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Journal Articles

Loss of Cystathionine-β-Synthase Activity Results in Increased Oxidative Phosphorylation and Cytarabine Resistance in Myeloid Leukemia Associated with Down Syndrome

Jenna Thibodeau, Jianlei Zhao, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn H White, Maik Hüttemann, Tasnim Arroum, Lucynda Pham, Austin C. Boucher, John D. Crispino, Jeffrey W. Taub, Yubin Ge
Journal: Blood
Blood (2024) 144 (Supplement 1): 1376.
https://doi.org/10.1182/blood-2024-203961
Published: 2024
Journal Articles

Old Meets New: Hydroxyurea Synergistically Enhances the Antileukemic Activity of Gilteritinibagainst FLT3-ITD AML

Nibal Eid, Jianlei Zhao, Jenna Thibodeau, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn H White, Steven Buck, Jeffrey W. Taub, Yubin Ge
Journal: Blood
Blood (2024) 144 (Supplement 1): 5805.
https://doi.org/10.1182/blood-2024-207855
Published: 2024
Journal Articles

Multi-Pronged Effects of Cohesin Mutations in the Myeloid Leukemia of Down Syndrome

Austin C. Boucher, Wojciech Rosikiewicz, Ricky Tirtakusuma, Anitria Cotton, Madeline Niederkorn, Elvin Wagenblast, Paul G. Thomas, Yubin Ge, Jeffrey W. Taub, Jan-Henning Klusmann, John D. Crispino
Journal: Blood
Blood (2024) 144 (Supplement 1): 2731.
https://doi.org/10.1182/blood-2024-210782
Published: 2024
Journal Articles

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Natalia Baran, Lina Han, Lucille Stuani, Antonio Cavazos, Laurie Cooper, Cassandra L. Ramage, Vinitha MARY Kuruvilla, Qi Zhang, Marie Sabtier, Emeline Boet, Jason P Gay, Ninping Feng, Venkata Lokesh Battula, Emeline Chu-Van, Florence Castelli, Martin Carroll, Sergej Naumovich Konoplev, Beenu Thakral, Naval Daver, Joseph R Marszalek, Yubin Ge, Michael Andreeff, Jean-Emmanuel Sarry, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2952.
https://doi.org/10.1182/blood-2023-186514
Published: 2023
Journal Articles

A Novel Isoflavone, ME-344, Enhances Venetoclax Antileukemic Activity Against AML Via Suppression of Oxidative Phosphorylation and Purine Biosynthesis

Katie Hege Hurrish, Yongwei Su, Sandra Wiley, Zhanjun Hou, Jenna Carter, Hasini Kalpage, Maik Hüttemann, Holly Edwards, Lisa Polin, Jing Li, Jay Yang, Larry Matherly, Jeffrey W. Taub, Yubin Ge
Journal: Blood
Blood (2021) 138 (Supplement 1): 2238.
https://doi.org/10.1182/blood-2021-147004
Published: 2021
Journal Articles

Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia

Xiaojia Niu, Katharina Rothe, Min Chen, Sarah Grasedieck, Rick Li, Sung-Eun Nam, Xiuyan Zhang, German E. Novakovskiy, Ye-Hyeon Ahn, Irina Maksakova, Shenshen Lai, Hong Zhang, Jun Yan, Hong Liu, Yun Zhao, Depei Wu, Yubin Ge, Wyeth W. Wasserman, Arefeh Rouhi, Florian Kuchenbauer, Calvin K. Yip, Zaihui Zhang, Xiaoyan Jiang
Journal: Blood
Blood (2021) 137 (26): 3641–3655.
https://doi.org/10.1182/blood.2020007651
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting AXL Kinase Sensitizes Acute Myeloid Leukemia Stem and Progenitor Cells to Venetoclax Treatment

Katharina Rothe, PhD, Xiaojia Niu, PhD, Min Chen, PhD, Rick Li, Sungeun Nam, Xiuyan Zhang, German Novakovskiy, Yehyeon Ahn, Shenshen Lai, Hong Zhang, PhD, Jun Yan, Hong Liu, Yun Zhao, PhD, Depei Wu, MDPhD, Yubin Ge, PhD, Wyeth W. Wasserman, Calvin K. Yip, Zaihui Zhang, PhD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20.
https://doi.org/10.1182/blood-2020-140595
Published: 2020
Journal Articles

The Combination of CUDC-907 and Gilteritinib Shows Promising Antileukemic Activity in Vitro and In Vivo in Preclinical Models of FLT3-ITD AML

Tristan Knight, MD, Xinan Qiao, BS, Jun Ma, Holly Edwards, BS, Lisa Polin, PhD, Juiwanna Kushner, Sijana H Dzinic, PhD, Kathryn White, Hai Lin, MD, Yue Wang, Jeffrey W. Taub, MD, Yubin Ge, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1262.
https://doi.org/10.1182/blood-2019-123793
Published: 2019
Journal Articles

Venetoclax Synergistically Enhances the Antileukemic Activity of Imipridone ONC213, a Novel Imipridone ONC201 Analog, in Acute Myeloid Leukemia

Yongwei Su, Xinyu Li, Holly Edwards, BS, Lisa Polin, PhD, Juiwanna Kushner, Sijana H Dzinic, PhD, Katie Hege, Yu Fukuda, John D. Schuetz, PhD, Joshua E. Allen, PhD, Martin Stogniew, Varun Vijay Prabhu, BPharm, MS, PhD, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3936.
https://doi.org/10.1182/blood-2018-99-116997
Published: 2018
Journal Articles

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Margaret Shatara, MD, Tingting Wang, Xinyu Li, Holly Edwards, BS, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5224.
https://doi.org/10.1182/blood-2018-99-113937
Published: 2018
Journal Articles

Voruciclib, an Oral, Selective CDK9 Inhibitor, Enhances Cell Death Induced By the Bcl-2 Selective Inhibitor Venetoclax in Acute Myeloid Leukemia

Daniel A Luedtke, BS, Yongwei Su, Holly Edwards, BS, Lisa Polin, PhD, Juiwanna Kushner, Sijana H Dzinic, PhD, Hai Lin, MD, Jeffrey W. Taub, MD, Yubin Ge, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1361.
https://doi.org/10.1182/blood-2018-99-118372
Published: 2018
Journal Articles

Novel Therapy for FLT3-ITD Acute Myeloid Leukemia Utilizing the Combination of CUDC-907 and Gilteritinib

Tristan Knight, MD, Xinan Qiao, BS, Holly Edwards, BS, Hai Lin, MD, Jeffrey W. Taub, MD, Yubin Ge, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1427.
https://doi.org/10.1182/blood-2018-99-111177
Published: 2018
Journal Articles

Targeting PI3K, mTOR, ERK, and Bcl-2 Signaling Network Shows Superior Antileukemic Activity Against AML

Yongwei Su, Xinyu Li, Jianyun Zhao, Jun Ma, Shuang Liu, Holly Edwards, Jeffrey W. Taub, MD, Hai Lin, Yubin Ge, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1255.
https://doi.org/10.1182/blood.V130.Suppl_1.1255.1255
Published: 2017
Journal Articles

Targeting the GAS6/AXL Pathway with a Newly Developed AXL-Selective Inhibitor SLC-0211 for the Treatment of Acute Myeloid Leukemia

Xiaojia Niu, Katharina Roche, PhD, Min Chen, MD PhD, Hong Zhang, PhD, Jun Yan, Yubin Ge, PhD, Zaihui Zhang, PhD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2640.
https://doi.org/10.1182/blood.V130.Suppl_1.2640.2640
Published: 2017
Journal Articles

Inhibition of XPO1 By KPT-330 (Selinexor) Enhances Cell Death Induced By the Bcl-2 Selective Inhibitor ABT-199 (Venetoclax) through Downregulation of Mcl-1 in Acute Myeloid Leukemia

Daniel A Luedtke, BS, Yongwei Su, Holly Edwards, Hai Lin, Jeffrey W. Taub, MD, Yubin Ge, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3819.
https://doi.org/10.1182/blood.V130.Suppl_1.3819.3819
Published: 2017
Journal Articles

ONC213, a Novel Second Generation Analog of ONC201, Shows Promising Anti-Leukemic Activity Against AML Cells In Vitro and In Vivo

Yongwei Su, Xinyu Li, Holly Edwards, Joshua E. Allen, PhD, Martin Stogniew, Varun Vijay Prabhu, BPharm, MS, PhD, Jeffrey W. Taub, MD, Hai Lin, Yubin Ge, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3822.
https://doi.org/10.1182/blood.V130.Suppl_1.3822.3822
Published: 2017
Journal Articles

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Andrew Volk, PhD, Kaiwei Liang, PhD, Jianyun Zhao, Xinyu Li, Marinka Bulic, Stacy Marshall, Jeffrey W. Taub, MD, Yubin Ge, PhD, Sebastien Malinge, PhD, Elizabeth Bartom, PhD, Ali Shilatifard, PhD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 245.
https://doi.org/10.1182/blood.V130.Suppl_1.245.245
Published: 2017
Journal Articles

Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children’s Oncology Group AAML0431 trial

Clinical Trials & Observations
Jeffrey W. Taub, Jason N. Berman, Johann K. Hitzler, April D. Sorrell, Norman J. Lacayo, Kelley Mast, David Head, Susana Raimondi, Betsy Hirsch, Yubin Ge, Robert B. Gerbing, Yi-Cheng Wang, Todd A. Alonzo, Dario Campana, Elaine Coustan-Smith, Prasad Mathew, Alan S. Gamis
Journal: Blood
Blood (2017) 129 (25): 3304–3313.
https://doi.org/10.1182/blood-2017-01-764324
Published: 2017
Includes: Supplemental data
Journal Articles

Combination of Venetoclax and CUDC-907 Shows Superior Antileukemic Activity Against Acute Myeloid Leukemia Ex Vivo

Xinyu Li, Jun Ma, Yongwei Su, Jianyun Zhao, Holly Edwards, Yue Wang, Jay Yang, MD, Jeffrey W Taub, MD, Hai Lin, Yubin Ge, PhD
Journal: Blood
Blood (2016) 128 (22): 1571.
https://doi.org/10.1182/blood.V128.22.1571.1571
Published: 2016
Journal Articles

Inhibition of CHK1 Enhances Cell Death Induced By the Bcl-2-Selective Inhibitor ABT-199 in Acute Myeloid Leukemia Cells

Jianyun Zhao, Xiaojia Niu, Holly Edwards, Yue Wang, Jeffrey W Taub, MD, Hai Lin, Yubin Ge, PhD
Journal: Blood
Blood (2015) 126 (23): 2469.
https://doi.org/10.1182/blood.V126.23.2469.2469
Published: 2015