 (21): 1377.
https://doi.org/10.1182/blood.V118.21.1377.1377
Published: 2011
Journal Articles

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy, Michael P. Thomas, Allison J. Berger, Lenny Dang, Lawrence R. Dick, James J. Garnsey, Erik Koenig, Steven P. Langston, Mark Manfredi, Usha Narayanan, Mark Rolfe, Louis M. Staudt, Teresa A. Soucy, Jie Yu, Julie Zhang, Joseph B. Bolen, Peter G. Smith
Journal: Blood
Blood (2010) 116 (9): 1515–1523.
https://doi.org/10.1182/blood-2010-03-272567
Published: 2010
Includes: Supplemental data
Journal Articles

Pre-Clinical Antitumor activity of MLN4924, An Inhibitor of NEDD8-Activating Enzyme (NAE), in a Novel Primary Human DLBCL Xenograft Model.

Tary Traore, James J. Garnsey, Erik Koenig, Allison J Berger, Mark G Manfredi, PhD, Lilli Petruzzelli, MD, PhD, Peter G. Smith, PhD
Journal: Blood
Blood (2009) 114 (22): 927.
https://doi.org/10.1182/blood.V114.22.927.927
Published: 2009
Journal Articles

Antitumor Activity of MLN9708, a Second-Generation Proteasome Inhibitor, in Preclinical Models of Lymphoma.

Jill Donelan, Bret Bannerman, Kristen Bano, Trisha Babcock, Paul Hales, Bradley Stringer, Kristine Burke, Hadi Danaee, Laura Faron-Yowe, Erik Koenig, David Lichter, Erik Kupperman
Journal: Blood
Blood (2009) 114 (22): 3724.
https://doi.org/10.1182/blood.V114.22.3724.3724
Published: 2009
Journal Articles

MLN4924, a Novel Small Molecule Inhibitor of Nedd8-Activating Enzyme, Demonstrates Potent Anti-Tumor Activity in Diffuse Large B-Cell Lymphoma

Michael Milhollen, MSc, Usha Narayanan, Allison J Berger, PhD, Michael Thomas, Tary Traore, Jie Yu, Julie Zhang, Erik Koenig, James J. Garnsey, Steven P. Langston, Teresa A Soucy, PhD, Peter G Smith, PhD
Journal: Blood
Blood (2008) 112 (11): 606.
https://doi.org/10.1182/blood.V112.11.606.606
Published: 2008
Journal Articles

Pharmacogenomics Study of Biological Pathways Related to Bortezomib Activity in Myeloma.

George Mulligan, Barb Bryant, Steven Roels, Andrew Bolt, Yan Meng, Erik Koenig, Anthony Boral, Dixie-Lee Esseltine, Kenneth A. Anderson, Peter Leif Bergsagel, Pieter Sonneveld, Annemiek Broyl, Constantine Mitsiades, Wee-Joo Chng, Paul G. Richardson, William Trepicchio
Journal: Blood
Blood (2007) 110 (11): 392.
https://doi.org/10.1182/blood.V110.11.392.392
Published: 2007
Journal Articles

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib

Clinical Trials & Observations
George Mulligan, Constantine Mitsiades, Barb Bryant, Fenghuang Zhan, Wee J. Chng, Steven Roels, Erik Koenig, Andrew Fergus, Yongsheng Huang, Paul Richardson, William L. Trepicchio, Annemiek Broyl, Pieter Sonneveld, John D. Shaughnessy, Jr, P. Leif Bergsagel, David Schenkein, Dixie-Lee Esseltine, Anthony Boral, Kenneth C. Anderson
Journal: Blood
Blood (2006) 109 (8): 3177–3188.
https://doi.org/10.1182/blood-2006-09-044974
Published: 2006
Includes: Supplemental data