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Eric R. Lechman
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Journal Articles

Identification of Global miRNA Targetomes within Human Hematopoietic Progenitors and Acute Myeloid Leukemia Uncovers Unique Molecular Networks Centered on Mitochondria Function in Leukemic Stem Cells

Gabriela Krivdova, Brian Yee, Stefan Aigner, Martino Gabra, Alexander Shishkin, Long Nguyen, Jessica L McLeod, Leah Carley, Leonardo Salmena, Lorien Shakib, Mark D. Minden, Eric L Van Nostrand, Gene W. Yeo, Eric R. Lechman, John E. Dick
Journal: Blood
Blood (2022) 140 (Supplement 1): 8684–8685.
https://doi.org/10.1182/blood-2022-169849
Published: 2022
Journal Articles

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Liberalis Debraj Boila, Liqing Jin, Alex Murison, Subham K. Bandyopadhyay, Subhadeep Ghosh, Siva Sai Naga Anurag Muddineni, Andy G.X. Zeng, Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Nathan Mbong, Olga I. Gan, Andrea Arruda, Wasim Shaikh, Anwesha Bose, Satyaki Bhowmik, Sayan Chakraborty, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Journal: Blood
Blood (2021) 138 (Supplement 1): 25.
https://doi.org/10.1182/blood-2021-145491
Published: 2021
Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elvin Wagenblast, PhD, Joana Araújo, MD, Olga I. Gan, PhD, Sarah K Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova, BSc, Maria Azkanaz, Sabrina A Smith, Johann K Hitzler, MD, John E. Dick, PhD FRS, Eric R Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-135867
Published: 2020
Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-141733
Published: 2020
Journal Articles

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS, Gabriela Krivdova, BSc, Olga I. Gan, PhD, Jessica L. McLeod, John E. Dick, PhD FRS, Eric R. Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-142963
Published: 2020
Journal Articles

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

Richard N Armstrong, PhDBSc, Mariana Benicio, PhD, Houtan Moshiri, PhD, Hongbing Li, PhD, Bozana Zlateska, MD MSc, Olga I. Gan, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Yigal Dror, MD FRCPC
Journal: Blood
Blood (2020) 136 (Supplement 1): 37.
https://doi.org/10.1182/blood-2020-143103
Published: 2020
Journal Articles

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Gabriela Krivdova, BSc, Veronique Voisin, PhD, Sajid Marhon, Schoof E Erwin, Martino Gabra, Jessica L. McLeod, Leonardo Salmena, Mark D. Minden, Eric R. Lechman,, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-142652
Published: 2020
Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2531.
https://doi.org/10.1182/blood-2019-129259
Published: 2019
Journal Articles

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

Kerstin B. Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W. K. Ng, Shin-Ichiro Takayanagi, Amanda Mitchell, Erno Wienholds, Peter van Galen, Christian A. Cumbaa, Mike J. Tsay, Chiara Pastrello, Elvin Wagenblast, Gabriela Krivdova, Mark D. Minden, Eric R. Lechman, Sasan Zandi, Igor Jurisica, Jean C. Y. Wang, Stephanie Z. Xie, John E. Dick
Journal: Blood
Blood (2019) 133 (20): 2198–2211.
https://doi.org/10.1182/blood-2018-10-881441
Published: 2019
Includes: Supplemental data
Journal Articles

Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Lorien Shakib, Maria Azkanaz, Olga I. Gan, Eric R. Lechman,, PhD MSC, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3891.
https://doi.org/10.1182/blood-2018-99-110363
Published: 2018
Journal Articles

Functional and Molecular Consequences of Trisomy 21 on Human Fetal Hematopoiesis

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Olga I. Gan, PhD, Johann K. Hitzler, MD, John E. Dick, PhD, Eric R. Lechman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1317.
https://doi.org/10.1182/blood-2018-99-119734
Published: 2018
Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Rashim Pal Singh, MSc,PhD, Danny V. Jeyaraju, PhD, Veronique Voisin, PhD, Changjiang Xu, Samir H Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman,, PhD MSC, Neil MacLean, Mark D. Minden, MD PhD, Steven M Chan, MD PhD, John E. Dick, Gary D Bader, Aaron Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1339.
https://doi.org/10.1182/blood-2018-99-111015
Published: 2018
Journal Articles

Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape

Gabriela Krivdova, BSc, MSc, Schoof E Erwin, Veronique Voisin, PhD, Alex Murison, Karin G. Hermans, Laura Garcia Prat, Olga I. Gan, Elvin Wagenblast, PhD, Aaron Trotman-Grant, Eric R. Lechman,, PhD MSC, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3824.
https://doi.org/10.1182/blood-2018-99-116866
Published: 2018
Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 881.
https://doi.org/10.1182/blood.V130.Suppl_1.881.881
Published: 2017
Journal Articles

Mir-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Human Hematopoietic Committed Progenitors

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Erwin M. Schoof, PhD, Aaron Trotman-Grant, BS, Stephanie M Dobson, MSc, Gabriela Krivdova, MS, Janneke J. Elzinga, James A. Kennedy, MDPhD, Olga I Gan, PhD, John E Dick, PhD
Journal: Blood
Blood (2015) 126 (23): 900.
https://doi.org/10.1182/blood.V126.23.900.900
Published: 2015
Journal Articles

Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Stephanie M. Dobson, BSc, Olga I. Gan, PhD, James A. Kennedy, MDPhD, John Chen, PhD, Johann K. Hitzler, MD, John E. Dick, PhD
Journal: Blood
Blood (2014) 124 (21): 3579.
https://doi.org/10.1182/blood.V124.21.3579.3579
Published: 2014
Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 1647.
https://doi.org/10.1182/blood.V122.21.1647.1647
Published: 2013
Journal Articles

Enforced Expression Of Mir-125b Promotes the in vivo expansion Of Human Lin neg cord Blood Multi-Lymphoid Progenitors and Leukemia Stem Cells

Karin G. Hermans, PhD, Eric R. Lechman, PhD, Stephanie M. Dobson, BSc, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 1648.
https://doi.org/10.1182/blood.V122.21.1648.1648
Published: 2013
Journal Articles

A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias

Alice Giustacchini, PhD, Silvia Nucera, MD, Eric R. Lechman, PhD, Cristiana Fanciullo, Francesco E Boccalatte, Tiziana Plati, Anna Ranghetti, Luca Vago, MD, PhD, Massimo Bernardi, MD, Maurilio Ponzoni, MD, John E. Dick, PhD, Luigi Naldini, MD, PhD, Bernhard Gentner, MD
Journal: Blood
Blood (2013) 122 (21): 886.
https://doi.org/10.1182/blood.V122.21.886.886
Published: 2013