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Journal Articles

Phase 1 Study of AXL/MER/CSF1R Inhibitor Q702 with Azacitidine and Venetoclax for Relapsed or Refractory Acute Myeloid Leukemia

Abhishek Maiti, Sean M. Post, Courtney D. DiNardo, Naval Daver, Tapan M. Kadia, Allison Pike, Hyunsoo Hwang, Xuelin Huang, Michael Andreeff, Farhad Ravandi, Jinho CHOI, Hyunji Ahn, Jeongjun Kim, Kiyean Nam, Gautam Borthakur
Journal: Blood
Blood (2024) 144 (Supplement 1): 5994.
https://doi.org/10.1182/blood-2024-202834
Published: 2024
Journal Articles

A Potential Link between hnRNP K and Cebpα: Implications for Ribosomal Dysfunction in Acute Myeloid Leukemia (AML)

Sean M. Post, Kerstin Rhan, Shelley Herbrich, Oscar Benitez, Ashley G Rodriguez, Xiaorui Zhang, Michael R Meier, Jared Brottem, Martina Crysandt, Prerna Malaney, Isabel naarmann-Devries
Journal: Blood
Blood (2023) 142 (Supplement 1): 4119.
https://doi.org/10.1182/blood-2023-190737
Published: 2023
Journal Articles

Unraveling Novel Mechanisms for Targeting the Intra-S-Phase Checkpoint in p53-Mutated Acute Myeloid Leukemia

Sean M. Post, Ashley G Rodriguez, Oscar Benitez, Jared Brottem, Irene Wang, Joanne Chang, Mark G. Frattini, Abhishek Maiti
Journal: Blood
Blood (2023) 142 (Supplement 1): 1423.
https://doi.org/10.1182/blood-2023-189333
Published: 2023
Journal Articles

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Bofei Wang, Patrick K Reville, Fatima Z Jelloul, Poonam N Desai, Pamella Borges, Christopher Ly, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Nicole Vaugh, Natalia Baran, Qing Deng, Jairo Matthews, Preethi Gunaratne, Dinler A Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Y. Konopleva, Andy Futreal, Sean M. Post, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2796.
https://doi.org/10.1182/blood-2023-175010
Published: 2023
Journal Articles

Hnrnpk Overexpression Drives Nucleolar Aberrancies Causing Ribosomopathies

Pedro Aguilar-Garrido, Maria Velasco-Estevez, Miguel Ángel Navarro-Aguadero, María Hernández-Sánchez, Marta Ibáñez-Navarro, Prerna Malaney, Marisa Aitken, Xiaorui Zhang, Adrián Fernández, Alejandra Ortiz-Ruiz, Álvaro Otero-Sobrino, Diego Megías, Manuel Pérez, Jesús Gómez, Gadea Mata, Orlando Domínguez, Osvaldo Graña, Pilar Ximénez, Marta Isasa, Paloma Jimena-de Andrés, Sandra Rodríguez, Raúl Torres, Miguel Lafarga, Oleksandra Sirozh, Vanesa Lafarga, Joaquin Martinez-Lopez, Sean M. Post, Miguel Gallardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5659.
https://doi.org/10.1182/blood-2023-178022
Published: 2023
Journal Articles

Assay Development and Small Molecule Screens for Inhibitors of an RNA Binding Protein Implicated in Hematologic Malignancies

Sean M. Post, Lauren E. Chan, Xiaorui Zhang, Oscar Benitez, Kerstin Rahn, Todd Link, Clifford Stephan, Eun Cho, Kevin Dalby, Prerna Malaney
Journal: Blood
Blood (2022) 140 (Supplement 1): 4951–4952.
https://doi.org/10.1182/blood-2022-170426
Published: 2022
Journal Articles

Targeting the Oncogenic Functions of an RNA-Binding Protein Involved in Hematologic Malignancies

Sean M Post, Prerna Malaney, Lauren Chan, Xiaorui Zhang, Todd Link, Eun Cho, Juan Cerda, Marisa J Aitken, Mary Sobieski, Reid Powell, Nghi Nguyen, Clifford Stephan, Kevin Dalby
Journal: Blood
Blood (2021) 138 (Supplement 1): 2226.
https://doi.org/10.1182/blood-2021-154072
Published: 2021
Journal Articles

Increased hnRNP K Expression Impacts Myelopoiesis By Altering RUNX1 Splicing

Sean M Post, Marisa J Aitken, Prerna Malaney, Xiaorui Zhang, Todd Link, Rodrigo Jacamo, Rashmi Kanagal-Shamanna, Carlos E. Bueso-Ramos
Journal: Blood
Blood (2021) 138 (Supplement 1): 3317.
https://doi.org/10.1182/blood-2021-154149
Published: 2021
Journal Articles

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Sean M Post, PhD, Huaxian Ma, MS, Vivian Ruvolo, Xiaorui Zhang, BS, Tomoko Yasuhiro, Kohei Tanaka, Ryohei Kozaki, Toshio Yoshizawa, PhD, Jorge E. Cortes, MD, Courtney D. DiNardo, MDMSc, Marina Y Konopleva, MD PhD, Steven M. Kornblau, MD, Joseph D. Khoury, MD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2550.
https://doi.org/10.1182/blood-2019-128626
Published: 2019
Journal Articles

Combination Therapy with BTK Inhibitor Plus Anti-PD-1 Antibody Results in a Hyperprogressor Phenotype in a Mouse Model of CLL

Aidi Gu, PhD, Huaxian Ma, MS, Xiaorui Zhang, BS, Prerna Malaney, PhD, Miguel Gallardo, PhD, Jingwei Liu, MD, Sattva S. Neelapu, MD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4416.
https://doi.org/10.1182/blood-2018-99-118773
Published: 2018
Journal Articles

hnRNP K Overexpression Drives Myeloid Malignancy Via Interaction with RUNX1

Marisa J Hornbaker, BS, Prerna Malaney, PhD, Xiaorui Zhang, BS, Ruizhi Duan, M.Sc., Vrutant Shah, PhD, Shelley Herbrich, MS, Miguel Gallardo, PhD, Rodrigo Jacamo, PhD, Todd Link, PhD, Huaxian Ma, MS, Sanzhar Alybayev, MS, Steven M. Kornblau, MD, Peter Hu, PhD, Dos Sarbassov, PhD, Rashmi Kanagal-Shamanna, MD, Carlos E. Bueso-Ramos, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2622.
https://doi.org/10.1182/blood-2018-99-117387
Published: 2018
Journal Articles

TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia

Peter P. Ruvolo, PhD, Huaxian Ma, MS, Vivian Ruvolo, MS, Xiaorui Zhang, BS, Hong Mu, MD PhD, Tomoko Yasuhiro, Kohei Tanaka, Toshio Yoshizawa, PhD, Weiguo Zhang, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2642.
https://doi.org/10.1182/blood-2018-99-112211
Published: 2018
Journal Articles

hnRNP K: A Regulator of Global Transcription and Translation That Drives Lymphomagenesis

Prerna Malaney, PhD, Miguel Gallardo, PhD, Marisa J Hornbaker, BS, Xiaorui Zhang, BS, Todd Link, PhD, Vrutant Shah, PhD, Sanzhar Alybayev, MS, Meng-Han Wu, Laura R Pageon, DVM, Huaxian Ma, MS, Rodrigo Jacamo, PhD, Li Yu, MD, Zijun Yidan Xu-Monette, PhD, Haley Steinman, BS, Hun Ju Lee, MD, Dos Sarbassov, PhD, Inmaculada Rapado, Michelle Barton, PhD, Joaquin Martinez-Lopez, MDPhD, Carlos E. Bueso-Ramos, MD PhD, Ken H. Young, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1346.
https://doi.org/10.1182/blood-2018-99-116163
Published: 2018
Journal Articles

hnRNP K: A Driver of Myeloid Malignancy

Marisa J Hornbaker, BS, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Prerna Malaney, PhD, Shelley Herbrich, MS, Huaxian Ma, Peter Hu, PhD, Steven Kornblau, MD, Carlos E. Bueso-Ramos, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2511.
https://doi.org/10.1182/blood.V130.Suppl_1.2511.2511
Published: 2017
Journal Articles

One size doesn’t fit all in Ph-like ALL

Sean M. Post
Journal: Blood
Blood (2017) 129 (2): 140–141.
https://doi.org/10.1182/blood-2016-11-749168
Published: 2017
Journal Articles

AXL Inhibitor ONO-9330547 Suppresses PLK1 Gene and Protein Expression and Effectively Induces Growth Arrest and Apoptosis in FLT3 ITD Acute Myeloid Leukemia Cells

Peter Ruvolo, PhD, Huaxian Ma, BS, Vivian Ruvolo, MS, Hong Mu, MD PhD, Wendy Schober, Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Joseph D Khoury, MD, Jorge Cortes, MD, Michael Andreeff, MD PhD, Sean M. Post, PhD
Journal: Blood
Blood (2016) 128 (22): 3939.
https://doi.org/10.1182/blood.V128.22.3939.3939
Published: 2016
Journal Articles

hnRNP K Overexpression Drives AML Progression By Altering Pathways Critical for Myeloid Proliferation and Differentiation

Marisa J Hornbaker, BS, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Huaxian Ma, BS, Peter Hu, PhD, Joseph D Khoury, MD, Steven M. Kornblau, MD, Carlos E Bueso-Ramos, MD PhD, Sean M. Post, PhD
Journal: Blood
Blood (2016) 128 (22): 744.
https://doi.org/10.1182/blood.V128.22.744.744
Published: 2016
Journal Articles

Developing Therapeutic Strategies for CLL with Mutant p53

Hun Ju Lee, MD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Huaxian Ma, BS, Alfonso Quintas-Cardama, MD, Yuan Qi, Xiaoping Su, PhD, Sean M. Post, PhD
Journal: Blood
Blood (2015) 126 (23): 2476.
https://doi.org/10.1182/blood.V126.23.2476.2476
Published: 2015
Journal Articles

Amplification of hnRNP K Drives c-Myc-Dependent Malignancies and Represent a Novel Therapeutic Opportunity for Hematologic Malignancies

Miguel Gallardo, PhD, Xiaorui Zhang, BS, Mark McArthur, Taghi Manshouri, PhD, Sean M. Post, PhD
Journal: Blood
Blood (2015) 126 (23): 468.
https://doi.org/10.1182/blood.V126.23.468.468
Published: 2015
Journal Articles

hnRNP K Is a Novel Haploinsufficient Tumor Suppressor at the 9q21.32 Locus That Defines a Subset of AML

Miguel Gallardo, PhD, Hun Ju Lee, MD, Xiaorui Zhang, BS, Carlos E. Bueso-Ramos, MD, Laura Pageon, Mark McArthur, Asha Multani, Aziz Nazha, MD, Taghi Manshouri, PhD, Jan Parker-Thornburg, Peter Hu, Yuan Qi, Xiaoping Su, PhD, Inmaculada Rapado, Alfonso Quintás-Cardama, Steven M. Kornblau, MD, Joaquin Martinez-López, MDPhD, Sean M. Post, PhD
Journal: Blood
Blood (2015) 126 (23): 439.
https://doi.org/10.1182/blood.V126.23.439.439
Published: 2015