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Cassandra L. Ramage
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Journal Articles

Efficacy of a Novel BCL-XL Degrader, DT2216, in Preclinical Models of Post-Myeloproliferative Neoplasm Secondary AML

Zhe Wang, Anna Skwarska, Gowri Poigailwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini Papapetrou, Kapil N. Bhalla, Daohong Zhou, Adam J Mead, Raajit Rampal, Jeffrey W Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2024) 144 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2024-194031
Published: 2024
Journal Articles

Anti-Leukemia Combinatorial Efficacy of ABBV155, a B7H3-BCL-XL Inhibitor Antibody-Drug Conjugate, in Combination with Venetoclax through BCL-XL/BIM and BCL-2/BIM Complex Dissociations

Zhe Wang, Cassandra L. Ramage, Helen Ma, Haichao Zhang, Andrew Souers, Darren C Phillips, Marina Konopleva, Qi Zhang Tatarata
Journal: Blood
Blood (2024) 144 (Supplement 1): 2760.
https://doi.org/10.1182/blood-2024-193405
Published: 2024
Journal Articles

Elucidating Transcriptional Heterogeneity in Venetoclax Resistant AMLs

Vakul Mohanty, Natalia Baran, Yuefan Huang, Cassandra L. Ramage, Laurie Cooper, Sarah Gwen Pelletier, Shan He, Ramiz Iqbal, May Daher, MD, Jeffrey W. Tyner, Gordon B Mills, Marina Konopleva, Ken Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 2753.
https://doi.org/10.1182/blood-2024-204333
Published: 2024
Journal Articles

Targeting BCL-XL with a Novel VHL-Based BCL-XL Degrader DT-2216 in Pre-Clinical JAK2 -Mutant AML Post-MPN Models

Zhe WANG, Qi Zhang, Anna Skwarska, Cassandra L. Ramage, Guangrong Zheng, Kira Gritsman, Kapil N. Bhalla, Naveen Pemmaraju, Daohong Zhou, Jeffrey W Tyner, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4154.
https://doi.org/10.1182/blood-2023-178813
Published: 2023
Journal Articles

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Natalia Baran, Lina Han, Lucille Stuani, Antonio Cavazos, Laurie Cooper, Cassandra L. Ramage, Vinitha MARY Kuruvilla, Qi Zhang, Marie Sabtier, Emeline Boet, Jason P Gay, Ninping Feng, Venkata Lokesh Battula, Emeline Chu-Van, Florence Castelli, Martin Carroll, Sergej Naumovich Konoplev, Beenu Thakral, Naval Daver, Joseph R Marszalek, Yubin Ge, Michael Andreeff, Jean-Emmanuel Sarry, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2952.
https://doi.org/10.1182/blood-2023-186514
Published: 2023
Journal Articles

Dual BCL-XL/2 Protac 753B Not Only Potently Induces Apoptosis in Venetoclax-Resistant Primary AML Cells but Also Effectively Eliminates Chemotherapy-Induced Senescent AML Cells

Yannan Jia, Lina Han, Cassandra L Ramage, Connie C. Weng, Lei Yang, Simona Colla, Helen Ma, Weiguo Zhang, Michael Andreeff, Naval Daver, Nitin Jain, Naveen Pemmaraju, Kapil N. Bhalla, Satu Mustjoki, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Qi Zhang, Marina Konopleva
Journal: Blood
Blood (2022) 140 (Supplement 1): 3347–3349.
https://doi.org/10.1182/blood-2022-164541
Published: 2022
Journal Articles

Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease

Natalia Baran, Shraddha Patel, Cassandra L Ramage, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Kala Hayes, Zhihong Zeng, Laurie Cooper, Richard Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva
Journal: Blood
Blood (2022) 140 (Supplement 1): 8831–8832.
https://doi.org/10.1182/blood-2022-170713
Published: 2022
Journal Articles

Combined Blockade of CD47-Sirpa Interaction By 5F9 (Magrolimab) and Azacitidine/Venetoclax Therapy Facilitates Macrophage-Mediated Anti-Leukemia Efficacy in AML Pre-Clinical Models

Yannan Jia, Qi Zhang, Connie Weng, Cassandra L Ramage, Yuki Nishida, Mark Chao, Roy Louis Maute, Shelley Herbrich, Weiguo Zhang, Michael Andreeff, Naval Daver, Marina Konopleva
Journal: Blood
Blood (2021) 138 (Supplement 1): 510.
https://doi.org/10.1182/blood-2021-147479
Published: 2021
Journal Articles

Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Synthetic Lethality in T-ALL Via Mitochondrial Exhaustion

Natalia Baran, Shraddha Patel, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Cassandra L Ramage, Kala Hayes, Zhihong Zeng, Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva
Journal: Blood
Blood (2021) 138 (Supplement 1): 680.
https://doi.org/10.1182/blood-2021-152845
Published: 2021